{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T11:02:46Z","timestamp":1772449366804,"version":"3.50.1"},"reference-count":33,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.3892\/mmr.2017.6104","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T05:21:01Z","timestamp":1483593661000},"page":"1211-1221","source":"Crossref","is-referenced-by-count":26,"title":["MicroRNA expression signature and the therapeutic effect of the microRNA-21 antagomir in hypertrophic scarring"],"prefix":"10.3892","volume":"15","author":[{"given":"Liang","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guozheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,1,5]]},"reference":[{"key":"key20180108014734_b1-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1524-4725.2008.34406.x","article-title":"Hypertrophic scars and keloids-a review of their pathophysiology, risk factors, and therapeutic management","volume":"35","author":"Wolfram","year":"2009","journal-title":"Dermatol Surg"},{"key":"key20180108014734_b2-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5455\/aces.20120218125115","article-title":"A review of the prevention and treatment of hypertrophic scars: Part II experimental studies","volume":"2","author":"Karagoz","year":"2013","journal-title":"Arch Clin Exp Surg"},{"key":"key20180108014734_b3-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/ng1590","article-title":"Identification of hundreds of conserved and nonconserved human microRNAs","volume":"37","author":"Bentwich","year":"2005","journal-title":"Nat Genet"},{"key":"key20180108014734_b4-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"E2849","DOI":"10.1073\/pnas.1505017112","article-title":"Reanalysis of 3,707 novel human microRNA candidates","volume":"112","author":"Backes","year":"2015","journal-title":"Proc Natl AcadSci USA"},{"key":"key20180108014734_b5-mmr-15-03-1211","first-page":"255","article-title":"Regulation of microRNAs in cancer metastasis","volume":"1845","author":"Bouyssou","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"key20180108014734_b6-mmr-15-03-1211","first-page":"643","article-title":"Roles of microRNA in vascular diseases in cardiac and pulmonary systems","volume":"69","author":"Lei","year":"2014","journal-title":"Pharmazie"},{"key":"key20180108014734_b7-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108014734_b8-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1038\/nprot.2007.153","article-title":"Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections","volume":"2","author":"Obernosterer","year":"2007","journal-title":"Nat Protoc"},{"key":"key20180108014734_b9-mmr-15-03-1211","first-page":"1219","article-title":"The role of the epidermis in the control of scarring: Evidence for mechanism of action for silicone gel","volume":"61","author":"Tandara","year":"2008","journal-title":"J Plast ReconstrAesthet Surg"},{"key":"key20180108014734_b10-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11010-011-1100-2","article-title":"PTEN inhibits proliferation and functions of hypertrophic scar fibroblasts","volume":"361","author":"Guo","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"key20180108014734_b11-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"e109929","DOI":"10.1371\/journal.pone.0109929","article-title":"Activation of miR-21 by STAT3 induces proliferation and suppresses apoptosis in nasopharyngeal carcinoma by targeting PTEN gene","volume":"9","author":"Ou","year":"2014","journal-title":"PLoS One"},{"key":"key20180108014734_b12-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1016\/j.ddmod.2012.08.004","article-title":"MicroRNAs are potential therapeutic targets in fibrosing kidney disease: Lessons from animal models","volume":"10","author":"Duffield","year":"2013","journal-title":"Drug Discov Today Dis Models"},{"key":"key20180108014734_b13-mmr-15-03-1211","first-page":"565","article-title":"microRNA-21 promotes cardiac fibrosis and development of heart failure with preserved left ventricular ejection fraction by up-regulating Bcl-2","volume":"7","author":"Dong","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"key20180108014734_b14-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.pmr.2011.02.002","article-title":"Hypertrophic scar","volume":"22","author":"Gabriel","year":"2011","journal-title":"Phys Med Rehabil Clin N Am"},{"key":"key20180108014734_b15-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1093\/abbs\/gmt057","article-title":"Comparative study of microRNA profiling in keloid fibroblast and annotation of differential expressed microRNAs","volume":"45","author":"Li","year":"2013","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"key20180108014734_b16-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s10875-011-9647-y","article-title":"MicroRNA expression abnormalities in limited cutaneous scleroderma and diffuse cutaneous scleroderma","volume":"32","author":"Zhu","year":"2012","journal-title":"J Clin Immunol"},{"key":"key20180108014734_b17-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3892\/ol.2014.1868","article-title":"microRNA-503 inhibits gastric cancer