{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T11:07:41Z","timestamp":1648984061231},"reference-count":40,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.3892\/mmr.2017.7703","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T11:42:25Z","timestamp":1507030945000},"page":"9029-9034","source":"Crossref","is-referenced-by-count":0,"title":["Identifying dysregulated pathways in postmenopausal osteoporosis through investigation of crosstalk between pathways"],"prefix":"10.3892","volume":"16","author":[{"given":"Jian-Hua","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Jun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hou-Jie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge-Hui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Xiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Qiang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,10,3]]},"reference":[{"key":"key20180108005244_b1-mmr-16-06-9029","first-page":"115","article-title":"Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis","volume":"21","author":"Manolagas","year":"2000","journal-title":"Endocr Rev"},{"key":"key20180108005244_b2-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1056\/NEJM198606263142605","article-title":"Involutional osteoporosis","volume":"314","author":"Riggs","year":"1986","journal-title":"N Engl J Med"},{"key":"key20180108005244_b3-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00774-007-0793-5","article-title":"Bone quality: The material and structural basis of bone strength","volume":"26","author":"Seeman","year":"2008","journal-title":"J Bone Miner Metab"},{"key":"key20180108005244_b4-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1053\/beog.2002.0284","article-title":"Post-menopausal osteoporosis","volume":"16","author":"Marcus","year":"2002","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"key20180108005244_b5-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.cell.2006.12.002","article-title":"Sex steroids, not FSH, influence bone mass","volume":"127","author":"Seibel","year":"2006","journal-title":"Cell"},{"key":"key20180108005244_b6-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11657-013-0136-1","article-title":"Osteoporosis in the European Union: Medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA)","volume":"8","author":"Hernlund","year":"2013","journal-title":"Arch Osteoporos"},{"key":"key20180108005244_b7-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of osteoporosis-related fractures in the United States, 2005\u20132025","volume":"22","author":"Burge","year":"2007","journal-title":"J Bone Miner Res"},{"key":"key20180108005244_b8-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1001\/archinte.165.16.1825","article-title":"Genetic liability to fractures in the elderly","volume":"165","author":"Micha\u00eblsson","year":"2005","journal-title":"Arch Intern Med"},{"key":"key20180108005244_b9-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"30558","DOI":"10.1038\/srep30558","article-title":"Integrating epigenomic elements and GWASs identifies BDNF gene affecting bone mineral density and osteoporotic fracture risk","volume":"6","author":"Guo","year":"2016","journal-title":"Sci Rep"},{"key":"key20180108005244_b10-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1002\/jbmr.1711","article-title":"Susceptibility genes for osteoporotic fracture in postmenopausal Chinese women","volume":"27","author":"Wang","year":"2012","journal-title":"J Bone Miner Res"},{"key":"key20180108005244_b11-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S1673-8527(07)60098-8","article-title":"Association of CA repeat polymorphism in estrogen receptor \u03b2 gene with postmenopausal osteoporosis in Chinese","volume":"34","author":"Geng","year":"2007","journal-title":"J Genet Genomics"},{"key":"key20180108005244_b12-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.4238\/2013.September.3.4","article-title":"Association between single nucleotide polymorphisms of the osteoprotegerin gene and postmenopausal osteoporosis in Chinese women","volume":"12","author":"Song","year":"2013","journal-title":"Genet Mol Res"},{"key":"key20180108005244_b13-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"534352","DOI":"10.1155\/2013\/534352","article-title":"Serum \u03b2-catenin levels associated with the ratio of RANKL\/OPG in patients with postmenopausal osteoporosis","volume":"2013","author":"Xu","year":"2013","journal-title":"Int J Endocrinol"},{"key":"key20180108005244_b14-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/abbs\/gmu103","article-title":"Protective effects of resveratrol on postmenopausal osteoporosis: Regulation of SIRT1-NF-\u03baB signaling pathway","volume":"46","author":"Feng","year":"2014","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"key20180108005244_b15-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bone.2012.11.015","article-title":"Identification of transcriptional macromolecular associations in human bone using browser based in silico analysis in a giant correlation matrix","volume":"53","author":"Reppe","year":"2013","journal-title":"Bone"},{"key":"key20180108005244_b16-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.3892\/mmr.2015.4283","article-title":"In silico analysis of the molecular mechanism of postmenopausal osteoporosis","volume":"12","author":"Liu","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20180108005244_b17-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1037\/h0071325","article-title":"Analysis of a complex of statistical variables into principal components","volume":"24","author":"Hotelling","year":"1933","journal-title":"J Edu Psychol"},{"key":"key20180108005244_b18-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"Affy-analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"key20180108005244_b19-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"key20180108005244_b20-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"Bolstad","year":"2003","journal-title":"Bioinformatics"},{"issue":"Database