{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:06:39Z","timestamp":1790831199867,"version":"4.1.0"},"reference-count":34,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.3892\/mmr.2017.6472","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T07:20:14Z","timestamp":1491981614000},"page":"3521-3528","source":"Crossref","is-referenced-by-count":19,"title":["Synergistic antitumor effects of CDK inhibitor SNS-032 and an oncolytic adenovirus co-expressing TRAIL and Smac in pancreatic cancer"],"prefix":"10.3892","volume":"15","author":[{"given":"Yun","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buyun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Ru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhou","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,4,12]]},"reference":[{"key":"key20180108020027_b1-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3322\/caac.20073","article-title":"Cancer statistics, 2010","volume":"60","author":"Jemal","year":"2010","journal-title":"CA Cancer J Clin"},{"key":"key20180108020027_b2-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/S0959-8049(96)00324-3","article-title":"Assessing clinical benefit in the treatment of pancreas cancer: Gemcitabine compared to 5-fluorouracil","volume":"33","author":"Burris","year":"1997","journal-title":"Eur J Cancer"},{"key":"key20180108020027_b3-mmr-15-06-3521","first-page":"2895","article-title":"Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions","volume":"21","author":"Cheng","year":"2001","journal-title":"Anticancer Res"},{"key":"key20180108020027_b4-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/aps.2012.196","article-title":"Tumor suppressor in lung cancer-1 (TSLC1) mediated by dual-regulated oncolytic adenovirus exerts specific antitumor actions in a mouse model","volume":"34","author":"Lei","year":"2013","journal-title":"Acta Pharmacol Sin"},{"key":"key20180108020027_b5-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/sj.cgt.7700542","article-title":"Armed therapeutic viruses: Strategies and challenges to arming oncolytic viruses with therapeutic genes","volume":"9","author":"Hermiston","year":"2002","journal-title":"Cancer Gene Ther"},{"key":"key20180108020027_b6-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/sj.cr.7290191","article-title":"An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy","volume":"13","author":"Zhang","year":"2003","journal-title":"Cell Res"},{"key":"key20180108020027_b7-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1158\/1078-0432.CCR-06-0244","article-title":"Eliminating established tumor in nu\/nu nude mice by a tumor necrosis factor-alpha-related apoptosis-inducing ligand-armed oncolytic adenovirus","volume":"12","author":"Dong","year":"2006","journal-title":"Clin Cancer Res"},{"key":"key20180108020027_b8-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/sj.leu.2405034","article-title":"Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7\/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis","volume":"22","author":"Qian","year":"2008","journal-title":"Leukemia"},{"key":"key20180108020027_b9-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1111\/j.1745-7254.2007.00672.x","article-title":"Enhanced sensitivity of hepatocellular carcinoma cells to chemotherapy with a Smac-armed oncolytic adenovirus","volume":"28","author":"Pan","year":"2007","journal-title":"Acta Pharmacol Sin"},{"key":"key20180108020027_b10-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1002\/emmm.201302796","article-title":"Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas","volume":"5","author":"Li","year":"2013","journal-title":"EMBO Mol Med"},{"key":"key20180108020027_b11-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1089\/hum.2011.159","article-title":"Complete eradication of xenograft hepatoma by oncolytic adenovirus ZD55 harboring TRAIL-IETD-Smac gene with broad antitumor effect","volume":"23","author":"Wang","year":"2012","journal-title":"Hum Gene Ther"},{"key":"key20180108020027_b12-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/3-7643-7414-4_8","article-title":"Inhibitors of cyclin-dependent kinase modulators for cancer therapy","volume":"63","author":"Senderowicz","year":"2005","journal-title":"Prog Drug Res"},{"key":"key20180108020027_b13-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3747\/co.v16i2.428","article-title":"Development of cell-cycle inhibitors for cancer therapy","volume":"16","author":"Dickson","year":"2009","journal-title":"Curr Oncol"},{"key":"key20180108020027_b14-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1756-8722-6-18","article-title":"SNS-032 inhibits mTORC1\/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt","volume":"6","author":"Meng","year":"2013","journal-title":"J Hematol Oncol"},{"key":"key20180108020027_b15-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1158\/1078-0432.CCR-11-1971","article-title":"Cyclin-dependent kinase 7\/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor a and bcr-abl oncogene addiction in malignant hematologic cells","volume":"18","author":"Wu","year":"2012","journal-title":"Clin Cancer Res"},{"key":"key20180108020027_b16-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/leu.2010.290","article-title":"The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells and is highly synergistic with cytarabine","volume":"25","author":"Walsby","year":"2012","journal-title":"Leukemia"},{"key":"key20180108020027_b17-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3892\/ijo.2014.2467","article-title":"The