{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:51:56Z","timestamp":1758120716642},"reference-count":49,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.3892\/mmr.2017.7659","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T08:30:44Z","timestamp":1506587444000},"page":"8245-8252","source":"Crossref","is-referenced-by-count":5,"title":["Novel insights into the effect of paroxetine administration in pilocarpine-induced chronic epileptic rats"],"prefix":"10.3892","volume":"16","author":[{"given":"Wan-Hui","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Xing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Pin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"key20180108005343_b1-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1600-0447.1995.tb09576.x","article-title":"Effect of paroxetine on seizure length during electroconvulsive therapy","volume":"92","author":"Curran","year":"1995","journal-title":"Acta Psychiatr Scand"},{"key":"key20180108005343_b2-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.biopsych.2006.09.023","article-title":"Seizure incidence in psychopharmacological clinical trials: An analysis of Food and Drug Administration (FDA) summary basis of approval reports","volume":"62","author":"Alper","year":"2007","journal-title":"Biol Psychiatry"},{"key":"key20180108005343_b3-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.yebeh.2015.01.015","article-title":"Citalopram as a good candidate for treatment of depression in patients with epilepsy","volume":"44","author":"Payandemehr","year":"2015","journal-title":"Epilepsy Behav"},{"key":"key20180108005343_b4-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.brainresbull.2014.12.009","article-title":"Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats","volume":"111","author":"Shiha","year":"2015","journal-title":"Brain Res Bull"},{"key":"key20180108005343_b5-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1528-1167.2012.03436.x","article-title":"The antidepressants citalopram and reboxetine reduce seizure frequency in rats with chronic epilepsy","volume":"53","author":"Vermoesen","year":"2012","journal-title":"Epilepsia"},{"key":"key20180108005343_b6-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2012.12.007","article-title":"Seizure-induced 5-HT release and chronic impairment of serotonergic function in rats","volume":"534","author":"Lin","year":"2013","journal-title":"Neurosci Lett"},{"key":"key20180108005343_b7-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1038\/tp.2011.54","article-title":"Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16","volume":"1","author":"Launay","year":"2011","journal-title":"Transl Psychiatry"},{"key":"key20180108005343_b8-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"9522","DOI":"10.1038\/srep09522","article-title":"Genome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep"},{"key":"key20180108005343_b9-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1038\/srep04734","article-title":"Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy","volume":"4","author":"Li","year":"2014","journal-title":"Sci Rep"},{"key":"key20180108005343_b10-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/WCO.0000000000000079","article-title":"MicroRNA and epilepsy: Profiling, functions and potential clinical applications","volume":"27","author":"Henshall","year":"2014","journal-title":"Curr Opin Neurol"},{"key":"key20180108005343_b11-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1471-2202-13-115","article-title":"MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus","volume":"13","author":"Hu","year":"2012","journal-title":"BMC Neurosci"},{"key":"key20180108005343_b12-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/j.1528-1167.2012.03540.x","article-title":"Interleukin-1\u03b2 and microRNA-146a in an immature rat model and children with mesial temporal lobe epilepsy","volume":"53","author":"Omran","year":"2012","journal-title":"Epilepsia"},{"key":"key20180108005343_b13-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-3-319-22671-2_4","article-title":"microRNA and epilepsy","volume":"888","author":"Reschke","year":"2015","journal-title":"Adv Exp Med Biol"},{"key":"key20180108005343_b14-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/s12031-013-0013-9","article-title":"Expressions of tumor necrosis factor alpha and microRNA-155 in immature rat model of status epilepticus and children with mesial temporal lobe epilepsy","volume":"51","author":"Ashhab","year":"2013","journal-title":"J Mol Neurosci"},{"key":"key20180108005343_b15-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1007\/s00018-012-0992-7","article-title":"Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response","volume":"69","author":"Kan","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"key20180108005343_b16-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/bjh.13043","article-title":"Loss