{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:20:39Z","timestamp":1765268439499},"reference-count":56,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.3892\/mmr.2017.7785","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T11:54:50Z","timestamp":1507809290000},"page":"9431-9440","source":"Crossref","is-referenced-by-count":10,"title":["Adenoviral-bone morphogenetic protein-7 and\/or doxazosin therapies promote the reversion of fibrosis\/cirrhosis in a cirrhotic hamster model"],"prefix":"10.3892","volume":"16","author":[{"given":"Daniel","family":"Cervantes-Garcia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Guadalupe","family":"Cuellar-Juarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gissela","family":"Borrego-Soto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Rojas-Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liseth Rubi","family":"Aldaba-Muruato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Ventura-Juarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin Humberto","family":"Mu\u00f1oz-Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"key20200713222731_b1-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12916-014-0145-y","article-title":"Liver cirrhosis mortality in 187 countries between 1980 and 2010: A systematic analysis","volume":"12","author":"Mokdad","year":"2014","journal-title":"BMC Med"},{"key":"key20200713222731_b2-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1016\/j.clinthera.2015.05.507","article-title":"Understanding the complexities of cirrhosis","volume":"37","author":"Muir","year":"2015","journal-title":"Clin Ther"},{"key":"key20200713222731_b3-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"11552","DOI":"10.3748\/wjg.v21.i41.11552","article-title":"Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico","volume":"21","author":"Ramos-Lopez","year":"2015","journal-title":"World J Gastroenterol"},{"key":"key20200713222731_b4-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1111\/j.1440-1746.2006.04700.x","article-title":"Effect of losartan on early liver fibrosis development in a rat model of nonalcoholic steatohepatitis","volume":"22","author":"Iba\u00f1ez","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"key20200713222731_b5-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"key20200713222731_b6-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"665","DOI":"10.4254\/wjh.v8.i16.665","article-title":"Mechanisms of adaptation of the hepatic vasculature to the deteriorating conditions of blood circulation in liver cirrhosis","volume":"8","author":"Garbuzenko","year":"2016","journal-title":"World J Hepatol"},{"key":"key20200713222731_b7-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3892\/etm.2014.1682","article-title":"NF-\u03baB inhibition alleviates carbon tetrachloride-induced liver fibrosis via suppression of activated hepatic stellate cells","volume":"8","author":"Wang","year":"2014","journal-title":"Exp Ther Med"},{"key":"key20200713222731_b8-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"954502","DOI":"10.1155\/2014\/954502","article-title":"Protective effect of astaxanthin on liver fibrosis through modulation of TGF-\u03b21 expression and autophagy","volume":"2014","author":"Shen","year":"2014","journal-title":"Mediators Inflamm"},{"key":"key20200713222731_b9-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.3892\/mmr.2016.5392","article-title":"Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17\/Treg cell balance","volume":"14","author":"Gu","year":"2016","journal-title":"Mol Med Rep"},{"key":"key20200713222731_b10-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.yexmp.2005.03.008","article-title":"Hepatocyte production of modulators of extracellular liver matrix in normal and cirrhotic rat liver","volume":"80","author":"Garc\u00edade Le\u00f3n Mdel","year":"2006","journal-title":"Exp Mol Pathol"},{"key":"key20200713222731_b11-mmr-16-06-9431","first-page":"20463","article-title":"Zinc mediated hepatic stellate cell collagen synthesis reduction through TGF-\u03b2 signaling pathway inhibition","volume":"8","author":"Kang","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"key20200713222731_b12-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1136\/gutjnl-2013-305908","article-title":"Molecular targets for antifibrotic therapy in liver disease: Using magic bullets for crossfire rather than a one-sided shotgun attack","volume":"63","author":"Hellerbrand","year":"2014","journal-title":"Gut"},{"key":"key20200713222731_b13-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"101","DOI":"10.5009\/gnl14459","article-title":"Doxazosin treatment attenuates carbon tetrachloride-induced liver fibrosis in hamsters through a decrease in transforming growth factor \u03b2 secretion","volume":"10","author":"Mu\u00f1oz-Ortega","year":"2016","journal-title":"Gut Liver"},{"key":"key20200713222731_b14-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1080\/08037050902843726","article-title":"Doxazosin: Safety and efficacy in the treatment of resistant arteria hypertension","volume":"18","author":"Ceral","year":"2009","journal-title":"Blood Press"},{"key":"key20200713222731_b15-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1517\/14656566.5.6.1279","article-title":"The role of alpha-blockers in the management of prostate cancer","volume":"5","author":"Tahmatzopoulos","year":"2004","journal-title":"Expert Opin Pharmacother"},{"key":"key20200713222731_b16-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1200\/JCO.2005.00.463","article-title":"Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas","volume":"23","author":"Mazzolini","year":"2005","journal-title":"J Clin Oncol"},{"key":"key20200713222731_b17-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/S0888-7543(05)80181-8","article-title":"A bone morphogenetic protein subfamily: Chromosomal localization