{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T22:28:16Z","timestamp":1783808896222,"version":"3.55.0"},"reference-count":58,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2017.8232","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T12:23:35Z","timestamp":1512735815000},"source":"Crossref","is-referenced-by-count":16,"title":["High expression of FLT3 is a risk factor in leukemia"],"prefix":"10.3892","author":[{"given":"Jie","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, Jiangsu 215025, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, Jiangsu 215025, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, Jiangsu 215025, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lemei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, Jiangsu 215025, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, Jiangsu 215025, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,12,8]]},"reference":[{"key":"key20200713223815_b1-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"e0138257","DOI":"10.1371\/journal.pone.0138257","article-title":"Regulation of the Flt3 gene in haematopoietic stem and early progenitor cells","volume":"10","author":"Volpe","year":"2015","journal-title":"PLoS One"},{"key":"key20200713223815_b2-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1046\/j.1365-2141.2002.03820.x","article-title":"Reconstitution of human haematopoiesis in non-obese diabetic\/severe combined immunodeficient mice by clonal cells expanded from single CD34+CD38- cells expressing Flk2\/Flt3","volume":"119","author":"Ebihara","year":"2002","journal-title":"Br J Haematol"},{"key":"key20200713223815_b3-mmr-17-02-2885","first-page":"1911","article-title":"Internal tandem duplication of the flt3 gene found in acute myeloid leukemia","volume":"10","author":"Nakao","year":"1996","journal-title":"Leukemia"},{"key":"key20200713223815_b4-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/sj.leu.2401130","article-title":"Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product","volume":"12","author":"Kiyoi","year":"1998","journal-title":"Leukemia"},{"key":"key20200713223815_b5-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1038\/sj.leu.2400756","article-title":"Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho)","volume":"11","author":"Kiyoi","year":"1997","journal-title":"Leukemia"},{"key":"key20200713223815_b6-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1182\/blood.V97.11.3589","article-title":"FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia","volume":"97","author":"Stirewalt","year":"2001","journal-title":"Blood"},{"key":"key20200713223815_b7-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1182\/blood.V97.1.89","article-title":"Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia","volume":"97","author":"Meshinchi","year":"2001","journal-title":"Blood"},{"key":"key20200713223815_b8-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1182\/blood.V100.1.59","article-title":"Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease","volume":"100","author":"Schnittger","year":"2002","journal-title":"Blood"},{"key":"key20200713223815_b9-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"4326","DOI":"10.1182\/blood.V99.12.4326","article-title":"Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis","volume":"99","author":"Thiede","year":"2002","journal-title":"Blood"},{"key":"key20200713223815_b10-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1046\/j.1365-2141.2000.02317.x","article-title":"FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group","volume":"111","author":"Abu-Duhier","year":"2000","journal-title":"Br J Haematol"},{"key":"key20200713223815_b11-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1182\/blood.V98.6.1752","article-title":"The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials","volume":"98","author":"Kottaridis","year":"2001","journal-title":"Blood"},{"key":"key20200713223815_b12-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1365-2141.1999.01284.x","article-title":"Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children","volume":"105","author":"Xu","year":"1999","journal-title":"Br J Haematol"},{"key":"key20200713223815_b13-mmr-17-02-2885","first-page":"3074","article-title":"Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia","volume":"93","author":"Kiyoi","year":"1999","journal-title":"Blood"},{"key":"key20200713223815_b14-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1038\/sj.leu.2400770","article-title":"Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia","volume":"11","author":"Horiike","year":"1997","journal-title":"Leukemia"},{"key":"key20200713223815_b15-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1038\/sj.leu.2400812","article-title":"Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines","volume":"11","author":"Yokota","year":"1997","journal-title":"Leukemia"},{"key":"key20200713223815_b16-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1182\/blood.V97.8.2434","article-title":"Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies","volume":"97","author":"Yamamoto","year":"2001","journal-title":"Blood"},{"key":"key20200713223815_b17-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1046\/j.1365-2141.2001.02850.x","article-title":"Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia","volume":"113","author":"Abu-Duhier","year":"2001","journal-title":"Br