of MIR15A and MIR16-1 at 13q14 is associated with increased TP53 mRNA, de-repression of BCL2 and adverse outcome in chronic lymphocytic leukaemia","volume":"167","author":"Lin","year":"2014","journal-title":"Br J Haematol"},{"key":"key20180108005343_b17-mmr-16-06-8245","first-page":"161","volume-title":"The Rat Brain in Stereotactic Coordinates","author":"Paxinos","year":"2005","edition":"5th edition"},{"key":"key20180108005343_b18-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation. II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"key20180108005343_b19-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/B978-012088554-1\/50050-5","volume-title":"Models of Seizures and Epilepsy","author":"Veliskova","year":"2006"},{"key":"key20180108005343_b20-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180108005343_b21-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1471-4159.2006.04277.x","article-title":"Serotonin and epilepsy","volume":"100","author":"Bagdy","year":"2007","journal-title":"J Neurochem"},{"key":"key20180108005343_b22-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1535-7597.2003.03508.x","article-title":"Does serotonin play a role in epilepsy?","volume":"3","author":"Theodore","year":"2003","journal-title":"Epilepsy Curr"},{"key":"key20180108005343_b23-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"289","DOI":"10.5698\/1535-7597-13.6.289","article-title":"Serotonin and epilepsy: The story continues","volume":"13","author":"Gidal","year":"2013","journal-title":"Epilepsy Curr"},{"key":"key20180108005343_b24-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1528-1157.1979.tb04832.x","article-title":"Uptake of taurine, GABA, 5-HT, and dopamine by blood platelets in progressive myoclonus epilepsy","volume":"20","author":"Airaksinen","year":"1979","journal-title":"Epilepsia"},{"key":"key20180108005343_b25-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1111\/j.1528-1167.2010.02594.x","article-title":"Serotonin reuptake inhibitors are associated with reduced severity of ictal hypoxemia in medically refractory partial epilepsy","volume":"51","author":"Bateman","year":"2010","journal-title":"Epilepsia"},{"key":"key20180108005343_b26-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.eplepsyres.2008.08.010","article-title":"Serotonin depletion effects on the pilocarpine model of epilepsy","volume":"82","author":"Trindade-Filho","year":"2008","journal-title":"Epilepsy Res"},{"key":"key20180108005343_b27-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.eplepsyres.2014.12.013","article-title":"Hippocampal serotonin depletion is related to the presence of generalized tonic-clonic seizures, but not to psychiatric disorders in patients with temporal lobe epilepsy","volume":"111","author":"da Fonseca","year":"2015","journal-title":"Epilepsy Res"},{"key":"key20180108005343_b28-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.nbd.2013.11.020","article-title":"Chronic antidepressant treatment accelerates kindling epileptogenesis in rats","volume":"63","author":"Cardamone","year":"2014","journal-title":"Neurobiol Dis"},{"key":"key20180108005343_b29-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s13760-014-0400-1","article-title":"Association of serotonin transporter gene (5HTT) polymorphism and juvenile myoclonic epilepsy: A case-control study","volume":"115","author":"Esmail","year":"2015","journal-title":"Acta Neurol Belg"},{"key":"key20180108005343_b30-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1089\/gtmb.2013.0341","article-title":"Serotonin transporter (5-HTT) gene polymorphisms and susceptibility to epilepsy: A meta-analysis and meta-regression","volume":"17","author":"Yang","year":"2013","journal-title":"Genet Test Mol Biomarkers"},{"key":"key20180108005343_b31-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1212\/WNL.0b013e31828cf809","article-title":"The 5-HT1A receptor and 5-HT transporter in temporal lobe epilepsy","volume":"80","author":"Martinez","year":"2013","journal-title":"Neurology"},{"key":"key20180108005343_b32-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.eplepsyres.2011.03.013","article-title":"Serotonin transporter gene (5HTT) polymorphisms and temporal lobe epilepsy","volume":"95","author":"Schenkel","year":"2011","journal-title":"Epilepsy Res"},{"issue":"Suppl 4","key":"key20180108005343_b33-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1111\/j.1528-1167.2011.03145.x","article-title":"The methylation hypothesis: Do epigenetic chromatin modifications play a role in epileptogenesis?","volume":"52","author":"Kobow","year":"2011","journal-title":"Epilepsia"},{"key":"key20180108005343_b34-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1538\/expanim.14-0066","article-title":"Advances on genetic rat models of