{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:11:45Z","timestamp":1790806305392,"version":"4.1.0"},"reference-count":46,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.8774","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T07:17:21Z","timestamp":1521443841000},"source":"Crossref","is-referenced-by-count":6,"title":["Protection of Luteolin-7-O-glucoside against apoptosis induced by hypoxia\/reoxygenation through the MAPK pathways in H9c2 cells"],"prefix":"10.3892","author":[{"given":"Shenjie","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingsheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuangang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,3,19]]},"reference":[{"key":"key20200713225205_b1-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1161\/CIR.0b013e31826e1058","article-title":"Joint ESC\/ACCF\/AHA\/WHF Task Force for the Universal Definition of Myocardial Infarction, Katus HA, Lindahl B, Morrow DA, et al: Third universal definition of myocardial infarction","volume":"126","author":"Thygesen","year":"2012","journal-title":"Circulation"},{"key":"key20200713225205_b2-mmr-17-05-7156","unstructured":"ElrodJWCalvertJWMorrisonJDoellerJEKrausDWTaoLJiaoXScaliaRKissLSzaboCHydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial functionProc Natl Acad Sci USA1041556015565200710.1073\/pnas.0705891104178783062000503"},{"key":"key20200713225205_b3-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"6411","DOI":"10.1016\/j.bmcl.2010.09.086","article-title":"Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells","volume":"20","author":"Wang","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"key20200713225205_b4-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/S0735-1097(86)80236-4","article-title":"Quantitative structural analysis of the myocardium during physiologic growth and induced cardiac hypertrophy: A review","volume":"7","author":"Anversa","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"key20200713225205_b5-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1161\/01.RES.79.5.949","article-title":"Apoptosis in ischemic and reperfused rat myocardium","volume":"79","author":"Fliss","year":"1996","journal-title":"Circ Res"},{"key":"key20200713225205_b6-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/s12291-014-0475-8","article-title":"Pathophysiological role of peroxynitrite induced DNA damage in human diseases: A special focus on poly (ADP-ribose) polymerase (PARP)","volume":"30","author":"Islam","year":"2015","journal-title":"Indian J Clin Biochem"},{"key":"key20200713225205_b7-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1038\/ki.1997.239","article-title":"Agonistic anti-Fas antibodies induce glomerular cell apoptosis in mice in vivo","volume":"51","author":"Gonzalez-Cuadrado","year":"1997","journal-title":"Kidney Int"},{"key":"key20200713225205_b8-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1038\/ki.1996.155","article-title":"Anti-Fas antibodies induce cytolysis and apoptosis in cultured human mesangial cells","volume":"49","author":"Gonzalez-Cuadrado","year":"1996","journal-title":"Kidney Int"},{"key":"key20200713225205_b9-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.rvsc.2016.02.004","article-title":"Evaluation of apoptosis-associated protein (Bcl-2, Bax, cleaved caspase-3 and p53) expression in canine mammary tumors: An immunohistochemical and prognostic study","volume":"105","author":"Dolka","year":"2016","journal-title":"Res Vet Sci"},{"key":"key20200713225205_b10-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s11010-013-1686-7","article-title":"Exogenous hydrogen sulfide prevents cardiomyocyte apoptosis from cardiac hypertrophy induced by isoproterenol","volume":"381","author":"Lu","year":"2013","journal-title":"Mol Cell Biochem"},{"key":"key20200713225205_b11-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1089\/ars.2015.6522","article-title":"Oxidative stress by monoamine oxidase-A impairs transcription factor EB activation and autophagosome clearance, leading to cardiomyocyte necrosis and heart failure","volume":"25","author":"Santin","year":"2016","journal-title":"Antioxid Redox Signal"},{"key":"key20200713225205_b12-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1007\/s11655-015-2296-x","article-title":"Antioxidative effect of luteolin pretreatment on simulated ischemia\/reperfusion injury in cardiomyocyte and perfused rat heart","volume":"23","author":"Zhang","year":"2017","journal-title":"Chin J Integr Med"},{"key":"key20200713225205_b13-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ejphar.2016.02.063","article-title":"Activation of beta1-adrenoceptor triggers oxidative stress mediated myocardial membrane destabilization in isoproterenol induced myocardial infarcted rats: 7-hydroxycoumarin and its counter