{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:35:53Z","timestamp":1753886153335},"reference-count":45,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.9453","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T12:54:58Z","timestamp":1536065698000},"source":"Crossref","is-referenced-by-count":5,"title":["BACE1 gene silencing alleviates isoflurane anesthesia\u2011induced postoperative cognitive dysfunction in immature rats by activating the PI3K\/Akt signaling pathway"],"prefix":"10.3892","author":[{"given":"Ying\u2011Bin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2011Qin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong\u2011Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2011Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2011Hong","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,9,4]]},"reference":[{"key":"key20200713230922_b1-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.2174\/138955709791012229","article-title":"Anesthesia and postoperative cognitive dysfunction (POCD)","volume":"9","author":"Jungwirth","year":"2009","journal-title":"Mini Rev Med Chem"},{"key":"key20200713230922_b2-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"e79624","DOI":"10.1371\/journal.pone.0079624","article-title":"Role of peripheral inflammatory markers in postoperative cognitive dysfunction (POCD): A meta-analysis","volume":"8","author":"Peng","year":"2013","journal-title":"PLoS One"},{"key":"key20200713230922_b3-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.3892\/mmr.2015.3744","article-title":"Inhibiting tumor necrosis factor-\u03b1 signaling attenuates postoperative cognitive dysfunction in aged rats","volume":"12","author":"Ma","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20200713230922_b4-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"e37410","DOI":"10.1371\/annotation\/1cc38e55-23e8-44a5-ac2b-43c7b2a880f9","article-title":"Optimised anaesthesia to reduce post operative cognitive decline (POCD) in older patients undergoing elective surgery, a randomised controlled trial","volume":"7","author":"Ballard","year":"2012","journal-title":"PLoS One"},{"key":"key20200713230922_b5-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4137\/JEN.S33444","article-title":"Neuroprotective effects against POCD by Photobiomodulation: Evidence from assembly\/disassembly of the cytoskeleton","volume":"10","author":"Liebert","year":"2016","journal-title":"J Exp Neurosci"},{"key":"key20200713230922_b6-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.neuroscience.2016.02.015","article-title":"The effect of surgical and psychological stress on learning and memory function in aged C57BL\/6 mice","volume":"320","author":"Zhang","year":"2016","journal-title":"Neuroscience"},{"key":"key20200713230922_b7-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.3892\/mmr.2013.1322","article-title":"The role of the TLR4 signaling pathway in cognitive deficits following surgery in aged rats","volume":"7","author":"Wang","year":"2013","journal-title":"Mol Med Rep"},{"key":"key20200713230922_b8-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/jnc.13569","article-title":"The role of the Wnt\/\u03b2-catenin-Annexin A1 pathway in the process of sevoflurane-induced cognitive dysfunction","volume":"137","author":"Hu","year":"2016","journal-title":"J Neurochem"},{"key":"key20200713230922_b9-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/35086072","article-title":"Alzheimer's disease and Abeta toxicity: From top to bottom","volume":"2","author":"Small","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"key20200713230922_b10-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.neuro.2015.05.010","article-title":"Internalization of GluA2 and the underlying mechanisms of cognitive decline in aged rats following surgery and prolonged exposure to sevoflurane","volume":"49","author":"Hu","year":"2015","journal-title":"Neurotoxicology"},{"key":"key20200713230922_b11-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1007\/s00125-014-3269-x","article-title":"Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes","volume":"57","author":"Hamilton","year":"2014","journal-title":"Diabetologia"},{"key":"key20200713230922_b12-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.pharep.2016.05.006","article-title":"Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K\/Akt pathway in the brain of APP\/PS1 transgenic mouse","volume":"68","author":"He","year":"2016","journal-title":"Pharmacol Rep"},{"key":"key20200713230922_b13-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"4799","DOI":"10.1158\/1078-0432.CCR-08-0125","article-title":"Targeting the PI3K\/AKT pathway for the treatment of prostate