{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:37:13Z","timestamp":1773059833890,"version":"3.50.1"},"reference-count":40,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.3892\/mmr.2017.7571","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T01:57:36Z","timestamp":1505959056000},"page":"7745-7751","source":"Crossref","is-referenced-by-count":5,"title":["Antioxidant and anti-inflammatory effects of DHK-medicated serum on high glucose-induced injury in endothelial cells"],"prefix":"10.3892","volume":"16","author":[{"given":"Ziyang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenpei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yandong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianqin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenghao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoqin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,9,21]]},"reference":[{"key":"key20180108003722_b1-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"29240","DOI":"10.1038\/srep29240","article-title":"Bilirubin is an endogenous antioxidant in human vascular endothelial cells","volume":"6","author":"Ziberna","year":"2016","journal-title":"Sci Rep"},{"key":"key20180108003722_b2-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"9580234","DOI":"10.1155\/2016\/9580234","article-title":"Vascular protective role of Samul-Tang in HUVECs: Involvement of Nrf2\/HO-1 and NO","volume":"2016","author":"Choi","year":"2016","journal-title":"Evid Based Complement Alternat Med"},{"key":"key20180108003722_b3-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/bph.13517","article-title":"Targeting vascular (endothelial) dysfunction","volume":"174","author":"Daiber","year":"2017","journal-title":"Br J Pharmacol"},{"key":"key20180108003722_b4-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cmet.2012.11.012","article-title":"Vascular complications of diabetes: Mechanisms of injury and protective factors","volume":"17","author":"Rask-Madsen","year":"2013","journal-title":"Cell Metab"},{"key":"key20180108003722_b5-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2478\/v10102-011-0005-y","article-title":"Protection of the vascular endothelium in experimental situations","volume":"4","author":"Sotn\u00edkov\u00e1","year":"2011","journal-title":"Interdiscip Toxicol"},{"key":"key20180108003722_b6-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/FJC.0000000000000382","article-title":"Potential of food and natural products to promote endothelial and vascular health","volume":"68","author":"Auger","year":"2016","journal-title":"J Cardiovasc Pharmacol"},{"key":"key20180108003722_b7-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"403703","DOI":"10.1155\/2014\/403703","article-title":"Brazilin ameliorates high glucose-induced vascular inflammation via inhibiting ROS and CAMs production in human umbilical vein endothelial cells","volume":"2014","author":"Jayakumar","year":"2014","journal-title":"Biomed Res Int"},{"key":"key20180108003722_b8-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.freeradbiomed.2006.07.017","article-title":"Superoxide dismutase overexpression and cellular oxidative damage in diabetes. A commentary on \u2018Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress\u2019","volume":"41","author":"Jain","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"key20180108003722_b9-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pain.2004.06.004","article-title":"Superoxide-mediated nitration of spinal manganese superoxide dismutase: A novel pathway in N-methyl-Daspartate-mediated hyperalgesia","volume":"111","author":"Muscoli","year":"2004","journal-title":"Pain"},{"key":"key20180108003722_b10-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"21525","DOI":"10.3390\/ijms141121525","article-title":"Oxidative stress in diabetes: Implications for vascular and other complications","volume":"14","author":"Pitocco","year":"2013","journal-title":"Int J Mol Sci"},{"key":"key20180108003722_b11-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1159\/000369702","article-title":"Hyperketonemia (acetoacetate) upregulates NADPH oxidase 4 and elevates oxidative stress, ICAM-1, and monocyte adhesivity in endothelial cells","volume":"35","author":"Kanikarla-Marie","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"key20180108003722_b12-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/01.ATV.0000155462.24263.e4","article-title":"High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway","volume":"25","author":"Sheu","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20180108003722_b13-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s00125-007-0684-2","article-title":"Reactive