{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T01:22:42Z","timestamp":1773192162943,"version":"3.50.1"},"reference-count":44,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2017.7882","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T06:53:54Z","timestamp":1509000834000},"source":"Crossref","is-referenced-by-count":14,"title":["Human umbilical cord mesenchymal stem cells alleviate interstitial fibrosis and cardiac dysfunction in a dilated cardiomyopathy rat model by inhibiting TNF\u2011\u03b1 and TGF\u2011\u03b21\/ERK1\/2 signaling pathways"],"prefix":"10.3892","author":[{"given":"Changyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guichi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yezeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sizheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Maternal and Child Health Care Hospital of Pingshan District, Shenzhen, Guangdong 518000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lichun","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Maternal and Child Health Care Hospital of Pingshan District, Shenzhen, Guangdong 518000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonggang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Beijing Children's Hospital, Capital Medical Hospital, Beijing 100032, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiulan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"key20200713222909_b1-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"4087632","DOI":"10.1155\/2016\/4087632","article-title":"Inflammatory Cardiomyopathy: A current view on the pathophysiology, diagnosis, and treatment","volume":"2016","author":"Krejci","year":"2016","journal-title":"Biomed Res Int"},{"key":"key20200713222909_b2-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0735-1097(99)00485-4","article-title":"Antimyosin autoantibodies are associated with deterioration of systolic and diastolic left ventricular function in patients with chronic myocarditis","volume":"35","author":"Lauer","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"key20200713222909_b3-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1097\/00005344-200108000-00016","article-title":"Pharmacologic modulation of the immune interaction between cytotoxic lymphocytes and ventricular myocytes","volume":"38","author":"Binah","year":"2001","journal-title":"J Cardiovasc Pharmacol"},{"key":"key20200713222909_b4-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/0090-1229(90)90039-S","article-title":"A novel experimental model of giant cell myocarditis induced in rats by immunization with cardiac myosin fraction","volume":"57","author":"Kodama","year":"1990","journal-title":"Clin Immunol Immunopathol"},{"key":"key20200713222909_b5-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"e002149","DOI":"10.1161\/JAHA.115.002149","article-title":"Arrhythmogenic phenotype in dilated cardiomyopathy: Natural history and predictors of life-threatening arrhythmias","volume":"4","author":"Spezzacatene","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"key20200713222909_b6-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1161\/CIRCRESAHA.111.243147","article-title":"Mesenchymal stem cells: Biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease","volume":"109","author":"Williams","year":"2011","journal-title":"Circ Res"},{"key":"key20200713222909_b7-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1161\/CIRCRESAHA.113.300219","article-title":"Cell therapy for heart failure: A comprehensive overview of experimental and clinical studies, current challenges, and future directions","volume":"113","author":"Sanganalmath","year":"2013","journal-title":"Circ Res"},{"key":"key20200713222909_b8-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1016\/j.jacc.2015.09.010","article-title":"Mechanisms contributing to the progression of ischemic and nonischemic dilated cardiomyopathy: Possible modulating effects of paracrine activities of stem cells","volume":"66","author":"Kelkar","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"key20200713222909_b9-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s13287-015-0127-9","article-title":"Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression","volume":"6","author":"Mancini","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"key20200713222909_b10-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1001\/jama.2012.25321","article-title":"Comparison of allogeneic vs. autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: The POSEIDON randomized trial","volume":"308","author":"Hare","year":"2012","journal-title":"Jama"},{"key":"key20200713222909_b11-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1161\/CIRCRESAHA.116.303614","article-title":"Use of mesenchymal stem cells for therapy of cardiac disease","volume":"116","author":"Karantalis","year":"2015","journal-title":"Circ Res"},{"key":"key20200713222909_b12-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1152\/physrev.00019.2015","article-title":"Rebuilding