{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T15:13:40Z","timestamp":1747754020647},"reference-count":53,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.9238","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T12:16:22Z","timestamp":1530274582000},"source":"Crossref","is-referenced-by-count":4,"title":["Bioinformatic analysis of microRNA expression in Huntington's disease"],"prefix":"10.3892","author":[{"given":"Xiaoyu","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyan","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,6,29]]},"reference":[{"key":"key20200713230501_b1-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.3892\/etm.2016.3566","article-title":"Huntington's disease: Molecular basis of pathology and status of current therapeutic approaches","volume":"12","author":"Huang","year":"2016","journal-title":"Exp Ther Med"},{"key":"key20200713230501_b2-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-319-71779-1_1","article-title":"Clinical features of Huntington's disease","volume":"1049","author":"Ghosh","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"key20200713230501_b3-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington's disease: A clinical review","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur J Neurol"},{"key":"key20200713230501_b4-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.drudis.2014.03.005","article-title":"Genetics of Huntington's disease and related disorders","volume":"19","author":"Burgunder","year":"2014","journal-title":"Drug Discov Today"},{"key":"key20200713230501_b5-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/ajmg.a.20190","article-title":"Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease","volume":"119A","author":"Djouss\u00e9","year":"2003","journal-title":"Am J Med Genet A"},{"key":"key20200713230501_b6-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12920-015-0083-3","article-title":"miR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement","volume":"8","author":"Hoss","year":"2015","journal-title":"BMC Med Genomics"},{"key":"key20200713230501_b7-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"e23837","DOI":"10.1371\/journal.pone.0023837","article-title":"Regulation of miR-146a by RelA\/NFkB and p53 in STHdh(Q111)\/Hdh(Q111) cells, a cell model of Huntington's disease","volume":"6","author":"Ghose","year":"2011","journal-title":"PLos One"},{"key":"key20200713230501_b8-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.bbrc.2015.08.090","article-title":"Regulation of mitochondrial morphology and cell cycle by microRNA-214 targeting Mitofusin2","volume":"465","author":"Bucha","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713230501_b9-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.bbrc.2010.05.007","article-title":"Altered microRNAs in STHdh(Q111)\/Hdh(Q111) cells: miR-146a targets TBP","volume":"396","author":"Sinha","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713230501_b10-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.nbd.2007.11.001","article-title":"A microRNA-based gene dysregulation pathway in Huntington's disease","volume":"29","author":"Johnson","year":"2008","journal-title":"Neurobiol Dis"},{"key":"key20200713230501_b11-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"14341","DOI":"10.1523\/JNEUROSCI.2390-08.2008","article-title":"The bifunctional microRNA miR-9\/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease","volume":"28","author":"Packer","year":"2008","journal-title":"J Neurosci"},{"key":"key20200713230501_b12-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"e0190550","DOI":"10.1371\/journal.pone.0190550","article-title":"MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice","volume":"13","author":"Langfelder","year":"2018","journal-title":"PLoS One"},{"key":"key20200713230501_b13-mmr-18-03-2857","first-page":"335","article-title":"Late-onset and typical Huntington disease families from Crete have distinct genetic origins","volume":"17","author":"Kartsaki","year":"2006","journal-title":"Int J Mol Med"},{"key":"key20200713230501_b14-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.ymthe.2018.02.002","article-title":"Translation of MicroRNA-based huntingtin-lowering therapies from preclinical studies to the Clinic","volume":"26","author":"Miniarikova","year":"2018","journal-title":"Mol Ther"},{"key":"key20200713230501_b15-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3233\/JHD-160215","article-title":"Cellular analysis of silencing the Huntington's disease gene using AAV9 mediated delivery of artificial micro rna into the striatum of Q140\/Q140 mice","volume":"5","author":"Keeler","year":"2016","journal-title":"J Huntingtons Dis"},{"key":"key20200713230501_b16-mmr-18-03-2857","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2017.199","article-title":"Artificial miRNAs reduce human mutant huntingtin throughout the striatum in a transgenic sheep model of Huntington's disease","author":"Pfister","year":"2018","journal-title":"Hum Gene