of human genes for BMP5, BMP6, and BMP7","volume":"14","author":"Hahn","year":"1992","journal-title":"Genomics"},{"key":"key20200713222731_b18-mmr-16-06-9431","first-page":"243","article-title":"Inhibition of proliferation and induction of differentiation of pluripotent human embryonal carcinoma cells by osteogenic protein-1 (or bone morphogenetic protein-7)","volume":"71","author":"Andrews","year":"1994","journal-title":"Lab Invest"},{"key":"key20200713222731_b19-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/ijc.10856","article-title":"Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling","volume":"103","author":"Midorikawa","year":"2003","journal-title":"Int J Cancer"},{"key":"key20200713222731_b20-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1530\/rep.1.01074","article-title":"TGF-beta superfamily members and ovarian follicle development","volume":"132","author":"Knight","year":"2006","journal-title":"Reproduction"},{"key":"key20200713222731_b21-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.stem.2014.09.009","article-title":"BMP signaling and its pSMAD1\/5 target genes differentially regulate hair follicle stem cell lineages","volume":"15","author":"Genander","year":"2014","journal-title":"Cell Stem Cell"},{"key":"key20200713222731_b22-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s13577-014-0098-7","article-title":"BMP-7 improved proliferation and hematopoietic reconstitution potential of ex vivo expanded cord blood-derived CD34(+) cells","volume":"28","author":"Su","year":"2015","journal-title":"Hum Cell"},{"key":"key20200713222731_b23-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"G135","DOI":"10.1152\/ajpgi.00482.2005","article-title":"Bone morphogenetic protein signaling and growth suppression in colon cancer","volume":"291","author":"Beck","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key20200713222731_b24-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1465-9921-11-85","article-title":"Bone morphogenetic protein (BMP)-4 and BMP-7 regulate differentially transforming growth factor (TGF)-beta1 in normal human lung fibroblasts (NHLF)","volume":"11","author":"Pegorier","year":"2010","journal-title":"Respir Res"},{"key":"key20200713222731_b25-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.bbrc.2013.09.128","article-title":"The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling","volume":"440","author":"Zhang","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713222731_b26-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"20841","DOI":"10.1038\/srep20841","article-title":"ITF2357 transactivates Id3 and regulate TGF\u03b2\/BMP7 signaling pathways to attenuate corneal fibrosis","volume":"6","author":"Lim","year":"2016","journal-title":"Sci Rep"},{"key":"key20200713222731_b27-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"22089","DOI":"10.1074\/jbc.M700998200","article-title":"Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro","volume":"282","author":"Kaimori","year":"2007","journal-title":"J Biol Chem"},{"key":"key20200713222731_b28-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"23200","DOI":"10.1074\/jbc.M311998200","article-title":"Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells","volume":"279","author":"Wang","year":"2004","journal-title":"J Biol Chem"},{"key":"key20200713222731_b29-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"3686","DOI":"10.1093\/ndt\/gfs381","article-title":"Inhibitors\/antagonists of TGF-\u03b2 system in kidney fibrosis","volume":"27","author":"Yanagita","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"key20200713222731_b30-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.toxlet.2013.04.017","article-title":"Bone morphogenetic protein-7 inhibits silica-induced pulmonary fibrosis in rats","volume":"220","author":"Yang","year":"2013","journal-title":"Toxicol Lett"},{"key":"key20200713222731_b31-mmr-16-06-9431","first-page":"897","article-title":"Inhibitory effect of bone morphogenetic protein-7 on hepatic fibrosis in rats","volume":"6","author":"Wang","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"key20200713222731_b32-mmr-16-06-9431","first-page":"3537","article-title":"BMP-7 attenuates liver fibrosis via regulation of epidermal growth factor receptor","volume":"7","author":"Wang","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"key20200713222731_b33-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"7403890","DOI":"10.1155\/2016\/7403890","article-title":"Implant composed of demineralized bone and mesenchymal stem cells genetically modified with AdBMP2\/AdBMP7 for the regeneration of bone fractures in ovis aries","volume":"2016","author":"Hernandez-Hurtado","year":"2016","journal-title":"Stem Cells Int"},{"key":"key20200713222731_b34-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"key20200713222731_b35-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"key20200713222731_b36-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/S0168-8278(03)00377-5","article-title":"A blocking peptide for transforming growth factor-beta1 activation prevents hepatic fibrosis in vivo","volume":"39","author":"Kondou","year":"2003","journal-title":"J Hepatol"},{"key":"key20200713222731_b37-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1016\/j.ebiom.2015.10.010","article-title":"Inhibition of cyclic adenosine monophosphate (cAMP)-response element-binding protein (CREB)-binding protein (CBP)\/\u03b2-catenin reduces liver fibrosis in mice","volume":"2","author":"Osawa","year":"2015","journal-title":"EBioMedicine"},{"key":"key20200713222731_b38-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1258\/la.2012.011035","article-title":"Evaluation of the spontaneous reversibility of carbon tetrachloride-induced liver cirrhosis in rabbits","volume":"46","author":"Bravo","year":"2012","journal-title":"Lab