{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:28:25Z","timestamp":1778185705045,"version":"3.51.4"},"reference-count":33,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.3892\/mmr.2016.6031","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T03:02:57Z","timestamp":1481511777000},"page":"169-179","source":"Crossref","is-referenced-by-count":34,"title":["Midazolam anesthesia protects neuronal cells from oxidative stress-induced death via activation of the JNK-ERK pathway"],"prefix":"10.3892","volume":"15","author":[{"given":"Jing-Yu","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Shan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2016,12,12]]},"reference":[{"key":"key20180108015659_b1-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.toxlet.2009.10.017","article-title":"The effect of midazolam on mouse Leydig cell steroidogenesis and apoptosis","volume":"192","author":"So","year":"2010","journal-title":"Toxicol Lett"},{"key":"key20180108015659_b2-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1523\/JNEUROSCI.23-03-00876.2003","article-title":"Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits","volume":"23","author":"Jevtovic-Todorovic","year":"2003","journal-title":"J Neurosci"},{"key":"key20180108015659_b3-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/ALN.0b013e31819b602b","article-title":"Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system","volume":"110","author":"Head","year":"2009","journal-title":"Anesthesiology"},{"key":"key20180108015659_b4-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1097\/00000542-200505000-00016","article-title":"Clinically relevant concentrations of propofol but not midazolam alter in vitro dendritic development of isolated gamma-aminobutyric acid-positive interneurons","volume":"102","author":"Vutskits","year":"2005","journal-title":"Anesthesiology"},{"key":"key20180108015659_b5-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/ALN.0b013e31819c463d","article-title":"Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats","volume":"110","author":"Stratmann","year":"2009","journal-title":"Anesthesiology"},{"key":"key20180108015659_b6-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/ALN.0b013e3181dcd71c","article-title":"Effects of intrathecal ketamine in the neonatal rat: Evaluation of apoptosis and long-term functional outcome","volume":"113","author":"Walker","year":"2010","journal-title":"Anesthesiology"},{"key":"key20180108015659_b7-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/ALN.0b013e3181cd7942","article-title":"Volatile anesthetics rapidly increase dendritic spine density in the rat medial prefrontal cortex during synaptogenesis","volume":"112","author":"Briner","year":"2010","journal-title":"Anesthesiology"},{"key":"key20180108015659_b8-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"e7043","DOI":"10.1371\/journal.pone.0007043","article-title":"Anesthetics rapidly promote synaptogenesis during a critical period of brain development","volume":"4","author":"De Roo","year":"2009","journal-title":"PLoS One"},{"key":"key20180108015659_b9-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1097\/ALN.0b013e31821b5729","article-title":"Spinal anesthesia in infant rats: Development of a model and assessment of neurologic outcomes","volume":"114","author":"Yahalom","year":"2011","journal-title":"Anesthesiology"},{"key":"key20180108015659_b10-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/toxsci\/kfh224","article-title":"Developmental neurotoxicity of ketamine: Morphometric confirmation, exposure parameters, and multiple fluorescent labeling of apoptotic neurons","volume":"81","author":"Scallet","year":"2004","journal-title":"Toxicol Sci"},{"key":"key20180108015659_b11-mmr-15-01-0169","first-page":"8","article-title":"Propofol protects against ischemia\/reperfusion injury associated with reduced apoptosis in rat liver","author":"Abdel-Wahab","year":"2013","journal-title":"ISRN Anesthesiology 2013"},{"key":"key20180108015659_b12-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"18986","DOI":"10.1074\/jbc.M108084200","article-title":"Enhancement of hyperthermia-induced apoptosis by local anesthetics on human histiocytic lymphoma U937 cells","volume":"277","author":"Arai","year":"2002","journal-title":"J Biol Chem"},{"key":"key20180108015659_b13-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s10059-013-0050-9","article-title":"Midazolam induces cellular apoptosis in human cancer cells and inhibits tumor growth in xenograft mice","volume":"36","author":"Mishra","year":"2013","journal-title":"Mol Cells"},{"key":"key20180108015659_b14-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/sj.bjp.0706301","article-title":"Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain","volume":"146","author":"Young","year":"2005","journal-title":"Br J Pharmacol"},{"key":"key20180108015659_b15-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/AAP.0b013e318217a6c7","article-title":"Midazolam activates the intrinsic pathway of apoptosis independent of benzodiazepine and death receptor signaling","volume":"36","author":"Stevens","year":"2011","journal-title":"Reg Anesth Pain Med"},{"key":"key20180108015659_b16-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0197-0186(01)00118-8","article-title":"Peripheral