the damaged heart: Mesenchymal stem cells, cell-based therapy, and engineered heart tissue","volume":"96","author":"Golpanian","year":"2016","journal-title":"Physiol Rev"},{"key":"key20200713222909_b13-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1634\/stemcells.2004-0013","article-title":"Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord","volume":"22","author":"Wang","year":"2004","journal-title":"Stem Cells"},{"key":"key20200713222909_b14-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1182\/blood-2007-03-078774","article-title":"Immunogenicity of umbilical cord tissue derived cells","volume":"111","author":"Cho","year":"2008","journal-title":"Blood"},{"key":"key20200713222909_b15-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"144","DOI":"10.2174\/1574888X11308020005","article-title":"Mesenchymal stem cells derived from Wharton's Jelly of the umbilical cord: Biological properties and emerging clinical applications","volume":"8","author":"Batsali","year":"2013","journal-title":"Curr Stem Cell Res Ther"},{"key":"key20200713222909_b16-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1002\/art.27548","article-title":"Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus","volume":"62","author":"Sun","year":"2010","journal-title":"Arthritis Rheum"},{"key":"key20200713222909_b17-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.1089\/scd.2013.0023","article-title":"Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis: Safety and efficacy","volume":"22","author":"Wang","year":"2013","journal-title":"Stem Cells Dev"},{"key":"key20200713222909_b18-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3892\/ijmm.2013.1572","article-title":"Immunological characteristics of human umbilical cord mesenchymal stem cells and the therapeutic effects of their transplantion on hyperglycemia in diabetic rats","volume":"33","author":"Wang","year":"2014","journal-title":"Int J Mol Med"},{"key":"key20200713222909_b19-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1007\/s12015-015-9601-0","article-title":"Human umbilical cord mesenchymal stromal cell transplantation in myocardial ischemia (HUC-HEART Trial). A study protocol of a Phase 1\/2, controlled and randomized trial in combination with coronary artery bypass grafting","volume":"11","author":"Can","year":"2015","journal-title":"Stem Cell Rev"},{"key":"key20200713222909_b20-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.5966\/sctm.2015-0298","article-title":"Human umbilical cord-derived mesenchymal stromal cells improve left ventricular function, perfusion, and remodeling in a porcine model of chronic myocardial ischemia","volume":"5","author":"Liu","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"key20200713222909_b21-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1159\/000445554","article-title":"Celastrol-induced suppression of the MiR-21\/ERK signalling pathway attenuates cardiac fibrosis and dysfunction","volume":"38","author":"Cheng","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"key20200713222909_b22-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12872-015-0169-z","article-title":"Resveratrol ameliorates myocardial fibrosis by inhibiting ROS\/ERK\/TGF-\u03b2\/periostin pathway in STZ-induced diabetic mice","volume":"16","author":"Wu","year":"2016","journal-title":"BMC Cardiovasc Disord"},{"key":"key20200713222909_b23-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.ejps.2012.04.018","article-title":"Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic Rats: Possible involvement of PKC-MAPK signaling pathway","volume":"47","author":"Soetikno","year":"2012","journal-title":"Eur J Pharm Sci"},{"key":"key20200713222909_b24-mmr-17-01-0071","first-page":"1534","article-title":"Human umbilical cord mesenchymal stem cells derived from Wharton's jelly differentiate into insulin-producing cells in vitro","volume":"124","author":"Wang","year":"2011","journal-title":"Chinese Med J (Engl)"},{"key":"key20200713222909_b25-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.3892\/mmr.2017.6454","article-title":"Human umbilical cord mesenchymal stem cells alleviate acute myocarditis by modulating endoplasmic reticulum stress and extracellular signal regulated 1\/2-mediated apoptosis","volume":"15","author":"Zhang","year":"2017","journal-title":"Mol Med Rep"},{"key":"key20200713222909_b26-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713222909_b27-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1056\/NEJM199412083312307","article-title":"Idiopathic dilated cardiomyopathy","volume":"331","author":"Dec","year":"1994","journal-title":"N Engl J Med"},{"key":"key20200713222909_b28-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.tcm.2010.02.005","article-title":"Mechanisms of cardiac fibrosis in inflammatory heart disease","volume":"19","author":"Kania","year":"2009","journal-title":"Trends Cardiovasc Med"},{"key":"key20200713222909_b29-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.hfc.2011.08.012","article-title":"Changes