{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:37:52Z","timestamp":1776080272644,"version":"3.50.1"},"reference-count":47,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.3892\/mmr.2017.7651","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T06:56:42Z","timestamp":1506581802000},"page":"7959-7966","source":"Crossref","is-referenced-by-count":22,"title":["Bufalin induced apoptosis in SCC-4 human tongue cancer cells by decreasing Bcl-2 and increasing Bax expression via the mitochondria-dependent pathway"],"prefix":"10.3892","volume":"16","author":[{"given":"Han-Yu","family":"Chou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Shin","family":"Chueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Shih","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick Sai-Chuen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Lung","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Lin","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Jen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Wen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Gung","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"key20180108005832_b1-mmr-16-06-7959","first-page":"259","article-title":"Oral cancer: Risk factors, prevention and diagnostic","volume":"30","author":"Khalili","year":"2008","journal-title":"Exp Oncol"},{"key":"key20180108005832_b2-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"E437","DOI":"10.3390\/molecules22030437","article-title":"Bufalin induces apoptosis of human osteosarcoma U-2 os cells through endoplasmic reticulum stress, caspase- and mitochondria-dependent signaling pathways","volume":"22","author":"Lee","year":"2017","journal-title":"Molecules"},{"key":"key20180108005832_b3-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.ijrobp.2008.05.024","article-title":"Intensity-modulated radiotherapy in postoperative treatment of oral cavity cancers","volume":"73","author":"Gomez","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180108005832_b4-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"319489","DOI":"10.1155\/2013\/319489","article-title":"Cancer stem cell markers in head and neck squamous cell carcinoma","volume":"2013","author":"Major","year":"2013","journal-title":"Stem Cells Int"},{"key":"key20180108005832_b5-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1002\/cncr.28595","article-title":"What is the best treatment for patients with human papillomavirus-positive and -negative oropharyngeal cancer?","volume":"120","author":"Urban","year":"2014","journal-title":"Cancer"},{"key":"key20180108005832_b6-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-9422(97)00426-3","article-title":"Bufadienolides from animal and plant sources","volume":"48","author":"Krenn","year":"1998","journal-title":"Phytochemistry"},{"key":"key20180108005832_b7-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.1002\/cncr.24602","article-title":"Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer","volume":"115","author":"Meng","year":"2009","journal-title":"Cancer"},{"key":"key20180108005832_b8-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.3748\/wjg.v13.i24.3374","article-title":"Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice","volume":"13","author":"Han","year":"2007","journal-title":"World J Gastroenterol"},{"key":"key20180108005832_b9-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0145-2126(97)00061-1","article-title":"Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs","volume":"21","author":"Hashimoto","year":"1997","journal-title":"Leuk Res"},{"key":"key20180108005832_b10-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/sj.onc.1201592","article-title":"Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells","volume":"16","author":"Watabe","year":"1998","journal-title":"Oncogene"},{"key":"key20180108005832_b11-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/CAD.0b013e3283160fd6","article-title":"PI3 K\/Akt is involved in bufalin-induced apoptosis in gastric cancer cells","volume":"20","author":"Li","year":"2009","journal-title":"Anticancer Drugs"},{"key":"key20180108005832_b12-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1111\/j.1349-7006.2008.00966.x","article-title":"Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells","volume":"99","author":"Yu","year":"2008","journal-title":"Cancer Sci"},{"key":"key20180108005832_b13-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"212","DOI":"10.7150\/ijbs.8056","article-title":"Bufalin induces the interplay between apoptosis and autophagy in glioma cells through endoplasmic reticulum stress","volume":"10","author":"Shen","year":"2014","journal-title":"Int J Biol Sci"},{"key":"key20180108005832_b14-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mrfmmm.2011.09.010","article-title":"Bufalin induces G0\/G1 phase arrest through inhibiting the levels of cyclin D cyclin E, CDK2 and CDK4 and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells","volume":"732","author":"Huang","year":"2012","journal-title":"Mutat Res"},{"key":"key20180108005832_b15-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s10616-010-9310-0","article-title":"Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action","volume":"62","author":"Jiang","year":"2010","journal-title":"Cytotechnology"},{"key":"key20180108005832_b16-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/1477-7819-10-228","article-title":"Inhibition of Jak-STAT3 pathway enhances bufalin-induced apoptosis in colon cancer SW620 cells","volume":"10","author":"Zhu","year":"2012","journal-title":"World J Surg Oncol"},{"key":"key20180108005832_b17-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1142\/S0192415X14500475","article-title":"Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways","volume":"42","author":"Wu","year":"2014","journal-title":"Am J Chin Med."