{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:38:46Z","timestamp":1790933926216,"version":"4.1.0"},"reference-count":36,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.3892\/mmr.2017.7501","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T06:19:12Z","timestamp":1505715552000},"page":"7520-7526","source":"Crossref","is-referenced-by-count":26,"title":["Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K\/AKT\/FOXO3a pathway"],"prefix":"10.3892","volume":"16","author":[{"given":"Qi","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifa","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansheng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biqi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongzhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianpeng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"key":"key20180108003700_b1-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0016-5085(03)01048-5","article-title":"Protective strategies against ischemic injury of the liver","volume":"125","author":"Selzner","year":"2003","journal-title":"Gastroenterology"},{"key":"key20180108003700_b2-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion-from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat Med"},{"key":"key20180108003700_b3-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/hep.25710","article-title":"TIMP-1 deficiency leads to lethal partial hepatic ischemia and reperfusion injury","volume":"56","author":"Duarte","year":"2012","journal-title":"Hepatology"},{"key":"key20180108003700_b4-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.trre.2011.10.006","article-title":"Current strategies to minimize hepatic ischemia-reperfusion injury by tageting reactive oxygen species","volume":"26","author":"Jaeschke","year":"2012","journal-title":"Transplant Rev (Orlando)"},{"key":"key20180108003700_b5-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/00000658-195009000-00018","article-title":"General hypothermia for experimental intracardiac surgery","volume":"132","author":"Bigelow","year":"1950","journal-title":"Ann Surg"},{"key":"key20180108003700_b6-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"520745","DOI":"10.1155\/2015\/520745","article-title":"5\u2032-adenosine monophosphate-induced hypothermia attenuates brain ischemia\/reperfusion injury in a rat model by inhibiting the inflammatory response","volume":"2015","author":"Miao","year":"2015","journal-title":"Mediators Inflamm"},{"key":"key20180108003700_b7-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/ALN.0000000000000149","article-title":"Beneficial effects of nitric oxide on outcomes after cardiac arrest and cardiopulmonary resuscitation in hypothermia-treated mice","volume":"120","author":"Kida","year":"2014","journal-title":"Anesthesiology"},{"key":"key20180108003700_b8-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1478-3231.2006.01292.x","article-title":"Mild hypothermia reduces the inflammatory response and hepatic ischemia\/reperfusion injury in rats","volume":"26","author":"Behrends","year":"2006","journal-title":"Liver Int"},{"key":"key20180108003700_b9-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.surg.2006.01.021","article-title":"Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion","volume":"140","author":"Niemann","year":"2006","journal-title":"Surgery"},{"key":"key20180108003700_b10-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.jhep.2014.06.020","article-title":"Helium preconditioning protects mouse liver against ischemia and reperfusion injury through the PI3K\/Akt pathway","volume":"61","author":"Zhang","year":"2014","journal-title":"J Hepatol"},{"key":"key20180108003700_b11-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"e104043","DOI":"10.1371\/journal.pone.0104043","article-title":"Carvacrol alleviates ischemia reperfusion injury by regulating the PI3K-Akt pathway in rats","volume":"9","author":"Suo","year":"2014","journal-title":"PLoS One"},{"key":"key20180108003700_b12-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"19773","DOI":"10.1074\/jbc.M113.457622","article-title":"Enhanced phosphatidylinositol 3-kinase (PI3K)\/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress","volume":"288","author":"Uranga","year":"2013","journal-title":"J Biol Chem"},{"key":"key20180108003700_b13-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","article-title":"AKT promotes cells survival by phosphorylating and inhibiting a forkhead transcription factor","volume":"96","author":"Brunet","year":"1999","journal-title":"Cell"},{"key":"key20180108003700_b14-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1126\/science.278.5341.1319","article-title":"daf-16: An HNF-3\/forkhead family member that can function to double the life-span of Caenorhabditis elegans","volume":"278","author":"Lin","year":"1997","journal-title":"Science"},{"key":"key20180108003700_b15-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1042\/bj3490629","article-title":"Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues","volume":"349","author":"Furuyama","year":"2000","journal-title":"Biochem J"},{"key":"key20180108003700_b16-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1126\/science.1109083","article-title":"Functional interaction between beta-catenin and FOXO in oxidative stress signaling","volume":"308","author":"Essers","year":"2005","journal-title":"Science"},{"key":"key20180108003700_b17-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.bbamcr.2011.06.002","article-title":"FoxO transcription factors; Regulation by AKT and 14-3-3 