in the myocardial interstitium and contribution to the progression of heart failure","volume":"8","author":"Eckhouse","year":"2012","journal-title":"Heart Fail Clin"},{"key":"key20200713222909_b30-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ijcard.2015.04.064","article-title":"Myocardial factor revisited: The importance of myocardial fibrosis in adults with congenital heart disease","volume":"189","author":"Broberg","year":"2015","journal-title":"Int J Cardiol"},{"key":"key20200713222909_b31-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.ajpath.2012.11.014","article-title":"Regulation and role of connective tissue growth factor in AngII-induced myocardial fibrosis","volume":"182","author":"Rosin","year":"2013","journal-title":"Am J Pathol"},{"key":"key20200713222909_b32-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.yjmcc.2010.10.033","article-title":"Transforming growth factor (TGF)-\u03b2 signaling in cardiac remodeling","volume":"51","author":"Dobaczewski","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"key20200713222909_b33-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"H1253","DOI":"10.1152\/ajpheart.00578.2001","article-title":"Alterations of beta-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta(1)","volume":"283","author":"Rosenkranz","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key20200713222909_b34-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/hr.2010.67","article-title":"Telmisartan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy","volume":"33","author":"Sukumaran","year":"2010","journal-title":"Hypertension Res"},{"key":"key20200713222909_b35-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1016\/S0735-1097(01)01518-2","article-title":"Effects of combination of angiotensin-converting enzyme inhibitor and angiotensin receptor antagonist on inflammatory cellular infiltration and myocardial interstitial fibrosis after acute myocardial infarction","volume":"38","author":"Yu","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"key20200713222909_b36-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"303","DOI":"10.2353\/ajpath.2009.080629","article-title":"Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury","volume":"175","author":"Moodley","year":"2009","journal-title":"Am J Pathol"},{"key":"key20200713222909_b37-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1101\/gad.1167003","article-title":"Integration of Smad and MAPK pathways: A link and a linker revisited","volume":"17","author":"Massague","year":"2003","journal-title":"Genes Dev"},{"key":"key20200713222909_b38-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/cr.2008.302","article-title":"Signaling cross-talk between TGF-beta\/BMP and other pathways","volume":"19","author":"Guo","year":"2009","journal-title":"Cell research"},{"key":"key20200713222909_b39-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1042\/CS20150624","article-title":"FasL expression in cardiomyocytes activates the ERK1\/2 pathway, leading to dilated cardiomyopathy and advanced heart failure","volume":"130","author":"Huby","year":"2016","journal-title":"Clin Sci (Lond)."},{"key":"key20200713222909_b40-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1093\/intimm\/dxs056","article-title":"IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKC\u03b2\/Erk1\/2\/NF-kappaB-dependent signaling pathway","volume":"24","author":"Liu","year":"2012","journal-title":"Int Immunol"},{"key":"key20200713222909_b41-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1161\/HYPERTENSIONAHA.107.102152","article-title":"Involvement of tumor necrosis factor-alpha in angiotensin II-mediated effects on salt appetite, hypertension, and cardiac hypertrophy","volume":"51","author":"Sriramula","year":"2008","journal-title":"Hypertension"},{"key":"key20200713222909_b42-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1161\/CIRCULATIONAHA.106.643585","article-title":"Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state","volume":"115","author":"Sun","year":"2007","journal-title":"Circulation"},{"key":"key20200713222909_b43-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1161\/hc3401.093154","article-title":"Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor","volume":"104","author":"Sivasubramanian","year":"2001","journal-title":"Circulation"},{"key":"key20200713222909_b44-mmr-17-01-0071","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s00395-007-0673-0","article-title":"Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy","volume":"102","author":"Westermann","year":"2007","journal-title":"Basic Res Cardiol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T21:33:49Z","timestamp":1594676029000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.7882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,26]]},"references-count":44,"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.7882","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,26]]}}}