{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:54:25Z","timestamp":1772776465655,"version":"3.50.1"},"reference-count":51,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2017.7918","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T09:28:40Z","timestamp":1509096520000},"source":"Crossref","is-referenced-by-count":5,"title":["Metabolic alterations in the rat cerebellum following acute middle cerebral artery occlusion, as determined by 1H NMR spectroscopy"],"prefix":"10.3892","author":[{"given":"Zi\u2011Long","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University\/Zhejiang Province Key Laboratory of Aging and Neurological Disorder Research, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan\u2011Huan","family":"Xia","sequence":"additional","affiliation":[{"name":"Institute of Metabonomics and Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2011Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University\/Zhejiang Province Key Laboratory of Aging and Neurological Disorder Research, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Metabonomics and Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang\u2011Cai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Metabonomics and Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2011Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University\/Zhejiang Province Key Laboratory of Aging and Neurological Disorder Research, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi\u2011Chuan","family":"Zhuge","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University\/Zhejiang Province Key Laboratory of Aging and Neurological Disorder Research, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neng\u2011Zhi","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University\/Zhejiang Province Key Laboratory of Aging and Neurological Disorder Research, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2011Chang","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Metabonomics and Medical NMR, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2011Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University\/Zhejiang Province Key Laboratory of Aging and Neurological Disorder Research, Wenzhou, Zhejiang 325000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,10,27]]},"reference":[{"key":"key20200713223038_b1-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"S174","DOI":"10.1111\/j.1471-4159.2009.05940.x","article-title":"Acute changes in intermediary metabolism in cerebellum and contralateral hemisphere following middle cerebral artery occlusion in rat","volume":"109","author":"H\u00e5berg","year":"2009","journal-title":"J Neurochem"},{"key":"key20200713223038_b2-mmr-17-01-0531","first-page":"459","article-title":"\u2018Crossed cerebellar diaschisis\u2019 in human supratentorial brain infarction","volume":"105","author":"Baron","year":"1981","journal-title":"Trans Am Neurol Assoc"},{"key":"key20200713223038_b3-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1093\/brain\/109.4.677","article-title":"Crossed cerebellar diaschisis. Further studies","volume":"109","author":"Pantano","year":"1986","journal-title":"Brain"},{"key":"key20200713223038_b4-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1080\/01616412.1993.11740164","article-title":"Diaschisis","volume":"15","author":"Meyer","year":"1993","journal-title":"Neurol Res"},{"key":"key20200713223038_b5-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"7699","DOI":"10.1073\/pnas.112012499","article-title":"Neuronal deactivation explains decreased cerebellar blood flow in response to focal cerebral ischemia or suppressed neocortical function","volume":"99","author":"Gold","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713223038_b6-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1159\/000016060","article-title":"Remote effects of acute ischemic stroke: A xenon CT cerebral blood flow study","volume":"10","author":"Rubin","year":"2000","journal-title":"Cerebrovasc Dis"},{"key":"key20200713223038_b7-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/jcbfm.1984.32","article-title":"Crossed cerebellar diaschisis in ischemic stroke: A study of regional cerebral blood flow by 133Xe inhalation and single photon emission computerized tomography","volume":"4","author":"Meneghetti","year":"1984","journal-title":"J Cereb Blood Flow Metab"},{"key":"key20200713223038_b8-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/BF03000103","article-title":"Hemodynamic changes during neural deactivation in human brain: A positron emission tomography study of crossed cerebellar diaschisis","volume":"16","author":"Ito","year":"2002","journal-title":"Ann Nucl Med"},{"key":"key20200713223038_b9-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1038\/sj.jcbfm.9600467","article-title":"Crossed cerebellar diaschisis in acute ischemic stroke: A study with serial SPECT and MRI","volume":"27","author":"Liu","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"key20200713223038_b10-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"710","DOI":"10.3174\/ajnr.A1435","article-title":"Crossed cerebellar diaschisis in acute stroke detected by dynamic susceptibility contrast MR perfusion imaging","volume":"30","author":"Lin","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"key":"key20200713223038_b11-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1038\/jcbfm.2011.15","article-title":"Crossed cerebellar diaschisis after stroke: Can perfusion-weighted MRI show functional inactivation?","volume":"31","author":"Madai","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"key20200713223038_b12-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3348\/kjr.2012.13.1.12","article-title":"Brain Research Group: Dynamic CT perfusion imaging for the detection of crossed cerebellar diaschisis in acute ischemic stroke","volume":"13","author":"Jeon","year":"2012","journal-title":"Korean J Radiol"},{"key":"key20200713223038_b13-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.05.009","article-title":"Crossed cerebellar diaschisis