{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:01:43Z","timestamp":1792008103249,"version":"4.4.0"},"reference-count":57,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.8849","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T07:10:52Z","timestamp":1522912252000},"source":"Crossref","is-referenced-by-count":9,"title":["Saikosaponin\u2011d alleviates carbon\u2011tetrachloride induced acute hepatocellular injury by inhibiting oxidative stress and NLRP3 inflammasome activation in the HL\u20117702 cell line"],"prefix":"10.3892","author":[{"given":"Liubing","family":"Lin","sequence":"first","affiliation":[{"name":"Digestive Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renye","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Shen","sequence":"additional","affiliation":[{"name":"Digestive Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirong","family":"Chen","sequence":"additional","affiliation":[{"name":"Digestive Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Yan","sequence":"additional","affiliation":[{"name":"Digestive Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Digestive Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,4,5]]},"reference":[{"key":"key20200713225434_b1-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jchromb.2015.10.019","article-title":"Enrichment and purification of total flavonoids from Cortex Juglandis Mandshuricae extracts and their suppressive effect on carbon tetrachloride-induced hepatic injury in Mice","volume":"1007","author":"Zhao","year":"2015","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"key20200713225434_b2-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/j.1600-079X.2010.00807.x","article-title":"Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus","volume":"50","author":"Tu\u00f1\u00f3n","year":"2011","journal-title":"J Pineal Res"},{"key":"key20200713225434_b3-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1097\/MCC.0b013e3282f6a450","article-title":"Intensive care management of acute liver failure","volume":"14","author":"Auzinger","year":"2008","journal-title":"Curr Opin Crit Care"},{"key":"key20200713225434_b4-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"3153","DOI":"10.1016\/j.fct.2010.08.011","article-title":"Protective effects of garlic extract and vitamin C against in vivo cypermethrin-induced teratogenic effects in rat offspring","volume":"48","author":"Assayed","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"key20200713225434_b5-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1080\/10715760601118361","article-title":"S-allyl cysteine prevents CCl(4)-induced acute liver injury in rats","volume":"41","author":"Kodai","year":"2007","journal-title":"Free Radic Res"},{"key":"key20200713225434_b6-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0163-7258(89)90050-8","article-title":"Mechanisms of carbon tetrachloride toxicity","volume":"43","author":"Recknagel","year":"1989","journal-title":"Pharmacol Ther"},{"key":"key20200713225434_b7-mmr-17-06-7939","first-page":"330","article-title":"Antioxidant enzymes activities and plasma levels of oxidative stress markers in B-chronic lymphocytic leukemia patients","volume":"15","author":"Zelen","year":"2010","journal-title":"J BUON"},{"key":"key20200713225434_b8-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ejphar.2015.12.006","article-title":"Mangiferin alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation","volume":"770","author":"Pan","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"key20200713225434_b9-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.cyto.2014.03.007","article-title":"How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1","volume":"69","author":"Keyel","year":"2014","journal-title":"Cytokine"},{"key":"key20200713225434_b10-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S1521-6918(03)00053-2","article-title":"Advances in alcoholic liver disease","volume":"17","author":"Arteel","year":"2003","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"key20200713225434_b11-mmr-17-06-7939","first-page":"307","article-title":"Cytokines-central factors in alcoholic liver disease","volume":"27","author":"Neuman","year":"2003","journal-title":"Alcohol Res Health"},{"key":"key20200713225434_b12-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"3476","DOI":"10.1172\/JCI60777","article-title":"IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice","volume":"122","author":"Petrasek","year":"2012","journal-title":"J Clin Invest"},{"key":"key20200713225434_b13-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1089\/hum.2010.145","article-title":"Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice","volume":"22","author":"Zhu","year":"2011","journal-title":"Hum Gene Ther"},{"key":"key20200713225434_b14-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"e113107","DOI":"10.1371\/journal.pone.0113107","article-title":"The protective effect of Esculentoside A on experimental acute liver injury in mice","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"key20200713225434_b15-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/s12906-016-1121-1","article-title":"Amomum cardamomum L. ethyl acetate fraction protects against carbon tetrachloride-induced liver injury via an antioxidant mechanism in rats","volume":"16","author":"Lim","year":"2016","journal-title":"BMC Complement Altern Med"},{"key":"key20200713225434_b16-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1142\/S0192415X14500530","article-title":"Ocimum gratissimum is effective in prevention against liver fibrosis in vivo and in vitro","volume":"42","author":"Chiu","year":"2014","journal-title":"Am