{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:51:35Z","timestamp":1782514295263,"version":"3.54.5"},"reference-count":33,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.3892\/mmr.2017.7276","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T08:15:47Z","timestamp":1502957747000},"page":"5515-5522","source":"Crossref","is-referenced-by-count":30,"title":["Hypoxia suppresses osteogenesis of bone mesenchymal stem cells via the extracellular signal-regulated 1\/2 and p38-mitogen activated protein kinase signaling pathways"],"prefix":"10.3892","volume":"16","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinggang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siru","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuangqi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"key20180108003341_b1-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.ecl.2005.07.009","article-title":"Pathophysiology of age-related bone loss and osteoporosis","volume":"34","author":"Khosla","year":"2005","journal-title":"Endocrinol Metab Clin North Am"},{"key":"key20180108003341_b2-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s001980050093","article-title":"Updated data on proximal femur bone mineral levels of US adults","volume":"8","author":"Looker","year":"1998","journal-title":"Osteoporos Int"},{"key":"key20180108003341_b3-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00256-011-1122-6","article-title":"Hard arteries, weak bones","volume":"40","author":"Griffith","year":"2011","journal-title":"Skeletal Radiol"},{"key":"key20180108003341_b4-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/03008201003783011","article-title":"Reduced local blood supply to the tibial metaphysis is associated with ovariectomy-induced osteoporosis in mice","volume":"52","author":"Ding","year":"2011","journal-title":"Connect Tissue Res"},{"key":"key20180108003341_b5-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S0889-5406(96)80012-6","article-title":"Vascular changes in the periodontal ligament after removal of orthodontic forces","volume":"110","author":"Murrell","year":"1996","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"key20180108003341_b6-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.jacc.2007.12.025","article-title":"Hypoxia, hypoxia-inducible transcription factor and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis","volume":"51","author":"Sluimer","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"key20180108003341_b7-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00223-002-2027-0","article-title":"Mechanical control of human osteoblast apoptosis and proliferation in relation to differentiation","volume":"72","author":"Weyts","year":"2003","journal-title":"Calcif Tissue Int"},{"key":"key20180108003341_b8-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S8756-3282(99)00210-0","article-title":"Osteoblasts\/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor\/RANKL but not macrophage colony-stimulating factor: Receptor activator of NF-kappa B ligand","volume":"25","author":"Udagawa","year":"1999","journal-title":"Bone"},{"key":"key20180108003341_b9-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11914-013-0139-2","article-title":"Functional impairment of bone formation in the pathogenesis of osteoporosis: The bone marrow regenerative competence","volume":"11","author":"Bidwell","year":"2013","journal-title":"Curr Osteoporos Rep"},{"key":"key20180108003341_b10-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.bbrc.2007.12.076","article-title":"Hypoxic osteocytes recruit human MSCs through an OPN\/CD44-mediated pathway","volume":"366","author":"Raheja","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108003341_b11-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/bit.24827","article-title":"Hypoxia induces osteogenic\/angiogenic responses of bone marrow-derived mesenchymal stromal cells seeded on bone-derived scaffolds via ERK1\/2 and p38 pathways","volume":"110","author":"Zhou","year":"2013","journal-title":"Biotechnol Bioeng"},{"key":"key20180108003341_b12-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.yexcr.2006.02.007","article-title":"Hypoxia inhibits the growth, differentiation and bone-forming capacity of rat osteoblasts","volume":"312","author":"Utting","year":"2006","journal-title":"Exp Cell Res"},{"key":"key20180108003341_b13-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"key20180108003341_b14-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.200610046","article-title":"Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development","volume":"176","author":"Ge","year":"2007","journal-title":"J Cell Biol"},{"key":"key20180108003341_b15-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1172\/JCI42285","article-title":"The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice","volume":"120","author":"Greenblatt","year":"2010","journal-title":"J Clin Invest"},{"key":"key20180108003341_b16-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T))method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108003341_b17-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1101\/gad.1243304","article-title":"The