{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T22:23:48Z","timestamp":1775946228147,"version":"3.50.1"},"reference-count":54,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2017.8188","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T12:11:12Z","timestamp":1511957472000},"source":"Crossref","is-referenced-by-count":7,"title":["Quercetin synergistically reactivates human immunodeficiency virus type 1 latency by activating nuclear factor\u2011\u03baB"],"prefix":"10.3892","author":[{"given":"Xinyi","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxiao","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengtao","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibo","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuqiao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingya","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangcheng","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanzhang","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"key20200713223658_b1-mmr-17-02-2501","doi-asserted-by":"crossref","unstructured":"DaveyRTJrBhatNYoderCChunTWMetcalfJADewarRNatarajanVLempickiRAAdelsbergerJWMillerKDHIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppressionProc Natl Acad Sci USA961510915114199910.1073\/pnas.96.26.151091061134624781","DOI":"10.1073\/pnas.96.26.15109"},{"key":"key20200713223658_b2-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1146\/annurev-med-092112-152941","article-title":"Understanding HIV latency: The road to an HIV cure","volume":"66","author":"Dahabieh","year":"2015","journal-title":"Annu Rev Med"},{"key":"key20200713223658_b3-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"87","DOI":"10.7326\/0003-4819-146-2-200701160-00003","article-title":"Survival of persons with and without HIV infection in Denmark, 1995\u20132005","volume":"146","author":"Lohse","year":"2007","journal-title":"Ann Intern Med"},{"key":"key20200713223658_b4-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1126\/science.278.5341.1295","article-title":"Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy","volume":"278","author":"Finzi","year":"1997","journal-title":"Science"},{"key":"key20200713223658_b5-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1126\/science.278.5341.1291","article-title":"Recovery of replication-competent HIV despite prolonged suppression of plasma viremia","volume":"278","author":"Wong","year":"1997","journal-title":"Science"},{"key":"key20200713223658_b6-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1086\/428777","article-title":"Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1","volume":"191","author":"Strain","year":"2005","journal-title":"J Infect Dis"},{"key":"key20200713223658_b7-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/nm880","article-title":"Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells","volume":"9","author":"Siliciano","year":"2003","journal-title":"Nat Med"},{"key":"key20200713223658_b8-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"e11160","DOI":"10.1371\/journal.pone.0011160","article-title":"Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner","volume":"5","author":"Mehla","year":"2010","journal-title":"PLoS One"},{"key":"key20200713223658_b9-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.chom.2008.06.008","article-title":"Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough","volume":"4","author":"Han","year":"2008","journal-title":"Cell Host Microbe"},{"key":"key20200713223658_b10-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"5384","DOI":"10.1128\/JVI.02536-10","article-title":"Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model","volume":"85","author":"Shan","year":"2011","journal-title":"J Virol"},{"key":"key20200713223658_b11-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.chom.2008.05.016","article-title":"Transcriptional interference antagonizes proviral gene expression to promote HIV latency","volume":"4","author":"Lenasi","year":"2008","journal-title":"Cell Host Microbe"},{"key":"key20200713223658_b12-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"554","DOI":"10.2174\/157016211798998736","article-title":"Control of HIV latency by epigenetic and non-epigenetic mechanisms","volume":"9","author":"Mbonye","year":"2011","journal-title":"Curr HIV Res"},{"key":"key20200713223658_b13-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"aaf6517","DOI":"10.1126\/science.aaf6517","article-title":"Latency reversal and viral clearance to cure HIV-1","volume":"353","author":"Margolis","year":"2016","journal-title":"Science"},{"key":"key20200713223658_b14-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"6790","DOI":"10.1128\/AAC.03746-14","article-title":"Effect of suberoylanilide hydroxamic Acid (SAHA) administration on the residual virus pool in a model of combination antiretroviral therapy-mediated suppression in SIVmac239-infected indian rhesus macaques","volume":"58","author":"Del Prete","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key20200713223658_b15-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2174\/1574884708999140101144839","article-title":"Cardio-hepatic metabolic derangements and valproic acid","volume":"9","author":"Mazzoccoli","year":"2014","journal-title":"Curr Clin Pharmacol"},{"key":"key20200713223658_b16-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"22211","DOI":"10.1074\/jbc.M110.180224","article-title":"Inhibitors of histone deacetylases: Correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells","volume":"286","author":"Huber","year":"2011","journal-title":"J Biol Chem"},{"key":"key20200713223658_b17-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"993","DOI":"10.4161\/hv.23800","article-title":"Comparison