action","volume":"777","author":"Jagadeesh","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"key20200713225205_b14-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"634","DOI":"10.2174\/156800908786241050","article-title":"Luteolin, a flavonoid with potential for cancer prevention and therapy","volume":"8","author":"Lin","year":"2008","journal-title":"Curr Cancer Drug Targets"},{"key":"key20200713225205_b15-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ejphar.2010.05.053","article-title":"Proteomic analysis reveals ATP-dependent steps and chaperones involvement in luteolin-induced lung cancer CH27 cell apoptosis","volume":"642","author":"Lee","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"key20200713225205_b16-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.freeradbiomed.2011.01.027","article-title":"UVB-induced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo","volume":"50","author":"Wolfle","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"key20200713225205_b17-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1016\/j.lfs.2007.09.028","article-title":"Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages","volume":"81","author":"Chen","year":"2007","journal-title":"Life Sci"},{"key":"key20200713225205_b18-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.neulet.2008.10.046","article-title":"Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation","volume":"448","author":"Chen","year":"2008","journal-title":"Neurosci Lett"},{"key":"key20200713225205_b19-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1365-2958.2005.04822.x","article-title":"Protein phosphatases in MAPK signalling: We keep learning from yeast","volume":"58","author":"Martin","year":"2005","journal-title":"Mol Microbiol"},{"key":"key20200713225205_b20-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s11248-006-9052-0","article-title":"In vivo functions of mitogen-activated protein kinases: Conclusions from knock-in and knock-out mice","volume":"16","author":"Gerits","year":"2007","journal-title":"Transgenic Res"},{"key":"key20200713225205_b21-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.yjmcc.2004.11.004","article-title":"STRESS signaling pathways that modulate cardiac myocyte apoptosis","volume":"38","author":"Baines","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"key20200713225205_b22-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.tcm.2003.11.002","article-title":"Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies","volume":"14","author":"Petrich","year":"2004","journal-title":"Trends Cardiovasc Med"},{"key":"key20200713225205_b23-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1161\/01.CIR.0000120390.68287.BB","article-title":"Hypertrophy of the heart: A new therapeutic target?","volume":"109","author":"Frey","year":"2004","journal-title":"Circulation"},{"key":"key20200713225205_b24-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3389\/fphar.2015.00149","article-title":"Extracellular signal-regulated kinases 1\/2 as regulators of cardiac hypertrophy","volume":"6","author":"Mutlak","year":"2015","journal-title":"Front Pharmacol"},{"key":"key20200713225205_b25-mmr-17-05-7156","first-page":"3217","article-title":"Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK\/STAT pathway","volume":"9","author":"Al-Rasheed","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"key20200713225205_b26-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713225205_b27-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s12012-015-9317-z","article-title":"Protection of Luteolin-7-O-Glucoside against doxorubicin-induced injury through PTEN\/Akt and ERK pathway in H9c2 cells","volume":"16","author":"Yao","year":"2016","journal-title":"Cardiovasc Toxicol"},{"key":"key20200713225205_b28-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"e2344","DOI":"10.1038\/cddis.2016.201","article-title":"Luteolin-7-glucoside inhibits IL-22\/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model","volume":"7","author":"Palombo","year":"2016","journal-title":"Cell Death Dis"},{"key":"key20200713225205_b29-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12943-017-0648-1","article-title":"ROS signaling under metabolic stress: Cross-talk between AMPK and AKT pathway","volume":"16","author":"Zhao","year":"2017","journal-title":"Mol Cancer"},{"key":"key20200713225205_b30-mmr-17-05-7156","first-page":"19","article-title":"Protective effect of naringenin-7-O-glucoside against oxidative stress induced by doxorubicin in H9c2 cardiomyocytes","volume":"6","author":"Han","year":"2012","journal-title":"Biosci Trends"},{"key":"key20200713225205_b31-mmr-17-05-7156","first-page":"234","article-title":"On the catlase activity in rat Walker carcinoma. The effect of endoxan on enzymatic activity","volume":"26","author":"Kirsch","year":"1965","journal-title":"Arch Geschwulstforsch"},{"key":"key20200713225205_b32-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"18975","DOI":"10.1074\/jbc.M112.427062","article-title":"Cardiomyocyte