{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:52:53Z","timestamp":1768564373905,"version":"3.49.0"},"reference-count":24,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.9459","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T11:05:34Z","timestamp":1536145534000},"source":"Crossref","is-referenced-by-count":8,"title":["Theanine, an antitumor promoter, induces apoptosis of tumor cells via the mitochondrial pathway"],"prefix":"10.3892","author":[{"given":"Yinqiang","family":"Xin","sequence":"first","affiliation":[{"name":"Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiling","family":"Ben","sequence":"additional","affiliation":[{"name":"Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimin","family":"Yin","sequence":"additional","affiliation":[{"name":"Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,9,5]]},"reference":[{"key":"key20200713231008_b1-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.4314\/tjpr.v14i10.29","article-title":"Health benefits of theanine in green tea: A review","volume":"14","author":"Liang","year":"2015","journal-title":"Trop J Pharmaceut Res"},{"key":"key20200713231008_b2-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1271\/bbb.63.615","article-title":"Time-dependent changes of amino acids in the serum, liver, brain and urine of rats administered with theanine","volume":"63","author":"Terashima","year":"1999","journal-title":"Biosci Biotechnol Biochem"},{"key":"key20200713231008_b3-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0924-2244(99)00044-8","article-title":"L-theanine-a unique amino acid of green tea and its relaxation effect in humans","volume":"10","author":"Juneja","year":"1999","journal-title":"Trends Food Sci Technol"},{"key":"key20200713231008_b4-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s10548-008-0068-z","article-title":"The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task","volume":"22","author":"Gomez-Ramirez","year":"2009","journal-title":"Brain Topogr"},{"key":"key20200713231008_b5-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.neuro.2008.03.004","article-title":"Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death","volume":"29","author":"Cho","year":"2008","journal-title":"Neurotoxicology"},{"key":"key20200713231008_b6-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/S0899-9007(97)83038-9","article-title":"Glutamine supplementation in cancer patients receiving chemotherapy: A double-blind randomized study","volume":"13","author":"Bozzetti","year":"1997","journal-title":"Nutrition"},{"key":"key20200713231008_b7-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/S0024-3205(98)00029-0","article-title":"Hypotensive effect of gamma-glutamylmethylamide in spontaneously hypertensive rats","volume":"62","author":"Yokogoshi","year":"1998","journal-title":"Life Sci"},{"key":"key20200713231008_b8-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"8528","DOI":"10.18632\/oncotarget.2336","article-title":"Inhibition of lung tumor growth by targeting EGFR\/VEGFR-Akt\/NF-\u03baB pathways with novel theanine derivatives","volume":"5","author":"Zhang","year":"2014","journal-title":"Oncotarget"},{"key":"key20200713231008_b9-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1177\/153537020623100201","article-title":"Targeting apoptosis with dietary bioactive agents","volume":"231","author":"Martin","year":"2006","journal-title":"Exp Biol Med (Maywood)"},{"key":"key20200713231008_b10-mmr-18-05-4535","first-page":"317","article-title":"Catechin, a green tea component, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo","volume":"90","author":"Nakazato","year":"2005","journal-title":"Haematologica"},{"key":"key20200713231008_b11-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1093\/carcin\/19.4.611","article-title":"Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols","volume":"19","author":"Yang","year":"1998","journal-title":"Carcinogenesis"},{"key":"key20200713231008_b12-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.canlet.2004.12.035","article-title":"Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin","volume":"230","author":"Kundu","year":"2005","journal-title":"Cancer Lett"},{"key":"key20200713231008_b13-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1023\/A:1014005423181","article-title":"Inhibitory effects of theanine and sera from theanine-fed rats on receptor-mediated cancer cell invasion beneath mesothelial-cell monolayers","volume":"36","author":"Zhang","year":"2001","journal-title":"Cytotechnology"},{"key":"key20200713231008_b14-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s10616-009-9223-y","article-title":"Effects of theanine on growth of human lung cancer and leukemia cells as well as migration and invasion of human lung cancer cells","volume":"59","author":"Liu","year":"2009","journal-title":"Cytotechnology"},{"key":"key20200713231008_b15-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.canlet.2004.03.040","article-title":"Theanine, a specific glutamate derivative in green tea, reduces the adverse reactions of doxorubicin by changing the glutathione level","volume":"212","author":"Sugiyama","year":"2004","journal-title":"Cancer Lett"},{"key":"key20200713231008_b16-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1002\/jnr.21637","article-title":"Theanine, an ingredient of green tea, inhibits [3H]glutamine transport in neurons and astroglia in rat brain","volume":"86","author":"Kakuda","year":"2008","journal-title":"J Neurosci Res"},{"key":"key20200713231008_b17-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1021\/jf062276h","article-title":"Structure-activity relationships of tea compounds against human cancer cells","volume":"55","author":"Friedman","year":"2007","journal-title":"J Agric Food Chem"},{"key":"key20200713231008_b18-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1097-2765(02)00482-3","article-title":"Mechanisms of caspase activation and inhibition during apoptosis","volume":"9","author":"Shi","year":"2002","journal-title":"Mol Cell"},{"key":"key20200713231008_b19-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1152\/physrev.00013.2006","article-title":"Mitochondrial membrane permeabilization in cell death","volume":"87","author":"Kroemer","year":"2007","journal-title":"Physiol Rev"},{"key":"key20200713231008_b20-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.canlet.2009.07.001","article-title":"Novel treatments for hepatocellular cancer","volume":"286","author":"Kerr","year":"2009","journal-title":"Cancer Lett"},{"key":"key20200713231008_b21-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00394-009-0082-2","article-title":"Glutamine as indispensable nutrient in oncology: Experimental and clinical evidence","volume":"49","author":"Kuhn","year":"2010","journal-title":"Eur J Nutr"},{"key":"key20200713231008_b22-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.fct.2005.07.010","article-title":"Efficacy of theanine is connected with theanine metabolism by any enzyme, not only drug metabolizing enzymes","volume":"44","author":"Sadzuka","year":"2006","journal-title":"Food Chem Toxicol"},{"key":"key20200713231008_b23-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00109-011-0731-9","article-title":"Glutamine: Pleiotropic roles in tumor growth and stress resistance","volume":"89","author":"Shanware","year":"2011","journal-title":"J Mol Med (Berl)"},{"key":"key20200713231008_b24-mmr-18-05-4535","doi-asserted-by":"publisher","first-page":"929","DOI":"10.2174\/156800911797264725","article-title":"L-Asparaginase and inhibitors of glutamine synthetase disclose glutamine addiction of \u03b2-catenin-mutated human hepatocellular carcinoma cells","volume":"11","author":"Tardito","year":"2011","journal-title":"Curr Cancer Drug Targets"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T23:04:01Z","timestamp":1594681441000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.9459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,5]]},"references-count":24,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.9459","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,5]]}}}