{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:40:31Z","timestamp":1775263231943,"version":"3.50.1"},"reference-count":49,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.9624","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T03:57:28Z","timestamp":1541390248000},"source":"Crossref","is-referenced-by-count":2,"title":["Long\u2011term treatment with salicylate enables NMDA receptors and impairs AMPA receptors in C57BL\/6J mice inner hair cell ribbon synapse"],"prefix":"10.3892","author":[{"given":"Wanming","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116013, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haolin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116013, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116013, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116013, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116013, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingxing","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116013, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116013, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116013, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"key20200713231404_b1-mmr-19-01-0051","article-title":"Dimenso\u0303es do espac\u0327o paranaense","author":"Fresca","year":"2002","journal-title":"Editora UEL, Londrina"},{"key":"key20200713231404_b2-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0030-6665(02)00170-6","article-title":"Pathophysiology of tinnitus","volume":"36","author":"Moller","year":"2003","journal-title":"Otolaryngol Clin North Am"},{"key":"key20200713231404_b3-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/S0079-6123(07)66040-3","article-title":"Tinnitus retraining therapy","volume":"166","author":"Jastreboff","year":"2007","journal-title":"Prog Brain Res"},{"key":"key20200713231404_b4-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1097\/01.mao.0000231604.64079.77","article-title":"Tinnitus sensitization: Sensory and psychophysiological aspects of a new pathway of acquired centralization of chronic tinnitus","volume":"27","author":"Zenner","year":"2006","journal-title":"Otol Neurotol"},{"key":"key20200713231404_b5-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0079-6123(07)66012-9","article-title":"Salicylate-induced tinnitus: molecular mechanisms and modulation by anxiety","volume":"166","author":"Puel","year":"2007","journal-title":"Prog Brain Res"},{"key":"key20200713231404_b6-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neuron.2010.12.002","article-title":"Dysregulation of limbic and auditory networks in tinnitus","volume":"69","author":"Leaver","year":"2011","journal-title":"Neuron"},{"key":"key20200713231404_b7-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1517\/14728210903206975","article-title":"Emerging pharmacotherapy of tinnitus","volume":"14","author":"Langguth","year":"2009","journal-title":"Expert Opin Emerg Drugs"},{"key":"key20200713231404_b8-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.amjmed.2010.02.015","article-title":"Prevalence and characteristics of tinnitus among US adults","volume":"123","author":"Shargorodsky","year":"2010","journal-title":"Am J Med"},{"key":"key20200713231404_b9-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0301-0082(00)00027-7","article-title":"Auditory sensori-neural alterations induced by salicylate","volume":"62","author":"Cazals","year":"2000","journal-title":"Prog Neurobiol"},{"key":"key20200713231404_b10-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1037\/0735-7044.102.6.811","article-title":"Phantom auditory sensation in rats: An animal model for tinnitus","volume":"102","author":"Jastreboff","year":"1988","journal-title":"Behav Neurosci"},{"key":"key20200713231404_b11-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1288\/00005537-198803000-00008","article-title":"An animal model for tinnitus","volume":"98","author":"Jastreboff","year":"1988","journal-title":"Laryngoscope"},{"key":"key20200713231404_b12-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/0090-6980(85)90082-6","article-title":"Prostaglandin synthesis by the cochlea of the guinea pig. Influence of aspirin, gentamicin and acoustic stimulation","volume":"29","author":"Escoubet","year":"1985","journal-title":"Prostaglandins"},{"key":"key20200713231404_b13-mmr-19-01-0051","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/16512251.1992.12561258","article-title":"Effect of round window membrane application of salicylate and indomethacin on hearing and levels of arachidonic acid metabolites in perilymph","volume":"493","author":"Jung","year":"1992","journal-title":"Acta Otolaryngol Suppl"},{"key":"key20200713231404_b14-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1288\/00005537-199306000-00004","article-title":"Salicylate-induced changes in cat auditory nerve activity","volume":"103","author":"Martin","year":"1993","journal-title":"Laryngoscope"},{"key":"key20200713231404_b15-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s12035-012-8372-8","article-title":"Noise-induced inner hair cell ribbon loss disturbs central arc mobilization: A novel molecular