epilepsy","volume":"64","author":"Serikawa","year":"2015","journal-title":"Exp Anim"},{"issue":"Database issue","key":"key20180108005343_b35-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"D893","DOI":"10.1093\/nar\/gku943","article-title":"EpilepsyGene: A genetic resource for genes and mutations related to epilepsy","volume":"43","author":"Ran","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"key20180108005343_b36-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s13311-014-0262-5","article-title":"Genetic biomarkers in epilepsy","volume":"11","author":"Weber","year":"2014","journal-title":"Neurotherapeutics"},{"key":"key20180108005343_b37-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"e85617","DOI":"10.1371\/journal.pone.0085617","article-title":"Unique behavioral characteristics and microRNA signatures in a drug resistant epilepsy model","volume":"9","author":"Moon","year":"2014","journal-title":"PloS one"},{"key":"key20180108005343_b38-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neuroscience.2013.02.027","article-title":"Epilepsy and microRNA","volume":"238","author":"Jimenez-Mateos","year":"2013","journal-title":"Neuroscience"},{"key":"key20180108005343_b39-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/jcmm.12445","article-title":"Attenuation of microRNA-16 derepresses the cyclins D1, D2 and E1 to provoke cardiomyocyte hypertrophy","volume":"19","author":"Huang","year":"2015","journal-title":"J Cell Mol Med"},{"key":"key20180108005343_b40-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.3892\/mmr.2015.3718","article-title":"Paeoniflorin inhibits proliferation and induces apoptosis of human glioma cells via microRNA-16 upregulation and matrix metalloproteinase-9 downregulation","volume":"12","author":"Li","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20180108005343_b41-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/s11626-015-9872-4","article-title":"Overexpression of microRNA-16 declines cellular growth, proliferation and induces apoptosis in human breast cancer cells","volume":"51","author":"Mobarra","year":"2015","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"key20180108005343_b42-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"e46921","DOI":"10.1371\/journal.pone.0046921","article-title":"Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life","volume":"7","author":"Bai","year":"2012","journal-title":"PLoS One"},{"key":"key20180108005343_b43-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.3892\/or.2013.2731","article-title":"Cisplatin regulates SH-SY5Y cell growth through downregulation of BDNF via miR-16","volume":"30","author":"Sun","year":"2013","journal-title":"Oncol Rep"},{"key":"key20180108005343_b44-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.seizure.2012.01.004","article-title":"Elevated serum Bcl-2 in children with temporal lobe epilepsy","volume":"21","author":"Kilany","year":"2012","journal-title":"Seizure"},{"key":"key20180108005343_b45-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.55.2.250","article-title":"Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy","volume":"55","author":"Henshall","year":"2000","journal-title":"Neurology"},{"key":"key20180108005343_b46-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1046\/j.1535-7597.2002.t01-1-00033.x","article-title":"Does BDNF contribute to temporal lobe epilepsy?","volume":"2","author":"Scharfman","year":"2002","journal-title":"Epilepsy Curr"},{"key":"key20180108005343_b47-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.brainres.2010.10.054","article-title":"BDNF-secreting capsule exerts neuroprotective effects on epilepsy model of rats","volume":"1368","author":"Kuramoto","year":"2011","journal-title":"Brain Res"},{"key":"key20180108005343_b48-mmr-16-06-8245","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jad.2015.02.022","article-title":"CSF miR-16 is decreased in major depression patients and its neutralization in rats induces depression-like behaviors via a serotonin transmitter system","volume":"178","author":"Song","year":"2015","journal-title":"J Affect Disord"},{"key":"key20180108005343_b49-mmr-16-06-8245","article-title":"Reciprocal microrna expression in mesocortical circuit and its interplay with serotonin transporter define resilient rats in the chronic mild stress","author":"Zurawek","year":"2016","journal-title":"Mol Neurobiol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T01:46:10Z","timestamp":1515375970000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.7659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,28]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,9,28]]},"published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.3892\/mmr.2017.7659"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.7659","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,28]]}}}