{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:27:38Z","timestamp":1784903258198,"version":"3.55.0"},"reference-count":44,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.3892\/mmr.2017.6190","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T13:06:09Z","timestamp":1486731969000},"page":"1925-1935","source":"Crossref","is-referenced-by-count":30,"title":["Expression profile of BAFF in peripheral blood from patients of IgA nephropathy: Correlation with clinical features and Streptococcus pyogenes infection"],"prefix":"10.3892","volume":"15","author":[{"given":"Nuoyan","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinning","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongqiong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"key":"key20180108015028_b1-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.semnephrol.2011.06.006","article-title":"Primary IgA nephropathy: New insights into pathogenesis","volume":"31","author":"Barratt","year":"2011","journal-title":"Semin Nephrol"},{"key":"key20180108015028_b2-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1136\/jcp.49.1.38","article-title":"Increased dimeric IgA producing B cells in the bone marrow in IgA nephropathy determined by in situ hybridisation for J chain mRNA","volume":"49","author":"Harper","year":"1996","journal-title":"J Clin Pathol"},{"key":"key20180108015028_b3-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/ki.2011.501","article-title":"An update on the pathogenesis and treatment of IgA nephropathy","volume":"81","author":"Boyd","year":"2012","journal-title":"Kidney Int"},{"key":"key20180108015028_b4-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/ndt\/gfs467","article-title":"Experimental evidence of cell dissemination playing a role in pathogenesis of IgA nephropathy in multiple lymphoid organs","volume":"28","author":"Nakata","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"key20180108015028_b5-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1359-6101(03)00023-6","article-title":"The TNF family members BAFF and APRIL: The growing complexity","volume":"14","author":"Mackay","year":"2003","journal-title":"Cytokine Growth Factor Rev"},{"key":"key20180108015028_b6-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0952-7915(02)00332-1","article-title":"BAFFled B cells survive and thrive: Roles of BAFF in B-cell development","volume":"14","author":"Rolink","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"key20180108015028_b7-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.4049\/jimmunol.175.5.2814","article-title":"B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells","volume":"175","author":"Yang","year":"2005","journal-title":"J Immunol"},{"key":"key20180108015028_b8-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1172\/JCI45563","article-title":"Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy","volume":"121","author":"Mccarthy","year":"2011","journal-title":"J Clin Invest"},{"key":"key20180108015028_b9-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1073\/pnas.0307348101","article-title":"Impaired IgA class switching in APRIL-deficient mice","volume":"101","author":"Castigli","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108015028_b10-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/ng.1047","article-title":"A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy","volume":"44","author":"Yu","year":"2011","journal-title":"Nat Genet"},{"key":"key20180108015028_b11-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1084\/jem.189.11.1747","article-title":"BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth","volume":"189","author":"Schneider","year":"1999","journal-title":"J Exp Med"},{"key":"key20180108015028_b12-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"38220","DOI":"10.1074\/jbc.M306852200","article-title":"DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF","volume":"278","author":"Gavin","year":"2003","journal-title":"J Biol Chem"},{"key":"key20180108015028_b13-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.smim.2006.04.006","article-title":"BAFF, APRIL and their receptors: Structure, function and signaling","volume":"18","author":"Bossen","year":"2006","journal-title":"Semin Immunol"},{"key":"key20180108015028_b14-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nri2572","article-title":"Cracking the BAFF code","volume":"9","author":"Mackay","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"key20180108015028_b15-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/icb.2011.111","article-title":"BAFF and innate immunity: New therapeutic targets for systemic lupus erythematosus","volume":"90","author":"Vincent","year":"2012","journal-title":"Immunol Cell Biol"},{"key":"key20180108015028_b16-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2177\/jsci.28.333","article-title":"The role of BAFF in autoimmune diseases","volume":"28","author":"Matsushita","year":"2005","journal-title":"Nihon Rinsho Meneki Gakkai Kaishi"},{"key":"key20180108015028_b17-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/rheumatology\/ker282","article-title":"Increased levels of BAFF in patients with systemic lupus erythematosus are associated with acute-phase reactants, independent of BAFF genetics: A case-control study","volume":"50","author":"Eilertsen","year":"2011","journal-title":"Rheumatology (Oxford)"},{"key":"key20180108015028_b18-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/art.21526","article-title":"Elevated serum BAFF levels in patients with systemic sclerosis: Enhanced BAFF signaling in systemic sclerosis B lymphocytes","volume":"54","author":"Matsushita","year":"2006","journal-title":"Arthritis Rheum"},{"key":"key20180108015028_b19-mmr-15-04-1925","first-page":"1256","article-title":"Concentrations of BAFF correlate with autoantibody levels, clinical disease activity, and response to treatment in early rheumatoid arthritis","volume":"35","author":"Bosello","year":"2008","journal-title":"J Rheumatol"},{"key":"key20180108015028_b20-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/ard.62.2.168","article-title":"The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sj\u00f6gren's syndrome","volume":"62","author":"Mariette","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"key20180108015028_b21-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1196\/annals.1313.004","article-title":"BAFF overexpression is associated with autoantibody production in autoimmune diseases","volume":"1050","author":"Pers","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"key20180108015028_b22-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2249.2009.04007.x","article-title":"BAFF: A local and systemic target in autoimmune diseases","volume":"158","author":"Moisini","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"key20180108015028_b23-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"683","DOI":"10.5301\/jn.5000218","article-title":"Serum BAFF is