paradigm for understanding tinnitus","volume":"47","author":"Singer","year":"2013","journal-title":"Mol Neurobiol"},{"key":"key20200713231404_b16-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1017\/S0022215100067852","article-title":"Further observations on salicylate ototoxicity","volume":"81","author":"Bernstein","year":"1967","journal-title":"J Laryngol Otol"},{"key":"key20200713231404_b17-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0378-5955(93)90108-D","article-title":"The vascular component of sodium salicylate ototoxicity in the guinea pig","volume":"69","author":"Didier","year":"1993","journal-title":"Hear Res"},{"key":"key20200713231404_b18-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0378-5955(84)90114-X","article-title":"Aspirin-induced hearing loss as a model of sensorineural hearing loss","volume":"16","author":"McFadden","year":"1984","journal-title":"Hear Res"},{"key":"key20200713231404_b19-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0196-0709(84)80033-2","article-title":"Temporary hearing loss induced by combinations of intense sounds and nonsteroidal anti-inflammatory drugs","volume":"5","author":"McFadden","year":"1984","journal-title":"Am J Otolaryngol"},{"key":"key20200713231404_b20-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.heares.2010.02.010","article-title":"Too much of a good thing: Long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity","volume":"265","author":"Chen","year":"2010","journal-title":"Hear Res"},{"key":"key20200713231404_b21-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1007\/s00018-008-8195-y","article-title":"Prestin up-regulation in chronic salicylate (aspirin) administration: An implication of functional dependence of prestin expression","volume":"65","author":"Yu","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"key20200713231404_b22-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3109\/00206099909072997","article-title":"Changes in auditory brainstem responses in alpha-linolenic acid deficiency as a function of age in rats","volume":"38","author":"Bourre","year":"1999","journal-title":"Audiology"},{"key":"key20200713231404_b23-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1113\/jphysiol.2006.114835","article-title":"Mechanisms underlying the temporal precision of sound coding at the inner hair cell ribbon synapse","volume":"576","author":"Moser","year":"2006","journal-title":"J Physiol"},{"key":"key20200713231404_b24-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1093\/brain\/119.3.741","article-title":"Auditory neuropathy","volume":"119","author":"Starr","year":"1996","journal-title":"Brain"},{"key":"key20200713231404_b25-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1146\/annurev.neuro.26.041002.131412","article-title":"The synaptic vesicle cycle","volume":"27","author":"Sudhof","year":"2004","journal-title":"Annu Rev Neurosci"},{"key":"key20200713231404_b26-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.cell.2006.08.040","article-title":"Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse","volume":"127","author":"Roux","year":"2006","journal-title":"Cell"},{"key":"key20200713231404_b27-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1750-1326-8-25","article-title":"LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype","volume":"8","author":"Maier","year":"2013","journal-title":"Mol Neurodegener"},{"key":"key20200713231404_b28-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"7938","DOI":"10.1523\/JNEUROSCI.1434-10.2011","article-title":"Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro","volume":"31","author":"Wang","year":"2011","journal-title":"J Neurosci"},{"key":"key20200713231404_b29-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1073\/pnas.0711412105","article-title":"Endocytosis and recycling of AMPA receptors lacking GluR2\/3","volume":"105","author":"Biou","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713231404_b30-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.micron.2007.10.007","article-title":"Serial sectioning and three-dimensional reconstruction of mouse Peyer's patch","volume":"39","author":"Ma","year":"2008","journal-title":"Micron"},{"key":"key20200713231404_b31-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.cmpb.2007.10.011","article-title":"Analysis of existing methods for 3D modelling of femurs starting from two orthogonal images and development of a script for a commercial software package","volume":"89","author":"Filippi","year":"2008","journal-title":"Comput Methods Programs Biomed"},{"key":"key20200713231404_b32-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.jsb.2007.10.008","article-title":"Electron tomography of vitreous sections from cultured mammalian cells","volume":"161","author":"Gruska","year":"2008","journal-title":"J Struct Biol"},{"key":"key20200713231404_b33-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1002\/jemt.20602","article-title":"3D reconstruction of high-resolution STED microscope images","volume":"71","author":"Punge","year":"2008","journal-title":"Microsc Res Tech"},{"key":"key20200713231404_b34-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1152\/jn.1991.65.3.715","article-title":"Excitatory