{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:11:58Z","timestamp":1778541118584,"version":"3.51.4"},"reference-count":44,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.3892\/mmr.2017.7262","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T08:27:37Z","timestamp":1502872057000},"page":"5523-5528","source":"Crossref","is-referenced-by-count":11,"title":["Polaprezinc inhibits liver fibrosis and proliferation in hepatocellular carcinoma"],"prefix":"10.3892","volume":"16","author":[{"given":"Jun","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengsen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minfang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinliang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,8,16]]},"reference":[{"key":"key20180108002841_b1-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","article-title":"Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis","volume":"132","author":"El-Serag","year":"2007","journal-title":"Gastroenterology"},{"key":"key20180108002841_b2-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3748\/wjg.v7.i4.445","article-title":"Hepatocellular carcinoma-cause, treatment and metastasis","volume":"7","author":"Tang","year":"2001","journal-title":"World J Gastroenterol"},{"key":"key20180108002841_b3-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1245\/s10434-007-9705-0","article-title":"Systemic therapy for hepatocellular carcinoma: Cytotoxic chemotherapy, targeted therapy and immunotherapy","volume":"15","author":"Thomas","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"key20180108002841_b4-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol Rev"},{"key":"key20180108002841_b5-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/CS20060242","article-title":"Liver fibrosis: Cellular mechanisms of progression and resolution","volume":"112","author":"Henderson","year":"2007","journal-title":"Clin Sci (Lond)"},{"key":"key20180108002841_b6-mmr-16-04-5523","first-page":"213","article-title":"Etiology of hepatocellular carcinoma in Italian patients with and without cirrhosis","volume":"9","author":"Chiesa","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key20180108002841_b7-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1189\/jlb.0506297","article-title":"The role of cytokines in hepatocellular carcinoma","volume":"80","author":"Budhu","year":"2006","journal-title":"J Leukoc Biol"},{"key":"key20180108002841_b8-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1053\/j.gastro.2003.12.049","article-title":"Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance","volume":"126","author":"Sangiovanni","year":"2004","journal-title":"Gastroenterology"},{"key":"key20180108002841_b9-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1586\/egh.11.92","article-title":"Update on hepatic stellate cells: Pathogenic role in liver fibrosis and novel isolation techniques","volume":"6","author":"Tacke","year":"2012","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"key20180108002841_b10-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.jhep.2014.02.003","article-title":"Stellate cells and the development of liver cancer: Therapeutic potential of targeting the stroma","volume":"60","author":"Coulouarn","year":"2014","journal-title":"J Hepatol"},{"key":"key20180108002841_b11-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat Commun"},{"key":"key20180108002841_b12-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.2741\/4067","article-title":"Regulation of hepatic stellate cells by connective tissue growth factor","volume":"17","author":"Huang","year":"2012","journal-title":"Front Biosci (Landmark Ed)"},{"key":"key20180108002841_b13-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/j.1582-4934.2010.01072.x","article-title":"Integrin expression and function in the response of primary culture hepatic stellate cells to connective tissue growth factor (CCN2)","volume":"15","author":"Huang","year":"2011","journal-title":"J Cell Mol Med"},{"key":"key20180108002841_b14-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/labinvest.2010.88","article-title":"Hepatic stellate cells' involvement in progenitor-mediated liver regeneration","volume":"90","author":"Pintilie","year":"2010","journal-title":"Lab Invest"},{"key":"key20180108002841_b15-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1053\/j.gastro.2013.01.002","article-title":"Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma","volume":"144","author":"Hernandez-Gea","year":"2013","journal-title":"Gastroenterology"},{"key":"key20180108002841_b16-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1002\/ijc.25920","article-title":"Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice","volume":"129","author":"Zhao","year":"2011","journal-title":"Int J Cancer"},{"key":"key20180108002841_b17-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1309\/AJCP86PPBNGOHNNL","article-title":"Peritumoral activated hepatic stellate cells predict poor clinical outcome in hepatocellular carcinoma after curative resection","volume":"131","author":"Ju","year":"2009","journal-title":"Am J Clin Pathol"},{"key":"key20180108002841_b18-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1349-7006.2009.01087.x","article-title":"Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma","volume":"100","author":"Amann","year":"2009","journal-title":"Cancer Sci"},{"key":"key20180108002841_b19-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.drudis.2013.05.013","article-title":"Cell-specific delivery of biologicals: Problems, pitfalls and possibilities of antifibrotic compounds in the liver","volume":"18","author":"Poelstra","year":"2013","journal-title":"Drug Discov Today"},{"key":"key20180108002841_b20-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3892\/mco.2014.479","article-title":"Polaprezinc reduces the severity of radiation-induced mucositis in head and neck cancer patients","volume":"3","author":"Doi","year":"2015","journal-title":"Mol Clin Oncol"},{"key":"key20180108002841_b21-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/apt.12044","article-title":"Review article: The reversibility of cirrhosis","volume":"36","author":"Sohrabpour","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"key20180108002841_b22-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108002841_b23-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"e82190","DOI":"10.1371\/journal.pone.0082190","article-title":"Attenuation of CCl4-induced hepatic fibrosis in mice by vaccinating against