oxygen species mediate a cellular \u2018memory\u2019 of high glucose stress signalling","volume":"50","author":"Ihnat","year":"2007","journal-title":"Diabetologia"},{"key":"key20180108003722_b14-mmr-16-05-7745","first-page":"BC04","article-title":"A Study on the level of oxidative stress and inflammatory markers in type 2 diabetes mellitus patients with different treatment modalities","volume":"9","author":"Palem","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"key20180108003722_b15-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.clinbiochem.2008.08.074","article-title":"Biomarkers of oxidative stress and endothelial dysfunction in glucose intolerance and diabetes mellitus","volume":"41","author":"Pereira","year":"2008","journal-title":"Clin Biochem"},{"key":"key20180108003722_b16-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/biof.1312","article-title":"Low nanomolar caffeic acid attenuates high glucose-induced endothelial dysfunction in primary human umbilical-vein endothelial cells by affecting NF-\u03baB and Nrf2 pathways","volume":"43","author":"Fratantonio","year":"2017","journal-title":"Biofactors"},{"key":"key20180108003722_b17-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3746\/pnf.2013.18.1.038","article-title":"Effect of Polyopes lancifolia extract on oxidative stress in human umbilical vein endothelial cells induced by high glucose","volume":"18","author":"Min","year":"2013","journal-title":"Prev Nutr Food Sci"},{"key":"key20180108003722_b18-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1080\/09168451.2014.991679","article-title":"Grape seed proanthocyanidin extracts prevent high glucose-induced endothelia dysfunction via PKC and NF-\u03baB inhibition","volume":"79","author":"Jiang","year":"2015","journal-title":"Biosci Biotechnol Biochem"},{"key":"key20180108003722_b19-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"e108844","DOI":"10.1371\/journal.pone.0108844","article-title":"The role of TLR2 and 4-mediated inflammatory pathways in endothelial cells exposed to high glucose","volume":"9","author":"Mudaliar","year":"2014","journal-title":"PLoS One"},{"key":"key20180108003722_b20-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2013.10.034","article-title":"Protective effects of chronic resveratrol treatment on vascular inflammatory injury in streptozotocin-induced type 2 diabetic rats: Role of NF-kappa B signaling","volume":"720","author":"Zheng","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"key20180108003722_b21-mmr-16-05-7745","first-page":"599","article-title":"Preventive effect of danhong huayu koufuye on diabetic retinopathy in rats","volume":"4","author":"Lin","year":"2011","journal-title":"Int J Ophthalmol"},{"key":"key20180108003722_b22-mmr-16-05-7745","first-page":"1218","article-title":"Effect of danhong huayu oral liquid combined with insulin on prevention and progression of early diabetic cardiomyopathy in rats","volume":"37","author":"Lin","year":"2014","journal-title":"Zhong Yao Cai"},{"key":"key20180108003722_b23-mmr-16-05-7745","first-page":"1094","article-title":"Danhong Huayu Koufuye combined with metformin attenuated diabetic retinopathy in Zucker diabetic fatty rats","volume":"8","author":"Chen","year":"2015","journal-title":"Int J Ophthalmol"},{"key":"key20180108003722_b24-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jss.2015.11.008","article-title":"Danhong huayu koufuye prevents deep vein thrombosis through anti-inflammation in rats","volume":"201","author":"Zhang","year":"2016","journal-title":"J Surg Res"},{"key":"key20180108003722_b25-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3892\/mmr.2016.5235","article-title":"Protective effects of hyperoside against H2O2-induced apoptosis in human umbilical vein endothelial cells","volume":"14","author":"Hao","year":"2016","journal-title":"Mol Med Rep"},{"key":"key20180108003722_b26-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/ptr.2547","article-title":"Buddleja officinalis inhibits high glucose induced matrix metalloproteinase activity in human umbilical vein endothelial cells","volume":"22","author":"Lee","year":"2008","journal-title":"Phytother Res"},{"key":"key20180108003722_b27-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1089\/ars.2008.2027","article-title":"Redox control of endothelial function and dysfunction: Molecular mechanisms and therapeutic opportunities","volume":"10","author":"Thomas","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"key20180108003722_b28-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/aps.2011.191","article-title":"Traditional