{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:02:12Z","timestamp":1785542532282,"version":"3.56.0"},"reference-count":35,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.9085","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T06:53:31Z","timestamp":1527576811000},"source":"Crossref","is-referenced-by-count":14,"title":["Glucagon\u2011like peptide\u20111 protects mouse podocytes against high glucose\u2011induced apoptosis, and suppresses reactive oxygen species production and proinflammatory cytokine secretion, through sirtuin 1 activation in\ufffdvitro"],"prefix":"10.3892","author":[{"given":"Jian\u2011Xia","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"key20200713230153_b1-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"538737","DOI":"10.1155\/2014\/538737","article-title":"Sitagliptin prevents inflammation and apoptotic cell death in the kidney of type 2 diabetic animals","volume":"2014","author":"Marques","year":"2014","journal-title":"Mediators Inflamm"},{"key":"key20200713230153_b2-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"883","DOI":"10.2337\/dc14-2276","article-title":"FinnDiane Study Group: Urinary adiponectin is an independent predictor of progression to end-stage renal disease in patients with type 1 diabetes and diabetic nephropathy","volume":"38","author":"Panduru","year":"2015","journal-title":"Diabetes Care"},{"key":"key20200713230153_b3-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cyto.2008.06.015","article-title":"Nephrin and podocin loss is prevented by mycophenolate mofetil in early experimental diabetic nephropathy","volume":"44","author":"Wu","year":"2008","journal-title":"Cytokine"},{"key":"key20200713230153_b4-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"e36041","DOI":"10.1371\/journal.pone.0036041","article-title":"Dysregulated nephrin in diabetic nephropathy of type 2 diabetes: A cross sectional study","volume":"7","author":"Jim","year":"2012","journal-title":"PLoS One"},{"key":"key20200713230153_b5-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1016\/j.bbamcr.2013.02.031","article-title":"High glucose induces podocyte apoptosis by stimulating TRPC6 via elevation of reactive oxygen species","volume":"1833","author":"Liu","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"key20200713230153_b6-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"6835","DOI":"10.1074\/jbc.M112.419101","article-title":"Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells","volume":"288","author":"Shah","year":"2013","journal-title":"J Biol Chem"},{"key":"key20200713230153_b7-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"451","DOI":"10.2337\/db07-0013","article-title":"Attenuation of interstitial fibrosis and tubular apoptosis in db\/db transgenic mice overexpressing catalase in renal proximal tubular cells","volume":"57","author":"Brezniceanu","year":"2008","journal-title":"Diabetes"},{"key":"key20200713230153_b8-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"169","DOI":"10.2147\/JPR.S21751","article-title":"High TNF-alpha plasma levels and macrophages iNOS and TNF-alpha expression as risk factors for painful diabetic neuropathy","volume":"4","author":"Purwata","year":"2011","journal-title":"J Pain Res"},{"key":"key20200713230153_b9-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.intimp.2016.06.024","article-title":"Danshen injection ameliorates STZ-induced diabetic nephropathy in association with suppression of oxidative stress, pro-inflammatory factors and fibrosis","volume":"38","author":"Xu","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"key20200713230153_b10-mmr-18-02-1789","first-page":"54","article-title":"Immunohistochemical aspects of cell death in diabetic nephropathy","volume":"54","author":"B\u0103l\u0103\u015fescu","year":"2016","journal-title":"Rom J Intern Med"},{"key":"key20200713230153_b11-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cmet.2006.01.004","article-title":"The biology of incretin hormones","volume":"3","author":"Drucker","year":"2006","journal-title":"Cell Metab"},{"key":"key20200713230153_b12-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.dsx.2016.09.003","article-title":"Glucagon like peptide-1 and its receptor agonists: Their roles in management of Type 2 diabetes mellitus","volume":"11","author":"Gupta","year":"2017","journal-title":"Diabetes Metab Syndr"},{"key":"key20200713230153_b13-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"146194","DOI":"10.1155\/2012\/146194","article-title":"The synergistic effect of valsartan and LAF237 ((S)-1-((3-hydroxy-1-adamantyl)ammo)acetyl-2-cyanopyrrolidine) on vascular oxidative stress and inflammation in type 2 diabetic mice","volume":"2012","author":"Shen","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"key20200713230153_b14-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.metabol.2011.01.010","article-title":"Glucagon-like peptide-1 suppresses advanced glycation end product-induced monocyte chemoattractant protein-1 expression in mesangial cells by reducing advanced glycation end product receptor level","volume":"60","author":"Ishibashi","year":"2011","journal-title":"Metabolism"},{"key":"key20200713230153_b15-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.2337\/db12-1025","article-title":"Glucagon-like peptide-1 protects against cardiac microvascular injury in diabetes via a cAMP\/PKA\/Rho-dependent