{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T09:20:02Z","timestamp":1770542402040,"version":"3.49.0"},"reference-count":54,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.9301","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T07:49:24Z","timestamp":1532332164000},"source":"Crossref","is-referenced-by-count":9,"title":["Role of autophagy in a model of obesity: A long\u2011term high fat diet induces cardiac dysfunction"],"prefix":"10.3892","author":[{"given":"Yan","family":"Che","sequence":"first","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao\u2011Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2011Ge","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2011Xia","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi\u2011Zhu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,7,23]]},"reference":[{"key":"key20200713230610_b1-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1093\/ajcn\/71.3.693","article-title":"Overweight among children and adolescents in a Native Canadian community: Prevalence and associated factors","volume":"71","author":"Hanley","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"key20200713230610_b2-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/ajhb.22257","article-title":"Overweight and obesity among North American Indian infants, children, and youth","volume":"24","author":"Schell","year":"2012","journal-title":"Am J Hum Biol"},{"key":"key20200713230610_b3-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1161\/STROKEAHA.112.665190","article-title":"Lifestyle risk factors for ischemic stroke and transient ischemic attack in young adults in the stroke in Young Fabry patients study","volume":"44","author":"von Sarnowski","year":"2013","journal-title":"Stroke"},{"key":"key20200713230610_b4-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"43475","DOI":"10.1038\/srep43475","article-title":"Diet-induced obesity impairs spermatogenesis: A potential role for autophagy","volume":"7","author":"Mu","year":"2017","journal-title":"Sci Rep"},{"key":"key20200713230610_b5-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1080\/0886022X.2016.1274662","article-title":"Advance of autophagy in chronic kidney diseases","volume":"39","author":"Deng","year":"2017","journal-title":"Ren Fail"},{"key":"key20200713230610_b6-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1002\/jcb.25814","article-title":"Type 2 diabetes inhibited human mesenchymal stem cells angiogenic response by over-activity of the autophagic pathway","volume":"118","author":"Rezabakhsh","year":"2017","journal-title":"J Cell Biochem"},{"key":"key20200713230610_b7-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1111\/j.1440-1681.2011.05638.x","article-title":"Unmasking the janus faces of autophagy in obesity-associated insulin resistance and cardiac dysfunction","volume":"39","author":"Xu","year":"2012","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"key20200713230610_b8-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s12272-013-0024-7","article-title":"Role of autophagy in the progression from obesity to diabetes and in the control of energy balance","volume":"36","author":"Quan","year":"2013","journal-title":"Arch Pharm Res"},{"key":"key20200713230610_b9-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.bbrc.2016.11.093","article-title":"Autophagy protects against cholesterol-induced apoptosis in pancreatic \u03b2-cells","volume":"482","author":"Wu","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713230610_b10-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"4417","DOI":"10.1172\/JCI85705","article-title":"Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment","volume":"126","author":"Starobinets","year":"2016","journal-title":"J Clin Invest"},{"key":"key20200713230610_b11-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3945\/an.113.003798","article-title":"PPAR-\u03b1 as a key nutritional and environmental sensor for metabolic adaptation","volume":"4","author":"Contreras","year":"2013","journal-title":"Adv Nutr"},{"key":"key20200713230610_b12-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1002\/jcb.25858","article-title":"Link between ER-stress, PPAR-alpha activation and BET inhibition in relation to apolipoprotein A-I transcription in HepG2 cells","volume":"118","author":"van der Krieken","year":"2017","journal-title":"J Cell Biochem"},{"key":"key20200713230610_b13-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.1101\/gad.1250704","article-title":"CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum","volume":"18","author":"Marciniak","year":"2004","journal-title":"Genes Dev"},{"key":"key20200713230610_b14-mmr-18-03-3251","first-page":"291","article-title":"BiP: Master regulator of the unfolded protein response and crucial factor in flavivirus biology","volume":"90","author":"Lewy","year":"2017","journal-title":"Yale J Biol Med"},{"key":"key20200713230610_b15-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.tem.2011.05.002","article-title":"Stressed out about obesity: IRE1\u03b1-XBP1 in metabolic disorders","volume":"22","author":"Sha","year":"2011","journal-title":"Trends Endocrinol Metab"},{"key":"key20200713230610_b16-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1096\/fj.201500119","article-title":"Endoplasmic reticulum stress up-regulates Nedd4-2 to induce autophagy","volume":"30","author":"Wang","year":"2016","journal-title":"FASEB J"},{"key":"key20200713230610_b17-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"24131","DOI":"10.1074\/jbc.M702824200","article-title":"p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy","volume":"282","author":"Pankiv","year":"2007","journal-title":"J Biol Chem"},{"key":"key20200713230610_b18-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/45257","article-title":"Induction