{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:03:34Z","timestamp":1773155014231,"version":"3.50.1"},"reference-count":27,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.3892\/mmr.2017.7684","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T02:51:37Z","timestamp":1506912697000},"page":"8643-8648","source":"Crossref","is-referenced-by-count":7,"title":["Macrophage migration inhibitory factor knockdown inhibit viability and induce apoptosis of PVM\/Ms"],"prefix":"10.3892","volume":"16","author":[{"given":"Wenjing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Neng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaobing","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,10,2]]},"reference":[{"key":"key20180108005309_b1-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"2S1","DOI":"10.1016\/j.otohns.2008.05.598","article-title":"R442-Antioxidant therapy prevents presbycusis In C57BL6 mice","volume":"139","author":"Heman-Ackah","year":"2008","journal-title":"Otolaryngology Head & Neck Surgery"},{"key":"key20180108005309_b2-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1001\/archinternmed.2008.597","article-title":"Prevalence of age-related hearing loss in older adults: Blue mountains study","volume":"169","author":"Gopinath","year":"2009","journal-title":"Arch Intern Med"},{"key":"key20180108005309_b3-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0378-5955(97)00006-3","article-title":"Speech recognition in noise and presbycusis: Relations to possible neural mechanisms","volume":"106","author":"Frisina","year":"1997","journal-title":"Hear Res"},{"key":"key20180108005309_b4-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","article-title":"Presbycusis","volume":"366","author":"Gates","year":"2005","journal-title":"Lancet"},{"key":"key20180108005309_b5-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.heares.2012.08.017","article-title":"Parvalbumin immunoreactivity in the auditory cortex of a mouse model of presbycusis","volume":"294","author":"del Campo","year":"2012","journal-title":"Hear Res"},{"key":"key20180108005309_b6-mmr-16-06-8643","first-page":"72","article-title":"Blood-labyrinth barrier and fluid dynamics of the inner ear","volume":"7","author":"Juhn","year":"2001","journal-title":"Int Tinnitus J"},{"key":"key20180108005309_b7-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/000348948109000208","article-title":"Nature of blood-labyrinth barrier in experimental conditions","volume":"90","author":"Juhn","year":"1981","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"key20180108005309_b8-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1288\/00005537-198708000-00020","article-title":"Mechanisms of endocochlear potential generation by stria vascularis","volume":"97","author":"Salt","year":"1987","journal-title":"Laryngoscope"},{"key":"key20180108005309_b9-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-5955(01)00252-0","article-title":"Three-dimensional and ultrastructural relationships between intermediate cells and capillaries in the gerbil stria vascularis","volume":"155","author":"Takeuchi","year":"2001","journal-title":"Hear Res"},{"key":"key20180108005309_b10-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.2353\/ajpath.2010.100340","article-title":"Bone marrow cell recruitment mediated by inducible nitric oxide synthase\/stromal cell-derived factor-1alpha signaling repairs the acoustically damaged cochlear blood-babyrinth barrier","volume":"177","author":"Dai","year":"2010","journal-title":"Am J Pathol"},{"key":"key20180108005309_b11-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00441-010-1040-2","article-title":"Resident macrophages in the cochlear blood-labyrinth barrier and their renewal via migration of bone-marrow-derived cells","volume":"342","author":"Shi","year":"2010","journal-title":"Cell Tissue Res"},{"key":"key20180108005309_b12-mmr-16-06-8643","unstructured":"ZhangWDaiMFridbergerAHassanADegagneJNengLZhangFHeWRenTTruneDPerivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrierProc Natl Acad Sci USA1091038810393201210.1073\/pnas.1205210109226899493387119"},{"key":"key20180108005309_b13-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neuroscience.2014.08.042","article-title":"Role of macrophage migration inhibitory factor in age-related hearing loss","volume":"279","author":"Kariya","year":"2014","journal-title":"Neuroscience"},{"key":"key20180108005309_b14-mmr-16-06-8643","first-page":"659","article-title":"The role of macrophage migration inhibitory factor (MIF) in cell proliferation signal transmission","volume":"79","author":"Obikane","year":"2004","journal-title":"Hokkaido Igaku Zasshi"},{"key":"key20180108005309_b15-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1089\/10799900050151012","article-title":"Macrophage migration inhibitory factor (MIF): Its essential role in the immune system and cell growth","volume":"20","author":"Nishihira","year":"2000","journal-title":"J Interferon Cytokine Res"},{"key":"key20180108005309_b16-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-5955(03)00365-4","article-title":"Age-related hearing loss and the ahl locus in mice","volume":"188","author":"Keithley","year":"2004","journal-title":"Hear Res"},{"key":"key20180108005309_b17-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0378-5955(87)90137-7","article-title":"Aging and the auditory brainstem response in mice with severe or minimal presbycusis","volume":"30","author":"Hunter","year":"1987","journal-title":"Hear Res"},{"key":"key20180108005309_b18-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nprot.2013.033","article-title":"Isolation and culture of endothelial cells, pericytes and perivascular resident macrophage-like melanocytes from the young mouse ear","volume":"8","author":"Neng","year":"2013","journal-title":"Nat Protoc"},{"key":"key20180108005309_b19-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1038\/cddis.2011.63","article-title":"Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation","volume":"2","author":"Kaur","year":"2011","journal-title":"Cell Death Dis"},{"key":"key20180108005309_b20-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10162-011-0283-2","article-title":"Age-related primary cochlear neuronal degeneration in human temporal bones","volume":"12","author":"Makary","year":"2011","journal-title":"J Assoc Res Otolaryngol"},{"key":"key20180108005309_b21-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s10162-013-0403-2","article-title":"Characterization and inflammatory response of perivascular-resident macrophage-like melanocytes in the vestibular system","volume":"14","author":"Zhang","year":"2013","journal-title":"J Assoc Res Otolaryngol"},{"key":"key20180108005309_b22-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00441-015-2147-2","article-title":"Structural changes in thestrial blood-labyrinth barrier of aged C57BL\/6 mice","volume":"361","author":"Neng","year":"2015","journal-title":"Cell Tissue Res"},{"key":"key20180108005309_b23-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3109\/00016489.2014.880795","article-title":"Genes involved in immunity and apoptosis are associated with human presbycusis based on microarray analysis","volume":"134","author":"Dong","year":"2014","journal-title":"Acta Oto-laryngol"},{"key":"key20180108005309_b24-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.4049\/jimmunol.170.6.3337","article-title":"The cytokine macrophage migration inhibitory factor reduces pro-oxidative stress-induced apoptosis","volume":"170","author":"Nguyen","year":"2003","journal-title":"J Immunol"},{"key":"key20180108005309_b25-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1096\/fj.03-0110com","article-title":"Macrophage migration inhibitory factor delays apoptosis in neutrophils by inhibiting the mitochondria-dependent death pathway","volume":"17","author":"Baumann","year":"2003","journal-title":"FASEB J"},{"key":"key20180108005309_b26-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/icb.2011.89","article-title":"Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis","volume":"90","author":"Saksida","year":"2012","journal-title":"Immunol Cell Biol"},{"key":"key20180108005309_b27-mmr-16-06-8643","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/MAO.0000000000000755","article-title":"Macrophage migration inhibitory factor deficiency causes prolonged hearing loss after acoustic overstimulation","volume":"36","author":"Kariya","year":"2015","journal-title":"Otol & Neurot"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T20:42:33Z","timestamp":1515357753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.7684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,2]]},"references-count":27,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,10,2]]},"published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.3892\/mmr.2017.7684"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.7684","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,2]]}}}