benzodiazepine receptors and mitochondrial function","volume":"40","author":"Casellas","year":"2002","journal-title":"Neurochem Int"},{"key":"key20180108015659_b17-mmr-15-01-0169","first-page":"2761","article-title":"Mouse model of middle cerebral artery occlusion","volume":"pii","author":"Chiang","year":"2011","journal-title":"J Vis Exp"},{"key":"key20180108015659_b18-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"key20180108015659_b19-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108015659_b20-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.nbd.2005.12.015","article-title":"Neuroapoptosis in the infant mouse brain triggered by a transient small increase in blood alcohol concentration","volume":"22","author":"Young","year":"2006","journal-title":"Neurobiol Dis"},{"key":"key20180108015659_b21-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0006-8993(99)01228-7","article-title":"Glutathione depletion and neuronal cell death: The role of reactive oxygen intermediates and mitochondrial function","volume":"826","author":"W\u00fcllner","year":"1999","journal-title":"Brain Res"},{"key":"key20180108015659_b22-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.freeradbiomed.2004.02.013","article-title":"Reactive oxygen species induce different cell death mechanisms in cultured neurons","volume":"36","author":"Valencia","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"key20180108015659_b23-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/bja\/aet015","article-title":"Symptomatic local anaesthetic toxicity and plasma ropivacaine concentrations after transversus abdominis plane block for Caesarean section","volume":"110","author":"Griffiths","year":"2013","journal-title":"Br J Anaesth"},{"key":"key20180108015659_b24-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1213\/01.ANE.0000155960.61157.12","article-title":"The comparative neurotoxicity of intrathecal lidocaine and bupivacaine in rats","volume":"101","author":"Sakura","year":"2005","journal-title":"Anesth Analg"},{"key":"key20180108015659_b25-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.3109\/02699052.2014.947624","article-title":"An in vitro study of the neuroprotective effect of propofol on hypoxic hippocampal slice","volume":"28","author":"Zhang","year":"2014","journal-title":"Brain Inj"},{"key":"key20180108015659_b26-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/ANA.0b013e31828c6af5","article-title":"Propofol attenuates cerebral ischemia\/reperfusion injury partially using heme oxygenase-1","volume":"25","author":"Liang","year":"2013","journal-title":"J Neurosurg Anesthesiol"},{"key":"key20180108015659_b27-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3233\/JAD-132792","article-title":"Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice","volume":"41","author":"Shao","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"key20180108015659_b28-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cbi.2009.05.010","article-title":"Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells","volume":"181","author":"Shi","year":"2009","journal-title":"Chem Biol Interact"},{"key":"key20180108015659_b29-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s10571-009-9411-5","article-title":"Protective effects of resveratrol and quercetin against MPP+ -induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons","volume":"29","author":"Bournival","year":"2009","journal-title":"Cell Mol Neurobiol"},{"key":"key20180108015659_b30-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4097\/kjae.2012.62.2.166","article-title":"Midazolam protects B35 neuroblastoma cells through Akt-phosphorylation in reactive oxygen species derived cellular injury","volume":"62","author":"Chong","year":"2012","journal-title":"Korean J Anesthesiol"},{"key":"key20180108015659_b31-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0304-3940(00)01229-5","article-title":"Neuroprotection by MAPK\/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons","volume":"288","author":"Satoh","year":"2000","journal-title":"Neurosci Lett"},{"key":"key20180108015659_b32-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"12200","DOI":"10.1074\/jbc.275.16.12200","article-title":"Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures","volume":"275","author":"Stanciu","year":"2000","journal-title":"J Biol Chem"},{"key":"key20180108015659_b33-mmr-15-01-0169","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.bbamcr.2006.10.001","article-title":"Roles of the Raf\/MEK\/ERK pathway in cell growth, malignant transformation and drug resistance","volume":"1773","author":"McCubrey","year":"2007","journal-title":"Biochim Biophys Acta"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.6031\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T08:16:30Z","timestamp":1568621790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.6031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,12]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,12]]},"published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.3892\/mmr.2016.6031"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.6031","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,12]]}}}