{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:24:08Z","timestamp":1790835848804,"version":"4.1.0"},"reference-count":41,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.3892\/mmr.2017.7110","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T06:49:46Z","timestamp":1501224586000},"page":"3965-3973","source":"Crossref","is-referenced-by-count":17,"title":["Aliskiren has chondroprotective efficacy in a rat model of osteoarthritis through suppression of the local renin-angiotensin system"],"prefix":"10.3892","volume":"16","author":[{"given":"Kaizhong","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"key20180108002812_b1-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"e0130882","DOI":"10.1371\/journal.pone.0130882","article-title":"Eupatilin exerts antinociceptive and chondroprotective properties in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes","volume":"10","author":"Jeong","year":"2015","journal-title":"PloS One"},{"key":"key20180108002812_b2-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"321","DOI":"10.7326\/0003-4819-133-5-200009050-00007","article-title":"Joint injury in young adults and risk for subsequent knee and hip osteoarthritis","volume":"133","author":"Gelber","year":"2000","journal-title":"Ann Intern Med"},{"key":"key20180108002812_b3-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/01.bor.0000151406.64393.00","article-title":"Joint injury causes knee osteoarthritis in young adults","volume":"17","author":"Roos","year":"2005","journal-title":"Curr Opin Rheumatol"},{"key":"key20180108002812_b4-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0033-8389(03)00169-6","article-title":"Radiographic evaluation of osteoarthritis","volume":"42","author":"Gupta","year":"2004","journal-title":"Radiol Clin North Am"},{"key":"key20180108002812_b5-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.joca.2010.01.013","article-title":"OARSI recommendations for the management of hip and knee osteoarthritis: Part III: Changes in evidence following systematic cumulative update of research published through January 2009","volume":"18","author":"Zhang","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"key20180108002812_b6-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1994.03510410061034","article-title":"Patient outcomes following tricompartmental total knee replacement: A meta-analysis","volume":"271","author":"Callahan","year":"1994","journal-title":"JAMA"},{"key":"key20180108002812_b7-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/ar3222","article-title":"Molecular targets of natural health products in arthritis","volume":"13","author":"Khalif\u00e9","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"key20180108002812_b8-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/annrheumdis-2012-201745","article-title":"A novel disease-modifying osteoarthritis drug candidate targeting Runx1","volume":"72","author":"Yano","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"key20180108002812_b9-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.joca.2013.01.008","article-title":"Parathyroid hormone [1-34] improves articular cartilage surface architecture and integration and subchondral bone reconstitution in osteochondral defects in vivo","volume":"21","author":"Orth","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"key20180108002812_b10-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"932691","DOI":"10.1155\/2013\/932691","article-title":"Potential of RAS inhibition to improve metabolic bone disorders","volume":"2013","author":"Gebru","year":"2013","journal-title":"Biomed Res Int"},{"key":"key20180108002812_b11-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1677\/joe.0.1520005","article-title":"Angiotensin II is generated from angiotensin I by bone cells and stimulates osteoclastic bone resorption in vitro","volume":"152","author":"Hatton","year":"1997","journal-title":"J Endocrinol"},{"key":"key20180108002812_b12-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/bbrc.1996.5914","article-title":"Angiotensin II stimulates the proliferation of osteoblast-rich populations of cells from rat calvariae","volume":"230","author":"Hiruma","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108002812_b13-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1074\/jbc.M807610200","article-title":"Angiotensin II Type 2 Receptor Blockade Increases Bone Mass","volume":"284","author":"Izu","year":"2009","journal-title":"J Biol Chem"},{"key":"key20180108002812_b14-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00296-004-0564-8","article-title":"Renin and angiotensin-converting enzyme (ACE) as active components of the local synovial renin-angiotensin system in rheumatoid arthritis","volume":"25","author":"Cobankara","year":"2005","journal-title":"Rheumatol Int"},{"key":"key20180108002812_b15-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1111\/j.1476-5381.2010.00651.x","article-title":"Inhibition of angiotensin-converting enzyme stimulates fracture healing and periosteal callus formation - role of a local renin-angiotensin system","volume":"159","author":"Garcia","year":"2010","journal-title":"Br J Pharmacol"},{"key":"key20180108002812_b16-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.4081\/ejh.2014.2387","article-title":"Expressions of local renin-angiotensin system components in chondrocytes","volume":"58","author":"Tsukamoto","year":"2014","journal-title":"Eur J Histochem"},{"key":"key20180108002812_b17-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1248\/bpb.b14-00576","article-title":"Renin inhibition improves ovariectomy-induced osteoporosis of lumbar vertebra in mice","volume":"37","author":"Zhang","year":"2014","journal-title":"Biol Pharm Bull"},{"key":"key20180108002812_b18-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"648537","DOI":"10.1155\/2012\/648537","article-title":"Expression of angiotensin II receptor-1 in human articular chondrocytes","volume":"2012","author":"Kawakami","year":"2012","journal-title":"Arthritis"},{"key":"key20180108002812_b19-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/hr.2015.18","article-title":"Continuous infusion of angiotensin II modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse","volume":"38","author":"Kawahata","year":"2015","journal-title":"Hypertens Res"},{"key":"key20180108002812_b20-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"971","DOI":"10.2147\/VHRM.S3215","article-title":"The renin angiotensin system in the development of cardiovascular disease: Role