Ther"},{"key":"key20200713230501_b17-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"e0160295","DOI":"10.1371\/journal.pone.0160295","article-title":"Correction: RNA sequence analysis of human huntington disease brain reveals an extensive increase in inflammatory and developmental gene expression","volume":"11","author":"Labadorf","year":"2016","journal-title":"PLoS One"},{"key":"key20200713230501_b18-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"key20200713230501_b19-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"Elife"},{"key":"key20200713230501_b20-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1002\/pmic.201400515","article-title":"FunRich: An open access standalone functional enrichment and interaction network analysis tool","volume":"15","author":"Pathan","year":"2015","journal-title":"Proteomics"},{"key":"key20200713230501_b21-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"key20200713230501_b22-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1126\/science.1090599","article-title":"Nuclear export of microRNA precursors","volume":"303","author":"Lund","year":"2004","journal-title":"Science"},{"key":"key20200713230501_b23-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.pneurobio.2007.03.004","article-title":"Transcriptional signatures in Huntington's disease","volume":"83","author":"Cha","year":"2007","journal-title":"Prog Neurobiol"},{"key":"key20200713230501_b24-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"key20200713230501_b25-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.pharmthera.2011.10.002","article-title":"MicroRNAs in neurodegenerative diseases and their therapeutic potential","volume":"133","author":"Junn","year":"2012","journal-title":"Pharmacol Ther"},{"key":"key20200713230501_b26-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/j.1471-4159.2012.07925.x","article-title":"Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin","volume":"123","author":"Jin","year":"2012","journal-title":"J Neurochem"},{"key":"key20200713230501_b27-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.expneurol.2010.10.012","article-title":"Altered microRNA regulation in Huntington's disease models","volume":"227","author":"Lee","year":"2011","journal-title":"Exp Neurol"},{"key":"key20200713230501_b28-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1093\/brain\/awt355","article-title":"HTT-lowering reverses Huntington's disease immune dysfunction caused by NF\u03baB pathway dysregulation","volume":"137","author":"Tr\u00e4ger","year":"2014","journal-title":"Brain"},{"key":"key20200713230501_b29-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neuron.2017.05.026","article-title":"Physico-pathologic mechanisms involved in neurodegeneration: Misfolded protein-plasma membrane interactions","volume":"95","author":"Shrivastava","year":"2017","journal-title":"Neuron"},{"key":"key20200713230501_b30-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1186\/s12864-017-3745-z","article-title":"The dynamics of early-state transcriptional changes and aggregate formation in a Huntington's disease cell model","volume":"18","author":"van Hagen","year":"2017","journal-title":"BMC Genomics"},{"key":"key20200713230501_b31-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.pneurobio.2006.11.003","article-title":"N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease","volume":"81","author":"Fan","year":"2007","journal-title":"Prog Neurobiol"},{"key":"key20200713230501_b32-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3389\/fneur.2013.00127","article-title":"Multiple aspects of gene dysregulation Huntington's disease","volume":"4","author":"Moumne","year":"2013","journal-title":"Front Neurol"},{"key":"key20200713230501_b33-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1126\/science.1072613","article-title":"Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease","volume":"296","author":"Dunah","year":"2002","journal-title":"Science"},{"key":"key20200713230501_b34-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.mad.2005.09.010","article-title":"Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation","volume":"127","author":"Squitieri","year":"2006","journal-title":"Mech Ageing Dev"},{"key":"key20200713230501_b35-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.it.2015.04.007","article-title":"The choreography of neuroinflammation in Huntington's disease","volume":"36","author":"Crotti","year":"2015","journal-title":"Trends Immunol"},{"key":"key20200713230501_b36-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1111\/jnc.13539","article-title":"lmmunomodulation-a disease-modifying avenue for treatment of Huntington's disease?","volume":"137","author":"Bj\u00f6rkqvist","year":"2016","journal-title":"J Neurochem"},{"key":"key20200713230501_b37-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"4142","DOI":"10.1093\/hmg\/ddu137","article-title":"The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease","volume":"23","author":"Butland","year":"2014","journal-title":"Hum Mol