{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:47:53Z","timestamp":1788335273216,"version":"build-2803163510"},"reference-count":44,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.3892\/mmr.2017.6943","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T08:47:40Z","timestamp":1499330860000},"page":"2907-2914","source":"Crossref","is-referenced-by-count":36,"title":["Ginsenoside Rc protects against UVB-induced photooxidative damage in epidermal keratinocytes"],"prefix":"10.3892","volume":"16","author":[{"given":"Yuri","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Won","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Hark","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Young","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyunghoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Jin","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,7,6]]},"reference":[{"key":"key20180108002630_b1-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.foodchem.2010.06.014","article-title":"Simultaneous determination of nineginsenosides in functional foods by high performance liquid chromatography with diode array detector detection","volume":"123","author":"Shi","year":"2010","journal-title":"Food Chem"},{"key":"key20180108002630_b2-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/ajcn\/73.6.1101","article-title":"Variability in commercial ginseng products: An analysis of 25 preparations","volume":"73","author":"Harkey","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"key20180108002630_b3-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s12272-013-0223-2","article-title":"Ginsenoside Rc modulates Akt\/FoxO1 pathways and suppresses oxidative stress","volume":"37","author":"Kim","year":"2014","journal-title":"Arch Pharm Res"},{"key":"key20180108002630_b4-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jep.2009.11.022","article-title":"Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism","volume":"127","author":"Lee","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"key20180108002630_b5-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jphotobiol.2011.01.019","article-title":"Photoaging and chronological aging profile: Understanding oxidation of the skin","volume":"103","author":"Peres","year":"2011","journal-title":"J Photochem Photobiol B"},{"key":"key20180108002630_b6-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/(SICI)1096-9896(199911)189:3<300::AID-PATH456>3.0.CO;2-C","article-title":"Matrix metalloproteinases in tumour invasion and metastasis","volume":"189","author":"Curran","year":"1999","journal-title":"J Pathol"},{"key":"key20180108002630_b7-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1006\/bbrc.1995.1067","article-title":"Detection of hydrogen peroxide and hydroxyl radicals in murine skin fibroblasts under UVB irradiation","volume":"206","author":"Masaki","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108002630_b8-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/php.12061","article-title":"Fucosterol inhibits matrix metalloproteinase expression and promotes type-1 procollagen production in UVB-induced HaCaT cells","volume":"89","author":"Kim","year":"2013","journal-title":"Photochem Photobiol"},{"key":"key20180108002630_b9-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.1523-1747.2003.12021.x","article-title":"Possible involvement of gelatinases in basement membrane damage and wrinkle formation in chronically ultraviolet B-exposed hairless mouse","volume":"120","author":"Inomata","year":"2003","journal-title":"J Invest Dermatol"},{"key":"key20180108002630_b10-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.molmed.2007.10.006","article-title":"The filaggrin story: Novel insights into skin-barrier function and disease","volume":"14","author":"McGrath","year":"2008","journal-title":"Trends Mol Med"},{"key":"key20180108002630_b11-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jaci.2011.12.989","article-title":"Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency","volume":"129","author":"Kezic","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"key20180108002630_b12-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1590\/1414-431X20144047","article-title":"Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response","volume":"48","author":"Dang","year":"2015","journal-title":"Braz J Med Biol Res"},{"key":"key20180108002630_b13-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1242\/jcs.033969","article-title":"Filaggrin in the frontline: Role in skin barrier function and disease","volume":"122","author":"Sandilands","year":"2009","journal-title":"J Cell Sci"},{"key":"key20180108002630_b14-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1600-0625.2011.01280.x","article-title":"Regulation of caspase 14 expression in keratinocytes by