{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:37:01Z","timestamp":1790696221575,"version":"4.1.0"},"reference-count":45,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.9248","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T12:08:15Z","timestamp":1530619695000},"source":"Crossref","is-referenced-by-count":6,"title":["ROS\u2011mediated autophagy through the AMPK signaling pathway protects INS\u20111 cells from human islet amyloid polypeptide\u2011induced cytotoxicity"],"prefix":"10.3892","author":[{"given":"Guanghao","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolic Disease, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiehong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Disease, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Disease, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Disease, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Disease, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Disease, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,7,3]]},"reference":[{"key":"key20200713230442_b1-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"8628","DOI":"10.1073\/pnas.84.23.8628","article-title":"Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients","volume":"84","author":"Cooper","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713230442_b2-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"634","DOI":"10.2337\/diab.39.5.634","article-title":"Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells","volume":"39","author":"Kahn","year":"1990","journal-title":"Diabetes"},{"key":"key20200713230442_b3-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1007\/BF00285291","article-title":"Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets","volume":"32","author":"Lukinius","year":"1989","journal-title":"Diabetologia"},{"key":"key20200713230442_b4-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1177\/030098589303000401","article-title":"Islet amyloid polypeptide: A review of its biology and potential roles in the pathogenesis of diabetes mellitus","volume":"30","author":"O'Brien","year":"1993","journal-title":"Vet Pathol"},{"key":"key20200713230442_b5-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1152\/physrev.00042.2009","article-title":"Islet amyloid polypeptide, islet amyloid, and diabetes mellitus","volume":"91","author":"Westermark","year":"2011","journal-title":"Physiol Rev"},{"key":"key20200713230442_b6-mmr-18-03-2744","first-page":"110","article-title":"Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited","volume":"4","author":"Kloppel","year":"1985","journal-title":"Surv Synth Pathol Res"},{"key":"key20200713230442_b7-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"327","DOI":"10.2337\/db12-1326","article-title":"\u03b2-Cell failure in type 2 diabetes: A case of asking too much of too few?","volume":"62","author":"Costes","year":"2013","journal-title":"Diabetes"},{"key":"key20200713230442_b8-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/368756a0","article-title":"Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus","volume":"368","author":"Lorenzo","year":"1994","journal-title":"Nature"},{"key":"key20200713230442_b9-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"861","DOI":"10.2353\/ajpath.2010.090532","article-title":"Evidence for proteotoxicity in beta cells in type 2 diabetes: Toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway","volume":"176","author":"Gurlo","year":"2010","journal-title":"Am J Pathol"},{"key":"key20200713230442_b10-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"528354","DOI":"10.1155\/2008\/528354","article-title":"Importance of aggregated islet amyloid polypeptide for the progressive beta-cell failure in type 2 diabetes and in transplanted human islets","volume":"2008","author":"Westermark","year":"2008","journal-title":"Exp Diabetes Res"},{"key":"key20200713230442_b11-mmr-18-03-2744","first-page":"145","article-title":"Role of mitochondria in reactive oxygen species generation and removal; relevance to signaling and programmed cell death","volume":"52","author":"Czarna","year":"2006","journal-title":"Postepy Biochem"},{"key":"key20200713230442_b12-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.1210\/jc.2016-3735","article-title":"Pancreas atrophy and islet amyloid deposition in patients with elderly-onset type 2 diabetes","volume":"102","author":"Xin","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"key20200713230442_b13-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1016\/j.biocel.2009.01.002","article-title":"Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways","volume":"41","author":"Li","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"key20200713230442_b14-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"4949","DOI":"10.1111\/j.1742-4658.2005.04903.x","article-title":"Thiol reducing compounds prevent human amylin-evoked cytotoxicity","volume":"272","author":"Konarkowska","year":"2005","journal-title":"FEBS J"},{"key":"key20200713230442_b15-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.tibs.2010.07.007","article-title":"Regulation of autophagy by ROS: Physiology and pathology","volume":"36","author":"Scherz-Shouval","year":"2011","journal-title":"Trends Biochem Sci"},{"key":"key20200713230442_b16-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1111\/j.1745-7254.2005.00235.x","article-title":"Molecular mechanism and regulation of autophagy","volume":"26","author":"Yang","year":"2005","journal-title":"Acta Pharmacol Sin"},{"key":"key20200713230442_b17-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.freeradbiomed.2013.07.013","article-title":"Deconvoluting the role of reactive oxygen species and autophagy in human diseases","volume":"65","author":"Wen","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"key20200713230442_b18-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"3629","DOI":"10.1210\/jc.2004-0405","article-title":"Islet amyloid: A critical entity in the pathogenesis of type 2 diabetes","volume":"89","author":"Hull","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key20200713230442_b19-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/j.2040-1124.2010.00065.x","article-title":"Autophagy protects against human islet amyloid polypeptide-associated apoptosis","volume":"2","author":"Morita","year":"2011","journal-title":"J Diabetes Investig"},{"key":"key20200713230442_b20-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.cmet.2008.08.009","article-title":"Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet","volume":"8","author":"Ebato","year":"2008","journal-title":"Cell Metab"},{"key":"key20200713230442_b21-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"42534","DOI":"10.1074\/jbc.M111.242412","article-title":"Fatty acids suppress autophagic turnover in \u03b2-cells","volume":"286","author":"Las","year":"2011","journal-title":"J Biol