{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T02:47:32Z","timestamp":1782355652274,"version":"3.54.5"},"reference-count":37,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.8766","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T08:59:06Z","timestamp":1521190746000},"source":"Crossref","is-referenced-by-count":13,"title":["KCC2-GABAA pathway correlates with the analgesic effect of electro-acupuncture in CCI rats"],"prefix":"10.3892","author":[{"given":"Si\u2011Si","family":"Li","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2011Zhan","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2011Qian","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2011Ru","family":"Qian","sequence":"additional","affiliation":[{"name":"Integrative and Optimized Medicine Research Center, China\u2011US Institute for Acupuncture and Rehabilitation of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan\u2011Hu","family":"Yang","sequence":"additional","affiliation":[{"name":"Integrative and Optimized Medicine Research Center, China\u2011US Institute for Acupuncture and Rehabilitation of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2011Miao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2011Ci","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Lu","sequence":"additional","affiliation":[{"name":"Protein Quality Control and Diseases Laboratory, Attardi Institute of Mitochondrial Biomedicine, School of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song\u2011He","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,3,16]]},"reference":[{"key":"key20200713225132_b1-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1152\/physrev.1986.66.4.1091","article-title":"Stress-induced analgesia: Adaptive pain suppression","volume":"66","author":"Amit","year":"1986","journal-title":"Physiol Rev"},{"key":"key20200713225132_b2-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0304-3959(00)00474-7","article-title":"The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain","volume":"92","author":"Fox","year":"2001","journal-title":"Pain"},{"key":"key20200713225132_b3-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1016\/S0140-6736(99)01307-0","article-title":"Neuropathic pain: Aetiology, symptoms, mechanisms, and management","volume":"353","author":"Woolf","year":"1999","journal-title":"Lancet"},{"key":"key20200713225132_b4-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.pain.2007.10.016","article-title":"Loose ligation of the sciatic nerve is associated with TrkB receptor-dependent decreases in KCC2 protein levels in the ipsilateral spinal dorsal horn","volume":"137","author":"Miletic","year":"2008","journal-title":"Pain"},{"key":"key20200713225132_b5-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.neuroscience.2007.12.037","article-title":"Reduced potassium-chloride co-transporter expression in spinal cord dorsal horn neurons contributes to inflammatory pain hypersensitivity in rats","volume":"152","author":"Zhang","year":"2008","journal-title":"Neuroscience"},{"key":"key20200713225132_b6-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1038\/nature01868","article-title":"Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain","volume":"424","author":"Coull","year":"2003","journal-title":"Nature"},{"key":"key20200713225132_b7-mmr-17-05-6961","first-page":"309","article-title":"Cation-chloride cotransporters in neuronal communication","volume":"15","author":"Delpire","year":"2000","journal-title":"News Physiol Sci"},{"key":"key20200713225132_b8-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fncel.2014.00027","article-title":"Current view on the functional regulation of the neuronal K(+)-Cl(\u2212) cotransporter KCC2","volume":"8","author":"Medina","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"key20200713225132_b9-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"8746","DOI":"10.1523\/JNEUROSCI.6089-11.2012","article-title":"Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain","volume":"32","author":"Acton","year":"2012","journal-title":"J Neurosci"},{"key":"key20200713225132_b10-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"547","DOI":"10.2174\/1568026054367629","article-title":"Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia","volume":"5","author":"Price","year":"2005","journal-title":"Curr Top Med Chem"},{"key":"key20200713225132_b11-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.brainresrev.2008.12.015","article-title":"Chloride regulation in the pain pathway","volume":"60","author":"Price","year":"2009","journal-title":"Brain Res Rev"},{"key":"key20200713225132_b12-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/0306-4522(87)90098-4","article-title":"GABAA and GABAB receptor site distribution in the rat central nervous system","volume":"20","author":"Bowery","year":"1987","journal-title":"Neuroscience"},{"key":"key20200713225132_b13-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1523\/JNEUROSCI.10-07-02330.1990","article-title":"Functional characteristics and sites of gene expression of the alpha 1, beta 1, gamma 2-isoform of the rat GABAA receptor","volume":"10","author":"Malherbe","year":"1990","journal-title":"J Neurosci"},{"key":"key20200713225132_b14-mmr-17-05-6961","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0031-6997(24)01363-2","article-title":"International union of pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: Classification on the basis of subunit structure and receptor function","volume":"50","author":"Barnard","year":"1998","journal-title":"Pharmacol Rev"},{"key":"key20200713225132_b15-mmr-17-05-6961","unstructured":"BonnertTPMcKernanRMFarrarSle Bourdell\u00e8sBHeavensRPSmithDWHewsonLRigbyMRSirinathsinghjiDJBrownNtheta, a novel gamma-aminobutyric acid type A receptor subunitProc Natl Acad Sci USA9698919896199910.1073\/pnas.96.17.98911044979022306"},{"key":"key20200713225132_b16-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"795","DOI":"10.2174\/1568026023393507","article-title":"Subunit composition, distribution and function of GABA(A) receptor subtypes","volume":"2","author":"Sieghart","year":"2002","journal-title":"Curr Top Med Chem"},{"key":"key20200713225132_b17-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/0306-4522(92)90119-M","article-title":"Localization