{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:11:28Z","timestamp":1759741888856},"reference-count":46,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.3892\/mmr.2017.6291","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T09:45:32Z","timestamp":1488879932000},"page":"2521-2529","source":"Crossref","is-referenced-by-count":10,"title":["p75 neurotrophin receptor: A potential surface marker of tongue squamous cell carcinoma stem cells"],"prefix":"10.3892","volume":"15","author":[{"given":"Dongdong","family":"Tong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenghe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"key20180108015350_b1-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.oraloncology.2008.06.002","article-title":"Global epidemiology of oral and oropharyngeal cancer","volume":"45","author":"Warnakulasuriya","year":"2009","journal-title":"Oral Oncol"},{"key":"key20180108015350_b2-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1126\/science.560061","article-title":"Primary bioassay of human tumor stem cells","volume":"197","author":"Hamburger","year":"1977","journal-title":"Science"},{"key":"key20180108015350_b3-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","article-title":"Stem cells, cancer, and cancer stem cells","volume":"414","author":"Reya","year":"2001","journal-title":"Nature"},{"key":"key20180108015350_b4-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature03128","article-title":"Identification of human brain tumour initiating cells","volume":"432","author":"Singh","year":"2004","journal-title":"Nature"},{"key":"key20180108015350_b5-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1601-0825.2006.01264.x","article-title":"Cancer stem cells - new and potentially important targets for the therapy of oral squamous cell carcinoma","volume":"12","author":"Costea","year":"2006","journal-title":"Oral Dis"},{"key":"key20180108015350_b6-mmr-15-05-2521","first-page":"5821","article-title":"Identification of a cancer stem cell in human brain tumors","volume":"63","author":"Singh","year":"2003","journal-title":"Cancer Res"},{"key":"key20180108015350_b7-mmr-15-05-2521","first-page":"729","article-title":"Cancer stem cell characteristics in retinoblastoma","volume":"11","author":"Seigel","year":"2005","journal-title":"Mol Vis"},{"key":"key20180108015350_b8-mmr-15-05-2521","first-page":"165","article-title":"Cancer stem cells and individualized therapy","volume":"4","author":"Chumsri","year":"2007","journal-title":"Cancer Genomics Proteomics"},{"key":"key20180108015350_b9-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"8944","DOI":"10.1158\/0008-5472.CAN-05-0931","article-title":"Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines","volume":"65","author":"Locke","year":"2005","journal-title":"Cancer Res"},{"key":"key20180108015350_b10-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1087-0024.2004.09310.x","article-title":"Intrinsic patterns of behavior of epithelial stem cells","volume":"9","author":"Tudor","year":"2004","journal-title":"J Investig Dermatol Symp Proc"},{"key":"key20180108015350_b11-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrc1590","article-title":"Tumour stem cells and drug resistance","volume":"5","author":"Dean","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"key20180108015350_b12-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s10147-011-0358-4","article-title":"Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma","volume":"18","author":"Kiyosue","year":"2013","journal-title":"Int J Clin Oncol"},{"key":"key20180108015350_b13-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1359-6101(03)00018-2","article-title":"Ten years on: Mediation of cell death by the common neurotrophin receptor p75(NTR)","volume":"14","author":"Rabizadeh","year":"2003","journal-title":"Cytokine Growth Factor Rev"},{"key":"key20180108015350_b14-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1093\/emboj\/16.16.4999","article-title":"NMR structure of the death domain of the p75 neurotrophin receptor","volume":"16","author":"Liepinsh","year":"1997","journal-title":"EMBO J"},{"key":"key20180108015350_b15-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/j.1460-2075.1992.tb05130.x","article-title":"Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor","volume":"11","author":"Rodr\u00edguez-T\u00e9bar","year":"1992","journal-title":"EMBO J"},{"key":"key20180108015350_b16-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"33812","DOI":"10.1074\/jbc.M010548200","article-title":"Characterization of a p75(NTR) apoptotic signaling pathway using a novel cellular model","volume":"276","author":"Wang","year":"2001","journal-title":"J Biol Chem"},{"key":"key20180108015350_b17-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1074\/jbc.C000815200","article-title":"Inhibition of JNK by overexpression of the JNL binding domain of JIP-1 prevents apoptosis in sympathetic neurons","volume":"276","author":"Harding","year":"2001","journal-title":"J Biol Chem"},{"key":"key20180108015350_b18-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1523\/JNEUROSCI.20-09-03104.2000","article-title":"Involvement of retinoblastoma family members and E2F\/DP complexes in the death of neurons evoked by DNA damage","volume":"20","author":"Park","year":"2000","journal-title":"J Neurosci"},{"key":"key20180108015350_b19-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"48043","DOI":"10.1074\/jbc.M205324200","article-title":"NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway","volume":"277","author":"Salehi","year":"2002","journal-title":"J Biol Chem"},{"key":"key20180108015350_b20-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijc.10160","article-title":"Neurotrophin receptor p75(NTR) suppresses growth and nerve growth factor-mediated metastasis of human prostate cancer cells","volume":"98","author":"Krygier","year":"2002","journal-title":"Int J Cancer"},{"key":"key20180108015350_b21-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/mc.10106","article-title":"Inhibition of cell-cycle effectors of proliferation in bladder tumor epithelial cells by the p75NTR tumor suppressor","volume":"36","author":"Khwaja","year":"2003","journal-title":"Mol Carcinog"},{"key":"key20180108015350_b22-mmr-15-05-2521","first-page":"5403","article-title":"Reduced expression of the low affinity nerve growth factor receptor in benign and malignant human prostate tissue and loss of expression in four human metastatic prostate tumor cell lines","volume":"52","author":"Pflug","year":"1992","journal-title":"Cancer Res"},{"key":"key20180108015350_b23-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1038\/sj.onc.1206525","article-title":"Neurotrophin receptor p75(NTR) characterizes human esophageal keratinocyte stem cells in vitro","volume":"22","author":"Okumura","year":"2003","journal-title":"Oncogene"},{"key":"key20180108015350_b24-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1095\/biolreprod64.2.464","article-title":"Mesenchymal