of autophagy and inhibition of tumorigenesis by beclin 1","volume":"402","author":"Liang","year":"1999","journal-title":"Nature"},{"key":"key20200713230610_b19-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.expneurol.2017.02.001","article-title":"Mitochondrial ferritin protects SH-SY5Y cells against H2O2-induced oxidative stress and modulates \u03b1-synuclein expression","volume":"291","author":"Guan","year":"2017","journal-title":"Exp Neurol"},{"key":"key20200713230610_b20-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.tcb.2017.02.007","article-title":"With the help of MOM: Mitochondrial contributions to cellular quality control","volume":"27","author":"Braun","year":"2017","journal-title":"Trends Cell Biol"},{"key":"key20200713230610_b21-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1038\/onc.2016.302","article-title":"Parkin and mitophagy in cancer","volume":"36","author":"Bernardini","year":"2017","journal-title":"Oncogene"},{"key":"key20200713230610_b22-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.yexcr.2016.12.015","article-title":"Pink1\/Parkin-mediated mitophagy play a protective role in cisplatin induced renal tubular epithelial cells injury","volume":"350","author":"Zhao","year":"2017","journal-title":"Exp Cell Res"},{"key":"key20200713230610_b23-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"31462","DOI":"10.1038\/srep31462","article-title":"Mfn2 is required for mitochondrial development and synapse formation in human induced pluripotent stem Cells\/hiPSC derived cortical neurons","volume":"6","author":"Fang","year":"2016","journal-title":"Sci Rep"},{"key":"key20200713230610_b24-mmr-18-03-3251","first-page":"478","article-title":"Single vegetable meal content equivalence as an alternative to fat for satiety: A randomised trial in Japanese women","volume":"25","author":"Adachi","year":"2016","journal-title":"Asia Pac J Clin Nutr"},{"key":"key20200713230610_b25-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00592-016-0917-2","article-title":"Mediterranean meal versus Western meal effects on postprandial ox-LDL, oxidative and inflammatory gene expression in healthy subjects: A randomized controlled trial for nutrigenomic approach in cardiometabolic risk","volume":"54","author":"De Lorenzo","year":"2017","journal-title":"Acta Diabetol"},{"key":"key20200713230610_b26-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1080\/15548627.2017.1283084","article-title":"Stagnation of autophagy: A novel mechanism of renal lipotoxicity","volume":"13","author":"Takabatake","year":"2017","journal-title":"Autophagy"},{"key":"key20200713230610_b27-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.3892\/ijmm.2017.2910","article-title":"Glucagon-like peptide 1 receptor agonist ameliorates the insulin resistance function of islet \u03b2 cells via the activation of PDX-1\/JAK signaling transduction in C57\/BL6 mice with high-fat diet-induced diabetes","volume":"39","author":"Hao","year":"2017","journal-title":"Int J Mol Med"},{"key":"key20200713230610_b28-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"42574","DOI":"10.1038\/srep42574","article-title":"Plin5 alleviates myocardial ischaemia\/reperfusion injury by reducing oxidative stress through inhibiting the lipolysis of lipid droplets","volume":"7","author":"Zheng","year":"2017","journal-title":"Sci Rep"},{"key":"key20200713230610_b29-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.yexcr.2017.01.004","article-title":"Eicosapentaenoic acid ameliorates palmitate-induced lipotoxicity via the AMP kinase\/dynamin-related protein-1 signaling pathway in differentiated H9c2 myocytes","volume":"351","author":"Sakamoto","year":"2017","journal-title":"Exp Cell Res"},{"key":"key20200713230610_b30-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/FJC.0000000000000431","article-title":"Puerarin suppresses Na+-K+-ATPase-mediated systemic inflammation and CD36 expression, and alleviates cardiac lipotoxicity in vitro and in vivo","volume":"68","author":"Qin","year":"2016","journal-title":"J Cardiovasc Pharmacol"},{"key":"key20200713230610_b31-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1093\/humrep\/dew048","article-title":"Diet-induced obesity impairs endometrial stromal cell decidualization: A potential role for impaired autophagy","volume":"31","author":"Rhee","year":"2016","journal-title":"Hum Reprod"},{"key":"key20200713230610_b32-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/nature04723","article-title":"Loss of autophagy in the central nervous system causes neurodegeneration in mice","volume":"441","author":"Komatsu","year":"2006","journal-title":"Nature"},{"key":"key20200713230610_b33-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.clnu.2016.06.002","article-title":"The high-fat diet induces myocardial fibrosis in the metabolically healthy obese minipigs-The role of ER stress and oxidative stress","volume":"36","author":"Li","year":"2017","journal-title":"Clin Nutr"},{"key":"key20200713230610_b34-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/ni.3709","article-title":"The metabolic ER stress sensor IRE1\u03b1 suppresses alternative activation of macrophages and impairs energy expenditure in obesity","volume":"18","author":"Shan","year":"2017","journal-title":"Nat Immunol"},{"key":"key20200713230610_b35-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/ijo.2014.174","article-title":"Macrophage migration inhibitory factor (MIF) knockout preserves cardiac homeostasis through alleviating Akt-mediated myocardial autophagy suppression in high-fat diet-induced obesity","volume":"39","author":"Xu","year":"2015","journal-title":"Int J Obes (Lond)"},{"key":"key20200713230610_b36-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"44746","DOI":"10.1038\/srep44746","article-title":"The