TGF-\u03b21","volume":"8","author":"Fan","year":"2013","journal-title":"PLoS One"},{"key":"key20180108002841_b24-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"e54499","DOI":"10.1371\/journal.pone.0054499","article-title":"Transforming growth factor \u03b2 neutralization ameliorates pre-existing hepatic fibrosis and reduces cholangiocarcinoma in thioacetamide-treated rats","volume":"8","author":"Ling","year":"2013","journal-title":"PLoS One"},{"key":"key20180108002841_b25-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ki.2011.33","article-title":"A phase 1, single-dose study of fresolimumab, an anti-TGF-\u03b2 antibody, in treatment-resistant primary focal segmental glomerulosclerosis","volume":"79","author":"Trachtman","year":"2011","journal-title":"Kidney Int"},{"key":"key20180108002841_b26-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"e90353","DOI":"10.1371\/journal.pone.0090353","article-title":"Phase I study of GC1008 (fresolimumab): A human anti-transforming growth factor-beta (TGF\u03b2) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma","volume":"9","author":"Morris","year":"2014","journal-title":"PLoS One"},{"key":"key20180108002841_b27-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/sj.bjp.0706172","article-title":"Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis","volume":"145","author":"de Gouville","year":"2005","journal-title":"Br J Pharmacol"},{"key":"key20180108002841_b28-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10238-013-0229-6","article-title":"Inhibition of connective tissue growth factor suppresses hepatic stellate cell activation in vitro and prevents liver fibrosis in vivo","volume":"14","author":"Hao","year":"2014","journal-title":"Clin Exp Med"},{"key":"key20180108002841_b29-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/hep.23412","article-title":"Insulin-like growth factor I gene transfer to cirrhotic liver induces fibrolysis and reduces fibrogenesis leading to cirrhosis reversion in rats","volume":"51","author":"Sobrevals","year":"2010","journal-title":"Hepatology"},{"key":"key20180108002841_b30-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/hep.23785","article-title":"Long-term entecavir therapy results in the reversal of fibrosis\/cirrhosis and continued histological improvement in patients with chronic hepatitis B","volume":"52","author":"Chang","year":"2010","journal-title":"Hepatology"},{"key":"key20180108002841_b31-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1053\/j.gastro.2012.06.036","article-title":"Deactivation of hepatic stellate cells during liver fibrosis resolution in mice","volume":"143","author":"Troeger","year":"2012","journal-title":"Gastroenterology"},{"key":"key20180108002841_b32-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/nm.3282","article-title":"Targeting of \u03b1v integrin identifies a core molecular pathway that regulates fibrosis in several organs","volume":"19","author":"Henderson","year":"2013","journal-title":"Nat Med"},{"key":"key20180108002841_b33-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"Iredale","year":"2007","journal-title":"J Clin Invest"},{"key":"key20180108002841_b34-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/03008208909103901","article-title":"Collagens of normal and cirrhotic human liver","volume":"23","author":"Aycock","year":"1989","journal-title":"Connect Tissue Res"},{"key":"key20180108002841_b35-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jhep.2014.06.010","article-title":"Inhibition of fibronectin deposition improves experimental liver fibrosis","volume":"62","author":"Altrock","year":"2015","journal-title":"J Hepatol"},{"key":"key20180108002841_b36-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.lfs.2011.10.022","article-title":"Polaprezinc prevents ongoing thioacetamide-induced liver fibrosis in rats","volume":"90","author":"Kono","year":"2012","journal-title":"Life Sci"},{"key":"key20180108002841_b37-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1111\/j.1440-1746.2008.05393.x","article-title":"Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis","volume":"23","author":"Sugino","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"key20180108002841_b38-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: Pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"key20180108002841_b39-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/bjc.2013.25","article-title":"Diabetes mellitus and risk of hepatocellular carcinoma: Findings from the Singapore Chinese Health Study","volume":"108","author":"Koh","year":"2013","journal-title":"Br J Cancer"},{"key":"key20180108002841_b40-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1245\/s10434-009-0568-4","article-title":"Hepatic stellate cells may relate to progression of intrahepatic cholangiocarcinoma","volume":"16","author":"Okabe","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"key20180108002841_b41-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1158\/0008-5472.CAN-11-3317","article-title":"Hepatocyte-stellate cell cross-talk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma","volume":"72","author":"Coulouarn","year":"2012","journal-title":"Cancer Res"},{"key":"key20180108002841_b42-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"6679","DOI":"10.1038\/onc.2008.264","article-title":"Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration","volume":"27","author":"Wu","year":"2008","journal-title":"Oncogene"},{"key":"key20180108002841_b43-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13148-015-0121-1","article-title":"Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach","volume":"7","author":"Gao","year":"2015","journal-title":"Clin Epigenetics"},{"key":"key20180108002841_b44-mmr-16-04-5523","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1053\/j.gastro.2016.02.040","article-title":"Tumor-associated neutrophils recruit macrophages and T-Regulatory cells to promote progression of hepatocellular carcinoma and resistance to sorafenib","volume":"150","author":"Zhou","year":"2016","journal-title":"Gastroenterology"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T23:00:06Z","timestamp":1750806006000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.7262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,16]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,8,16]]},"published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.3892\/mmr.2017.7262"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.7262","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,16]]}}}