biology of hypoxia: The role of oxygen sensing in development, normal function, and disease","volume":"18","author":"Giaccia","year":"2004","journal-title":"Genes Dev"},{"key":"key20180108003341_b18-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/jor.1100050412","article-title":"Changes in bone marrow blood flow with aging","volume":"5","author":"Kita","year":"1987","journal-title":"J Orthop Res"},{"key":"key20180108003341_b19-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1359\/jbmr.2000.15.11.2240","article-title":"Nitroglycerin therapy is as efficacious as standard estrogen replacement therapy (Premarin) in prevention of oophorectomy-induced bone loss: A human pilot clinical study","volume":"15","author":"Wimalawansa","year":"2000","journal-title":"J Bone Miner Res"},{"key":"key20180108003341_b20-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/jcp.20571","article-title":"Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs","volume":"207","author":"Grayson","year":"2006","journal-title":"J Cell Physiol"},{"key":"key20180108003341_b21-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.bone.2006.11.024","article-title":"Hypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic factor expression","volume":"40","author":"Potier","year":"2007","journal-title":"Bone"},{"key":"key20180108003341_b22-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/jcp.1081","article-title":"Cultivation of rat marrow-derived mesenchymal stem cells in reduced oxygen tension: Effects on in vitro and in vivo osteochondrogenesis","volume":"187","author":"Lennon","year":"2001","journal-title":"J Cell Physiol"},{"key":"key20180108003341_b23-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"e416","DOI":"10.1371\/journal.pone.0000416","article-title":"Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo","volume":"2","author":"Hung","year":"2007","journal-title":"PloS One"},{"key":"key20180108003341_b24-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.bbrc.2007.05.054","article-title":"Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells","volume":"358","author":"Grayson","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108003341_b25-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"C1139","DOI":"10.1152\/ajpcell.00415.2005","article-title":"Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells","volume":"290","author":"Malladi","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"key20180108003341_b26-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0168-9525(03)00176-8","article-title":"Transcriptional mechanisms in osteoblast differentiation and bone formation","volume":"19","author":"Nakashima","year":"2003","journal-title":"Trends Genet"},{"key":"key20180108003341_b27-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0092-8674(00)80259-7","article-title":"Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development","volume":"89","author":"Otto","year":"1997","journal-title":"Cell"},{"key":"key20180108003341_b28-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0092-8674(00)80260-3","article-title":"Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia","volume":"89","author":"Mundlos","year":"1997","journal-title":"Cell"},{"key":"key20180108003341_b29-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"8783","DOI":"10.1128\/MCB.20.23.8783-8792.2000","article-title":"Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12","volume":"20","author":"Lee","year":"2000","journal-title":"Mol Cell Biol"},{"key":"key20180108003341_b30-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.gene.2005.10.017","article-title":"Phosphorylation, acetylation and ubiquitination: The molecular basis of RUNX regulation","volume":"366","author":"Bae","year":"2006","journal-title":"Gene"},{"key":"key20180108003341_b31-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1038\/sj.onc.1210415","article-title":"MAP kinases and the control of nuclear events","volume":"26","author":"Turjanski","year":"2007","journal-title":"Oncogene"},{"key":"key20180108003341_b32-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"7403","DOI":"10.1074\/jbc.275.10.7403","article-title":"The differential time-course of extracellular-regulated kinase activity correlates with the macrophage response toward proliferation or activation","volume":"275","author":"Valledor","year":"2000","journal-title":"J Biol Chem"},{"key":"key20180108003341_b33-mmr-16-04-5515","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1074\/jbc.275.6.4453","article-title":"MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1","volume":"275","author":"Xiao","year":"2000","journal-title":"J Biol Chem"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T01:14:23Z","timestamp":1515374063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.7276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,17]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,8,17]]},"published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.3892\/mmr.2017.7276"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.7276","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,17]]}}}