ATP production, metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in vivo","volume":"288","author":"Bround","year":"2013","journal-title":"J Biol Chem"},{"key":"key20200713225205_b33-mmr-17-05-7156","first-page":"2724","article-title":"Over-expression of HSPA12B protects mice against myocardium ischemic\/reperfusion injury through a PPARgamma-dependent PI3K\/Akt\/eNOS pathway","volume":"7","author":"Sun","year":"2015","journal-title":"Am J Transl Res"},{"key":"key20200713225205_b34-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1016\/j.bbamcr.2009.10.002","article-title":"Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria","volume":"1793","author":"Ozaki","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"key20200713225205_b35-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3949\/ccjm.83a.16015","article-title":"Blood pressure management in the wake of SPRINT","volume":"83","author":"Filippone","year":"2016","journal-title":"Cleve Clin J Med"},{"key":"key20200713225205_b36-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"22344","DOI":"10.18632\/oncotarget.15765","article-title":"Protective effect of hydrogen sulphide against myocardial hypertrophy in mice","volume":"8","author":"Shao","year":"2017","journal-title":"Oncotarget"},{"key":"key20200713225205_b37-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1098\/rstb.2005.1772","article-title":"NADPH oxidase-derived reactive oxygen species in cardiac pathophysiology","volume":"360","author":"Cave","year":"2005","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"key20200713225205_b38-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1161\/01.HYP.0000032031.30374.32","article-title":"Activation of NADPH oxidase during progression of cardiac hypertrophy to failure","volume":"40","author":"Li","year":"2002","journal-title":"Hypertension"},{"key":"key20200713225205_b39-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1002\/ptr.871","article-title":"Effects of luteolin on the inhibition of proliferation and induction of apoptosis in human myeloid leukaemia cells","volume":"16","author":"Ko","year":"2002","journal-title":"Phytother Res"},{"key":"key20200713225205_b40-mmr-17-05-7156","doi-asserted-by":"crossref","first-page":"27471","DOI":"10.18632\/oncotarget.15832","article-title":"Luteolin inhibits cell proliferation and induces cell apoptosis via down-regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1 and KYSE450","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"key20200713225205_b41-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41598-017-00086-y","article-title":"Context-independent essential regulatory interactions for apoptosis and hypertrophy in the cardiac signaling network","volume":"7","author":"Kang","year":"2017","journal-title":"Sci Rep"},{"key":"key20200713225205_b42-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1161\/CIRCULATIONAHA.106.679589","article-title":"Mitogen-activated protein kinases in heart development and diseases","volume":"116","author":"Wang","year":"2007","journal-title":"Circulation"},{"key":"key20200713225205_b43-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"e64526","DOI":"10.1371\/annotation\/13aec20c-1d9d-4c18-a9a3-a8767987b9b8","article-title":"Isorhamnetin protects against doxorubicin-induced cardiotoxicity in vivo and in vitro","volume":"8","author":"Sun","year":"2013","journal-title":"PloS One"},{"key":"key20200713225205_b44-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1074\/jbc.M116.760868","article-title":"Activation of the stress response kinase JNK (c-Jun N-terminal kinase) attenuates insulin action in retina through a p70S6K1-dependent mechanism","volume":"292","author":"Miller","year":"2017","journal-title":"J Biol Chem"},{"key":"key20200713225205_b45-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"60640","DOI":"10.18632\/oncotarget.17457","article-title":"Wnt\/beta-catenin pathway in arrhythmogenic cardiomyopathy","volume":"8","author":"Lorenzon","year":"2017","journal-title":"Oncotarget"},{"key":"key20200713225205_b46-mmr-17-05-7156","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.freeradbiomed.2011.10.440","article-title":"Acute exercise stress activates Nrf2\/ARE signaling and promotes antioxidant mechanisms in the myocardium","volume":"52","author":"Muthusamy","year":"2012","journal-title":"Free Radic Biol Med"}],"updated-by":[{"DOI":"10.3892\/mmr.2025.13591","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"record-id":"68921"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T22:57:57Z","timestamp":1594681077000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.8774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,19]]},"references-count":46,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.8774","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,19]]}}}