mechanism","volume":"62","author":"Wang","year":"2013","journal-title":"Diabetes"},{"key":"key20200713230153_b16-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s00125-010-2028-x","article-title":"Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes","volume":"54","author":"Kodera","year":"2011","journal-title":"Diabetologia"},{"key":"key20200713230153_b17-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1681\/ASN.2006070778","article-title":"Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db\/db mice","volume":"18","author":"Park","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"key20200713230153_b18-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1042\/CS20120190","article-title":"Sirtuins and renal diseases: Relationship with aging and diabetic nephropathy","volume":"124","author":"Kitada","year":"2013","journal-title":"Clinical sci (Lond)"},{"key":"key20200713230153_b19-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/nrendo.2011.225","article-title":"Sirtuins mediate mammalian metabolic responses to nutrient availability","volume":"8","author":"Chalkiadaki","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"key20200713230153_b20-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1172\/JCI41563","article-title":"Sirt1 activation protects the mouse renal medulla from oxidative injury","volume":"120","author":"He","year":"2010","journal-title":"J Clin Invest"},{"key":"key20200713230153_b21-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1172\/JCI41376","article-title":"Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney","volume":"120","author":"Kume","year":"2010","journal-title":"J Clin Invest"},{"key":"key20200713230153_b22-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s12272-013-0019-4","article-title":"Anti-aging molecule, Sirt1: A novel therapeutic target for diabetic nephropathy","volume":"36","author":"Kume","year":"2013","journal-title":"Arch Pharm Res"},{"key":"key20200713230153_b23-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1039\/C5MB00722D","article-title":"Silencing of USP22 suppresses high glucose-induced apoptosis, ROS production and inflammation in podocytes","volume":"12","author":"Shi","year":"2016","journal-title":"Mol Biosyst"},{"key":"key20200713230153_b24-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713230153_b25-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/jdi.12258","article-title":"Mitochondrial reactive oxygen species in the pathogenesis of early diabetic nephropathy","volume":"6","author":"Nishikawa","year":"2015","journal-title":"J Diabetes Investig"},{"key":"key20200713230153_b26-mmr-18-02-1789","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fendo.2014.00166","article-title":"The Role of SIRT1 in diabetic kidney disease","volume":"5","author":"Yacoub","year":"2014","journal-title":"Front Endocrinol (Lausanne)"},{"key":"key20200713230153_b27-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2337\/diabetes.55.01.06.db05-0894","article-title":"Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy","volume":"55","author":"Susztak","year":"2006","journal-title":"Diabetes"},{"key":"key20200713230153_b28-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/S0002-9440(10)64421-5","article-title":"Co-localization of nephrin, podocin, and the actin cytoskeleton: Evidence for a role in podocyte foot process formation","volume":"161","author":"Saleem","year":"2002","journal-title":"Am J Pathol"},{"key":"key20200713230153_b29-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1073\/pnas.1218667110","article-title":"Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc","volume":"110","author":"Bock","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713230153_b30-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1096\/fj.02-0130fje","article-title":"High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases","volume":"17","author":"Allen","year":"2003","journal-title":"FASEB J"},{"key":"key20200713230153_b31-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1055\/s-0028-1105911","article-title":"Anti-apoptotic action of exendin-4 in INS-1 beta cells: comparative protein pattern analysis of isolated mitochondria","volume":"41","author":"Tews","year":"2009","journal-title":"Horm Metab Res"},{"key":"key20200713230153_b32-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"146154","DOI":"10.1155\/2012\/146154","article-title":"Inflammation in diabetic nephropathy","volume":"2012","author":"Lim","year":"2012","journal-title":"Mediators Inflamm"},{"key":"key20200713230153_b33-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"e5826","DOI":"10.1590\/1414-431x20165826","article-title":"Glucagon-like peptide 1 improves insulin resistance in vitro through anti-inflammation of macrophages","volume":"49","author":"Guo","year":"2016","journal-title":"Braz J Med Biol Res"},{"key":"key20200713230153_b34-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"622","DOI":"10.2174\/1389450111314060002","article-title":"Sirtuins as possible drug targets in type 2 diabetes","volume":"14","author":"Kitada","year":"2013","journal-title":"Curr Drug Targets"},{"key":"key20200713230153_b35-mmr-18-02-1789","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jpba.2016.03.025","article-title":"SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis","volume":"83","author":"Wang","year":"2016","journal-title":"Biomed Pharmacother"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T23:01:33Z","timestamp":1594681293000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.9085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,29]]},"references-count":35,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.9085","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,29]]}}}