cyclin-dependent kinase inhibitor SNS-032 induces apoptosis in breast cancer cells via depletion of Mcl-1 and X-linked inhibitor of apoptosis protein and displays antitumor activity in vivo","volume":"45","author":"Xie","year":"2014","journal-title":"Int J Oncol"},{"key":"key20180108020027_b18-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4161\/cbt.12.7.16475","article-title":"Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models","volume":"12","author":"Feldmann","year":"2011","journal-title":"Cancer Biol Ther"},{"key":"key20180108020027_b19-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/5517","article-title":"Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo","volume":"5","author":"Walczak","year":"1999","journal-title":"Nat Med"},{"key":"key20180108020027_b20-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(01)00272-0","article-title":"Structural basis of caspase-7 inhibition by XIAP","volume":"104","author":"Chai","year":"2001","journal-title":"Cell"},{"key":"key20180108020027_b21-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"27058","DOI":"10.1074\/jbc.M102415200","article-title":"X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and \u22127 in distinct modes","volume":"276","author":"Suzuki","year":"2001","journal-title":"J Biol Chem"},{"key":"key20180108020027_b22-mmr-15-06-3521","first-page":"1796","article-title":"Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias","volume":"6","author":"Tamm","year":"2000","journal-title":"Clin Cancer Res"},{"key":"key20180108020027_b23-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nm0897-917","article-title":"A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma","volume":"3","author":"Ambrosini","year":"1997","journal-title":"Nat Med"},{"key":"key20180108020027_b24-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/35065125","article-title":"A conserved XIAP-interaction motif in caspase-9 and Smac\/DIABLO regulates caspase activity and apoptosis","volume":"410","author":"Srinivasula","year":"2001","journal-title":"Nature"},{"key":"key20180108020027_b25-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/hep.20203","article-title":"An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in mice","volume":"39","author":"Pei","year":"2004","journal-title":"Hepatology"},{"key":"key20180108020027_b26-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1126\/science.1189749","article-title":"Cancer therapy reform","volume":"328","author":"Levinson","year":"2010","journal-title":"Science"},{"key":"key20180108020027_b27-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/sj.onc.1210666","article-title":"Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells","volume":"27","author":"Ehrhardt","year":"2008","journal-title":"Oncogene"},{"key":"key20180108020027_b28-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.1158\/1078-0432.CCR-0349-03","article-title":"Use of replicating oncolytic adenoviruses in combination therapy for cancer","volume":"10","author":"Chu","year":"2004","journal-title":"Clin Cancer Res"},{"key":"key20180108020027_b29-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/10430340252809784","article-title":"Toward a new generation of conditionally replicating adenoviruses: Pairing tumor selectivity with maximal oncolysis","volume":"13","author":"Kruyt","year":"2002","journal-title":"Hum Gene Ther"},{"key":"key20180108020027_b30-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1089\/104303403766682205","article-title":"Replicative oncolytic adenoviruses in multimodal cancer regimens","volume":"214","author":"Post","year":"2003","journal-title":"Hum Gene Ther"},{"key":"key20180108020027_b31-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1210\/en.2007-0752","article-title":"Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells","volume":"148","author":"Libertini","year":"2007","journal-title":"Endocrinology"},{"key":"key20180108020027_b32-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1200\/JCO.2008.18.9670","article-title":"Effect of recombinant adenovirus-p53 combined with radiotherapy on long-term prognosis of advanced nasopharyngeal carcinoma","volume":"27","author":"Pan","year":"2009","journal-title":"J Clin Oncol"},{"key":"key20180108020027_b33-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1158\/1535-7163.MCT-12-0102","article-title":"CDK-4 inhibitor P276 sensitizes pancreatic cancer cells to gemcitabine-induced apoptosis","volume":"11","author":"Subramaniam","year":"2012","journal-title":"Mol Cancer Ther"},{"key":"key20180108020027_b34-mmr-15-06-3521","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1158\/1535-7163.MCT-15-0028","article-title":"Combined inhibition of cyclin-dependent kinases (Dinaciclib) and AKT (MK-2206) blocks pancreatic tumor growth and metastases in patient-derived xenograft models","volume":"14","author":"Hu","year":"2015","journal-title":"Mol Cancer Ther"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/mmr.2017.6472\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T08:25:07Z","timestamp":1658910307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.6472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,12]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,4,12]]},"published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.3892\/mmr.2017.6472"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.6472","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,12]]}}}