Anim"},{"key":"key20200713222731_b39-mmr-16-06-9431","first-page":"293","article-title":"Spontaneous reversibility of advanced toxic liver cirrhosis","volume":"23","author":"Maros","year":"1975","journal-title":"Acta Morphol Acad Sci Hung"},{"key":"key20200713222731_b40-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/j.1742-7843.2005.pto_06.x","article-title":"Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: Effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid","volume":"96","author":"Muriel","year":"2005","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"key20200713222731_b41-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1111\/j.1478-3231.2010.02256.x","article-title":"Antifibrotic and fibrolytic properties of celecoxib in liver damage induced by carbon tetrachloride in the rat","volume":"30","author":"Ch\u00e1vez","year":"2010","journal-title":"Liver Int"},{"key":"key20200713222731_b42-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.3349\/ymj.2015.56.6.1572","article-title":"Thalidomide accelerates the degradation of extracellular matrix in rat hepatic cirrhosis via down-regulation of transforming growth factor-\u03b21","volume":"56","author":"Lv","year":"2015","journal-title":"Yonsei Med J"},{"key":"key20200713222731_b43-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1369\/0022155415627681","article-title":"TGF-\u03b2\/SMAD pathway and its regulation in hepatic fibrosis","volume":"64","author":"Xu","year":"2016","journal-title":"J Histochem Cytochem"},{"key":"key20200713222731_b44-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1038\/mt.2012.148","article-title":"Oral administration of recombinant adeno-associated virus-mediated bone morphogenetic protein-7 suppresses CCl(4)-induced hepatic fibrosis in mice","volume":"20","author":"Hao","year":"2012","journal-title":"Mol Ther"},{"key":"key20200713222731_b45-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"e66434","DOI":"10.1371\/journal.pone.0066434","article-title":"BMP7 gene transfer via gold nanoparticles into stroma inhibits corneal fibrosis in vivo","volume":"8","author":"Tandon","year":"2013","journal-title":"PLoS One"},{"key":"key20200713222731_b46-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.2337\/db06-1226","article-title":"Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors","volume":"56","author":"Sugimoto","year":"2007","journal-title":"Diabetes"},{"key":"key20200713222731_b47-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"4335","DOI":"10.3892\/mmr.2016.5071","article-title":"Attenuation of liver fibrosis by herbal compound 861 via upregulation of BMP-7\/Smad signaling in the bile duct ligation model rat","volume":"13","author":"Hou","year":"2016","journal-title":"Mol Med Rep"},{"key":"key20200713222731_b48-mmr-16-06-9431","first-page":"588","article-title":"Long-term organ protection by doxazosin and\/or quinapril as antihypertensive therapy","volume":"19","author":"Gallego-Delgado","year":"2006","journal-title":"J Nephrol"},{"key":"key20200713222731_b49-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1161\/01.HYP.0000185689.65045.4c","article-title":"Sympathectomy or doxazosin, but not propranolol, blunt myocardial interstitial fibrosis in pressure-overload hypertrophy","volume":"46","author":"Perlini","year":"2005","journal-title":"Hypertension"},{"key":"key20200713222731_b50-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1093\/ndt\/gfl230","article-title":"The role of the alpha-1 adrenoceptor in modulating human mesangial cell matrix production","volume":"21","author":"Pawluczyk","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"key20200713222731_b51-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1136\/gut.2003.026658","article-title":"Hepatic fibrogenesis requires sympathetic neurotransmitters","volume":"53","author":"Oben","year":"2004","journal-title":"Gut"},{"key":"key20200713222731_b52-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/S0270-9139(03)80308-7","article-title":"Sympathetic nervous system inhibition increases hepatic progenitors and reduces liver injury","volume":"38","author":"Oben","year":"2003","journal-title":"Hepatology"},{"key":"key20200713222731_b53-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1096\/fj.06-6837com","article-title":"BMP-7 functions as a novel hormone to facilitate liver regeneration","volume":"21","author":"Sugimoto","year":"2007","journal-title":"FASEB J"},{"key":"key20200713222731_b54-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"e46271","DOI":"10.1371\/journal.pone.0046271","article-title":"Hepatoprotective effect of MMP-19 deficiency in a mouse model of chronic liver fibrosis","volume":"7","author":"Jirouskova","year":"2012","journal-title":"PLoS One"},{"key":"key20200713222731_b55-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/j.1365-2184.2005.00350.x","article-title":"Enhanced matrix degradation after withdrawal of TGF-beta1 triggers hepatocytes from apoptosis to proliferation and regeneration","volume":"38","author":"Arendt","year":"2005","journal-title":"Cell Prolif"},{"key":"key20200713222731_b56-mmr-16-06-9431","doi-asserted-by":"publisher","first-page":"e27710","DOI":"10.1371\/journal.pone.0027710","article-title":"NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-\u03b21\/Smad pathway and altering the MMP2\/TIMP2 ratio in rats","volume":"6","author":"Yang","year":"2011","journal-title":"PLoS One"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T21:27:42Z","timestamp":1594675662000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.7785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,12]]},"references-count":56,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,10,12]]},"published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.3892\/mmr.2017.7785"],"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.7785","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,12]]}}}