cancer","volume":"15","author":"Sarker","year":"2009","journal-title":"Clin Cancer Res"},{"key":"key20200713230922_b14-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.scr.2013.01.002","article-title":"Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K\/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia\/reperfusion injury","volume":"10","author":"Arslan","year":"2013","journal-title":"Stem Cell Res"},{"key":"key20200713230922_b15-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1111\/ejn.12235","article-title":"Amyloid-\u03b2 protein (A\u03b2) Glu11 is the major \u03b2-secretase site of beta-site amyloid-\u03b2 precursor protein-cleaving enzyme 1 (BACE1) and shifting the cleavage site to A\u03b2 Asp1 contributes to Alzheimer pathogenesis","volume":"37","author":"Deng","year":"2013","journal-title":"Eur J Neurosci"},{"key":"key20200713230922_b16-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"7777","DOI":"10.1007\/s12035-016-0255-y","article-title":"MFG-E8 selectively inhibited A\u03b2-induced microglial M1 polarization via NF-\u03baB and PI3K-Akt pathways","volume":"54","author":"Shi","year":"2017","journal-title":"Mol Neurobiol"},{"key":"key20200713230922_b17-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"7060","DOI":"10.1073\/pnas.0909314107","article-title":"PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila","volume":"107","author":"Chiang","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713230922_b18-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nature20814","article-title":"Structural variation in amyloid-\u03b2 fibrils from Alzheimer's disease clinical subtypes","volume":"541","author":"Qiang","year":"2017","journal-title":"Nature"},{"key":"key20200713230922_b19-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.cell.2017.07.004","article-title":"Alzheimer's-causing mutations shift A\u03b2 length by destabilizing \u03b3-secretase-A\u03b2n interactions","volume":"170","author":"Szaruga","year":"2017","journal-title":"Cell"},{"key":"key20200713230922_b20-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1523\/JNEUROSCI.4396-06.2007","article-title":"Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: Implications for Alzheimer's disease pathogenesis","volume":"27","author":"Zhao","year":"2007","journal-title":"J Neurosci"},{"key":"key20200713230922_b21-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13195-014-0075-0","article-title":"\u03b2-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces A\u03b25-X peptides through alternative amyloid precursor protein cleavage","volume":"6","author":"Portelius","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"key20200713230922_b22-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.1021\/jm4002154","article-title":"Spirocyclic \u03b2-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: From hit to lowering of cerebrospinal fluid (CSF) amyloid \u03b2 in a higher species","volume":"56","author":"Hunt","year":"2013","journal-title":"J Med Chem"},{"key":"key20200713230922_b23-mmr-18-05-4259","first-page":"329","article-title":"Aquatic environment, housing and management in the eighth edition of the guide for the care and use of laboratory animals: Additional considerations and recommendations","volume":"51","author":"Mason","year":"2012","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"key20200713230922_b24-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative pcr and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713230922_b25-mmr-18-05-4259","first-page":"3403","article-title":"Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143","volume":"19","author":"Tuo","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"key20200713230922_b26-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10048-012-0348-3","article-title":"Splice variants of the Alzheimer's disease beta-secretase, BACE1","volume":"14","author":"Holsinger","year":"2013","journal-title":"Neurogenetics"},{"key":"key20200713230922_b27-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4137\/BECB.S8383","article-title":"Application of a bioinformatics-based approach to identify novel putative in vivo BACE1 substrates","volume":"5","author":"Johnson","year":"2013","journal-title":"Biomed Eng Comput Biol"},{"key":"key20200713230922_b28-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1007\/s12272-017-0891-4","article-title":"Anti-Alzheimer's disease activity of compounds from the root bark of Morus alba L","volume":"40","author":"Kuk","year":"2017","journal-title":"Arch Pharm Res"},{"key":"key20200713230922_b29-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nrd2926","article-title":"Targeting the phosphoinositide 3-kinase