},{"key":"key20180108005832_b18-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.biomed.2013.05.001","article-title":"Inhibitory effect of alpinate Oxyphyllae fructus extracts on Ang II-induced cardiac pathological remodeling-related pathways in H9c2 cardiomyoblast cells","volume":"3","author":"Chang","year":"2013","journal-title":"Biomedicine"},{"key":"key20180108005832_b19-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/tox.20658","article-title":"Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways","volume":"27","author":"Yu","year":"2012","journal-title":"Environ Toxicol"},{"key":"key20180108005832_b20-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3892\/or.2012.2170","article-title":"Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes","volume":"29","author":"Chueh","year":"2013","journal-title":"Oncol Rep"},{"key":"key20180108005832_b21-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/tox.21769","article-title":"The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells","volume":"29","author":"Liu","year":"2014","journal-title":"Environ Toxicol"},{"key":"key20180108005832_b22-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.biomed.2013.09.001","article-title":"Leptin induces cell invasion and the upregulation of matrilysin in human colon cancer cells","volume":"3","author":"Lin","year":"2013","journal-title":"Biomedicine"},{"key":"key20180108005832_b23-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"9200","DOI":"10.1074\/jbc.M112.411371","article-title":"Chromatin collapse during caspase-dependent apoptotic cell death requires DNA fragmentation factor, 40-kDa subunit-\/caspase-activated deoxyribonuclease-mediated 3\u2032-OH single-strand DNA breaks","volume":"288","author":"Iglesias-Guimarais","year":"2013","journal-title":"J Biol Chem"},{"key":"key20180108005832_b24-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1007\/s13277-014-1911-3","article-title":"Bufalin induces cell cycle arrest and apoptosis in gallbladder carcinoma cells","volume":"35","author":"Jiang","year":"2014","journal-title":"Tumour Biol"},{"key":"key20180108005832_b25-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejphar.2012.06.045","article-title":"Bufotalin from venenum bufonis inhibits growth of multidrug resistant HepG2 cells through G2\/M cell cycle arrest and apoptosis","volume":"692","author":"Zhang","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"key20180108005832_b26-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/tox.22325","article-title":"Bufalin induces apoptosis in vitro and has Antitumor activity against human lung cancer xenografts in vivo","volume":"32","author":"Wu","year":"2017","journal-title":"Environ Toxicol"},{"key":"key20180108005832_b27-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.7314\/APJCP.2012.13.11.5339","article-title":"Anti-tumor activity and apoptosis-regulation mechanisms of bufalin in various cancers: new hope for cancer patients","volume":"13","author":"Yin","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"key":"key20180108005832_b28-mmr-16-06-7959","first-page":"3420","article-title":"Bufalin promotes apoptosis of gastric cancer by down-regulation of miR-298 targeting bax","volume":"8","author":"Zhao","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"key20180108005832_b29-mmr-16-06-7959","first-page":"114","article-title":"Bufalin induces apoptosis through activation of both the intrinsic and extrinsic pathways in human bladder cancer cells","volume":"27","author":"Hong","year":"2012","journal-title":"Oncol Rep"},{"key":"key20180108005832_b30-mmr-16-06-7959","first-page":"1193","article-title":"Cell cycle arrest and protein kinase modulating effect of bufalin on human leukemia ML1 cells","volume":"14","author":"Jing","year":"1994","journal-title":"Anticancer Res"},{"key":"key20180108005832_b31-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/jcp.1041600114","article-title":"Involvement of Na+, K(+)-ATPase inhibition in K562 cell differentiation induced by bufalin","volume":"160","author":"Numazawa","year":"1994","journal-title":"J Cell Physiol"},{"key":"key20180108005832_b32-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1475-2867-13-10","article-title":"Synergistic effect of paclitaxel and epigenetic agent phenethyl isothiocyanate on growth inhibition, cell cycle arrest and apoptosis in breast cancer