detected by arterial spin-labeled perfusion magnetic resonance imaging in subacute ischemic stroke","volume":"23","author":"Chen","year":"2014","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"key20200713223038_b14-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.3174\/ajnr.A4366","article-title":"Correlation of asymmetry indices measured by arterial spin-labeling MR imaging and SPECT in patients with crossed cerebellar diaschisis","volume":"36","author":"Kang","year":"2015","journal-title":"AJNR Am J Neuroradiol"},{"key":"key20200713223038_b15-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1080\/01616412.1989.11739856","article-title":"Regional brain glycogen stores and metabolism during complete global ischaemia","volume":"11","author":"Swanson","year":"1989","journal-title":"Neurol Res"},{"key":"key20200713223038_b16-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/mrm.1910390110","article-title":"Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS","volume":"39","author":"Pouwels","year":"1998","journal-title":"Magn Reson Med"},{"key":"key20200713223038_b17-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.neuroimage.2011.12.038","article-title":"The neurochemical profile quantified by in vivo 1H NMR spectroscopy","volume":"61","author":"Duarte","year":"2012","journal-title":"Neuroimage"},{"key":"key20200713223038_b18-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/nbm.1727","article-title":"Regional neurochemical profiles in the human brain measured by (1)H MRS at 7 T using local B(1) shimming","volume":"25","author":"Emir","year":"2012","journal-title":"NMR Biomed"},{"key":"key20200713223038_b19-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/j.1600-0404.2011.01576.x","article-title":"Correlation between crossed cerebellar diaschisis and clinical neurological scales","volume":"125","author":"Szil\u00e1gyi","year":"2012","journal-title":"Acta Neurol Scand"},{"key":"key20200713223038_b20-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.aca.2008.06.051","article-title":"Metabonomic profiling of renal cell carcinoma: High-resolution proton nuclear magnetic resonance spectroscopy of human serum with multivariate data analysis","volume":"624","author":"Gao","year":"2008","journal-title":"Anal Chim Acta"},{"key":"key20200713223038_b21-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"key20200713223038_b22-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s11306-009-0185-z","article-title":"Multivariate paired data analysis: Multilevel PLSDA versus OPLSDA","volume":"6","author":"Westerhuis","year":"2010","journal-title":"Metabolomics"},{"key":"key20200713223038_b23-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1021\/ac048803i","article-title":"Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies","volume":"77","author":"Cloarec","year":"2005","journal-title":"Anal Chem"},{"key":"key20200713223038_b24-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.neuint.2006.09.012","article-title":"Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution 1H NMR spectroscopy","volume":"50","author":"Gao","year":"2007","journal-title":"Neurochem Int"},{"key":"key20200713223038_b25-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1111\/j.1471-4159.1993.tb09803.x","article-title":"Coupling among energy failure, loss of ion homeostasis, and phospholipase A2 and C activation during ischemia","volume":"61","author":"Katsura","year":"1993","journal-title":"J Neurochem"},{"key":"key20200713223038_b26-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/S0006-8993(01)02579-3","article-title":"1H magnetic resonance spectroscopic imaging of permanent focal cerebral ischemia in rat: Longitudinal metabolic changes in ischemic core and rim","volume":"907","author":"Igarashi","year":"2001","journal-title":"Brain Res"},{"key":"key20200713223038_b27-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.3171\/jns.2005.102.6.1076","article-title":"Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: A microdialysis and positron emission tomography study in nonhuman primates","volume":"102","author":"Frykholm","year":"2005","journal-title":"J Neurosurg"},{"key":"key20200713223038_b28-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cca.2008.07.016","article-title":"Evaluation of lactate as a marker of metabolic stress and cause of secondary damage in acute ischemic stroke or TIA","volume":"397","author":"Brouns","year":"2008","journal-title":"Clin Chim Acta"},{"key":"key20200713223038_b29-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1161\/STROKEAHA.108.525626","article-title":"Associations between diffusion and perfusion parameters, N-acetyl aspartate, and lactate in acute ischemic stroke","volume":"40","author":"Cvoro","year":"2009","journal-title":"Stroke"},{"key":"key20200713223038_b30-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/mrm.1910090115","article-title":"Cerebral metabolism in man after acute stroke: New observations using localized proton NMR spectroscopy","volume":"9","author":"Bruhn","year":"1989","journal-title":"Magn Reson Med"},{"key":"key20200713223038_b31-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1161\/01.STR.29.8.1618","article-title":"Studies of acute ischemic stroke with proton magnetic resonance spectroscopy: Relation between time from onset, neurological deficit, metabolite abnormalities in the infarct, blood flow, and clinical outcome","volume":"29","author":"Wardlaw","year":"1998","journal-title":"Stroke"},{"key":"key20200713223038_b32-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1001\/archneur.55.4.489","article-title":"Prognostic value of proton magnetic resonance spectroscopy in ischemic stroke","volume":"55","author":"Federico","year":"1998","journal-title":"Arch Neurol"},{"key":"key20200713223038_b33-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1161\/01.STR.30.8.1577","article-title":"Measurement of initial N-acetyl aspartate concentration by magnetic resonance spectroscopy and initial infarct volume by MRI predicts outcome in patients with middle cerebral artery territory