Chem"},{"key":"key20200713230442_b22-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"11","DOI":"10.4161\/auto.1.1.1513","article-title":"Autophagy and its possible roles in nervous system diseases, damage and repair","volume":"1","author":"Rubinsztein","year":"2005","journal-title":"Autophagy"},{"key":"key20200713230442_b23-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.4161\/auto.6886","article-title":"Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalase-regulated manner","volume":"4","author":"Oh","year":"2008","journal-title":"Autophagy"},{"key":"key20200713230442_b24-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"4952","DOI":"10.1073\/pnas.0511288103","article-title":"Autophagic programmed cell death by selective catalase degradation","volume":"103","author":"Yu","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713230442_b25-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"3634","DOI":"10.1172\/JCI69866","article-title":"Human IAPP-induced pancreatic \u03b2 cell toxicity and its regulation by autophagy","volume":"124","author":"Shigihara","year":"2014","journal-title":"J Clin Invest"},{"key":"key20200713230442_b26-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"Klionsky","year":"2012","journal-title":"Autophagy"},{"key":"key20200713230442_b27-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","article-title":"LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing","volume":"19","author":"Kabeya","year":"2000","journal-title":"EMBO J"},{"key":"key20200713230442_b28-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"key20200713230442_b29-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.cbi.2017.06.001","article-title":"Oxidative stress plays a key role in butyrate-mediated autophagy via Akt\/mTOR pathway in hepatoma cells","volume":"273","author":"Pant","year":"2017","journal-title":"Chem Biol Interact"},{"key":"key20200713230442_b30-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2017.11.025","article-title":"Crosstalk between autophagy and oxidative stress regulates proteolysis in the diaphragm during mechanical ventilation","volume":"115","author":"Smuder","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"key20200713230442_b31-mmr-18-03-2744","article-title":"Resveratrol protects Leydig cells from nicotine-induced oxidative damage through enhanced autophagy","author":"Liu","year":"2017","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"key20200713230442_b32-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellsig.2013.08.046","article-title":"Activation of AMPK protects against hydrogen peroxide-induced osteoblast apoptosis through autophagy induction and NADPH maintenance: New implications for osteonecrosis treatment?","volume":"26","author":"She","year":"2014","journal-title":"Cell Signal"},{"key":"key20200713230442_b33-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat Cell Biol"},{"key":"key20200713230442_b34-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1126\/science.1196371","article-title":"Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy","volume":"331","author":"Egan","year":"2011","journal-title":"Science"},{"key":"key20200713230442_b35-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1007\/s00125-008-1255-x","article-title":"Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis","volume":"52","author":"Zraika","year":"2009","journal-title":"Diabetologia"},{"key":"key20200713230442_b36-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0925-4439(98)00022-2","article-title":"Role of intracellular second messengers and reactive oxygen species in the pathophysiology of V. cholera O139 treated rabbit ileum","volume":"1407","author":"Gorowara","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"key20200713230442_b37-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"8596","DOI":"10.1016\/j.biomaterials.2014.06.056","article-title":"Inhibition of islet amyloid polypeptide fibril formation by selenium-containing phycocyanin and prevention of beta cell apoptosis","volume":"35","author":"Li","year":"2014","journal-title":"Biomaterials"},{"key":"key20200713230442_b38-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1463-1326.2005.00561.x","article-title":"AMP-activated protein kinase: Role in metabolism and therapeutic implications","volume":"8","author":"Schimmack","year":"2006","journal-title":"Diabetes Obes Metab"},{"key":"key20200713230442_b39-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"8204","DOI":"10.1073\/pnas.0502857102","article-title":"The coordinate regulation of the p53 and mTOR pathways in cells","volume":"102","author":"Feng","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713230442_b40-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s12020-012-9826-5","article-title":"Rosiglitazone protects against palmitate-induced pancreatic beta-cell death by activation of autophagy via 5\u2032-AMP-activated protein kinase modulation","volume":"44","author":"Wu","year":"2013","journal-title":"Endocrine"},{"key":"key20200713230442_b41-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1042\/BJ20090429","article-title":"Activation of autophagy through modulation of 5\u2032-AMP-activated protein kinase protects pancreatic beta-cells from high glucose","volume":"425","author":"Han","year":"2010","journal-title":"Biochem J"},{"key":"key20200713230442_b42-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.freeradbiomed.2006.10.047","article-title":"Reactive oxygen species in in vitro pesticide-induced neuronal cell (SH-SY5Y) cytotoxicity: Role of NFkappaB and caspase-3","volume":"42","author":"Jia","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"key20200713230442_b43-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"42351","DOI":"10.1074\/jbc.R400019200","article-title":"Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes","volume":"279","author":"Robertson","year":"2004","journal-title":"J Biol Chem"},{"key":"key20200713230442_b44-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1172\/JCI13505","article-title":"Role of AMP-activated protein kinase in mechanism of metformin action","volume":"108","author":"Zhou","year":"2001","journal-title":"J Clin Invest"},{"key":"key20200713230442_b45-mmr-18-03-2744","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1159\/000471769","article-title":"Pioglitazone attenuates injury-induced neointima formation in mouse femoral artery partially through the activation of AMP-activated protein kinase","volume":"100","author":"Osman","year":"2017","journal-title":"Pharmacology"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T23:02:20Z","timestamp":1594681340000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.9248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,3]]},"references-count":45,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.9248","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,3]]}}}