{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:05:07Z","timestamp":1790154307623,"version":"4.0.1"},"reference-count":31,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.3892\/mmr.2017.6333","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T04:40:19Z","timestamp":1489639219000},"page":"2788-2794","source":"Crossref","is-referenced-by-count":21,"title":["High glucose promotes the osteogenic differentiation capability of human periodontal ligament fibroblasts"],"prefix":"10.3892","volume":"15","author":[{"given":"Sujiwan","family":"Seubbuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hathaitip","family":"Sritanaudomchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julalux","family":"Kasetsuwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudee","family":"Surarit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,3,16]]},"reference":[{"key":"key20180108015127_b1-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1902\/annals.1998.3.1.30","article-title":"Glycemic control and alveolar bone loss progression in type 2 diabetes","volume":"3","author":"Taylor","year":"1998","journal-title":"Ann Periodontol"},{"key":"key20180108015127_b2-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1902\/jop.1998.69.1.76","article-title":"Non-insulin dependent diabetes mellitus and alveolar bone loss progression over 2 years","volume":"69","author":"Taylor","year":"1998","journal-title":"J Periodontol"},{"key":"key20180108015127_b3-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4041\/kjod.2012.42.6.307","article-title":"Differentiation and characteristics of undifferentiated mesenchymal stem cells originating from adult premolar periodontal ligaments","volume":"42","author":"Kim","year":"2012","journal-title":"Korean J Orthod"},{"key":"key20180108015127_b4-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1600-051X.2011.01716.x","article-title":"Isolation and characterization of human periodontal ligament (PDL) stem cells (PDLSCs) from the inflamed PDL tissue: In vitro and in vivo evaluations","volume":"38","author":"Park","year":"2011","journal-title":"J Clin Periodontol"},{"key":"key20180108015127_b5-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1600-0765.2006.00870.x","article-title":"Stem cell properties of human periodontal ligament cells","volume":"41","author":"Nagatomo","year":"2006","journal-title":"J Periodont Res"},{"key":"key20180108015127_b6-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s12013-012-9470-y","article-title":"High levels of glucose induced the caspase-3\/PARP signaling pathway, leading to apoptosis in human periodontal ligament fibroblasts","volume":"66","author":"Liu","year":"2013","journal-title":"Cell Biochem Biophys"},{"key":"key20180108015127_b7-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1007\/s12010-013-0287-y","article-title":"High levels of glucose induces a dose-dependent apoptosis in human periodontal ligament fibroblasts by activating caspase-3 signaling pathway","volume":"170","author":"Liu","year":"2013","journal-title":"Appl Biochem Biotechnol"},{"key":"key20180108015127_b8-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1177\/00220345960750090801","article-title":"Glucose-mediated alteration of cellular function in human periodontal ligament cells","volume":"75","author":"Nishimura","year":"1996","journal-title":"J Dent Res"},{"key":"key20180108015127_b9-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2008.08.036","article-title":"Mesenchymal stem cell-like cells derived from human gastric cancer tissues","volume":"274","author":"Cao","year":"2009","journal-title":"Cancer Lett"},{"key":"key20180108015127_b10-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1245\/s10434-009-0617-z","article-title":"Correlation of CD133, OCT4 and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy","volume":"16","author":"Saigusa","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"key20180108015127_b11-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s12015-010-9147-0","article-title":"Distinct stem cells subpopulations isolated from human adipose tissue exhibit different chondrogenic and osteogenic differentiation potential","volume":"7","author":"Rada","year":"2011","journal-title":"Stem Cell Rev"},{"key":"key20180108015127_b12-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"6440","DOI":"10.1093\/nar\/gkr302","article-title":"NF-kappaB P50\/P65 hetero-dimer mediates differential regulation of CD166\/ALCAM expression via interaction with micoRNA-9 after serum deprivation, providing evidence for a novel negative auto-regulatory loop","volume":"39","author":"Wang","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"key20180108015127_b13-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"987185","DOI":"10.1155\/2012\/987185","article-title":"Periostin as a biomarker of the amniotic membrane","volume":"2012","author":"Dobreva","year":"2012","journal-title":"Stem Cells Int"},{"key":"key20180108015127_b14-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"e510","DOI":"10.1038\/cddis.2013.14","article-title":"Nuclear factor-\u03baB modulates osteogenesis of periodontal ligament stem cells through competition with \u03b2-catenin signaling in inflammatory microenvironments","volume":"4","author":"Chen","year":"2013","journal-title":"Cell Death Dis"},{"key":"key20180108015127_b15-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.1600-051X.2011.01741.x","article-title":"Porphyromonas