{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:14:00Z","timestamp":1773270840785,"version":"3.50.1"},"reference-count":27,"publisher":"Spandidos Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.3892\/mmr.2017.6990","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T11:09:25Z","timestamp":1500030565000},"page":"3551-3556","source":"Crossref","is-referenced-by-count":17,"title":["NLRC5 silencing ameliorates cardiac fibrosis by inhibiting the TGF-\u03b21\/Smad3 signaling pathway"],"prefix":"10.3892","volume":"16","author":[{"given":"Hongtao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"key":"key20180108002449_b1-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/jcp.22322","article-title":"The origin of fibroblasts and mechanism of cardiac fibrosis","volume":"225","author":"Krenning","year":"2010","journal-title":"J Cell Physiol"},{"key":"key20180108002449_b2-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s00059-002-2354-y","article-title":"Cardiac fibrosis as a cause of diastolic dysfunction","volume":"27","author":"Burlew","year":"2002","journal-title":"Herz"},{"key":"key20180108002449_b3-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1161\/CIRCRESAHA.110.217737","article-title":"Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation","volume":"106","author":"Leask","year":"2010","journal-title":"Circ Res"},{"key":"key20180108002449_b4-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0008-6363(99)00431-9","article-title":"Myocardial matrix degradation and metalloproteinase activation in the failing heart: A potential therapeutic target","volume":"46","author":"Spinale","year":"2000","journal-title":"Cardiovasc Res"},{"key":"key20180108002449_b5-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1161\/01.CIR.102.12.1388","article-title":"Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease","volume":"102","author":"Brilla","year":"2000","journal-title":"Circulation"},{"key":"key20180108002449_b6-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1006\/mgme.2000.3032","article-title":"Induction of cardiac fibrosis by transforming growth factor-beta(1)","volume":"71","author":"Lijnen","year":"2000","journal-title":"Mol Genet Metab"},{"key":"key20180108002449_b7-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.4049\/jimmunol.1003111","article-title":"Cutting edge: NLRC5-dependent activation of the inflammasome","volume":"186","author":"Davis","year":"2011","journal-title":"J Immunol 186"},{"key":"key20180108002449_b8-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.4049\/jimmunol.0900557","article-title":"The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses","volume":"184","author":"Kuenzel","year":"2010","journal-title":"J Immunol"},{"key":"key20180108002449_b9-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"13794","DOI":"10.1073\/pnas.1008684107","article-title":"NLR family member NLRC5 is a transcriptional regulator of MHC class I genes","volume":"107","author":"Meissner","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180108002449_b10-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.4049\/jimmunol.1102671","article-title":"NLRC5 deficiency selectively impairs MHC class I-dependent lymphocyte killing by cytotoxic T cells","volume":"188","author":"Staehli","year":"2012","journal-title":"J Immunol"},{"key":"key20180108002449_b11-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biocel.2015.11.010","article-title":"NLRC5 regulates TGF-\u03b21-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis","volume":"70","author":"Xu","year":"2016","journal-title":"Int J Biochem Cell Biol"},{"key":"key20180108002449_b12-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108002449_b13-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/mt.2014.25","article-title":"miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-\u03b2\/Smad3 signaling","volume":"22","author":"Zhang","year":"2014","journal-title":"Mol Ther"},{"key":"key20180108002449_b14-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pharmthera.2009.05.002","article-title":"Cardiac fibroblasts: At the heart of myocardial remodeling","volume":"123","author":"Porter","year":"2009","journal-title":"Pharmacol Ther"},{"key":"key20180108002449_b15-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.vph.2012.07.003","article-title":"The role of cardiac fibroblasts in the transition from inflammation to fibrosis following myocardial infarction","volume":"58","author":"van Nieuwenhoven","year":"2013","journal-title":"Vasc Pharmacol"},{"key":"key20180108002449_b16-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3317\/jraas.2003.011","article-title":"Transforming growth factor-beta 1-mediated collagen gel contraction by cardiac fibroblasts","volume":"4","author":"Lijnen","year":"2003","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"key20180108002449_b17-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/01.RES.69.1.116","article-title":"Collagen expression in mechanically stimulated cardiac fibroblasts","volume":"69","author":"Carver","year":"1991","journal-title":"Circ Res"},{"key":"key20180108002449_b18-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1006\/jmcc.2000.1215","article-title":"CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis","volume":"32","author":"Chen","year":"2000","journal-title":"J Mol Cell Cardiol"},{"key":"key20180108002449_b19-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cardiores.2006.10.002","article-title":"The role of TGF-beta signaling in myocardial infarction and cardiac remodeling","volume":"74","author":"Bujak","year":"2007","journal-title":"Cardiovasc Res"},{"key":"key20180108002449_b20-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-2362.2002.00985.x","article-title":"Myocardial fibrosis in transforming growth factor-beta(1) (TGF-beta(1)) transgenic mice is associated with inhibition of interstitial collagenase","volume":"32","author":"Seeland","year":"2002","journal-title":"Eur J Clin Invest"},{"key":"key20180108002449_b21-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s11010-007-9676-2","article-title":"Chymase induces profibrotic response via transforming growth factor-beta 1\/Smad activation in rat cardiac fibroblasts","volume":"310","author":"Zhao","year":"2008","journal-title":"Mol Cell Biochem"},{"key":"key20180108002449_b22-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1086\/345882","article-title":"Implication of transforming growth factor-beta1 in Chagas disease myocardiopathy","volume":"186","author":"Ara\u00fajo-Jorge","year":"2002","journal-title":"J Infect Dis"},{"key":"key20180108002449_b23-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/eurjhf\/hfq011","article-title":"Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts","volume":"12","author":"Shyu","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"key20180108002449_b24-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"e63896","DOI":"10.1371\/journal.pone.0063896","article-title":"Relaxin prevents cardiac fibroblast-myofibroblast transition via notch-1-mediated inhibition of TGF-\u03b2\/Smad3 signaling","volume":"8","author":"Sassoli","year":"2013","journal-title":"PLoS One"},{"key":"key20180108002449_b25-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cardiores.2006.07.012","article-title":"TGFbeta, cardiac fibroblasts, and the fibrotic response","volume":"74","author":"Leask","year":"2007","journal-title":"Cardiovasc Res"},{"key":"key20180108002449_b26-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1161\/CIRCULATIONAHA.107.704197","article-title":"Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling","volume":"116","author":"Bujak","year":"2007","journal-title":"Circulation"},{"key":"key20180108002449_b27-mmr-16-03-3551","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/CIRCRESAHA.109.216101","article-title":"Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction","volume":"107","author":"Dobaczewski","year":"2010","journal-title":"Circ Res"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T01:04:30Z","timestamp":1515373470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.6990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,7,14]]},"published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.3892\/mmr.2017.6990"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.6990","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}