cell growth and epithelial-to-mesenchymal transition","volume":"7","author":"Peng","year":"2014","journal-title":"Oncol Lett"},{"key":"key20180108014734_b18-mmr-15-03-1211","first-page":"1355","article-title":"MicroRNA-34a regulates cardiac fibrosis after myocardial infarction by targeting Smad4","volume":"18","author":"Huang","year":"2014","journal-title":"Expert Opin Ther Targets"},{"key":"key20180108014734_b19-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"F793","DOI":"10.1152\/ajprenal.00273.2011","article-title":"Identification of a microRNA signature in renal fibrosis: Role of miR-21","volume":"301","author":"Zarjou","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"key20180108014734_b20-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijrobp.2014.05.003","article-title":"microRNA alterations driving acute and late stages of radiation-induced fibrosis in a murine skin model","volume":"90","author":"Simone","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180108014734_b21-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.4238\/2014.April.14.2","article-title":"Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts","volume":"13","author":"Wu","year":"2014","journal-title":"Genet Mol Res"},{"key":"key20180108014734_b22-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"e58014","DOI":"10.1371\/journal.pone.0058014","article-title":"Increased circulating miR-21 levels are associated with kidney fibrosis","volume":"8","author":"Glowacki","year":"2013","journal-title":"PLoS One"},{"key":"key20180108014734_b23-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1007\/s10875-013-9896-z","article-title":"MicroRNA-21 in scleroderma fibrosis and its function in TGF-\u03b2-regulated fibrosis-related genes expression","volume":"33","author":"Zhu","year":"2013","journal-title":"J Clin Immunol"},{"key":"key20180108014734_b24-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3892\/ijmm.2014.1712","article-title":"Expression analysis of serum microRNAs in idiopathic pulmonary fibrosis","volume":"33","author":"Li","year":"2014","journal-title":"Int J Mol Med"},{"key":"key20180108014734_b25-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/cvr\/cvq196","article-title":"miR-21: A miRaculous Socratic paradox","volume":"87","author":"da Costa Martins","year":"2010","journal-title":"Cardiovasc Res"},{"key":"key20180108014734_b26-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/j.ajpath.2012.08.022","article-title":"miR-21 regulates skin wound healing by targeting multiple aspects of the healing process","volume":"181","author":"Wang","year":"2012","journal-title":"Am J Pathol"},{"key":"key20180108014734_b27-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"371","DOI":"10.5732\/cjc.30.0371","article-title":"Apoptosis and the target genes of microRNA-21","volume":"30","author":"Buscaglia","year":"2011","journal-title":"Chin J Cancer"},{"key":"key20180108014734_b28-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/00006534-199709000-00021","article-title":"Acute and chronic animal models for excessive dermal scarring: Quantitative studies","volume":"100","author":"Morris","year":"1997","journal-title":"Plast Reconstr Surg"},{"key":"key20180108014734_b29-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1165\/rcmb.2006-0227TR","article-title":"Regulation of microRNA by antagomirs: A new class of pharmacological antagonists for the specific regulation of gene function?","volume":"36","author":"Mattes","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key20180108014734_b30-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1084\/jem.20100035","article-title":"miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis","volume":"207","author":"Liu","year":"2010","journal-title":"J Exp Med"},{"key":"key20180108014734_b31-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ccr.2010.08.013","article-title":"Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21","volume":"18","author":"Hatley","year":"2010","journal-title":"Cancer Cell"},{"key":"key20180108014734_b32-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1038\/jid.2011.156","article-title":"Loss of PTEN expression by dermal fibroblasts causes skin fibrosis","volume":"131","author":"Parapuram","year":"2011","journal-title":"J Invest Dermatol"},{"key":"key20180108014734_b33-mmr-15-03-1211","doi-asserted-by":"crossref","first-page":"e97114","DOI":"10.1371\/journal.pone.0097114","article-title":"MicroRNA-21 regulates hTERT via PTEN in hypertrophic scar fibroblasts","volume":"9","author":"Zhu","year":"2014","journal-title":"PLoS One"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2017.6104\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T01:10:43Z","timestamp":1568682643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.6104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,5]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,1,5]]},"published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.3892\/mmr.2017.6104"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.6104","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,5]]}}}