inflammatory cytokines-a possible link between reduced skin barrier function and inflammation?","volume":"20","author":"Hvid","year":"2011","journal-title":"Exp Dermatol"},{"key":"key20180108002630_b15-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/jcb.22425","article-title":"Purification and characterization of active caspase-14 from human epidermis and development of the cleavage site-directed antibody","volume":"109","author":"Hibino","year":"2010","journal-title":"J Cell Biochem"},{"key":"key20180108002630_b16-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"key20180108002630_b17-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1006\/abbi.1993.1222","article-title":"Evaluation of 2\u2032,7\u2032-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells","volume":"302","author":"Royall","year":"1993","journal-title":"Arch Biochem Biophys"},{"key":"key20180108002630_b18-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jbbm.2005.10.003","article-title":"Fluorescence probes used for detection of reactive oxygen species","volume":"65","author":"Gomes","year":"2005","journal-title":"J Biochem Biophys Methods"},{"key":"key20180108002630_b19-mmr-16-03-2907","volume-title":"Culture of Animal Cells: A Manual of Basic Technique","author":"Freshney","year":"1994","edition":"4th"},{"key":"key20180108002630_b20-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1006\/abio.1994.1186","article-title":"Quantitative zymography: Detection of picogram quantities of gelatinases","volume":"218","author":"Kleiner","year":"1994","journal-title":"Anal Biochem"},{"key":"key20180108002630_b21-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1016\/S0021-9258(19)39562-6","article-title":"Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines","volume":"265","author":"Nakagawa","year":"1990","journal-title":"J Biol Chem"},{"key":"key20180108002630_b22-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1016-8478(23)15108-9","article-title":"Activities of antioxidant and redox enzymes in human normal hepatic and hepatoma cell lines","volume":"14","author":"Lee","year":"2002","journal-title":"Mol Cells"},{"key":"key20180108002630_b23-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1562\/2004-02-26-RA-091.1","article-title":"Molecular mechanism(s) for UV-B irradiation-induced glutathione depletion in cultured human keratinocytes","volume":"80","author":"Zhu","year":"2004","journal-title":"Photochem Photobiol"},{"key":"key20180108002630_b24-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/j.1365-2230.2007.02474.x","article-title":"Direct monitoring of UV-induced free radical generation in HaCaT keratinocytes","volume":"32","author":"Aitken","year":"2007","journal-title":"Clin Exp Dermatol"},{"key":"key20180108002630_b25-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1001\/archderm.138.11.1462","article-title":"Mechanisms of photoaging and chronological skin aging","volume":"138","author":"Fisher","year":"2002","journal-title":"Arch Dermatol"},{"key":"key20180108002630_b26-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00403-011-1153-9","article-title":"Inhibitory effects of TRPV1 blocker on UV-induced responses in the hairless mice","volume":"303","author":"Lee","year":"2011","journal-title":"Arch Dermatol Res"},{"key":"key20180108002630_b27-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.pdpdt.2013.12.001","article-title":"9-Hydroxypheophorbide \u03b1-mediated photodynamic therapy induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in Hep-2 cells via ROS-mediated suppression of the ERK pathway","volume":"11","author":"Zhang","year":"2014","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"key20180108002630_b28-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.3892\/or.2014.3103","article-title":"Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP-2 and MMP-9 via downregulation of NF-\u03baB signaling pathway","volume":"31","author":"Lee","year":"2014","journal-title":"Oncol Rep"},{"key":"key20180108002630_b29-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/jcp.24481","article-title":"Amsacrine suppresses matrix metalloproteinase-2 (MMP-2)\/MMP-9 expression in human leukemia cells","volume":"229","author":"Liu","year":"2014","journal-title":"J Cell Physiol"},{"key":"key20180108002630_b30-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3164\/jcbn.11-54","article-title":"(\u00b1)Equol inhibits invasion in prostate cancer DU145 cells possibly via down-regulation of matrix metalloproteinase-9, matrix metalloproteinase-2 and urokinase-type plasminogen activator by antioxidant activity","volume":"51","author":"Zheng","year":"2012","journal-title":"J Clin Biochem Nutr"},{"key":"key20180108002630_b31-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jep.2014.04.020","article-title":"Prevention of UV radiation-induced