{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:27:03Z","timestamp":1792106823356,"version":"4.4.0"},"reference-count":36,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.3892\/mmr.2017.6168","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T06:50:02Z","timestamp":1486363802000},"page":"1539-1546","source":"Crossref","is-referenced-by-count":46,"title":["Estrogen stimulates osteoprotegerin expression via the suppression of miR-145 expression in MG-63 cells"],"prefix":"10.3892","volume":"15","author":[{"given":"Jun","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengxing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiantie","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"key20180108015035_b1-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: Now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"key20180108015035_b2-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s00198-008-0609-z","article-title":"Sex hormones, their receptors and bone health","volume":"19","author":"Venken","year":"2008","journal-title":"Osteoporos Int"},{"key":"key20180108015035_b3-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.metabol.2015.07.011","article-title":"Novel therapies for osteoporosis","volume":"64","author":"Makras","year":"2015","journal-title":"Metabolism"},{"key":"key20180108015035_b4-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1677\/joe.0.1710425","article-title":"Estrogen receptor alpha, but not estrogen receptor beta, is involved in the regulation of the OPG\/RANKL (osteoprotegerin\/receptor activator of NF-kappa B ligand) ratio and serum interleukin-6 in male mice","volume":"171","author":"Lindberg","year":"2001","journal-title":"J Endocrinol"},{"key":"key20180108015035_b5-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of RANKL\/RANK\/OPG in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"key20180108015035_b6-mmr-15-04-1539","first-page":"209","article-title":"Rank\/Rankl\/opg: Literature review","volume":"36","author":"Silva","year":"2011","journal-title":"Acta Reumatol Port"},{"key":"key20180108015035_b7-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrd3705","article-title":"Bench to bedside: Elucidation of the OPG-RANK-RANKL pathway and the development of denosumab","volume":"11","author":"Lacey","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"key20180108015035_b8-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI200317215","article-title":"Role of RANK ligand in mediating increased bone resorption in early postmenopausal women","volume":"111","author":"Eghbali-Fatourechi","year":"2003","journal-title":"J Clin Invest"},{"key":"key20180108015035_b9-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/emm.2002.49","article-title":"Osteoprotegerin is present on the membrane of osteoclasts isolated from mouse long bones","volume":"34","author":"Woo","year":"2002","journal-title":"Exp Mol Med"},{"key":"key20180108015035_b10-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1359\/JBMR.040604","article-title":"1 Alpha, 25 dihydroxyvitamin D3 rapidly regulates the mouse osteoprotegerin gene through dual pathways","volume":"19","author":"Kondo","year":"2004","journal-title":"J Bone Miner Res"},{"key":"key20180108015035_b11-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/36593","article-title":"A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function","volume":"390","author":"Anderson","year":"1997","journal-title":"Nature"},{"key":"key20180108015035_b12-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1073\/pnas.96.7.3540","article-title":"Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand","volume":"96","author":"Hsu","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108015035_b13-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1210\/endo.140.9.7131","article-title":"Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells","volume":"140","author":"Hofbauer","year":"1999","journal-title":"Endocrinology"},{"key":"key20180108015035_b14-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S8756-3282(02)00953-5","article-title":"The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts","volume":"32","author":"Bord","year":"2003","journal-title":"Bone"},{"key":"key20180108015035_b15-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1210\/endo.142.6.8220","article-title":"17beta-estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-alpha","volume":"142","author":"Saika","year":"2001","journal-title":"Endocrinology"},{"key":"key20180108015035_b16-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s10266-014-0178-x","article-title":"Estradiol induces osteoprotegerin expression by human dental pulp cells","volume":"104","author":"Manokawinchoke","year":"2016","journal-title":"Odontology"},{"key":"key20180108015035_b17-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1359\/jbmr.2001.16.2.348","article-title":"The effect of a single dose of osteoprotegerin in postmenopausal women","volume":"16","author":"Bekker","year":"2001","journal-title":"J Bone Miner Res"},{"key":"key20180108015035_b18-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1359\/JBMR.050803","article-title":"Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption","volume":"20","author":"Michael","year":"2005","journal-title":"J