endoplasmic reticulum stress\/autophagy pathway is involved in cholesterol-induced pancreatic \u03b2-cell injury","volume":"7","author":"Kong","year":"2017","journal-title":"Sci Rep"},{"key":"key20200713230610_b37-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.bbrc.2017.08.034","article-title":"The endotoxemia cardiac dysfunction is attenuated by AMPK\/mTOR signaling pathway regulating autophagy","volume":"492","author":"Zhang","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713230610_b38-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ejphar.2017.02.038","article-title":"Regulation of autophagy by some natural products as a potential therapeutic strategy for cardiovascular disorders","volume":"802","author":"Hashemzaei","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"key20200713230610_b39-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1089\/ars.2010.3488","article-title":"Oxidative stress stimulates autophagic flux during ischemia\/reperfusion","volume":"14","author":"Hariharan","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"key20200713230610_b40-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"276","DOI":"10.7150\/ijbs.17617","article-title":"PKD knockdown inhibits pressure overload-induced cardiac hypertrophy by promoting autophagy via AKT\/mTOR pathway","volume":"13","author":"Zhao","year":"2017","journal-title":"Int J Biol Sci"},{"key":"key20200713230610_b41-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.yjmcc.2013.07.002","article-title":"Apelin administration ameliorates high fat diet induced cardiac hypertrophy and contractile dysfunction","volume":"63","author":"Ceylan-Isik","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"key20200713230610_b42-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"852754","DOI":"10.1155\/2013\/852754","article-title":"Chronic caloric restriction and exercise improve metabolic conditions of dietary-induced obese mice in autophagy correlated manner without involving AMPK","volume":"2013","author":"Cui","year":"2013","journal-title":"J Diabetes Res"},{"key":"key20200713230610_b43-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1007\/s00394-015-1034-7","article-title":"High-fat diet induces cardiomyocyte apoptosis via the inhibition of autophagy","volume":"55","author":"Hsu","year":"2016","journal-title":"Eur J Nutr"},{"key":"key20200713230610_b44-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.metabol.2015.04.010","article-title":"Chronic high fat diet induces cardiac hypertrophy and fibrosis in mice","volume":"64","author":"Wang","year":"2015","journal-title":"Metabolism"},{"key":"key20200713230610_b45-mmr-18-03-3251","first-page":"212","article-title":"Canadian Council on Animal Care: Guide to the care and use of experimental animals","volume":"1","year":"1993","journal-title":"Ottawa ON, CCAC"},{"key":"key20200713230610_b46-mmr-18-03-3251","first-page":"69","article-title":"Proposed institutional animal care and use committee guidelines for death as an endpoint in rodent studies","volume":"34","author":"Hamm","year":"1995","journal-title":"Contemporary Topics Lab Animal Sci"},{"key":"key20200713230610_b47-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1159\/000335675","article-title":"Mitochondria and oxidative stress in the cardiorenal metabolic syndrome","volume":"2","author":"Aroor","year":"2012","journal-title":"Cardiorenal Med"},{"key":"key20200713230610_b48-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00441-016-2485-8","article-title":"Mitochondrial quality control by the Pink1\/Parkin system","volume":"367","author":"R\u00fcb","year":"2017","journal-title":"Cell Tissue Res"},{"key":"key20200713230610_b49-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"e2455","DOI":"10.1371\/annotation\/ba489c2a-5cf2-481c-aff7-d2c8c4ecdcfa","article-title":"PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons","volume":"3","author":"Wood-Kaczmar","year":"2008","journal-title":"PLoS One"},{"key":"key20200713230610_b50-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"9572","DOI":"10.1073\/pnas.1106291108","article-title":"PTEN-inducible kinase 1 (PINK1)\/Park6 is indispensable for normal heart function","volume":"108","author":"Billia","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713230610_b51-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1073\/pnas.0911187107","article-title":"PINK1-dependent recruitment of Parkin to mitochondria in mitophagy","volume":"107","author":"Vives-Bauza","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713230610_b52-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/ncb2220","article-title":"During autophagy mitochondria elongate, are spared from degradation and sustain cell viability","volume":"13","author":"Gomes","year":"2011","journal-title":"Nat Cell Biol"},{"key":"key20200713230610_b53-mmr-18-03-3251","first-page":"R564","article-title":"Long-term measurement of arterial blood pressure in conscious mice","volume":"274","author":"Mattson","year":"1998","journal-title":"Am J Physiol"},{"key":"key20200713230610_b54-mmr-18-03-3251","doi-asserted-by":"publisher","first-page":"e60931","DOI":"10.1371\/journal.pone.0060931","article-title":"Mice long-term high-fat diet feeding recapitulates human cardiovascular alterations: An animal model to study the early phases of diabetic cardiomyopathy","volume":"8","author":"Calligaris","year":"2013","journal-title":"PLoS One"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T23:02:46Z","timestamp":1594681366000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.9301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,23]]},"references-count":54,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.9301","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,23]]}}}