cutaneous photoaging in mice by topical administration of patchouli oil","volume":"154","author":"Lin","year":"2014","journal-title":"J Ethnopharmacol"},{"key":"key20180108002630_b32-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/biof.5520300301","article-title":"Coenzyme Q_{10} effects on manganese superoxide dismutase and glutathione peroxidase in the hairless mouse skin induced by ultraviolet B irradiation","volume":"30","author":"Kim","year":"2007","journal-title":"Biofactors"},{"key":"key20180108002630_b33-mmr-16-03-2907","first-page":"381","article-title":"Protective properties of ginsenoside Rb1 against UV-B radiation-induced oxidative stress in human dermal keratinocytes","volume":"70","author":"Oh","year":"2015","journal-title":"Pharmazie"},{"key":"key20180108002630_b34-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000431154","article-title":"Ginsenoside Rb2 attenuates UV-B radiation-induced reactive oxygen species and matrix metalloproteinase-2 through upregulation of antioxidant components in human dermal fibroblasts","volume":"96","author":"Oh","year":"2015","journal-title":"Pharmacology"},{"key":"key20180108002630_b35-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1080\/09168451.2015.1020752","article-title":"Suppressive properties of ginsenoside Rb2, a protopanaxadiol-type ginseng saponin, on reactive oxygen species and matrix metalloproteinase-2 in UV-B-irradiated human dermal keratinocytes","volume":"79","author":"Oh","year":"2015","journal-title":"Biosci Biotechnol Biochem"},{"key":"key20180108002630_b36-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/09168451.2015.1075862","article-title":"Protective properties of ginsenoside Rb3 against UV-B radiation-induced oxidative stress in HaCaT keratinocytes","volume":"80","author":"Oh","year":"2015","journal-title":"Biosci Biotechnol Biochem"},{"key":"key20180108002630_b37-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1248\/bpb.b14-00167","article-title":"Stereoselective skin anti-photoaging properties of ginsenoside Rg3 in UV-B-irradiated keratinocytes","volume":"37","author":"Lim","year":"2014","journal-title":"Biol Pharm Bull"},{"key":"key20180108002630_b38-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s12038-014-9460-x","article-title":"Skin anti-photoaging properties of ginsenoside Rh2 epimers in UV-B-irradiated human keratinocyte cells","volume":"39","author":"Oh","year":"2014","journal-title":"J Biosci"},{"key":"key20180108002630_b39-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.2042-7158.2012.01598.x","article-title":"Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes","volume":"65","author":"Choi","year":"2013","journal-title":"J Pharm Pharmacol"},{"key":"key20180108002630_b40-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1139\/cjpp-2014-0273","article-title":"Stereoselective suppressive effects of protopanaxadiol epimers on UV-B-induced reactive oxygen species and matrix metalloproteinase-2 in human dermal keratinocytes","volume":"93","author":"Oh","year":"2015","journal-title":"Can J Physiol Pharmacol"},{"key":"key20180108002630_b41-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jphotobiol.2016.10.034","article-title":"Stereospecificity of ginsenoside Rg2 epimers in the protective response against UV-B radiation-induced oxidative stress in human epidermal keratinocytes","volume":"165","author":"Kang","year":"2016","journal-title":"J Photochem Photobiol B"},{"key":"key20180108002630_b42-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.3892\/mmr.2016.5581","article-title":"Photoprotective properties of 20(S)-protopanaxatriol, an aglycone of ginseng saponins: Protection from ultraviolet-B radiation-induced oxidative stress in human epidermal keratinocytes","volume":"14","author":"Oh","year":"2016","journal-title":"Mol Med Rep"},{"key":"key20180108002630_b43-mmr-16-03-2907","first-page":"1","article-title":"Ginsenoside Re improves skin barrier function in HaCaT keratinocytes under normal growth conditions","volume":"13","author":"Oh","year":"2016","journal-title":"Biosci Biotechnol Biochem"},{"key":"key20180108002630_b44-mmr-16-03-2907","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1080\/09168451.2015.1065170","article-title":"Antioxidative properties of ginsenoside Ro against UV-B-induced oxidative stress in human dermal fibroblasts","volume":"79","author":"Kang","year":"2015","journal-title":"Biosci Biotechnol Biochem"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T08:14:50Z","timestamp":1719303290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.6943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,7,6]]},"published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.3892\/mmr.2017.6943"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.6943","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}