of HDAC inhibitors in clinical development: Effect on HIV production in latently infected cells and T-cell activation","volume":"9","author":"Rasmussen","year":"2013","journal-title":"Hum Vaccin Immunother"},{"key":"key20200713223658_b18-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"e48832","DOI":"10.1371\/journal.pone.0048832","article-title":"Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB","volume":"7","author":"Hao","year":"2012","journal-title":"PLoS One"},{"key":"key20200713223658_b19-mmr-17-02-2501","doi-asserted-by":"crossref","unstructured":"FolksTMClouseKAJustementJRabsonADuhEKehrlJHFauciASTumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell cloneProc Natl Acad Sci USA8623652368198910.1073\/pnas.86.7.23652784570286913","DOI":"10.1073\/pnas.86.7.2365"},{"key":"key20200713223658_b20-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.antiviral.2013.10.010","article-title":"As2O3 synergistically reactivate latent HIV-1 by induction of NF-\u03baB","volume":"100","author":"Wang","year":"2013","journal-title":"Antiviral Res"},{"key":"key20200713223658_b21-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/1743-422X-7-266","article-title":"Cell line-dependent variability in HIV activation employing DNMT inhibitors","volume":"7","author":"Fernandez","year":"2010","journal-title":"Virol J"},{"key":"key20200713223658_b22-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"16538","DOI":"10.1074\/jbc.M110.103531","article-title":"Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294","volume":"285","author":"Imai","year":"2010","journal-title":"J Biol Chem"},{"key":"key20200713223658_b23-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"42008","DOI":"10.1074\/jbc.M402124200","article-title":"Prostratin antagonizes HIV latency by activating NF-kappaB","volume":"279","author":"Williams","year":"2004","journal-title":"J Biol Chem"},{"key":"key20200713223658_b24-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1099\/0022-1317-74-11-2401","article-title":"Hexamethylene bisacetamide activates the human immunodeficiency virus type 1 provirus by an NF-kappa B-independent mechanism","volume":"74","author":"Vlach","year":"1993","journal-title":"J Gen Virol"},{"key":"key20200713223658_b25-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"6060","DOI":"10.1128\/JVI.02033-10","article-title":"Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation","volume":"85","author":"Xing","year":"2011","journal-title":"J Virol"},{"key":"key20200713223658_b26-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3945\/an.111.001271","article-title":"Therapeutic potential of quercetin to decrease blood pressure: Review of efficacy and mechanisms","volume":"3","author":"Larson","year":"2012","journal-title":"Adv Nutr"},{"key":"key20200713223658_b27-mmr-17-02-2501","unstructured":"FesenMRKohnKWLeteurtreFPommierYInhibitors of human immunodeficiency virus integraseProc Natl Acad Sci USA9023992403199310.1073\/pnas.90.6.2399846015146094"},{"key":"key20200713223658_b28-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"5238","DOI":"10.1016\/j.bmc.2009.05.049","article-title":"Novel 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents","volume":"17","author":"Tanaka","year":"2009","journal-title":"Bioorg Med Chem"},{"key":"key20200713223658_b29-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"e48832","DOI":"10.1371\/journal.pone.0048832","article-title":"Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB","volume":"7","author":"Ying","year":"2012","journal-title":"PLoS One"},{"key":"key20200713223658_b30-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.antiviral.2013.10.010","article-title":"As2O3 synergistically reactivate latent HIV-1 by induction of NF-\u03baB","volume":"100","author":"Wang","year":"2013","journal-title":"Antiviral Res"},{"key":"key20200713223658_b31-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.virol.2013.02.022","article-title":"Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation","volume":"440","author":"Ding","year":"2013","journal-title":"Virology"},{"key":"key20200713223658_b32-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nprot.2009.22","article-title":"Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors","volume":"4","author":"Kutner","year":"2009","journal-title":"Nat Protoc"},{"key":"key20200713223658_b33-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"202","DOI":"10.2174\/157016211796320333","article-title":"HIV-1 reactivation induced by apicidin involves histone modification in latently infected cells","volume":"9","author":"Lin","year":"2011","journal-title":"Curr HIV Res"},{"key":"key20200713223658_b34-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1172\/JCI200522574","article-title":"IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART","volume":"115","author":"Wang","year":"2005","journal-title":"J Clin Invest"},{"key":"key20200713223658_b35-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"e2112","DOI":"10.1371\/journal.pone.0002112","article-title":"Infected cell killing by HIV-1 protease promotes NF-kappaB dependent HIV-1 replication","volume":"3","author":"Bren","year":"2008","journal-title":"PLoS One"},{"key":"key20200713223658_b36-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/sj.onc.1206111","article-title":"p53-associated 3\u2032\u21925\u2032 exonuclease activity in nuclear and cytoplasmic compartments of cells","volume":"22","author":"Lilling","year":"2003","journal-title":"Oncogene"},{"key":"key20200713223658_b37-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1182\/blood.V98.10.3006","article-title":"Prostratin: Activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART","volume":"98","author":"Kulkosky","year":"2001","journal-title":"Blood"},{"key":"key20200713223658_b38-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"e6093","DOI":"10.1371\/journal.pone.0006093","article-title":"Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: Implications for treatment of latent infection","volume":"4","author":"Reuse","year":"2009","journal-title":"PLoS One"},{"key":"key20200713223658_b39-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1089\/aid.2011.0263","article-title":"Transcriptional control of HIV replication by multiple modulators and their implication for a novel antiviral therapy","volume":"28","author":"Victoriano","year":"2012","journal-title":"AIDS Res Hum Retroviruses"},{"key":"key20200713223658_b40-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1128\/JVI.77.3.1659-1665.2003","article-title":"Latency in human immunodeficiency virus Type 1 infection: No easy answers","volume":"77","author":"Persaud","year":"2003","journal-title":"J Virol"},{"key":"key20200713223658_b41-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/bies.201200170","article-title":"From reactivation of latent HIV-1 to elimination of the latent reservoir: The presence of multiple barriers to viral eradication","volume":"35","author":"Shan","year":"2013","journal-title":"Bioessays"},{"key":"key20200713223658_b42-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"9055","DOI":"10.1128\/JVI.00793-12","article-title":"Selected drugs with reported secondary cell-differentiating capacity prime latent HIV-1 infection for reactivation","volume":"86","author":"Shishido","year":"2012","journal-title":"J Virol"},{"key":"key20200713223658_b43-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1016\/S0140-6736(13)60104-X","article-title":"Barriers to a cure for HIV: New ways to target and eradicate HIV-1 reservoirs","volume":"381","author":"Katlama","year":"2013","journal-title":"Lancet"},{"key":"key20200713223658_b44-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1097\/COH.0000000000000279","article-title":"Shocking HIV out of hiding: Where are we with clinical trials of latency reversing agents?","volume":"11","author":"Rasmussen","year":"2016","journal-title":"Curr Opin HIV AIDS"},{"key":"key20200713223658_b45-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.drudis.2012.12.008","article-title":"Targeting HIV latency: Pharmacologic strategies toward eradication","volume":"18","author":"Xing","year":"2013","journal-title":"Drug Discov Today"},{"issue":"8","key":"key20200713223658_b46-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.it.2016.12.003","article-title":"HIV latency: should we shock or lock?","volume":"38","author":"Darcis","year":"2017","journal-title":"Trends Immunol"},{"key":"key20200713223658_b47-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3844\/ajidsp.2009.135.141","article-title":"The Flavonoid, Quercetin, Inhibits HIV-1 Infection in normal peripheral blood mononuclear cells","volume":"5","author":"Nair","year":"2009","journal-title":"Am J Infect Dis"},{"key":"key20200713223658_b48-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1099\/0022-1317-77-9-1993","article-title":"Sodium valproate, an anticonvulsant drug, stimulates human immunodeficiency virus type 1 replication independently of glutathione levels","volume":"77","author":"Moog","year":"1996","journal-title":"J Gen Virol"},{"key":"key20200713223658_b49-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1358\/dnp.2005.18.8.944543","article-title":"Prostratin as a new therapeutic agent targeting HIV viral reservoirs","volume":"18","author":"Hezareh","year":"2005","journal-title":"Drug News Perspect"},{"key":"key20200713223658_b50-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.bcp.2007.12.004","article-title":"Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation","volume":"75","author":"M\u00e1rquez","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"key20200713223658_b51-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"e77749","DOI":"10.1371\/journal.pone.0077749","article-title":"Calcium\/calcineurin synergizes with prostratin to promote NF-\u03baB dependent activation of latent HIV","volume":"8","author":"Chan","year":"2013","journal-title":"PLoS One"},{"key":"key20200713223658_b52-mmr-17-02-2501","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1128\/JVI.69.10.6572-6576.1995","article-title":"Sp1 transcription factor is required for in vitro basal and Tat-activated transcription from the human immunodeficiency virus type 1 long terminal repeat","volume":"69","author":"Su\u00f1\u00e9","year":"1995","journal-title":"J Virol"},{"key":"key20200713223658_b53-mmr-17-02-2501","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1002\/j.1460-2075.1993.tb06029.x","article-title":"A cooperative interaction between NF-kappaB and Sp1 is required for HIV-1 enhancer activation","volume":"12","author":"Perkins","year":"1993","journal-title":"EMBO J"},{"key":"key20200713223658_b54-mmr-17-02-2501","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/1756-0500-6-275","article-title":"Quercetin suppresses inflammation by reducing ERK1\/2 phosphorylation and NF kappaB activation in Leptin-induced human umbilical vein endothelial cells (HUVECs)","volume":"6","author":"Indra","year":"2013","journal-title":"BMC Res Notes"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T22:33:51Z","timestamp":1594679631000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.8188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,29]]},"references-count":54,"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.8188","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,29]]}}}