cells","volume":"13","author":"Liu","year":"2013","journal-title":"Cancer Cell Int"},{"key":"key20180108005832_b33-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"9839","DOI":"10.1021\/jf403241s","article-title":"Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy","volume":"61","author":"Chu","year":"2013","journal-title":"J Agric Food Chem"},{"key":"key20180108005832_b34-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"R620","DOI":"10.1016\/j.cub.2016.05.023","article-title":"Just so stories about the evolution of apoptosis","volume":"26","author":"Green","year":"2016","journal-title":"Curr Biol"},{"key":"key20180108005832_b35-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1016\/j.biomaterials.2011.02.008","article-title":"The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles","volume":"32","author":"Li","year":"2011","journal-title":"Biomaterials"},{"key":"key20180108005832_b36-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2337\/db08-0178","article-title":"Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells","volume":"58","author":"Grunnet","year":"2009","journal-title":"Diabetes"},{"key":"key20180108005832_b37-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.2337\/db11-0758","article-title":"PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic beta-cell apoptosis via regulation of the BH3-only protein Bim","volume":"60","author":"Santin","year":"2011","journal-title":"Diabetes"},{"key":"key20180108005832_b38-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1158\/1535-7163.MCT-15-0400","article-title":"Dual agonist surrobody simultaneously activates death receptors dr4 and dr5 to induce cancer cell death","volume":"15","author":"Milutinovic","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"key20180108005832_b39-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ejphar.2010.10.005","article-title":"Activation of p38 MAPK by damnacanthal mediates apoptosis in SKHep 1 cells through the DR5\/TRAIL and TNFR1\/TNF-alpha and p53 pathways","volume":"650","author":"Lin","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"key20180108005832_b40-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/cdd.2009.49","article-title":"Superoxide is the major reactive oxygen species regulating autophagy","volume":"16","author":"Chen","year":"2009","journal-title":"Cell Death Differ"},{"key":"key20180108005832_b41-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1442-2042.2011.02876.x","article-title":"Bee venom induces apoptosis through intracellular Ca2+ -modulated intrinsic death pathway in human bladder cancer cells","volume":"19","author":"Ip","year":"2012","journal-title":"Int J Urol"},{"key":"key20180108005832_b42-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/01635581.2012.725503","article-title":"Diallyl sulfide promotes cell-cycle arrest through the p53 expression and triggers induction of apoptosis via caspase- and mitochondria-dependent signaling pathways in human cervical cancer Ca Ski cells","volume":"65","author":"Chiu","year":"2013","journal-title":"Nutr Cancer"},{"key":"key20180108005832_b43-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/tox.22208","article-title":"Dithiothreitol enhanced arsenic-trioxide-induced cell apoptosis in cultured oral cancer cells via mitochondrial dysfunction and endoplasmic reticulum stress","volume":"32","author":"Tsai","year":"2015","journal-title":"Environ Toxicol"},{"key":"key20180108005832_b44-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.phymed.2012.05.012","article-title":"Involvement of NF-kappaB and Bcl2\/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A","volume":"19","author":"Mohan","year":"2012","journal-title":"Phytomedicine"},{"key":"key20180108005832_b45-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/tox.21827","article-title":"Crude extract of Rheum palmatum L induced cell death in LS1034 human colon cancer cells acts through the caspase-dependent and -independent pathways","volume":"29","author":"Ma","year":"2014","journal-title":"Environ Toxicol"},{"key":"key20180108005832_b46-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"20659","DOI":"10.3390\/molecules201119729","article-title":"Cyclovirobuxine D inhibits cell proliferation and induces mitochondria-mediated apoptosis in human gastric cancer cells","volume":"20","author":"Wu","year":"2015","journal-title":"Molecules"},{"key":"key20180108005832_b47-mmr-16-06-7959","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1021\/tx100248s","article-title":"Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways","volume":"24","author":"Chiang","year":"2011","journal-title":"Chem Res Toxicol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T02:00:40Z","timestamp":1515376840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.7651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,28]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,9,28]]},"published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.3892\/mmr.2017.7651"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.7651","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,28]]}}}