Issue","key":"key20180108005244_b21-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"D428","DOI":"10.1093\/nar\/gki072","article-title":"Reactome: A knowledgebase of biological pathways","volume":"33","author":"Joshi-Tope","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"key20180108005244_b22-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"i422","DOI":"10.1093\/bioinformatics\/btu449","article-title":"Personalized identification of altered pathways in cancer using accumulated normal tissue data","volume":"30","author":"Ahn","year":"2014","journal-title":"Bioinformatics"},{"issue":"Database Issue","key":"key20180108005244_b23-mmr-16-06-9029","first-page":"D808","article-title":"STRING v9.1: Protein-protein interaction networks, with increased coverage and integration","volume":"41","author":"Franceschini","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"key20180108005244_b24-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/wsbm.121","article-title":"Protein-protein interaction networks and subnetworks in the biology of disease","volume":"3","author":"Nibbe","year":"2011","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"key20180108005244_b25-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1093\/bioinformatics\/bti343","article-title":"A web-based tool for principal component and significance analysis of microarray data","volume":"21","author":"Sharov","year":"2005","journal-title":"Bioinformatics"},{"key":"key20180108005244_b26-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1038\/ng1561","article-title":"From signatures to models: Understanding cancer using microarrays","volume":"37","author":"Segal","year":"2005","journal-title":"Nat Genet"},{"key":"key20180108005244_b27-mmr-16-06-9029","first-page":"390","article-title":"Personalized discovery of altered pathways in clear cell renal cell carcinoma using accumulated normal sample data","volume":"21","author":"Wang","year":"2016","journal-title":"J BUON"},{"key":"key20180108005244_b28-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1093\/bioinformatics\/btp406","article-title":"Unite and conquer: Univariate and multivariate approaches for finding differentially expressed gene sets","volume":"25","author":"Glazko","year":"2009","journal-title":"Bioinformatics"},{"key":"key20180108005244_b29-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-4-S2-S11","article-title":"Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains","volume":"4","author":"Liu","year":"2010","journal-title":"BMC Syst Biol"},{"key":"key20180108005244_b30-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"e4346","DOI":"10.1371\/journal.pone.0004346","article-title":"A pathway-based view of human diseases and disease relationships","volume":"4","author":"Li","year":"2009","journal-title":"PLoS One"},{"key":"key20180108005244_b31-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1146\/annurev.biochem.73.011303.073950","article-title":"Analyzing cellular biochemistry in terms of molecular networks","volume":"73","author":"Xia","year":"2004","journal-title":"Biochemistry"},{"key":"key20180108005244_b32-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1186\/1471-2105-11-S1-S32","article-title":"Detection of characteristic sub pathway network for angiogenesis based on the comprehensive pathway network","volume":"11","author":"Huang","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"key20180108005244_b33-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"e1151","DOI":"10.1038\/cddis.2014.117","article-title":"Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe","volume":"5","author":"Mu","year":"2014","journal-title":"Cell Death Dis"},{"key":"key20180108005244_b34-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1126\/science.287.5462.2486","article-title":"Mitotic misregulation and human aging","volume":"287","author":"Ly","year":"2000","journal-title":"Science"},{"key":"key20180108005244_b35-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1101\/gad.12.13.1986","article-title":"Identification of Xenopus SMC protein complexes required for sister chromatid cohesion","volume":"12","author":"Losada","year":"1998","journal-title":"Genes Dev"},{"key":"key20180108005244_b36-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1128\/MCB.13.3.1883","article-title":"The yeast PRP19 protein is not tightly associated with small nuclear RNAs, but appears to associate with the spliceosome after binding of U2 to the pre-mRNA and prior to formation of the functional spliceosome","volume":"13","author":"Tarn","year":"1993","journal-title":"Mol Cell Biol"},{"key":"key20180108005244_b37-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nature08869","article-title":"Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes","volume":"464","author":"Neumann","year":"2010","journal-title":"Nature"},{"key":"key20180108005244_b38-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"e74851","DOI":"10.1371\/journal.pone.0074851","article-title":"The Prp19 complex directly functions in mitotic spindle assembly","volume":"8","author":"Hofmann","year":"2013","journal-title":"PLoS One"},{"key":"key20180108005244_b39-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"948","DOI":"10.15252\/embr.201438640","article-title":"Sororin pre-mRNA splicing is required for proper sister chromatid cohesion in human cells","volume":"15","author":"Watrin","year":"2014","journal-title":"EMBO Rep"},{"key":"key20180108005244_b40-mmr-16-06-9029","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1146\/annurev-physiol-030212-183715","article-title":"Genome instability and aging","volume":"75","author":"Vijg","year":"2013","journal-title":"Annu Rev Physiol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T01:41:01Z","timestamp":1515375661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.7703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,3]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,10,3]]},"published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.3892\/mmr.2017.7703"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.7703","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,3]]}}}