of aliskiren in risk reduction","volume":"4","author":"Verdecchia","year":"2008","journal-title":"Vasc Health Risk Manag"},{"key":"key20180108002812_b21-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jacc.2007.10.027","article-title":"Renin Inhibition in hypertension","volume":"51","author":"Gradman","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"key20180108002812_b22-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/1471-2474-14-312","article-title":"Knee loading reduces MMP13 activity in the mouse cartilage","volume":"14","author":"Hamamura","year":"2013","journal-title":"Bmc Musculoskelet Disord"},{"key":"key20180108002812_b23-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2106\/00004623-197153030-00009","article-title":"Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data","volume":"53","author":"Mankin","year":"1971","journal-title":"J Bone Joint Surg Am"},{"key":"key20180108002812_b24-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"6672","DOI":"10.1118\/1.3662891","article-title":"Quantifying the tibiofemoral joint space using x-ray tomosynthesis","volume":"38","author":"Kalinosky","year":"2011","journal-title":"Med Phys"},{"key":"key20180108002812_b25-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108002812_b26-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/jbmr.5650020510","article-title":"Procollagen type I carboxy-terminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with iliac bone formation rates and comparison with total alkaline phosphatase","volume":"2","author":"Parfitt","year":"1987","journal-title":"J Bone Miner Res"},{"key":"key20180108002812_b27-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-84628-701-5_3","article-title":"Cytokines, Growth Factors and Bone-Derived Factors in Cartilage","volume":"4","author":"Goldring","year":"2007","journal-title":"Bone and Osteoarthritis"},{"key":"key20180108002812_b28-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1136\/ard.56.9.542","article-title":"Gene expression of matrix metalloproteinases 1, 3 and 9 by chondrocytes in osteoarthritic human knee articular cartilage is zone and grade specific","volume":"56","author":"Freemont","year":"1997","journal-title":"Ann Rheum Dis"},{"key":"key20180108002812_b29-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/art.1780330412","article-title":"Effects of tumor necrosis factor alpha and beta on resorption of human articular cartilage and production of plasminogen activator by human articular chondrocytes","volume":"33","author":"Campbell","year":"1990","journal-title":"Arthritis Rheum"},{"key":"key20180108002812_b30-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.joca.2006.01.017","article-title":"Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells: Potential role of Runx2 in mediating p38 effects","volume":"14","author":"Pei","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"key20180108002812_b31-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/excr.1998.4071","article-title":"Carbonic anhydrase II plays a major role in osteoclast differentiation and bone resorption by effecting the steady state intracellular pH and Ca2+","volume":"242","author":"Lehenkari","year":"1998","journal-title":"Exp Cell Res"},{"key":"key20180108002812_b32-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.3317\/jraas.2006.035","article-title":"Direct renin inhibition-a new way of targeting the renin system","volume":"7","author":"Brown","year":"2006","journal-title":"J Renin Angiotensin Aldosterone Sys"},{"key":"key20180108002812_b33-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S1074-5521(00)00134-4","article-title":"Structure-based drug design: The discovery of novel nonpeptide orally active inhibitors of human renin","volume":"7","author":"Rahuel","year":"2000","journal-title":"Chem Biol"},{"key":"key20180108002812_b34-mmr-16-04-3965","first-page":"57","article-title":"Overexpression of the local bone marrow renin-angiotensin system in acute myeloid leukemia","volume":"99","author":"Beyazit","year":"2007","journal-title":"J Natl Med Assoc"},{"key":"key20180108002812_b35-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0306-9877(96)90122-X","article-title":"A local renin-angiotensin system in the bone marrow","volume":"46","author":"Haznedaro\u011flu","year":"1996","journal-title":"Med Hypotheses"},{"key":"key20180108002812_b36-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1677\/joe.0.1560543","article-title":"Deceleration by angiotensin II of the differentiation and bone formation of rat calvarial osteoblastic cells","volume":"156","author":"Hagiwara","year":"1998","journal-title":"J Endocrinol"},{"key":"key20180108002812_b37-mmr-16-04-3965","first-page":"453","article-title":"Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors","volume":"5","author":"Pimenta","year":"2009","journal-title":"Vasc Health Risk Manag"},{"key":"key20180108002812_b38-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1002\/art.11248","article-title":"Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro","volume":"48","author":"Bobacz","year":"2003","journal-title":"Arthritis Rheum"},{"key":"key20180108002812_b39-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1096\/fj.07-098954","article-title":"Angiotensin II accelerates osteoporosis by activating osteoclasts","volume":"22","author":"Shimizu","year":"2008","journal-title":"FASEB J"},{"key":"key20180108002812_b40-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1359\/jbmr.081006","article-title":"Activation of renin-angiotensin system induces osteoporosis independently of hypertension","volume":"24","author":"Asaba","year":"2009","journal-title":"J Bone Miner Res"},{"key":"key20180108002812_b41-mmr-16-04-3965","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/10454411990100010201","article-title":"The developmental control of osteoblast-specific gene expression: Role of specific transcription factors and the extracellular matrix environment","volume":"10","author":"Franceschi","year":"1999","journal-title":"Crit Rev Oral Biol Med"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T20:59:44Z","timestamp":1719349184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.7110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,28]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,7,28]]},"published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.3892\/mmr.2017.7110"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.7110","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,28]]}}}