{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:57:53Z","timestamp":1789610273735,"version":"build-2803163510"},"reference-count":29,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.3892\/mmr.2016.6065","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T10:42:49Z","timestamp":1482403369000},"page":"689-695","source":"Crossref","is-referenced-by-count":53,"title":["Tim-3 is upregulated in human colorectal carcinoma and associated with tumor progression"],"prefix":"10.3892","volume":"15","author":[{"given":"Muming","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yancun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Me","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,12,22]]},"reference":[{"key":"key20180108015504_b1-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics, 2013","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"key20180108015504_b2-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/1746-1596-8-199","article-title":"Hypermethylation of EDNRB promoter contributes to the risk of colorectal cancer","volume":"8","author":"Chen","year":"2013","journal-title":"Diagn Pathol"},{"key":"key20180108015504_b3-mmr-15-02-0689","first-page":"6988","article-title":"Up-regulated miR-155-5p promotes cell proliferation, invasion and metastasis in colorectal carcinoma","volume":"8","author":"Qu","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"key20180108015504_b4-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.1016\/S1470-2045(14)70263-3","article-title":"Cancer-related inflammation and treatment effectiveness","volume":"15","author":"Diakos","year":"2014","journal-title":"Lancet Oncol"},{"key":"key20180108015504_b5-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"key20180108015504_b6-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"key20180108015504_b7-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta14320","article-title":"Chemoprevention of colorectal cancer: Systematic review and economic evaluation","volume":"14","author":"Cooper","year":"2010","journal-title":"Health Technol Assess"},{"key":"key20180108015504_b8-mmr-15-02-0689","first-page":"7407","article-title":"Post-operative aspirin use and colorectal cancer-specific survival in patients with stage I\u2013III colorectal cancer","volume":"34","author":"Goh","year":"2014","journal-title":"Anticancer Res"},{"key":"key20180108015504_b9-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1056\/NEJMoa051424","article-title":"Effector memory T cells, early metastasis, and survival in colorectal cancer","volume":"353","author":"Pag\u00e8s","year":"2005","journal-title":"N Engl J Med"},{"key":"key20180108015504_b10-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1200\/JCO.2010.30.5425","article-title":"Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction","volume":"29","author":"Mlecnik","year":"2011","journal-title":"J Clin Oncol"},{"key":"key20180108015504_b11-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/sj.bjc.6601757","article-title":"Evaluation of a cumulative prognostic score based on the systemic inflammatory response in patients undergoing potentially curative surgery for colorectal cancer","volume":"90","author":"Canna","year":"2004","journal-title":"Br J Cancer"},{"key":"key20180108015504_b12-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/bjc.2013.330","article-title":"Comparison of the prognostic value of longitudinal measurements of systemic inflammation in patients undergoing curative resection of colorectal cancer","volume":"109","author":"Guthrie","year":"2013","journal-title":"Br J Cancer"},{"key":"key20180108015504_b13-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ni988","article-title":"Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance","volume":"4","author":"Sabatos","year":"2003","journal-title":"Nat Immunol"},{"key":"key20180108015504_b14-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/415536a","article-title":"Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease","volume":"415","author":"Monney","year":"2002","journal-title":"Nature"},{"key":"key20180108015504_b15-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3892\/ol.2016.4774","article-title":"TIM-3 expression in lymphoma cells predicts chemoresistance in patients with adult T-cell leukemia\/lymphoma","volume":"12","author":"Horlad","year":"2016","journal-title":"Oncol Lett"},{"key":"key20180108015504_b16-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/CJI.0000000000000122","article-title":"Targeting PD-1 and Tim-3 pathways to reverse CD8 T-cell exhaustion and enhance ex vivo T-cell responses to autologous dendritic\/tumor vaccines","volume":"39","author":"Liu","year":"2016","journal-title":"J Immunother"},{"key":"key20180108015504_b17-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nri1111","article-title":"The TIM gene family: Emerging roles in immunity and disease","volume":"3","author":"Kuchroo","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"key20180108015504_b18-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.7314\/APJCP.2013.14.6.3897","article-title":"Prognostic value of T cell immunoglobulin mucin-3 in prostate cancer","volume":"14","author":"Piao","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"key20180108015504_b19-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"11409","DOI":"10.1007\/s13277-014-2464-1","article-title":"Analysis of Tim-3 as a therapeutic target in prostate cancer","volume":"35","author":"Piao","year":"2014","journal-title":"Tumour Biol"},{"key":"key20180108015504_b20-mmr-15-02-0689","first-page":"7029","article-title":"Distinct role of Tim-3 in systemic lupus erythematosus and clear cell renal cell carcinoma","volume":"8","author":"Zheng","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"key20180108015504_b21-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"6567","DOI":"10.1158\/0008-5472.CAN-11-1487","article-title":"Prospects for TIM3-targeted antitumor immunotherapy","volume":"71","author":"Ngiow","year":"2011","journal-title":"Cancer Res"},{"key":"key20180108015504_b22-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/sj.jid.5700616","article-title":"TIM-3 is expressed in melanoma cells and is upregulated in TGF-beta stimulated mast cells","volume":"127","author":"Wiener","year":"2007","journal-title":"J Invest Dermatol"},{"key":"key20180108015504_b23-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1136\/gutjnl-2014-307671","article-title":"Tim-3 fosters HCC development by enhancing TGF-\u03b2-mediated alternative activation of macrophages","volume":"64","author":"Yan","year":"2015","journal-title":"Gut"},{"key":"key20180108015504_b24-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1084\/jem.20100643","article-title":"Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity","volume":"207","author":"Sakuishi","year":"2010","journal-title":"J Exp Med"},{"key":"key20180108015504_b25-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"e23585","DOI":"10.1371\/journal.pone.0023585","article-title":"In vivo safety and persistence of endoribonuclease gene-transduced CD4+ T cells in cynomolgus macaques for HIV-1 gene therapy model","volume":"6","author":"Chono","year":"2011","journal-title":"PLoS One"},{"key":"key20180108015504_b26-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.2217\/pgs.15.83","article-title":"Genetic markers of recurrence in colorectal cancer","volume":"16","author":"Smolle","year":"2015","journal-title":"Pharmacogenomics"},{"key":"key20180108015504_b27-mmr-15-02-0689","first-page":"370","article-title":"Expression of TIM-3, human \u03b2-defensin-2, and FOXP3 and correlation with disease activity in pediatric crohn's disease with infliximab therapy","volume":"9","author":"Kim","year":"2015","journal-title":"Gut Liver"},{"key":"key20180108015504_b28-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/hep.26305","article-title":"MicroRNA-26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin-6-Stat3 pathway","volume":"58","author":"Yang","year":"2013","journal-title":"Hepatology"},{"key":"key20180108015504_b29-mmr-15-02-0689","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.canlet.2012.04.003","article-title":"DNA damage induces the IL-6\/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors","volume":"323","author":"Yun","year":"2012","journal-title":"Cancer Lett"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2016.6065\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T21:02:16Z","timestamp":1568667736000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2016.6065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,22]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,12,22]]},"published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.3892\/mmr.2016.6065"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2016.6065","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,22]]}}}