{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:03:13Z","timestamp":1790960593076,"version":"4.1.0"},"reference-count":37,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2017.8275","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T12:34:52Z","timestamp":1513082092000},"source":"Crossref","is-referenced-by-count":9,"title":["Human parvovirus B19 nonstructural protein NS1 activates NLRP3 inflammasome signaling in adult\u2011onset Still's disease"],"prefix":"10.3892","author":[{"given":"Der\u2011Yuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medical Education and Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2011Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2011Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2011Wei","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning\u2011Rong","family":"Gung","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2011Ting","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bor\u2011Show","family":"Tzang","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsai\u2011Ching","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"key20200713224003_b1-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nature06664","article-title":"The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response","volume":"452","author":"Muruve","year":"2008","journal-title":"Nature"},{"key":"key20200713224003_b2-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00281-007-0079-y","article-title":"NALP inflammasome: A central role in innate immunity","volume":"29","author":"Martinon","year":"2007","journal-title":"Semin Immunopathol"},{"key":"key20200713224003_b3-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"key20200713224003_b4-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nrm1019","article-title":"NALPs: A novel protein family involved in inflammation","volume":"4","author":"Tschopp","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20200713224003_b5-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.immuni.2008.02.005","article-title":"The NLR gene family: A standard nomenclature","volume":"28","author":"Ting","year":"2008","journal-title":"Immunity"},{"key":"key20200713224003_b6-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1136\/ard.2007.078014","article-title":"Inflammasomes and rheumatic diseases: Evolving concepts","volume":"67","author":"Sidiropoulos","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"key20200713224003_b7-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1093\/rheumatology\/ker524","article-title":"Microcrystals as DAMPs and their role in joint inflammation","volume":"51","author":"Busso","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"key20200713224003_b8-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"4579","DOI":"10.3892\/mmr.2015.3236","article-title":"Polymorphism in the NLRP3 inflammasome-associated EIF2K2 gene and inflammatory bowel disease","volume":"11","author":"Varghese","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20200713224003_b9-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0092-8674(00)80721-7","article-title":"Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes","volume":"97","author":"McDermott","year":"1999","journal-title":"Cell"},{"key":"key20200713224003_b10-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev.immunol.25.022106.141627","article-title":"Horror autoinflammaticus: The molecular pathophysiology of autoinflammatory disease (*)","volume":"27","author":"Masters","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"key20200713224003_b11-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.cell.2010.03.002","article-title":"Autoinflammatory disease reloaded: A clinical perspective","volume":"140","author":"Kastner","year":"2010","journal-title":"Cell"},{"key":"key20200713224003_b12-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.autrev.2014.01.058","article-title":"Adult-onset Still's disease","volume":"13","author":"Gerfaud-Valentin","year":"2014","journal-title":"Autoimmun Rev"},{"key":"key20200713224003_b13-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3109\/07853890.2014.971052","article-title":"Adult-onset Still's disease-pathogenesis, clinical manifestations, and new treatment options","volume":"47","author":"Kadavath","year":"2015","journal-title":"Ann Med"},{"key":"key20200713224003_b14-mmr-17-02-3364","first-page":"424","article-title":"Preliminary criteria for classification of adult Still's disease","volume":"19","author":"Yamaguchi","year":"1992","journal-title":"J Rheumatol"},{"key":"key20200713224003_b15-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1002\/1529-0131(200103)44:3<550::AID-ANR103>3.0.CO;2-5","article-title":"Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease","volume":"44","author":"Kawashima","year":"2001","journal-title":"Arthritis Rheum"},{"key":"key20200713224003_b16-mmr-17-02-3364","first-page":"2422","article-title":"Serum cytokine profiles in patients with adult onset Still's disease","volume":"30","author":"Choi","year":"2003","journal-title":"J Rheumatol"},{"key":"key20200713224003_b17-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1093\/rheumatology\/keq284","article-title":"Potential role of Th17 cells in the pathogenesis of adult-onset still's disease","volume":"49","author":"Chen","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"key20200713224003_b18-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1093\/rheumatology\/keq397","article-title":"Markely increased