proteins","volume":"1813","author":"Tzivion","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"key20180108003700_b18-mmr-16-05-7520","first-page":"pdb.prot4986","article-title":"Hematoxylin and eosin staining of tissue and cell sections","volume":"2008","author":"Fischer","year":"2008","journal-title":"CSH Protoc"},{"key":"key20180108003700_b19-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1097\/00007890-199306000-00011","article-title":"Neutriphil infiltration as an important factor in liver ishcemia and reperfusion injury. Modulating effects of FK506 and cyclosporine","volume":"55","author":"Suzuki","year":"1993","journal-title":"Transplantation"},{"key":"key20180108003700_b20-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108003700_b21-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.brainres.2016.05.042","article-title":"Hypothermia-induced ischemic tolerance is associated with Drp1 inhibition in cerebral ischemia-reperfusion injury of mice","volume":"1646","author":"Tang","year":"2016","journal-title":"Brain Res"},{"key":"key20180108003700_b22-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jss.2008.08.030","article-title":"Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines","volume":"158","author":"Niemann","year":"2010","journal-title":"J Surg Res"},{"key":"key20180108003700_b23-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1056\/NEJMoa1501969","article-title":"Therapeutic hypothermia in deceased organ donors and kidney-graft function","volume":"373","author":"Niemann","year":"2015","journal-title":"New Engl J Med"},{"key":"key20180108003700_b24-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa003289","article-title":"Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia","volume":"346","author":"Bernard","year":"2002","journal-title":"New Engl J Med"},{"key":"key20180108003700_b25-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.4049\/jimmunol.1102979","article-title":"Protein kinase C-\u03b8 inhibits inducible regulatory T cell differentiation via an AKT-Foxo1\/3a-dependent pathway","volume":"188","author":"Ma","year":"2012","journal-title":"J Immunol"},{"key":"key20180108003700_b26-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"1232103","DOI":"10.1155\/2016\/1232103","article-title":"Hydroxytyrosol protects against myocardial ischemia\/reperfusion injury through a PI3K\/Akt-dependent mechanism","volume":"2016","author":"Pei","year":"2016","journal-title":"Mediators Inflamm"},{"key":"key20180108003700_b27-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuint.2014.01.006","article-title":"Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia\/reperfusion-induced apoptosis through PI3K\/Akt\/GSK3\u03b2 pathway in rats","volume":"66","author":"Chen","year":"2014","journal-title":"Neurochem Int"},{"key":"key20180108003700_b28-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jss.2010.07.041","article-title":"Testosterone-down-regulated Akt pathway during cardiac ischemia\/reperfusion: A mechanism involving BAD, Bcl-2 and FOXO3a","volume":"164","author":"Huang","year":"2010","journal-title":"J Surg Res"},{"key":"key20180108003700_b29-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","article-title":"Cell death and cell death responses in liver disease: Mechanisms and clinical relevance","volume":"147","author":"Luedde","year":"2014","journal-title":"Gastroenterology"},{"key":"key20180108003700_b30-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.4049\/jimmunol.1200596","article-title":"FOXO transcription factors regulate innate immune mechanisms in respiratory epithelial cells","volume":"190","author":"Seiler","year":"2013","journal-title":"J Immunol"},{"key":"key20180108003700_b31-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1111\/j.1600-6143.2011.03579.x","article-title":"Liver ischemia and reperfusion injury: New insights into mechanisms of innate adaptive immune-mediated tissue inflammation","volume":"11","author":"Zhai","year":"2011","journal-title":"Am J Transplant"},{"key":"key20180108003700_b32-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-kappaB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"key20180108003700_b33-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12929-015-0147-x","article-title":"Altered exosomal protein expression in the serum of NF-\u03baB knockout mice following skeletal muscle ischemia-reperfusion injury","volume":"22","author":"Yang","year":"2015","journal-title":"J Biomed Sci"},{"key":"key20180108003700_b34-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/ajt.12954","article-title":"ATF3-mediated NRF2\/HO-1 signaling regulates TLR4 innate immune responses in mouse liver ischemia\/reperfusion injury","volume":"15","author":"Rao","year":"2015","journal-title":"Am J Transplant"},{"key":"key20180108003700_b35-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.STR.0000120732.45951.26","article-title":"Nuclear factor-kappaB contributes to infarction after permanent focal ischemia","volume":"35","author":"Nurmi","year":"2004","journal-title":"Stroke"},{"key":"key20180108003700_b36-mmr-16-05-7520","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.2337\/db09-0232","article-title":"FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages","volume":"58","author":"Su","year":"2009","journal-title":"Diabetes"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T20:18:10Z","timestamp":1515356290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.7501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,9,18]]},"published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.3892\/mmr.2017.7501"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.7501","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]}}}