gingivalis lipopolysaccharide lipid a heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblasts","volume":"38","author":"Herath","year":"2011","journal-title":"J Clin Periodontol"},{"key":"key20180108015127_b16-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108015127_b17-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/iwj.12218","article-title":"High glucose improves healing of periodontal wound by inhibiting proliferation and osteogenetic differentiation of human PDL cells","volume":"13","author":"Li","year":"2016","journal-title":"Int Wound J"},{"key":"key20180108015127_b18-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1016\/j.bbadis.2014.07.030","article-title":"High glucose-induced hyperosmolarity impacts proliferation, cytoskeleton remodeling and migration of human induced pluripotent stem cells via aquaporin-1","volume":"1842","author":"Madonna","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"key20180108015127_b19-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"e205","DOI":"10.1902\/jop.2014.130461","article-title":"Characterization of highly osteoblast\/cementoblast cell clones from a CD105-enriched periodontal ligament progenitor cell population","volume":"85","author":"Saito","year":"2014","journal-title":"J Periodontol"},{"key":"key20180108015127_b20-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ijos.2015.2","article-title":"Diabetes mellitus related bone metabolism and periodontal disease","volume":"7","author":"Wu","year":"2015","journal-title":"Int J Oral Sci"},{"key":"key20180108015127_b21-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2337\/diab.44.7.775","article-title":"Bone loss and bone turnover in diabetes","volume":"44","author":"Krakauer","year":"1995","journal-title":"Diabetes"},{"key":"key20180108015127_b22-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1189\/jlb.1004583","article-title":"Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: Association with periodontitis","volume":"78","author":"Karima","year":"2005","journal-title":"J Leukoc Biol"},{"key":"key20180108015127_b23-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00125-014-3470-y","article-title":"Diabetes reduces mesenchymal stem cells in fracture healing through a TNF\u03b1-mediated mechanism","volume":"58","author":"Ko","year":"2015","journal-title":"Diabetologia"},{"key":"key20180108015127_b24-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.diabet.2011.05.004","article-title":"Effects of periodontal therapy on glucose management in people with diabetes mellitus","volume":"37","author":"Calabrese","year":"2011","journal-title":"Diabetes Metab"},{"key":"key20180108015127_b25-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1177\/154405910208100609","article-title":"Identification of genes differentially expressed in cultured human periodontal ligament fibroblasts vs. human gingival fibroblasts by DNA microarray analysis","volume":"81","author":"Han","year":"2002","journal-title":"J Dent Res"},{"key":"key20180108015127_b26-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/ijo.2009.148","article-title":"Identification of secreted proteins associated with obesity and type 2 diabetes in Psammomys obesus","volume":"33","author":"Bolton","year":"2009","journal-title":"Int J Obes (Lond)"},{"key":"key20180108015127_b27-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1359\/jbmr.1999.14.7.1239","article-title":"Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta","volume":"14","author":"Horiuchi","year":"1999","journal-title":"J Bone Miner Res"},{"key":"key20180108015127_b28-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10059-010-0139-3","article-title":"Wnt\/\u03b2-catenin signaling enhances osteoblastogenic differentiation from human periodontal ligament fibroblasts","volume":"30","author":"Heo","year":"2010","journal-title":"Mol Cells"},{"key":"key20180108015127_b29-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1002\/jbmr.440","article-title":"High levels of \u03b2-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway","volume":"26","author":"Liu","year":"2011","journal-title":"J Bone Miner Res"},{"key":"key20180108015127_b30-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.bbagen.2013.11.003","article-title":"Canonical Wnt signaling differently modulates osteogenic differentiation of mesenchymal stem cells derived from bone marrow and from periodontal ligament under inflammatory conditions","volume":"1840","author":"Liu","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"key20180108015127_b31-mmr-15-05-2788","doi-asserted-by":"crossref","first-page":"13142","DOI":"10.1038\/srep13142","article-title":"DKK1 rescues osteogenic differentiation of mesenchymal stem cells isolated from periodontal ligaments of patients with diabetes mellitus induced periodontitis","volume":"5","author":"Liu","year":"2015","journal-title":"Sci Rep"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2017.6333\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T22:45:50Z","timestamp":1515365150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.6333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,16]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,3,16]]},"published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.3892\/mmr.2017.6333"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.6333","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,16]]}}}