{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T07:15:56Z","timestamp":1782026156920,"version":"3.54.5"},"reference-count":27,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.3892\/mmr.2017.7268","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T06:58:17Z","timestamp":1502953097000},"page":"5269-5276","source":"Crossref","is-referenced-by-count":12,"title":["Licochalcone E protects against carbon tetrachloride-induced liver toxicity by activating peroxisome proliferator-activated receptor gamma"],"prefix":"10.3892","volume":"16","author":[{"given":"Jichun","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiusheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"key20180108002845_b1-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"168905","DOI":"10.1155\/2015\/168905","article-title":"Drug induced steatohepatitis: An uncommon culprit of a common disease","volume":"2015","author":"Rabinowich","year":"2015","journal-title":"Biomed Res Int"},{"key":"key20180108002845_b2-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2174\/138161210790883787","article-title":"Hepatocellular carcinoma and non-alcoholic fatty liver disease: From a clinical to a molecular association","volume":"16","author":"Petta","year":"2010","journal-title":"Curr Pharm Des"},{"key":"key20180108002845_b3-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2169\/internalmedicine.47.0595","article-title":"Retrospective evaluation of serum markers APRI and AST\/ALT for assessing liver fibrosis and cirrhosis in chronic hepatitis B and C patients with hepatocellular carcinoma","volume":"47","author":"Lin","year":"2008","journal-title":"Intern Med"},{"key":"key20180108002845_b4-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"696383","DOI":"10.1155\/2014\/696383","article-title":"Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride-(CCl4-) induced liver injury in mice","volume":"2014","author":"Rocha","year":"2014","journal-title":"Mediators Inflamm"},{"key":"key20180108002845_b5-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1615\/JEnvironPatholToxicolOncol.2015013837","article-title":"D-Pinitol protects against carbon tetrachloride-induced hepatotoxicity in rats","volume":"34","author":"Rengarajan","year":"2015","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"key20180108002845_b6-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/toxsci\/kfw045","article-title":"Vinyl chloride metabolites potentiate inflammatory liver injury caused by LPS in mice","volume":"151","author":"Anders","year":"2016","journal-title":"Toxicol Sci"},{"key":"key20180108002845_b7-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5625\/lar.2016.32.1.24","article-title":"Role of mitogen-activated protein kinases and nuclear factor-kappa B in 1,3-dichloro-2-propanol-induced hepatic injury","volume":"32","author":"Lee","year":"2016","journal-title":"Lab Anim Res"},{"key":"key20180108002845_b8-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s12011-015-0283-x","article-title":"Oxidative stress markers and histological analysis in diverse organs from rats treated with a hepatotoxic dose of Cr(VI): Effect of Curcumin","volume":"167","author":"Garc\u00eda-Ni\u00f1o","year":"2015","journal-title":"Biol Trace Elem Res"},{"key":"key20180108002845_b9-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3109\/08958378.2014.986314","article-title":"Roles of oxidative damage and mitochondria-mediated apoptosis in ethylbenzene-induced hepatotoxic effects in rat","volume":"27","author":"Zhang","year":"2015","journal-title":"Inhal Toxicol"},{"key":"key20180108002845_b10-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3892\/or.2015.4068","article-title":"Anti-oxidative and hepatoprotective effects of lithospermic acid against carbon tetrachloride-induced liver oxidative damage in vitro and in vivo","volume":"34","author":"Chan","year":"2015","journal-title":"Oncol Rep"},{"key":"key20180108002845_b11-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12906-015-0636-1","article-title":"Supplementation of fresh ucche (Momordica charantia L. var. muricata Willd) prevented oxidative stress, fibrosis and hepatic damage in CCl4 treated rats","volume":"15","author":"Sagor","year":"2015","journal-title":"BMC Complement Altern Med"},{"key":"key20180108002845_b12-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.apsb.2015.05.005","article-title":"The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb","volume":"5","author":"Wang","year":"2015","journal-title":"Acta Pharm Sin B"},{"key":"key20180108002845_b13-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"10926","DOI":"10.3390\/ijms140610926","article-title":"Mechanisms by which licochalcone e exhibits potent anti-inflammatory properties: Studies with phorbol ester-treated mouse skin and lipopolysaccharide-stimulated murine macrophages","volume":"14","author":"Lee","year":"2013","journal-title":"Int J Mol