elevated in patients with IgA nephropathy and associated with clinical and histopathological features","volume":"26","author":"Xin","year":"2013","journal-title":"J Nephrol"},{"key":"key20180108015028_b24-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3892\/mmr.2014.2359","article-title":"TLR9 and BAFF: Their expression in patients with IgA nephropathy","volume":"10","author":"Li","year":"2014","journal-title":"Mol Med Rep"},{"key":"key20180108015028_b25-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cellimm.2006.08.002","article-title":"BAFF induces a hyper-IgA syndrome in the intestinal lamina propria concomitant with IgA deposition in the kidney independent of LIGHT","volume":"241","author":"Mccarthy","year":"2006","journal-title":"Cell Immunol"},{"key":"key20180108015028_b26-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/ki.2009.243","article-title":"The Oxford classification of IgA nephropathy: Rationale, clinicopathological correlations, and classification","volume":"76","author":"Working Group of the International IgA Nephropathy Network and the Renal Pathology Society","year":"2009","journal-title":"Kidney Int"},{"key":"key20180108015028_b27-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1007\/s10157-012-0613-7","article-title":"Overweight and obesity accelerate the progression of IgA nephropathy: Prognostic utility of a combination of BMI and histopathological parameters","volume":"16","author":"Kataoka","year":"2012","journal-title":"Clin Exp Nephrol"},{"key":"key20180108015028_b28-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108015028_b29-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.resmic.2005.01.010","article-title":"Rapid identification of Streptococcus pyogenes with PCR primers from a putative transcriptional regulator gene","volume":"156","author":"Liu","year":"2005","journal-title":"Res Microbiol"},{"key":"key20180108015028_b30-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1158\/0008-5472.CAN-10-0300","article-title":"A functional receptor for B-cell-activating factor is expressed on human acute lymphoblastic leukemias","volume":"70","author":"Parameswaran","year":"2010","journal-title":"Cancer Res"},{"key":"key20180108015028_b31-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1182\/blood.V97.1.198","article-title":"Synthesis and release of B-lymphocyte stimulator from myeloid cells","volume":"97","author":"Nardelli","year":"2001","journal-title":"Blood"},{"key":"key20180108015028_b32-mmr-15-04-1925","first-page":"1041","article-title":"Changes of serum BAFF and IL-21 levels in patients with systemic lupus erythematosus and their clinical significance","volume":"23","author":"Wang","year":"2007","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"key20180108015028_b33-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1177\/0961203313496302","article-title":"Association of serum B cell activating factor from the tumour necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) with central nervous system and renal disease in systemic lupus erythematosus","volume":"22","author":"Vincent","year":"2013","journal-title":"Lupus"},{"key":"key20180108015028_b34-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1128\/CMR.13.3.470-511.2000","article-title":"Pathogenesis of group A streptococcal infections","volume":"13","author":"Cunningham","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"key20180108015028_b35-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/intimm\/dxh043","article-title":"BAFF production by antigen-presenting cells provides T cell co-stimulation","volume":"16","author":"Huard","year":"2004","journal-title":"Int Immunol"},{"key":"key20180108015028_b36-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.coi.2005.04.005","article-title":"The role of APRIL and BAFF in lymphocyte activation","volume":"17","author":"Schneider","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"key20180108015028_b37-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000440819","article-title":"Synthetic double-stranded RNA Poly (I:C) aggravates IgA nephropathy by triggering IgA class switching recombination through the TLR3-BAFF axis","volume":"42","author":"He","year":"2015","journal-title":"Am J Nephrol"},{"key":"key20180108015028_b38-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"608","DOI":"10.2353\/ajpath.2010.090428","article-title":"Tissue deposits of IgA-binding streptococcal M proteins in IgA nephropathy and Henoch-Schonlein purpura","volume":"176","author":"Schmitt","year":"2010","journal-title":"Am J Pathol"},{"key":"key20180108015028_b39-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/ndt\/15.6.772","article-title":"Streptococcal M protein enhances TGF-beta production and increases surface IgA-positive B cells in vitro in IgA nephropathy","volume":"15","author":"Nishikawa","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"key20180108015028_b40-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00011-011-0347-0","article-title":"Expression of IgA class switching gene in tonsillar mononuclear cells in patients with IgA nephropathy","volume":"60","author":"Liu","year":"2011","journal-title":"Inflamm Res"},{"key":"key20180108015028_b41-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1002\/art.24628","article-title":"Systemic activation of the immune system induces aberrant BAFF and APRIL expression in B cells in patients with systemic lupus erythematosus","volume":"60","author":"Chu","year":"2009","journal-title":"Arthritis Rheum"},{"key":"key20180108015028_b42-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"e22202","DOI":"10.1371\/journal.pone.0022202","article-title":"The expression of BAFF, APRIL and TWEAK is altered in eczema skin but not in the circulation of atopic and seborrheic eczema patients","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"key":"key20180108015028_b43-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/03009740701286615","article-title":"Expression of BAFF and BAFF-R in the synovial tissue of patients with rheumatoid arthritis","volume":"36","author":"Nakajima","year":"2007","journal-title":"Scand J Rheumatol"},{"key":"key20180108015028_b44-mmr-15-04-1925","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1002\/art.11354","article-title":"B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: Longitudinal observations","volume":"48","author":"Stohl","year":"2003","journal-title":"Arthritis Rheum"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2017.6190\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T03:44:44Z","timestamp":1515383084000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.6190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,10]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,2,10]]},"published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.3892\/mmr.2017.6190"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.6190","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,10]]}}}