pathway in cancer","volume":"8","author":"Liu","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"key20200713230922_b30-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/nrc2664","article-title":"Targeting PI3K signalling in cancer: Opportunities, challenges and limitations","volume":"9","author":"Engelman","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"key20200713230922_b31-mmr-18-05-4259","first-page":"13821","article-title":"Wortmannin, PI3K\/Akt signaling pathway inhibitor, attenuates thyroid injury associated with severe acute pancreatitis in rats","volume":"8","author":"Abliz","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"key20200713230922_b32-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"e81767","DOI":"10.1371\/journal.pone.0081767","article-title":"Regulatory roles of the PI3K\/Akt signaling pathway in rats with severe acute pancreatitis","volume":"8","author":"Xu","year":"2013","journal-title":"PLoS One"},{"key":"key20200713230922_b33-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1460-9568.2009.07031.x","article-title":"Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice","volume":"31","author":"Devi","year":"2010","journal-title":"Eur J Neurosci"},{"key":"key20200713230922_b34-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"957","DOI":"10.2353\/ajpath.2009.080480","article-title":"The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells","volume":"174","author":"Nishitsuji","year":"2009","journal-title":"Am J Pathol"},{"key":"key20200713230922_b35-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"29615","DOI":"10.1074\/jbc.R800019200","article-title":"Amyloid precursor protein trafficking, processing, and function","volume":"283","author":"Thinakaran","year":"2008","journal-title":"J Biol Chem"},{"key":"key20200713230922_b36-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.ccr.2008.10.011","article-title":"Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice","volume":"14","author":"Tu","year":"2008","journal-title":"Cancer Cell"},{"key":"key20200713230922_b37-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S0140-6736(08)60453-5","article-title":"Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial","volume":"371","author":"Smolen","year":"2008","journal-title":"Lancet"},{"key":"key20200713230922_b38-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"key20200713230922_b39-mmr-18-05-4259","first-page":"116","article-title":"Ginsenoside Rg1 attenuates isoflurane-induced caspase-3 activation via inhibiting mitochondrial dysfunction","volume":"28","author":"Miao","year":"2015","journal-title":"Biomed Environ Sci"},{"key":"key20200713230922_b40-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/ana.22082","article-title":"Role of interleukin-1beta in postoperative cognitive dysfunction","volume":"68","author":"Cibelli","year":"2010","journal-title":"Ann Neurol"},{"key":"key20200713230922_b41-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.mehy.2013.11.015","article-title":"Tau hyperphosphorylation: A downstream effector of isoflurane-induced neuroinflammation in aged rodents","volume":"82","author":"Luo","year":"2014","journal-title":"Med Hypotheses"},{"key":"key20200713230922_b42-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.anclin.2015.05.008","article-title":"Postoperative cognitive dysfunction: Minding the gaps in our knowledge of a common postoperative complication in the elderly","volume":"33","author":"Berger","year":"2015","journal-title":"Anesthesiol Clin"},{"key":"key20200713230922_b43-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.brainres.2015.08.047","article-title":"Involvement of caspase-3\/PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells","volume":"1625","author":"Chen","year":"2015","journal-title":"Brain Res"},{"key":"key20200713230922_b44-mmr-18-05-4259","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.neuropharm.2011.08.011","article-title":"Isoflurane induces hippocampal cell injury and cognitive impairments in adult rats","volume":"61","author":"Lin","year":"2011","journal-title":"Neuropharmacology"},{"key":"key20200713230922_b45-mmr-18-05-4259","first-page":"903","article-title":"Isoflurane anesthesia aggravates cognitive impairment in streptozotocin-induced diabetic rats","volume":"7","author":"Yang","year":"2014","journal-title":"Int J Clin Exp Med"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T23:03:48Z","timestamp":1594681428000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.9453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,4]]},"references-count":45,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.9453","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,4]]}}}