IL-18 liver expression in adult-onset Still's disease-related hepatitis","volume":"50","author":"Priori","year":"2011","journal-title":"Rheumatology (Oxford)"},{"key":"key20200713224003_b19-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1056\/NEJMra030840","article-title":"Parvovirus B19","volume":"350","author":"Young","year":"2004","journal-title":"N Engl J Med"},{"key":"key20200713224003_b20-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1128\/JVI.76.4.2014-2018.2002","article-title":"The VP1 unique region of parvovirus B19 and its constituent phospholipase A2-like activity","volume":"76","author":"Dorsch","year":"2002","journal-title":"J Virol"},{"key":"key20200713224003_b21-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.virusres.2014.06.017","article-title":"Persistent parvovirus B19 infection in non-erythroid tissues: Possible role in the inflammatory and disease process","volume":"190","author":"Adamson-Small","year":"2014","journal-title":"Virus Res"},{"key":"key20200713224003_b22-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.cca.2012.01.027","article-title":"Significant association of past parvovirus B19 infection with cytopenia in both adult-onset Still's disease and systemic lupus erythematosus patients","volume":"413","author":"Chen","year":"2012","journal-title":"Clin Chim Acta"},{"key":"key20200713224003_b23-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1006\/abio.1987.9999","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"key20200713224003_b24-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713224003_b25-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cca.2006.10.016","article-title":"The association of VP1 unique region protein in acute parvovirus B19 infection and anti-phospholipid antibody production","volume":"378","author":"Tzang","year":"2007","journal-title":"Clin Chim Acta"},{"key":"key20200713224003_b26-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3109\/08916934.2011.637532","article-title":"Polymorphisms in inflammasome genes are involved in the predisposition to systemic lupus erythematosus","volume":"45","author":"Pontillo","year":"2012","journal-title":"Autoimmunity"},{"key":"key20200713224003_b27-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: The convergence of multiple signaling pathways on ROS production","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"key20200713224003_b28-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/j.1365-2249.2009.03972.x","article-title":"Expression and regulation of the NALP3 inflammasome complex in periodontal diseases","volume":"157","author":"Bostanci","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"key20200713224003_b29-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"51897","DOI":"10.1074\/jbc.M406741200","article-title":"PAN1\/NALP2\/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages","volume":"279","author":"Bruey","year":"2004","journal-title":"J Biol Chem"},{"key":"key20200713224003_b30-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.micinf.2013.04.001","article-title":"NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease","volume":"15","author":"Radian","year":"2013","journal-title":"Microbes Infect"},{"key":"key20200713224003_b31-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.immuni.2012.02.001","article-title":"An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages","volume":"36","author":"Khare","year":"2012","journal-title":"Immunity"},{"key":"key20200713224003_b32-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"21720","DOI":"10.1074\/jbc.M410057200","article-title":"PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion","volume":"280","author":"Kinoshita","year":"2005","journal-title":"J Biol Chem"},{"key":"key20200713224003_b33-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.jmb.2011.09.024","article-title":"The NLRP12 pyrin domain: Structure, dynamics, and functional insights","volume":"413","author":"Pinheiro","year":"2011","journal-title":"J Mol Biol"},{"key":"key20200713224003_b34-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/jhg.2011.16","article-title":"De novo 19q13.42 duplications involving NLRP gene cluster in a patient with systemic-onset juvenile idiopathic arthritis","volume":"56","author":"Tadaki","year":"2011","journal-title":"J Hum Genet"},{"key":"key20200713224003_b35-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1093\/intimm\/dxh081","article-title":"PYNOD, a novel Apaf-1\/CED4-like protein is an inhibitor of ASC and caspase-1","volume":"16","author":"Wang","year":"2004","journal-title":"Int Immunol"},{"key":"key20200713224003_b36-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"138, 1","DOI":"10.1095\/biolreprod.111.093583","article-title":"NLRP5 mediates mitochondrial function in mouse oocytes and embryos","volume":"86","author":"Fernandes","year":"2012","journal-title":"Biol Reprod"},{"key":"key20200713224003_b37-mmr-17-02-3364","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1128\/JVI.01265-10","article-title":"Adenovirus membrane penetration activates the NLRP3 inflammasome","volume":"85","author":"Barlan","year":"2011","journal-title":"J Virol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T22:46:01Z","timestamp":1594680361000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2017.8275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,12]]},"references-count":37,"URL":"https:\/\/doi.org\/10.3892\/mmr.2017.8275","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,12]]}}}