of GABAA-receptor gamma 2-subunit mRNA-containing neurons in the rat central nervous system","volume":"47","author":"Araki","year":"1992","journal-title":"Neuroscience"},{"key":"key20200713225132_b18-mmr-17-05-6961","first-page":"481","article-title":"Acupuncture for pain","volume":"80","author":"Kelly","year":"2009","journal-title":"Am Fam Physician"},{"key":"key20200713225132_b19-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0006-3223(97)00394-6","article-title":"Electroacupuncture: Mechanisms and clinical application","volume":"44","author":"Ulett","year":"1998","journal-title":"Biol Psychiatry"},{"key":"key20200713225132_b20-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"642081","DOI":"10.1155\/2015\/642081","article-title":"Regulation of neurotrophin-3 and interleukin-1\u03b2 and inhibition of spinal glial activation contribute to the analgesic effect of electroacupuncture in chronic neuropathic pain states of rats","volume":"2015","author":"Tu","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"key20200713225132_b21-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1002\/jnr.23451","article-title":"Electroacupuncture and A-317491 depress the transmission of pain on primary afferent mediated by the P2X3 receptor in rats with chronic neuropathic pain states","volume":"92","author":"Wang","year":"2014","journal-title":"J Neurosci Res"},{"key":"key20200713225132_b22-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.neuint.2012.01.006","article-title":"Analgesic effect of electroacupuncture on chronic neuropathic pain mediated by P2X3 receptors in rat dorsal root ganglion neurons","volume":"60","author":"Tu","year":"2012","journal-title":"Neurochem Int"},{"key":"key20200713225132_b23-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jams.2012.01.002","article-title":"Effectiveness of electroacupuncture at Zusanli (ST36) on the immunohistochemical density of enteroendocrine cells related to gastrointestinal function","volume":"5","author":"Lee","year":"2012","journal-title":"J Acupunct Meridian Stud"},{"key":"key20200713225132_b24-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12993-016-0096-x","article-title":"Involvement of hippocampal acetylcholinergic receptors in electroacupuncture analgesia in neuropathic pain rats","volume":"12","author":"Chen","year":"2016","journal-title":"Behav Brain Funct"},{"key":"key20200713225132_b25-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.expneurol.2004.11.003","article-title":"Effects of synchronous or asynchronous electroacupuncture stimulation with low versus high frequency on spinal opioid release and tail flick nociception","volume":"192","author":"Wang","year":"2005","journal-title":"Exp Neurol"},{"key":"key20200713225132_b26-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jpain.2010.04.008","article-title":"Analgesia induced by 2- or 100-Hz electroacupuncture in the rat tail-flick test depends on the activation of different descending pain inhibitory mechanisms","volume":"12","author":"Silva","year":"2011","journal-title":"J Pain"},{"key":"key20200713225132_b27-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713225132_b28-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/j.neubiorev.2008.03.009","article-title":"Spinal glial activation contributes to pathological pain states","volume":"32","author":"Cao","year":"2008","journal-title":"Neurosci Biobehav Rev"},{"key":"key20200713225132_b29-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1523\/JNEUROSCI.3792-03.2004","article-title":"Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia","volume":"24","author":"Suzuki","year":"2004","journal-title":"J Neurosci"},{"key":"key20200713225132_b30-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/nature04223","article-title":"BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain","volume":"438","author":"Coull","year":"2005","journal-title":"Nature"},{"key":"key20200713225132_b31-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/ncpneuro0883","article-title":"Roles of the cation-chloride cotransporters in neurological disease","volume":"4","author":"Kahle","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"key":"key20200713225132_b32-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1177\/1087057109355708","article-title":"A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators","volume":"15","author":"Zhang","year":"2010","journal-title":"J Biomol Screen"},{"key":"key20200713225132_b33-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.coph.2006.11.005","article-title":"Altered chloride homeostasis in neurological disorders: A new target","volume":"7","author":"De Koninck","year":"2007","journal-title":"Curr Opin Pharmacol"},{"key":"key20200713225132_b34-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.neures.2006.08.012","article-title":"Expression changes of cation chloride cotransporters in the rat spinal cord following intraplantar formalin","volume":"56","author":"Nomura","year":"2006","journal-title":"Neurosci Res"},{"key":"key20200713225132_b35-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1056\/NEJMct0806114","article-title":"Acupuncture for chronic low back pain","volume":"363","author":"Berman","year":"2010","journal-title":"N Engl J Med"},{"key":"key20200713225132_b36-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s11655-011-0783-2","article-title":"Effect of electro-acupuncture on tumor necrosis factor-\u03b1 and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis","volume":"17","author":"Ouyang","year":"2011","journal-title":"Chin J Integr Med"},{"key":"key20200713225132_b37-mmr-17-05-6961","doi-asserted-by":"publisher","first-page":"429412","DOI":"10.1155\/2012\/429412","article-title":"Neural acupuncture unit: A new concept for interpreting effects and mechanisms of acupuncture","volume":"2012","author":"Zhang","year":"2012","journal-title":"Evid Based Complement Alternat Med"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T20:54:12Z","timestamp":1751489652000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.8766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,16]]},"references-count":37,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.8766","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,16]]}}}