infarction","volume":"30","author":"Pereira","year":"1999","journal-title":"Stroke"},{"key":"key20200713223038_b34-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/jcbfm.1993.11","article-title":"Limiting ischemic injury by inhibition of excitatory amino acid release","volume":"13","author":"Graham","year":"1993","journal-title":"J Cereb Blood Flow Metab"},{"key":"key20200713223038_b35-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1161\/01.STR.30.11.2448","article-title":"Striatal outflow of adenosine, excitatory amino acids, gamma-aminobutyric acid, and taurine in awake freely moving rats after middle cerebral artery occlusion: Correlations with neurological deficit and histopathological damage","volume":"30","author":"Melani","year":"1999","journal-title":"Stroke"},{"key":"key20200713223038_b36-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1002\/nbm.1385","article-title":"Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: An in vivo localized (1)H MRS study","volume":"22","author":"Iltis","year":"2009","journal-title":"NMR Biomed"},{"key":"key20200713223038_b37-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1097\/00004647-199811000-00008","article-title":"In vivo injection of [1-13C]glucose and [1,2-13C]acetate combined with ex vivo 13C nuclear magnetic resonance spectroscopy: A novel approach to the study of middle cerebral artery occlusion in the rat","volume":"18","author":"H\u00e5berg","year":"1998","journal-title":"J Cereb Blood Flow Metab"},{"key":"key20200713223038_b38-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/cne.902630202","article-title":"D-[3H]aspartate retrograde labelling of callosal and association neurones of somatosensory areas I and II of cats","volume":"263","author":"Barbaresi","year":"1987","journal-title":"J Comp Neurol"},{"key":"key20200713223038_b39-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/nbm.1940080505","article-title":"Evolution of acute focal cerebral ischaemia in rats observed by localized 1H MRS, diffusion-weighted MRI, and electrophysiological monitoring","volume":"8","author":"Gyngell","year":"1995","journal-title":"NMR Biomed"},{"key":"key20200713223038_b40-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1038\/jcbfm.2014.155","article-title":"Non-invasive diagnostic biomarkers for estimating the onset time of permanent cerebral ischemia","volume":"34","author":"Berthet","year":"2014","journal-title":"J Cereb Blood Flow Metab"},{"key":"key20200713223038_b41-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1111\/j.1471-4159.2004.02583.x","article-title":"N-acetylaspartate: A literature review of animal research on brain ischaemia","volume":"90","author":"Demougeot","year":"2004","journal-title":"J Neurochem"},{"key":"key20200713223038_b42-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/nbm.1940040203","article-title":"A review of chemical issues in 1H NMR spectroscopy: N-acetyl-L-aspartate, creatine and choline","volume":"4","author":"Miller","year":"1991","journal-title":"NMR Biomed"},{"key":"key20200713223038_b43-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1007\/s11064-011-0570-7","article-title":"Retinal metabolic changes in an experimental model of optic nerve transection by ex vivo 1H magnetic resonance spectroscopy","volume":"36","author":"Li","year":"2011","journal-title":"Neurochem Res"},{"key":"key20200713223038_b44-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1097\/00002142-200112000-00005","article-title":"Magnetic resonance spectroscopy of the pediatric brain","volume":"12","author":"Cecil","year":"2001","journal-title":"Top Magn Reson Imaging"},{"key":"key20200713223038_b45-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.talanta.2011.10.022","article-title":"NMR analysis of the rat neurochemical changes induced by middle cerebral artery occlusion","volume":"88","author":"Yang","year":"2012","journal-title":"Talanta"},{"key":"key20200713223038_b46-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/nbm.1740","article-title":"High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice","volume":"25","author":"Alf","year":"2012","journal-title":"NMR Biomed"},{"key":"key20200713223038_b47-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0022-510X(98)00062-8","article-title":"Changes in brain organic osmolytes in experimental cerebral ischemia","volume":"157","author":"Nonaka","year":"1998","journal-title":"J Neurol Sci"},{"key":"key20200713223038_b48-mmr-17-01-0531","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0021-9258(18)51740-3","article-title":"Effect of ischemia on known substrates and cofactors of the glycolytic pathway in brain","volume":"239","author":"Lowry","year":"1964","journal-title":"J Biol Chem"},{"key":"key20200713223038_b49-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1471-4159.1988.tb04850.x","article-title":"High-resolution proton magnetic resonance spectroscopy of rabbit brain: Regional metabolite levels and postmortem changes","volume":"51","author":"Petroff","year":"1988","journal-title":"J Neurochem"},{"key":"key20200713223038_b50-mmr-17-01-0531","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1523\/JNEUROSCI.22-13-05581.2002","article-title":"Brain glycogen decreases with increased periods of wakefulness: Implications for homeostatic drive to sleep","volume":"22","author":"Kong","year":"2002","journal-title":"J Neurosci"},{"key":"key20200713223038_b51-mmr-17-01-0531","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1097\/01.WCB.0000034362.37277.C0","article-title":"High glycogen levels in brains of rats with minimal environmental stimuli: Implications for metabolic contributions of working astrocytes","volume":"22","author":"Cruz","year":"2002","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T17:55:33Z","timestamp":1659722133000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.7918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,27]]},"references-count":51,"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.7918","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,27]]}}}