J Chin Med"},{"key":"key20200713225434_b17-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/jgh.12366","article-title":"Regulation by resveratrol of the cellular factors mediating liver damage and regeneration after acute toxic liver injury","volume":"29","author":"Chan","year":"2014","journal-title":"J Gastroenterol Hepatol"},{"key":"key20200713225434_b18-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1631\/jzus.B1400104","article-title":"Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism","volume":"15","author":"Zhang","year":"2014","journal-title":"J Zhejiang Univ Sci B"},{"key":"key20200713225434_b19-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"e16064","DOI":"10.1371\/journal.pone.0016064","article-title":"Risk of liver injury associated with Chinese herbal products containing radix bupleuri in 639,779 patients with hepatitis B virus infection","volume":"6","author":"Lee","year":"2011","journal-title":"PLoS One"},{"key":"key20200713225434_b20-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"745295","DOI":"10.1155\/2013\/745295","article-title":"Saikosaponin-d enhances the anticancer potency of TNF-\u03b1 via overcoming its undesirable response of activating NF-Kappa B signalling in cancer cells","volume":"2013","author":"Wong","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"key20200713225434_b21-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.cbi.2013.08.006","article-title":"Saikosaponin D disrupts platelet-derived growth factor-\u03b2 receptor\/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: A potential mechanism of hepatotoxicity","volume":"206","author":"Chen","year":"2013","journal-title":"Chem Biol Interact"},{"key":"key20200713225434_b22-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1139\/O07-010","article-title":"Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury","volume":"85","author":"Fan","year":"2007","journal-title":"Biochem Cell Biol"},{"key":"key20200713225434_b23-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.intimp.2012.06.010","article-title":"Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-\u03baB signaling pathway","volume":"14","author":"Lu","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"key20200713225434_b24-mmr-17-06-7939","first-page":"15137","article-title":"Saikosaponin-d attenuates ventilator-induced lung injury in rats","volume":"8","author":"Wang","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"key20200713225434_b25-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.fct.2013.08.041","article-title":"Protective effect of compounds from the flowers of Citrus aurantium L. var. amara Engl against carbon tetrachloride-induced hepatocyte injury","volume":"62","author":"Lu","year":"2013","journal-title":"Food Chem Toxicol"},{"key":"key20200713225434_b26-mmr-17-06-7939","first-page":"761","article-title":"Augmenter of liver regeneration promotes the proliferation of HL-7702 cells in carbon tetrachloride-induced acute liver injury via increasing autophag","volume":"24","author":"Han","year":"2016","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"key20200713225434_b27-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nature10189","article-title":"Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis","volume":"475","author":"DeNicola","year":"2011","journal-title":"Nature"},{"key":"key20200713225434_b28-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"key20200713225434_b29-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/s12906-017-1733-0","article-title":"Saikosaponins induced hepatotoxicity in mice via lipid metabolism dysregulation and oxidative stress: A proteomic study","volume":"17","author":"Li","year":"2017","journal-title":"BMC Complement Altern Med"},{"key":"key20200713225434_b30-mmr-17-06-7939","first-page":"6472","article-title":"Saikosaponin-d protects renal tubular epithelial cell against high glucose induced injury through modulation of SIRT3","volume":"8","author":"Zhao","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"key20200713225434_b31-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3892\/mmr.2014.2153","article-title":"Saikosaponind inhibits proliferation of DU145 human prostate cancer cells by inducing apoptosis and arresting the cell cycle at G0\/G1 phase","volume":"10","author":"Yao","year":"2014","journal-title":"Mol Med Rep"},{"key":"key20200713225434_b32-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.freeradbiomed.2004.09.017","article-title":"Biomarkers of oxidative stress study II: Are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?","volume":"38","author":"Kadiiska","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"key20200713225434_b33-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"936486","DOI":"10.1155\/2012\/936486","article-title":"Reactive oxygen species in health and disease","volume":"2012","author":"Alfadda","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"key20200713225434_b34-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1089\/ars.2012.4785","article-title":"Redox control of inflammation in macrophages","volume":"19","author":"Br\u00fcne","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"key20200713225434_b35-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1002\/hep.22109","article-title":"Public Policy Committee of the American Association for the Study of Liver Disease: Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease","volume":"47","author":"Kim","year":"2008","journal-title":"Hepatology"},{"key":"key20200713225434_b36-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0741-8329(02)00215-X","article-title":"Ethanol, oxidative