J Haematol"},{"key":"key20200713223815_b18-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/sj.onc.1203354","article-title":"Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines","volume":"19","author":"Hayakawa","year":"2000","journal-title":"Oncogene"},{"key":"key20200713223815_b19-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.1038\/sj.onc.1205332","article-title":"Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain","volume":"21","author":"Kiyoi","year":"2002","journal-title":"Oncogene"},{"key":"key20200713223815_b20-mmr-17-02-2885","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1182\/blood.V96.12.3907","article-title":"Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways","volume":"96","author":"Mizuki","year":"2000","journal-title":"Blood"},{"key":"key20200713223815_b21-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.1182\/blood-2002-03-0953","article-title":"A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia","volume":"100","author":"Spiekermann","year":"2002","journal-title":"Blood"},{"key":"key20200713223815_b22-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/leu.2012.191","article-title":"Mutations of FLT3\/ITD confer resistance to multiple tyrosine kinase inhibitors","volume":"27","author":"Williams","year":"2013","journal-title":"Leukemia"},{"key":"key20200713223815_b23-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"e336","DOI":"10.1038\/bcj.2015.61","article-title":"Quantitative fragment analysis of FLT3-ITD efficiently identifying poor prognostic group with high mutant allele burden or long ITD length","volume":"5","author":"Kim","year":"2015","journal-title":"Blood Cancer J"},{"key":"key20200713223815_b24-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"3724","DOI":"10.1182\/blood-2005-08-3453","article-title":"Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia","volume":"107","author":"Stirewalt","year":"2006","journal-title":"Blood"},{"key":"key20200713223815_b25-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.exphem.2016.04.011","article-title":"Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia","volume":"44","author":"Griffith","year":"2016","journal-title":"Exp Hematol"},{"key":"key20200713223815_b26-mmr-17-02-2885","first-page":"1201","article-title":"FLT3 overexpression in acute promyelocytic leukemia patients without detectable FLT3-ITD or codon 835\u2013836 mutations: A pilot study","volume":"26","author":"Lilakos","year":"2006","journal-title":"Anticancer Res"},{"key":"key20200713223815_b27-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1038\/onc.2016.318","article-title":"Upregulation of Flt3 is a passive event in Hoxa9\/Meis1-induced acute myeloid leukemia in mice","volume":"36","author":"Staffas","year":"2017","journal-title":"Oncogene"},{"key":"key20200713223815_b28-mmr-17-02-2885","first-page":"2140","article-title":"Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells","volume":"9","author":"Spiekermann","year":"2003","journal-title":"Clin Cancer Res"},{"key":"key20200713223815_b29-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci Signal"},{"key":"key20200713223815_b30-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov"},{"key":"key20200713223815_b31-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nature11003","article-title":"The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity","volume":"483","author":"Barretina","year":"2012","journal-title":"Nature"},{"key":"key20200713223815_b32-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"key20200713223815_b33-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"6847","DOI":"10.18632\/oncotarget.6867","article-title":"Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A","volume":"7","author":"Wu","year":"2016","journal-title":"Oncotarget"},{"key":"key20200713223815_b34-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"key20200713223815_b35-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"affy-analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"key20200713223815_b36-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1093\/bioinformatics\/17.6.520","article-title":"Missing value estimation methods for DNA microarrays","volume":"17","author":"Troyanskaya","year":"2001","journal-title":"Bioinformatics"},{"key":"key20200713223815_b37-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1186\/1471-2105-7-469","article-title":"Evaluating different methods of microarray data normalization","volume":"7","author":"Fujita","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"key20200713223815_b38-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"key20200713223815_b39-mmr-17-02-2885","unstructured":"SubramanianATamayoPMoothaVKMukherjeeSEbertBLGilletteMAPaulovichAPomeroySLGolubTRLanderESMesirovJPGene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profilesProc Natl Acad Sci USA1021554515550200510.1073\/pnas.0506580102161995171239896"},{"key":"key20200713223815_b40-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat Genet"},{"key":"key20200713223815_b41-mmr-17-02-2885","unstructured":"LiaoCWangXYWeiHQLiSQMerghoubTPandolfiPPWolgemuthDJAltered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1Proc Natl Acad Sci USA9868536858200110.1073\/pnas.1215400981138114034442"},{"key":"key20200713223815_b42-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1074\/jbc.M804704200","article-title":"Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia","volume":"284","author":"Wang","year":"2009","journal-title":"J Biol Chem"},{"key":"key20200713223815_b43-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"905","DOI":"10.3324\/haematol.2015.124032","article-title":"Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia","volume":"100","author":"Garcia-Cuellar","year":"2015","journal-title":"Haematologica"},{"key":"key20200713223815_b44-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.ccell.2016.09.006","article-title":"Enhanced fructose utilization mediated by SLC2A5 is a unique metabolic feature of acute myeloid leukemia with therapeutic potential","volume":"30","author":"Chen","year":"2016","journal-title":"Cancer Cell"},{"key":"key20200713223815_b45-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/ni1010-969d","article-title":"Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia","volume":"11","author":"Hodson","year":"2010","journal-title":"Nat Immunol"},{"key":"key20200713223815_b46-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1182\/blood-2003-06-1845","article-title":"Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia","volume":"103","author":"Ozeki","year":"2004","journal-title":"Blood"},{"key":"key20200713223815_b47-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1182\/blood-2009-07-235358","article-title":"Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European Leukemia Net","volume":"115","author":"D\u00f6hner","year":"2010","journal-title":"Blood"},{"key":"key20200713223815_b48-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/ajh.22246","article-title":"Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management","volume":"87","author":"Estey","year":"2012","journal-title":"Am J Hematol"},{"key":"key20200713223815_b49-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1056\/NEJMoa1112304","article-title":"Prognostic relevance of integrated genetic profiling in acute myeloid leukemia","volume":"366","author":"Patel","year":"2012","journal-title":"N Engl J Med"},{"key":"key20200713223815_b50-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ccr.2014.01.022","article-title":"SYK is a critical regulator of FLT3 in acute myeloid leukemia","volume":"25","author":"Puissant","year":"2014","journal-title":"Cancer Cell"},{"key":"key20200713223815_b51-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1182\/blood-2013-04-493858","article-title":"MUC1-C oncoprotein promotes FLT3 receptor activation in acute myeloid leukemia cells","volume":"123","author":"Liu","year":"2014","journal-title":"Blood"},{"key":"key20200713223815_b52-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"57770","DOI":"10.18632\/oncotarget.10760","article-title":"Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling","volume":"7","author":"Moharram","year":"2016","journal-title":"Oncotarget"},{"key":"key20200713223815_b53-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.molonc.2013.02.020","article-title":"Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling","volume":"7","author":"Kazi","year":"2013","journal-title":"Mol Oncol"},{"key":"key20200713223815_b54-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1038\/leu.2013.23","article-title":"C\/EBP\u03b1 and MYB regulate FLT3 expression in AML","volume":"27","author":"Volpe","year":"2013","journal-title":"Leukemia"},{"key":"key20200713223815_b55-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.leukres.2005.07.010","article-title":"Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia","volume":"30","author":"Holm","year":"2006","journal-title":"Leuk Res"},{"key":"key20200713223815_b56-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1182\/blood-2005-12-007005","article-title":"The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia","volume":"108","author":"Palmqvist","year":"2006","journal-title":"Blood"},{"key":"key20200713223815_b57-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1182\/blood-2012-07-442004","article-title":"PBX3 is an important cofactor of HOXA9 in leukemogenesis","volume":"121","author":"Li","year":"2013","journal-title":"Blood"},{"key":"key20200713223815_b58-mmr-17-02-2885","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1158\/0008-5472.CAN-15-1566","article-title":"PBX3 and MEIS1 cooperate in hematopoietic cells to drive acute myeloid leukemias characterized by a core transcriptome of the MLL-rearranged disease","volume":"76","author":"Li","year":"2016","journal-title":"Cancer Res"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T22:39:03Z","timestamp":1594679943000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.8232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,8]]},"references-count":58,"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.8232","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,8]]}}}