{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T16:19:51Z","timestamp":1774887591244,"version":"3.50.1"},"reference-count":34,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.8471","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T10:28:59Z","timestamp":1516789739000},"source":"Crossref","is-referenced-by-count":11,"title":["Homocysteine-induced proliferation of vascular smooth muscle cells occurs via PTEN hypermethylation and is mitigated by Resveratrol"],"prefix":"10.3892","author":[{"given":"Sheng\u2011Chao","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2011Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2011Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2011Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An\u2011Ning","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2011Deng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"key20200713224615_b1-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4103\/0972-2327.168633","article-title":"Serum homocysteine as a risk factor for carotid intimal thickening in acute stroke: A cross sectional observational study","volume":"19","author":"Devasia","year":"2016","journal-title":"Ann Indian Acad Neurol"},{"key":"key20200713224615_b2-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s11010-015-2432-0","article-title":"Vascular smooth muscle cell differentiation to an osteogenic phenotype involves matrix metalloproteinase-2 modulation by homocysteine","volume":"406","author":"Liu","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"key20200713224615_b3-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.bbapap.2008.10.001","article-title":"Proteomic analysis of homocysteine induced proliferation of cultured neonatal rat vascular smooth muscle cells","volume":"1794","author":"Liu","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"key20200713224615_b4-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"947","DOI":"10.3892\/mmr.2014.2249","article-title":"Aberrant DNA methylation of the PDGF gene in homocysteine-mediated VSMC proliferation and its underlying mechanism","volume":"10","author":"Han","year":"2014","journal-title":"Mol Med Rep"},{"key":"key20200713224615_b5-mmr-17-04-5312","first-page":"154","article-title":"Plasma homocysteine and liver tissue S-adenosylmethionine, S-adenosylhomocysteine status in vitamin B6-deficient rats","volume":"19","author":"Taysi","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"key20200713224615_b6-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"e192","DOI":"10.1038\/nutd.2015.44","article-title":"Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans","volume":"6","author":"Elshorbagy","year":"2016","journal-title":"Nutr Diabetes"},{"key":"key20200713224615_b7-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s12031-016-0735-6","article-title":"DNA methylation profiling reveals correlation of differential methylation patterns with gene expression in human epilepsy","volume":"59","author":"Wang","year":"2016","journal-title":"J Mol Neurosci"},{"key":"key20200713224615_b8-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"3998","DOI":"10.1016\/j.febslet.2015.11.010","article-title":"High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(\u2212\/\u2212) mice","volume":"589","author":"Yang","year":"2015","journal-title":"FEBS Lett"},{"key":"key20200713224615_b9-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1089\/dna.2007.0658","article-title":"Homocysteine-mediated PPARalpha, gamma DNA methylation and its potential pathogenic mechanism in monocytes","volume":"27","author":"Yideng","year":"2008","journal-title":"DNA Cell Biol"},{"key":"key20200713224615_b10-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1161\/01.CIR.0000140764.15398.F3","article-title":"Protective effect of propylthiouracil independent of its hypothyroid effect on atherogenesis in cholesterol-fed rabbits: PTEN induction and inhibition of vascular smooth muscle cell proliferation and migration","volume":"110","author":"Chen","year":"2004","journal-title":"Circulation"},{"key":"key20200713224615_b11-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"e55445","DOI":"10.1371\/journal.pone.0055445","article-title":"Role of the phosphatase PTEN in early vascular remodeling","volume":"8","author":"Sedding","year":"2013","journal-title":"PLoS One"},{"key":"key20200713224615_b12-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.prostaglandins.2007.10.009","article-title":"PGF2alpha-associated vascular smooth muscle hypertrophy is ROS dependent and involves the activation of mTOR, p70S6k, and PTEN","volume":"85","author":"Rice","year":"2008","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"key20200713224615_b13-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1007\/s12013-014-0039-9","article-title":"Effect of recombinant hPTEN gene expression on PDGF induced VSMC proliferation","volume":"70","author":"Hu","year":"2014","journal-title":"Cell Biochem Biophys"},{"key":"key20200713224615_b14-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1093\/ndt\/gfw097","article-title":"Effect of Resveratrol on progression of polycystic kidney disease: A case of cautious optimism","volume":"31","author":"Moradi","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"key20200713224615_b15-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"117","DOI":"10.5604\/17322693.1195844","article-title":"The role of Resveratrol in the regulation of cell metabolism-a review","volume":"70","author":"Pieszka","year":"2016","journal-title":"Postepy Hig Med Dosw (Online)"},{"key":"key20200713224615_b16-mmr-17-04-5312","doi-asserted-by":"crossref","first-page":"53","DOI":"10.14712\/fb2016062020053","article-title":"Effect of simvastatin, coenzyme Q10, Resveratrol, acetylcysteine and acetylcarnitine on mitochondrial respiration","volume":"62","author":"Fi\u0161ar","year":"2016","journal-title":"Folia Biol (Praha)"},{"key":"key20200713224615_b17-mmr-17-04-5312","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7521","article-title":"Aberrant promoter methylation of multiple genes in VSMC proliferation induced by Hcy","author":"Ma","year":"2017","journal-title":"Mol Med Rep"},{"key":"key20200713224615_b18-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1007\/s12013-014-0039-9","article-title":"Effect of recombinant hPTEN gene expression on PDGF induced VSMC proliferation","volume":"70","author":"Hu","year":"2014","journal-title":"Cell Biochem Biophys"},{"key":"key20200713224615_b19-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/jcb.24315","article-title":"Inhibition of PTEN expression and activity by angiotensin II induces proliferation and migration of vascular smooth muscle cells","volume":"114","author":"Dong","year":"2013","journal-title":"J Cell Biochem"},{"key":"key20200713224615_b20-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1160\/TH14-10-0852","article-title":"Alternation of histone and DNA methylation in human atherosclerotic carotid plaques","volume":"114","author":"Grei\u00dfel","year":"2015","journal-title":"Thromb Haemost"},{"key":"key20200713224615_b21-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1097\/FJC.0000000000000370","article-title":"Polyphenols and polypeptides in Chinese rice wine inhibit homocysteine-induced proliferation and migration of vascular smooth muscle cells","volume":"67","author":"Meng","year":"2016","journal-title":"J Cardiovasc Pharmacol"},{"key":"key20200713224615_b22-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"28821","DOI":"10.18632\/oncotarget.8936","article-title":"Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids","volume":"7","author":"Swiader","year":"2016","journal-title":"Oncotarget"},{"key":"key20200713224615_b23-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s00395-009-0045-z","article-title":"Propylthiouracil, independent of its antithyroid effect, promotes vascular smooth muscle cells differentiation via PTEN induction","volume":"105","author":"Chen","year":"2010","journal-title":"Basic Res Cardiol"},{"key":"key20200713224615_b24-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.avsg.2016.04.003","article-title":"Influence of clinically relevant mechanical forces on vascular smooth muscle cells under chronic high glucose: An in vitro dynamic disease model","volume":"34","author":"Chawla","year":"2016","journal-title":"Ann Vasc Surg"},{"key":"key20200713224615_b25-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"C1466","DOI":"10.1152\/ajpcell.00304.2009","article-title":"Homocysteine promotes vascular smooth muscle cell migration by induction of the adipokine resistin","volume":"297","author":"Jiang","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"key20200713224615_b26-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1158\/1535-7163.MCT-15-0496","article-title":"Concomitant inhibition of PI3K\u03b2 and BRAF or MEK in PTEN-deficient\/BRAF-mutant melanoma treatment: Preclinical assessment of SAR260301 oral PI3K\u03b2-selective inhibitor","volume":"15","author":"Bonnevaux","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"key20200713224615_b27-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.humpath.2016.04.017","article-title":"ERG and PTEN status of isolated high-grade PIN occurring in cystoprostatectomy specimens without invasive prostatic adenocarcinoma","volume":"55","author":"Morais","year":"2016","journal-title":"Hum Pathol"},{"key":"key20200713224615_b28-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"35786","DOI":"10.1074\/jbc.M102479200","article-title":"The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival","volume":"276","author":"Schwartzbauer","year":"2001","journal-title":"J Biol Chem"},{"key":"key20200713224615_b29-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1159\/000481611","article-title":"Resveratrol enhances neurite outgrowth and synaptogenesis via sonic hedgehog signaling following oxygen-glucose deprivation\/reoxygenation injury","volume":"43","author":"Tang","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"key20200713224615_b30-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"82","DOI":"10.12659\/MSMBR.890858","article-title":"Resveratrol protects vascular smooth muscle cells against high glucose-induced oxidative stress and cell proliferation in vitro","volume":"20","author":"Guo","year":"2014","journal-title":"Med Sci Monit Basic Res"},{"key":"key20200713224615_b31-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"4791","DOI":"10.3892\/mmr.2016.5120","article-title":"Integration of gene expression and DNA methylation profiles provides a molecular subtype for risk assessment in atherosclerosis","volume":"13","author":"Ma","year":"2016","journal-title":"Mol Med Rep"},{"key":"key20200713224615_b32-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.cca.2016.02.026","article-title":"Aberrant DNA methylation in the pathogenesis of atherosclerosis","volume":"456","author":"Hai","year":"2016","journal-title":"Clin Chim Acta"},{"key":"key20200713224615_b33-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1007\/s11883-014-0476-3","article-title":"Epigenetic reprogramming in atherosclerosis","volume":"17","author":"Grimaldi","year":"2015","journal-title":"Curr Atheroscler Rep"},{"key":"key20200713224615_b34-mmr-17-04-5312","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1007\/s00277-016-2636-8","article-title":"On the potential role of DNMT1 in acute myeloid leukemia and myelodysplastic syndromes: Not another mutated epigenetic driver","volume":"95","author":"Benetatos","year":"2016","journal-title":"Ann Hematol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T18:21:22Z","timestamp":1719771682000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.8471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,24]]},"references-count":34,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.8471","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,24]]}}}