amino acid response in isolated spiral ganglion cells of guinea pig cochlea","volume":"65","author":"Nakagawa","year":"1991","journal-title":"J Neurophysiol"},{"key":"key20200713231404_b35-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/j.1469-7793.1999.0667p.x","article-title":"AMPA-preferring glutamate receptors in cochlear physiology of adult guinea-pig","volume":"518","author":"Ruel","year":"1999","journal-title":"J Physiol"},{"key":"key20200713231404_b36-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/nn796","article-title":"Transmitter release at the hair cell ribbon synapse","volume":"5","author":"Glowatzki","year":"2002","journal-title":"Nat Neurosci"},{"key":"key20200713231404_b37-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"7313","DOI":"10.1523\/JNEUROSCI.5335-07.2008","article-title":"Salicylate enables cochlear arachidonic-acid-sensitive NMDA receptor responses","volume":"28","author":"Ruel","year":"2008","journal-title":"J Neurosci"},{"key":"key20200713231404_b38-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/nature03418","article-title":"Hair cell synaptic ribbons are essential for synchronous auditory signalling","volume":"434","author":"Khimich","year":"2005","journal-title":"Nature"},{"key":"key20200713231404_b39-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1038\/npp.2011.12","article-title":"Group II metabotropic glutamate receptor agonist ameliorates MK801-induced dysfunction of NMDA receptors via the Akt\/GSK-3\u03b2 pathway in adult rat prefrontal cortex","volume":"36","author":"Xi","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"key20200713231404_b40-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/0306-4522(96)00301-6","article-title":"Tonic facilitation of glutamate release by presynaptic N-methyl-D-aspartate autoreceptors in the entorhinal cortex","volume":"75","author":"Berretta","year":"1996","journal-title":"Neuroscience"},{"key":"key20200713231404_b41-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1046\/j.1460-9568.1998.00008.x","article-title":"A presynaptic N-methyl-D-aspartate autoreceptor in rat hippocampus modulating amino acid release from a cytoplasmic pool","volume":"10","author":"Breukel","year":"1998","journal-title":"Eur J Neurosci"},{"key":"key20200713231404_b42-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1152\/jn.2001.86.4.1644","article-title":"NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons","volume":"86","author":"Woodhall","year":"2001","journal-title":"J Neurophysiol"},{"key":"key20200713231404_b43-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"3657","DOI":"10.1002\/jnr.21446","article-title":"N-methyl-D-aspartate autoreceptors respond to low and high agonist concentrations by facilitating, respectively, exocytosis and carrier-mediated release of glutamate in rat hippocampus","volume":"85","author":"Luccini","year":"2007","journal-title":"J Neurosci Res"},{"key":"key20200713231404_b44-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1038\/nn1974","article-title":"Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors","volume":"10","author":"Chen","year":"2007","journal-title":"Nat Neurosci"},{"key":"key20200713231404_b45-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.neulet.2011.10.060","article-title":"In vitro protection of auditory hair cells by salicylate from the gentamicin-induced but not neomycin-induced cell loss","volume":"506","author":"Mazurek","year":"2012","journal-title":"Neurosci Lett"},{"key":"key20200713231404_b46-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"e81566","DOI":"10.1371\/journal.pone.0081566","article-title":"Ribbon synapse plasticity in the cochleae of Guinea pigs after noise-induced silent damage","volume":"8","author":"Shi","year":"2013","journal-title":"PLoS One"},{"key":"key20200713231404_b47-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.neuron.2007.05.029","article-title":"Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2","volume":"54","author":"Chubykin","year":"2007","journal-title":"Neuron"},{"key":"key20200713231404_b48-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.1523\/JNEUROSCI.3671-13.2014","article-title":"Genetic evidence for the adhesion protein IgSF9\/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain","volume":"34","author":"Mishra","year":"2014","journal-title":"J Neurosci"},{"key":"key20200713231404_b49-mmr-19-01-0051","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.neuroscience.2018.02.016","article-title":"Enhancement of endocannabinoid-dependent depolarization-induced suppression of excitation in glycinergic neurons by prolonged exposure to high doses of salicylate","volume":"376","author":"Zugaib","year":"2018","journal-title":"Neuroscience"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T23:29:33Z","timestamp":1775258973000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.9624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,5]]},"references-count":49,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.9624","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,5]]}}}