Sci"},{"key":"key20180108002845_b14-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jnutbio.2011.07.012","article-title":"Licochalcone E activates Nrf2\/antioxidant response element signaling pathway in both neuronal and microglial cells: Therapeutic relevance to neurodegenerative disease","volume":"23","author":"Kim","year":"2012","journal-title":"J Nutr Biochem"},{"key":"key20180108002845_b15-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.intimp.2010.06.015","article-title":"Licochalcone E reduces chronic allergic contact dermatitis and inhibits IL-12p40 production through down-regulation of NF-kappa B","volume":"10","author":"Cho","year":"2010","journal-title":"Int Immunopharmacol"},{"key":"key20180108002845_b16-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jnutbio.2011.03.021","article-title":"Licochalcone E has an antidiabetic effect","volume":"23","author":"Park","year":"2012","journal-title":"J Nutr Biochem"},{"key":"key20180108002845_b17-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4103\/0975-7406.168029","article-title":"Hepatoprotective potential of kumaryasava and its concentrate against CCl4-induced hepatic toxicity in Wistar rats","volume":"7","author":"Khan","year":"2015","journal-title":"J Pharm Bioallied Sci"},{"key":"key20180108002845_b18-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.gene.2015.12.042","article-title":"Involvement of fibroblast-specific protein 1 (S100A4) and matrix metalloproteinase-13 (MMP-13) in CCl4-induced reversible liver fibrosis","volume":"579","author":"Louka","year":"2016","journal-title":"Gene"},{"key":"key20180108002845_b19-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.etap.2015.02.012","article-title":"Carbon tetrachloride-induced liver injury in mice is tissue factor dependent","volume":"39","author":"Abdel-Bakky","year":"2015","journal-title":"Environ Toxicol Pharmacol"},{"key":"key20180108002845_b20-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/imm.12460","article-title":"Peptidoglycan recognition protein-peptidoglycan complexes increase monocyte\/macrophage activation and enhance the inflammatory response","volume":"145","author":"De Marzi","year":"2015","journal-title":"Immunology"},{"key":"key20180108002845_b21-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/j.jnutbio.2013.07.004","article-title":"The effects of dietary fatty acids on the postprandial triglyceride-rich lipoprotein\/apoB48 receptor axis in human monocyte\/macrophage cells","volume":"24","author":"Varela","year":"2013","journal-title":"J Nutr Biochem"},{"key":"key20180108002845_b22-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"3","DOI":"10.36290\/csf.2016.001","article-title":"The relationship of lipid imbalance and chronic inflammation mediated by PPAR","volume":"65","author":"\u010cavojsk\u00fd","year":"2016","journal-title":"Ceska Slov Farm"},{"key":"key20180108002845_b23-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3109\/08820139.2015.1137935","article-title":"Trillin reduces liver chronic inflammation and fibrosis in carbon tetrachloride (CCl4) induced liver injury in mice","volume":"45","author":"Tan","year":"2016","journal-title":"Immunol Invest"},{"key":"key20180108002845_b24-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00204-003-0458-7","article-title":"Markers of experimental acute inflammation in the Wistar Han rat with particular reference to haptoglobin and C-reactive protein","volume":"77","author":"Giffen","year":"2003","journal-title":"Arch Toxicol"},{"key":"key20180108002845_b25-mmr-16-04-5269","first-page":"864839","article-title":"Erratum to \u201815-Deoxy-\u03b312,14-prostaglandin J2 reduces liver impairment in a model of ConA-induced acute hepatic inflammation by activation of PPAR\u03b3 and reduction in NF-\u03baB activity\u2019","volume":"2014","author":"Chen","year":"2014","journal-title":"PPAR Res"},{"key":"key20180108002845_b26-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"e97193","DOI":"10.1371\/journal.pone.0097193","article-title":"Telmisartan attenuates colon inflammation, oxidative perturbations and apoptosis in a rat model of experimental inflammatory bowel disease","volume":"9","author":"Arab","year":"2014","journal-title":"PLoS One"},{"key":"key20180108002845_b27-mmr-16-04-5269","doi-asserted-by":"crossref","first-page":"649568","DOI":"10.1155\/2015\/649568","article-title":"Liquiritigenin protects rats from carbon tetrachloride induced hepatic injury through PGC-1\u03b1 pathway","volume":"2015","author":"Zhang","year":"2015","journal-title":"Evid Based Complement Alternat Med"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T23:10:47Z","timestamp":1750806647000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.7268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,17]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,8,17]]},"published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.3892\/mmr.2017.7268"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.7268","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,17]]}}}