{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:46:13Z","timestamp":1780368373426,"version":"3.54.1"},"reference-count":32,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2017.8114","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T10:35:42Z","timestamp":1511174142000},"source":"Crossref","is-referenced-by-count":1,"title":["Antiangiogenic effects of catalpol on rat corneal\u00ef\u00bf\u00bdneovascularization"],"prefix":"10.3892","author":[{"given":"Yun","family":"Han","sequence":"first","affiliation":[{"name":"Eye Institute of Xiamen University, Medical College of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian 361102, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Shen","sequence":"additional","affiliation":[{"name":"Eye Institute of Xiamen University, Medical College of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian 361102, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2011Yuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2011Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Eye Institute of Xiamen University, Medical College of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian 361102, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2011Hong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui\u2011Ping","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"key20200713223602_b1-mmr-17-02-2187","first-page":"214","article-title":"Corneal blindness: A global perspective","volume":"79","author":"Whitcher","year":"2001","journal-title":"Bull World Health Organ"},{"key":"key20200713223602_b2-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s00705-008-0303-7","article-title":"HSV immune complex (HSV-IgG: IC) and HSV-DNA elicit the production of angiogenic factor VEGF and MMP-9","volume":"154","author":"Hayashi","year":"2009","journal-title":"Arch Virol"},{"key":"key20200713223602_b3-mmr-17-02-2187","first-page":"6","article-title":"Emphasizing the prevention and anti-inflammation research of dry eye disease","volume":"49","author":"Zhang","year":"2013","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"key20200713223602_b4-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1007\/s10072-014-1687-7","article-title":"Effects of catalpol on ATPase and amino acids in gerbils with cerebral ischemia\/reperfusion injury","volume":"35","author":"Liu","year":"2014","journal-title":"Neurol Sci"},{"key":"key20200713223602_b5-mmr-17-02-2187","first-page":"1189","article-title":"Review of Catalpol's pleiotropic signaling pathways","volume":"9","author":"Wang","year":"2015","journal-title":"Zhong Guo Yao Li Xue Tong Bao Bian Ji Bu"},{"key":"key20200713223602_b6-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.tiv.2012.09.023","article-title":"Catalpol inhibits LPS plus IFN-\u03b3-induced inflammatory response in astrocytes primary cultures","volume":"27","author":"Bi","year":"2013","journal-title":"Toxicol In Vitro"},{"key":"key20200713223602_b7-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1007\/s12013-014-0096-0","article-title":"Analgesic activity of catalpol in rodent models of neuropathic pain, and its spinal mechanism","volume":"70","author":"Wang","year":"2014","journal-title":"Cell Biochem Biophys"},{"key":"key20200713223602_b8-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1167\/iovs.11-8722","article-title":"Netrin-1 simultaneously suppresses corneal inflammation and neovascularization","volume":"53","author":"Han","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713223602_b9-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"476","DOI":"10.2105\/AJPH.91.3.476","article-title":"Policy statements adopted by the Governing Council of the American Public Health Association, November 15, 2000","volume":"91","year":"2001","journal-title":"Am J Public Health"},{"key":"key20200713223602_b10-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"e0122951","DOI":"10.1371\/journal.pone.0122951","article-title":"Therapeutic effects of topical netrin-4 inhibits corneal neovascularization in alkali-burn rats","volume":"10","author":"Han","year":"2015","journal-title":"PLoS One"},{"key":"key20200713223602_b11-mmr-17-02-2187","first-page":"6363","article-title":"Effects of intravitreal injection of netrin-1 in retinal neovascularization of streptozotocin-induced diabetic rats","volume":"9","author":"Yu","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"key20200713223602_b12-mmr-17-02-2187","first-page":"860","article-title":"Efficacy of the nucleotide-binding oligomerzation domain 1 inhibitor Nodinhibit-1 on corneal alkali burns in rats","volume":"8","author":"Huang","year":"2015","journal-title":"Int J Ophthalmol"},{"key":"key20200713223602_b13-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nprot.2010.6","article-title":"In vitro angiogenesis: Endothelial cell tube formation on gelled basement membrane extract","volume":"5","author":"Arnaoutova","year":"2010","journal-title":"Nat Protoc"},{"key":"key20200713223602_b14-mmr-17-02-2187","first-page":"444","article-title":"Corneal neovascularization and biological therapy","volume":"8","author":"Voiculescu","year":"2015","journal-title":"J Med Life"},{"key":"key20200713223602_b15-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0378-8741(01)00377-4","article-title":"Effects