Bone Miner Res"},{"key":"key20180108015035_b19-mmr-15-04-1539","first-page":"S17","article-title":"Identification of an estrogen response element in the osteoprotegerin promoter","volume":"33","author":"Rumpler","journal-title":"Bone"},{"key":"key20180108015035_b20-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"key20180108015035_b21-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.bone.2015.05.026","article-title":"Non-coding RNAs: Epigenetic regulators of bone development and homeostasis","volume":"81","author":"Hassan","year":"2015","journal-title":"Bone"},{"key":"key20180108015035_b22-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1016\/j.febslet.2013.07.030","article-title":"MiR-145 suppresses osteogenic differentiation by targeting Sp7","volume":"587","author":"Jia","year":"2013","journal-title":"FEBS Lett"},{"key":"key20180108015035_b23-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1016\/j.febslet.2015.09.024","article-title":"MicroRNA-145 regulates osteoblastic differentiation by targeting the transcription factor Cbfb","volume":"589","author":"Fukuda","year":"2015","journal-title":"FEBS Lett"},{"key":"key20180108015035_b24-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/jbmr.1798","article-title":"Tumor necrosis factor \u03b1 suppresses the mesenchymal stem cell osteogenesis promoter miR-21 in estrogen deficiency-induced osteoporosis","volume":"28","author":"Yang","year":"2013","journal-title":"J Bone Miner Res"},{"key":"key20180108015035_b25-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/jbmr.2032","article-title":"MiR-503 regulates osteoclastogenesis via targeting RANK","volume":"29","author":"Chen","year":"2014","journal-title":"J Bone Miner Res"},{"key":"key20180108015035_b26-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"27343","DOI":"10.18632\/oncotarget.4398","article-title":"Inhibition of miR-21 restores RANKL\/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts","volume":"6","author":"Pitari","year":"2015","journal-title":"Oncotarget"},{"key":"key20180108015035_b27-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108015035_b28-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.physiol.70.113006.100518","article-title":"Estrogen signaling through the transmembrane G protein-coupled receptor GPR30","volume":"70","author":"Prossnitz","year":"2008","journal-title":"Annu Rev Physiol"},{"key":"key20180108015035_b29-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.steroids.2005.04.011","article-title":"Changes in RANKL\/OPG\/RANK gene expression in peripheral mononuclear cells following treatment with estrogen or raloxifene","volume":"70","author":"Bashir","year":"2005","journal-title":"Steroids"},{"key":"key20180108015035_b30-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bbrc.2008.01.118","article-title":"17beta-Estradiol inhibits osteoprotegerin production by the estrogen receptor-alpha-positive human breast cancer cell line MCF-7","volume":"368","author":"Rachner","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108015035_b31-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"15732","DOI":"10.1073\/pnas.0906947106","article-title":"The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response","volume":"106","author":"Castellano","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108015035_b32-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2174\/138920209788185289","article-title":"Estrogen regulation of MicroRNA expression","volume":"10","author":"Klinge","year":"2009","journal-title":"Curr Genomics"},{"key":"key20180108015035_b33-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.mce.2015.01.035","article-title":"miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets","volume":"418","author":"Klinge","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"key20180108015035_b34-mmr-15-04-1539","first-page":"170","article-title":"miR-145-mediated suppression of cell growth, invasion and metastasis","volume":"2","author":"Sachdeva","year":"2010","journal-title":"Am J Transl Res"},{"key":"key20180108015035_b35-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.3892\/ol.2012.866","article-title":"Changes in microRNA expression in the MG-63 osteosarcoma cell line compared with osteoblasts","volume":"4","author":"Hu","year":"2012","journal-title":"Oncol Lett"},{"key":"key20180108015035_b36-mmr-15-04-1539","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.1007\/s13277-014-2031-9","article-title":"MiR-145 inhibits osteosarcoma cells proliferation and invasion by targeting ROCK1","volume":"35","author":"Li","year":"2014","journal-title":"Tumour Biol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2017.6168\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T08:56:55Z","timestamp":1568797015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.6168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,6]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,2,6]]},"published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.3892\/mmr.2017.6168"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.6168","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,6]]}}}