Chinese medicine formula Qing Huo Yi Hao as superoxide anion scavenger in high glucose-treated endothelial cells","volume":"33","author":"Xu","year":"2012","journal-title":"Acta Pharmacol Sin"},{"key":"key20180108003722_b29-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"e113716","DOI":"10.1371\/journal.pone.0113716","article-title":"Resveratrol ameliorates high glucose and high-fat\/sucrose diet-induced vascular hyperpermeability involving Cav-1\/eNOS regulation","volume":"9","author":"Peng","year":"2014","journal-title":"PLoS One"},{"key":"key20180108003722_b30-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"e88243","DOI":"10.1371\/journal.pone.0088243","article-title":"Tetramethylpyrazine ameliorates high glucose-Induced endothelial dysfunction by increasing mitochondrial biogenesis","volume":"9","author":"Xu","year":"2014","journal-title":"PLoS One"},{"key":"key20180108003722_b31-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3797\/scipharm.1408-16","article-title":"Curcumin attenuates oxidative stress and activation of redox-sensitive kinases in high fructose- and high-fat-fed male Wistar rats","volume":"83","author":"Maithili","year":"2014","journal-title":"Sci Pharm"},{"key":"key20180108003722_b32-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jep.2015.10.034","article-title":"Antidiabetic properties of lyophilized extract of acorn (Quercus brantii Lindl.) on experimentally STZ-induced diabetic rats","volume":"176","author":"Dogan","year":"2015","journal-title":"J Ethnopharmacol"},{"key":"key20180108003722_b33-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"H147","DOI":"10.1152\/ajpheart.00759.2014","article-title":"Increased activity of mitochondrial uncoupling protein 2 improves stress resistance in cultured endothelial cells exposed in vitro to high glucose levels","volume":"309","author":"Koziel","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key20180108003722_b34-mmr-16-05-7745","first-page":"22004","article-title":"TLR2 expression doesn't change in ox-LDL mediated inflammation in Human umbilical vein endothelial cells under high glucose culture","volume":"8","author":"Li","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"key20180108003722_b35-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1515\/cmble-2015-0053","article-title":"Ramipril inhibits high glucose stimulated up-regulation of adhesion molecules via the ERK1\/2 MAPK signaling pathway in human umbilical vein endothelial cells","volume":"20","author":"Kim","year":"2015","journal-title":"Cell Mol Biol Lett"},{"key":"key20180108003722_b36-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1080\/00325481.2015.1039451","article-title":"Atorvastatin counteracts high glucose-induced Kr\u00fcppel-like factor 2 suppression in human umbilical vein endothelial cells","volume":"127","author":"Liu","year":"2015","journal-title":"Postgrad Med"},{"key":"key20180108003722_b37-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.bbrc.2007.06.044","article-title":"Hyperglycemia increases the levels of vascular cellular adhesion molecule-1 and monocyte-chemoattractant-protein-1 in the diabetic endothelial cell","volume":"360","author":"Haubner","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180108003722_b38-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.diabres.2011.03.019","article-title":"Effect of pioglitazone on diabetic nephropathy and expression of HIF-1\u03b1 and VEGF in the renal tissues of type 2 diabetic rats","volume":"93","author":"Xu","year":"2011","journal-title":"Diabetes Res Clin Pract"},{"key":"key20180108003722_b39-mmr-16-05-7745","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/aps.2012.61","article-title":"Calcium mediates high glucose-induced HIF-1\u03b1 and VEGF expression in cultured rat retinal M\u00fcller cells through CaMKII-CREB pathway","volume":"33","author":"Li","year":"2012","journal-title":"Acta Pharmacol Sin"},{"key":"key20180108003722_b40-mmr-16-05-7745","article-title":"Epigallocatechin-3-gallate protects retinal vascular endothelial cells from high glucose stress in vitro via the MAPK\/ERK-VEGF pathway","volume":"15","author":"Zhang","year":"2016","journal-title":"Genet Mol Res"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T20:18:40Z","timestamp":1515356320000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.7571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,9,21]]},"published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.3892\/mmr.2017.7571"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.7571","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5]]}}}