of phenylpropanoid and iridoid glycosides on free radical-induced impairment of endothelium-dependent relaxation in rat aortic rings","volume":"79","author":"Ismailoglu","year":"2002","journal-title":"J Ethnopharmacol"},{"key":"key20200713223602_b16-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"5623","DOI":"10.1167\/iovs.09-4992","article-title":"Suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human corneal epithelial cells","volume":"51","author":"Li","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713223602_b17-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.fitote.2013.01.014","article-title":"Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells","volume":"86","author":"Choi","year":"2013","journal-title":"Fitoterapia"},{"key":"key20200713223602_b18-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1093\/cvr\/cvn120","article-title":"Cytokines and atherosclerosis: A comprehensive review of studies in mice","volume":"79","author":"Kleemann","year":"2008","journal-title":"Cardiovasc Res"},{"key":"key20200713223602_b19-mmr-17-02-2187","first-page":"17274","article-title":"Impact of catalpol on retinal ganglion cells in diabetic retinopathy","volume":"9","author":"Shao","year":"2016","journal-title":"Int J Clin Exp Med"},{"key":"key20200713223602_b20-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1126\/science.2479986","article-title":"Vascular endothelial growth factor is a secreted angiogenic mitogen","volume":"246","author":"Leung","year":"1989","journal-title":"Science"},{"key":"key20200713223602_b21-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1210\/edrv.18.1.0287","article-title":"The biology of vascular endothelial growth factor","volume":"18","author":"Ferrara","year":"1997","journal-title":"Endocr Rev"},{"key":"key20200713223602_b22-mmr-17-02-2187","first-page":"961","article-title":"Vascular endothelial growth factor (rhVEGF165) stimulates direct angiogenesis in the rabbit cornea","volume":"8","author":"Phillips","year":"1994","journal-title":"In Vivo"},{"key":"key20200713223602_b23-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"871272","DOI":"10.1155\/2012\/871272","article-title":"Role of pigment epithelium-derived factor in stem\/progenitor cell-associated neovascularization","volume":"2012","author":"Liu","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"key20200713223602_b24-mmr-17-02-2187","first-page":"2759","article-title":"Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor","volume":"37","author":"Ortego","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713223602_b25-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.exer.2005.10.016","article-title":"Focus on Molecules: Pigment epithelium-derived factor (PEDF)","volume":"82","author":"Becerra","year":"2006","journal-title":"Exp Eye Res"},{"key":"key20200713223602_b26-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"443","DOI":"10.7150\/ijbs.6.443","article-title":"Catalpol increases brain angio-genesis and up-regulates VEGF and EPO in the rat after permanent middle cerebral artery occlusion","volume":"6","author":"Zhu","year":"2010","journal-title":"Int J Biol Sci"},{"key":"key20200713223602_b27-mmr-17-02-2187","first-page":"2936","article-title":"Catalpol protect diabetic vascular endothelial function by inhibiting NADPH oxidase","volume":"39","author":"Liu","year":"2014","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"key20200713223602_b28-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"e16712","DOI":"10.1371\/journal.pone.0016712","article-title":"Anti-angiogenic and anti-inflammatory effects of SERPINA3K on corneal injury","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"key20200713223602_b29-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/S0002-9440(10)62357-7","article-title":"Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice","volume":"166","author":"Saika","year":"2005","journal-title":"Am J Pathol"},{"key":"key20200713223602_b30-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/mt.2009.263","article-title":"Pretranscriptional regulation of Tgf-beta1 by PI polyamide prevents scarring and accelerates wound healing of the cornea after exposure to alkali","volume":"18","author":"Chen","year":"2010","journal-title":"Mol Ther"},{"key":"key20200713223602_b31-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1167\/iovs.07-1396","article-title":"Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2","volume":"49","author":"Mochimaru","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713223602_b32-mmr-17-02-2187","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.etp.2008.10.010","article-title":"Effects of catalpol on mitochondrial function and working memory in mice after lipopolysaccharide-induced acute systemic inflammation","volume":"61","author":"Zhang","year":"2009","journal-title":"Exp Toxicol Pathol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T22:30:24Z","timestamp":1594679424000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.8114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,20]]},"references-count":32,"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.8114","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,20]]}}}