Genet"},{"key":"key20200713230501_b38-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"e0162890","DOI":"10.1371\/journal.pone.0162890","article-title":"Insulin-like growth factor-1 but not insulin predicts cognitive decline in Huntington's disease","volume":"11","author":"Salem","year":"2016","journal-title":"PLoS One"},{"key":"key20200713230501_b39-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"e1004188","DOI":"10.1371\/journal.pgen.1004188","article-title":"MicroRNAs located in the Hox gene clusters are implicated in Huntington's disease pathogenesis","volume":"10","author":"Hoss","year":"2014","journal-title":"PLoS Genet"},{"key":"key20200713230501_b40-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1093\/jmcb\/mju003","article-title":"The p53\/miR-34 axis in development and disease","volume":"6","author":"Rokavec","year":"2014","journal-title":"J Mol Cell Biol"},{"key":"key20200713230501_b41-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"274","DOI":"10.6026\/97320630009274","article-title":"Molecule of the month: miRNA and proteins DARPP-32, DRD1, SLC6A3, and CK2","volume":"9","author":"Shapshak","year":"2013","journal-title":"Bioinformation"},{"key":"key20200713230501_b42-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1042\/BJ20080963","article-title":"Regulation of gene expression in the nervous system","volume":"414","author":"Ooi","year":"2008","journal-title":"Biochem J"},{"key":"key20200713230501_b43-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/acr.22600","article-title":"Cytosolic 5\u2032-nucleotidase 1A As a target of circulating autoantibodies in autoimmune diseases","volume":"68","author":"Lloyd","year":"2016","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"key20200713230501_b44-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.ajhg.2013.05.025","article-title":"miR-196a ameliorates phenotypes of Huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models","volume":"93","author":"Cheng","year":"2013","journal-title":"Am J Hum Genet"},{"key":"key20200713230501_b45-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"e0137637","DOI":"10.1371\/journal.pone.0137637","article-title":"The potential regulatory mechanisms of miR-196a in Huntington's disease through bioinformatic analyses","volume":"10","author":"Fu","year":"2015","journal-title":"PLoS One"},{"key":"key20200713230501_b46-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"6399","DOI":"10.3892\/mmr.2015.4243","article-title":"Lipopolysaccharide-induced tumor necrosis factor-\u03b1 factor enhances inflammation and is associated with cancer (Review)","volume":"12","author":"Zou","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20200713230501_b47-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1084\/jem.177.2.547","article-title":"Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia","volume":"177","author":"Gerard","year":"1993","journal-title":"J Exp Med"},{"key":"key20200713230501_b48-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1002\/eji.1830270639","article-title":"Prevention of endotoxin-induced lethality in neonatal mice by interleukin-13","volume":"27","author":"Nicoletti","year":"1997","journal-title":"Eur J Immunol"},{"key":"key20200713230501_b49-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1111\/jnc.13553","article-title":"Laquinimod dampens hyperactive cytokine production in Huntington's disease patient myeloid cells","volume":"137","author":"Dobson","year":"2016","journal-title":"J Neurochem"},{"key":"key20200713230501_b50-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"705","DOI":"10.14348\/molcells.2014.0227","article-title":"Neural transcription factors: From embryos to neural stem cells","volume":"37","author":"Lee","year":"2014","journal-title":"Mol Cells"},{"key":"key20200713230501_b51-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"373","DOI":"10.2174\/156720512800107618","article-title":"The role of ER stress-induced apoptosis in neurodegeneration","volume":"9","author":"Stefani","year":"2012","journal-title":"Curr Alzheimer Res"},{"key":"key20200713230501_b52-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"27691","DOI":"10.1074\/jbc.M112.355917","article-title":"LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages","volume":"287","author":"Glowacka","year":"2012","journal-title":"J Biol Chem"},{"key":"key20200713230501_b53-mmr-18-03-2857","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3389\/fneur.2016.00168","article-title":"Emerging putative associations between non-coding RNAs and protein-coding genes in neuropathic pain: Added value from reusing microarray data","volume":"7","author":"Raju","year":"2016","journal-title":"Front Neurol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T23:02:26Z","timestamp":1594681346000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.9238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,29]]},"references-count":53,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.9238","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,29]]}}}