cell precursors of peritubular smooth muscle cells of the mouse testis can be identified by the presence of the p75 neurotrophin receptor","volume":"64","author":"Campagnolo","year":"2001","journal-title":"Biol Reprod"},{"key":"key20180108015350_b25-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jdermsci.2007.05.015","article-title":"Isolation of multipotent stem cells from mouse adipose tissue","volume":"48","author":"Yamamoto","year":"2007","journal-title":"J Dermatol Sci"},{"key":"key20180108015350_b26-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.exer.2007.09.003","article-title":"Nerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells","volume":"86","author":"Qi","year":"2008","journal-title":"Exp Eye Res"},{"key":"key20180108015350_b27-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10911-012-9258-0","article-title":"Determining mammosphere-forming potential: Application of the limiting dilution analysis","volume":"17","author":"Rota","year":"2012","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"key20180108015350_b28-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat Protoc"},{"key":"key20180108015350_b29-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/sj.cdd.4402283","article-title":"Identification and expansion of the tumorigenic lung cancer stem cell population","volume":"15","author":"Eramo","year":"2008","journal-title":"Cell Death Differ"},{"key":"key20180108015350_b30-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"10946","DOI":"10.1158\/0008-5472.CAN-05-2018","article-title":"Prospective identification of tumorigenic prostate cancer stem cells","volume":"65","author":"Collins","year":"2005","journal-title":"Cancer Res"},{"key":"key20180108015350_b31-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1053\/j.gastro.2007.04.025","article-title":"Identification and characterization of tumorigenic liver cancer stem\/progenitor cells","volume":"132","author":"Ma","year":"2007","journal-title":"Gastroenterology"},{"key":"key20180108015350_b32-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.2353\/ajpath.2007.060798","article-title":"Histological and culture studies with respect to ABCG2 expression support the existence of a cancer cell hierarchy in human hepatocellular carcinoma","volume":"170","author":"Zen","year":"2007","journal-title":"Am J Pathol"},{"key":"key20180108015350_b33-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1476-4598-6-75","article-title":"Gene expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells","volume":"6","author":"Seo","year":"2007","journal-title":"Mol Cancer"},{"key":"key20180108015350_b34-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1158\/0008-5472.CAN-06-0054","article-title":"Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells","volume":"66","author":"Liu","year":"2006","journal-title":"Cancer Res"},{"key":"key20180108015350_b35-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature05384","article-title":"Identification and expansion of human colon-cancer-initiating cells","volume":"445","author":"Ricci-Vitiani","year":"2007","journal-title":"Nature"},{"key":"key20180108015350_b36-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1158\/0008-5472.CAN-06-2030","article-title":"Identification of pancreatic cancer stem cells","volume":"67","author":"Li","year":"2007","journal-title":"Cancer Res"},{"key":"key20180108015350_b37-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1210\/en.2006-1553","article-title":"Characterization of side population in thyroid cancer cell lines: Cancer stem-like cells are enriched partly but not exclusively","volume":"148","author":"Mitsutake","year":"2007","journal-title":"Endocrinology"},{"key":"key20180108015350_b38-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nature05236","article-title":"Glioma stem cells promote radioresistance by preferential activation of the DNA damage response","volume":"444","author":"Bao","year":"2006","journal-title":"Nature"},{"key":"key20180108015350_b39-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1476-4598-5-67","article-title":"Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma","volume":"5","author":"Liu","year":"2006","journal-title":"Mol Cancer"},{"key":"key20180108015350_b40-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1593\/neo.07175","article-title":"p75 neurotrophin receptor suppresses the proliferation of human gastric cancer cells","volume":"9","author":"Jin","year":"2007","journal-title":"Neoplasia"},{"key":"key20180108015350_b41-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1002\/ijc.23356","article-title":"The p75 (NTR) neurotrophin receptor is a tumor suppressor in human and murine retinoblastoma development","volume":"122","author":"Dimaras","year":"2008","journal-title":"Int J Cancer"},{"key":"key20180108015350_b42-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.bbrc.2006.01.073","article-title":"The p75(NTR) tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells","volume":"341","author":"Khwaja","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108015350_b43-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/j.1440-1746.2006.04074.x","article-title":"Expression of nerve growth factor receptors is correlated with progression and prognosis of human pancreatic cancer","volume":"21","author":"Dang","year":"2006","journal-title":"J Gastroen Hepatol"},{"key":"key20180108015350_b44-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/jcb.10649","article-title":"p75 neurotrophin receptor functions as a survival receptor in brain-metastatic melanoma cells","volume":"91","author":"Marchetti","year":"2004","journal-title":"J Cell Biochem"},{"key":"key20180108015350_b45-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nchembio873","article-title":"Chemical genetics reveals a complex functional ground state of neural stem cells","volume":"3","author":"Diamandis","year":"2007","journal-title":"Nat Chem Biol"},{"key":"key20180108015350_b46-mmr-15-05-2521","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1365-2559.2008.03063.x","article-title":"Nerve growth factor receptor (p75 NTR) and pattern of invasion predict poor prognosis in oral squamous cell carcinoma","volume":"53","author":"Soland","year":"2008","journal-title":"Histopathology"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2017.6291\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T11:17:41Z","timestamp":1568891861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.6291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,7]]},"references-count":46,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,3,7]]},"published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.3892\/mmr.2017.6291"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.6291","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,7]]}}}