stress, and cytokine-induced liver cell injury","volume":"27","author":"Hoek","year":"2002","journal-title":"Alcohol"},{"key":"key20200713225434_b37-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit Rev Toxicol"},{"key":"key20200713225434_b38-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.fct.2012.11.022","article-title":"Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice","volume":"55","author":"Cheng","year":"2013","journal-title":"Food Chem Toxicol"},{"key":"key20200713225434_b39-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-2210-5-2","article-title":"Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney","volume":"5","author":"Tirkey","year":"2005","journal-title":"BMC Pharmacol"},{"key":"key20200713225434_b40-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"key20200713225434_b41-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1146\/annurev-immunol-031210-101405","article-title":"The inflammasome NLRs in immunity, inflammation, and associated diseases","volume":"29","author":"Davis","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"key20200713225434_b42-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1038\/sj.cdd.4402195","article-title":"Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration","volume":"14","author":"Petrilli","year":"2007","journal-title":"Cell Death Differ"},{"key":"key20200713225434_b43-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: A caspase-1-activation platform that regulates immune responses and disease pathogenesis","volume":"10","author":"Franchi","year":"2009","journal-title":"Nat Immunol"},{"key":"key20200713225434_b44-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1189\/jlb.1212662","article-title":"The many faces of HMGB1: Molecular structure-functional activity in inflammation, apoptosis, and chemotaxis","volume":"93","author":"Yang","year":"2013","journal-title":"J Leukoc Biol"},{"key":"key20200713225434_b45-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.cyto.2016.06.001","article-title":"Increased expression of high mobility group box 1 (HMGB1) in the cytoplasm of placental syncytiotrophoblast from preeclamptic placentae","volume":"85","author":"Chen","year":"2016","journal-title":"Cytokine"},{"key":"key20200713225434_b46-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.placenta.2015.08.006","article-title":"HMGB1-RAGE signaling pathway in severe preeclampsia","volume":"36","author":"Zhu","year":"2015","journal-title":"Placenta"},{"key":"key20200713225434_b47-mmr-17-06-7939","first-page":"305","article-title":"Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome","volume":"119","author":"Imaeda","year":"2009","journal-title":"J Clin Invest"},{"key":"key20200713225434_b48-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"80","DOI":"10.2174\/1874312901206010080","article-title":"The Role of the NLRP3 Inflammasome in Fibrosis","volume":"6","author":"Artlett","year":"2012","journal-title":"Open Rheumatol J"},{"key":"key20200713225434_b49-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.freeradbiomed.2013.08.178","article-title":"NLRP3 inflammasome activation in D-galactosamine and lipopolysaccharide-induced acute liver failure: Role of heme oxygenase-1","volume":"65","author":"Kim","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"key20200713225434_b50-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"83951","DOI":"10.18632\/oncotarget.13796","article-title":"Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis","volume":"7","author":"Gong","year":"2016","journal-title":"Oncotarget"},{"key":"key20200713225434_b51-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Science"},{"key":"key20200713225434_b52-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12989-016-0162-4","article-title":"The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases","volume":"13","author":"Sayan","year":"2016","journal-title":"Part Fibre Toxicol"},{"key":"key20200713225434_b53-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0378-1097(03)00953-4","article-title":"Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species","volume":"231","author":"Shen","year":"2004","journal-title":"FEMS Microbiol Lett"},{"key":"key20200713225434_b54-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1046\/j.1440-1746.2000.02207.x","article-title":"Reactive oxygen and mechanisms of inflammatory liver injury","volume":"15","author":"Jaeschke","year":"2000","journal-title":"J Gastroenterol Hepatol"},{"key":"key20200713225434_b55-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1089\/jmf.2007.555","article-title":"Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats","volume":"11","author":"Wu","year":"2008","journal-title":"J Med Food"},{"key":"key20200713225434_b56-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.intimp.2014.01.019","article-title":"Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation","volume":"19","author":"Yu","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"key20200713225434_b57-mmr-17-06-7939","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3748\/wjg.v13.i4.557","article-title":"Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats","volume":"13","author":"Dang","year":"2007","journal-title":"World J Gastroenterol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T22:58:33Z","timestamp":1594681113000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.8849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,5]]},"references-count":57,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.8849","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,5]]}}}