{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:25:47Z","timestamp":1778538347172,"version":"3.51.4"},"reference-count":46,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.9695","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T12:02:37Z","timestamp":1543233757000},"source":"Crossref","is-referenced-by-count":13,"title":["Characterization of circRNA\u2011associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation"],"prefix":"10.3892","author":[{"given":"Yangyang","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Arrhythmias of The Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianting","family":"Ke","sequence":"additional","affiliation":[{"name":"Key Laboratory of Arrhythmias of The Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Arrhythmias of The Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiue","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Arrhythmias of The Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Arrhythmias of The Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Arrhythmias of The Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Arrhythmias of The Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changfa","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwei","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Arrhythmias of The Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"key20200713231539_b1-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/415219a","article-title":"New ideas about atrial fibrillation 50 years on","volume":"415","author":"Nattel","year":"2002","journal-title":"Nature"},{"key":"key20200713231539_b2-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/nature06007","article-title":"Variants conferring risk of atrial fibrillation on chromosome 4q25","volume":"448","author":"Gudbjartsson","year":"2007","journal-title":"Nature"},{"key":"key20200713231539_b3-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1016\/j.jacc.2017.02.020","article-title":"Is atrial fibrillation a preventable disease?","volume":"69","author":"Du","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"key20200713231539_b4-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","article-title":"Worldwide epidemiology of atrial fibrillation: A Global Burden of Disease 2010 Study","volume":"129","author":"Chugh","year":"2014","journal-title":"Circulation"},{"key":"key20200713231539_b5-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1093\/eurheartj\/ehx584","article-title":"A biomarker-based risk score to predict death in patients with atrial fibrillation: The ABC (age, biomarkers, clinical history) death risk score","volume":"39","author":"Hijazi","year":"2018","journal-title":"Eur Heart J"},{"key":"key20200713231539_b6-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/S0140-6736(14)61774-8","article-title":"50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: A cohort study","volume":"386","author":"Schnabel","year":"2015","journal-title":"Lancet"},{"key":"key20200713231539_b7-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1016\/S0140-6736(17)31072-3","article-title":"The future of atrial fibrillation management: Integrated care and stratified therapy","volume":"390","author":"Kirchhof","year":"2017","journal-title":"Lancet"},{"key":"key20200713231539_b8-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"e015099","DOI":"10.1136\/bmjopen-2016-015099","article-title":"A review of rate control in atrial fibrillation, and the rationale and protocol for the RATE-AF trial","volume":"7","author":"Kotecha","year":"2017","journal-title":"BMJ Open"},{"key":"key20200713231539_b9-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1093\/europace\/euw295","article-title":"2016 ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS","volume":"18","author":"Kirchhof","year":"2016","journal-title":"Europace"},{"key":"key20200713231539_b10-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1160\/TH13-11-0948","article-title":"Stroke prevention in atrial fibrillation: An Asian perspective","volume":"111","author":"Chiang","year":"2014","journal-title":"Thromb Haemost"},{"key":"key20200713231539_b11-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.acvd.2015.06.002","article-title":"How to define valvular atrial fibrillation?","volume":"108","author":"Fauchier","year":"2015","journal-title":"Arch Cardiovasc Dis"},{"key":"key20200713231539_b12-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"491","DOI":"10.2459\/JCM.0000000000000236","article-title":"Non-valvular atrial fibrillation: Potential clinical implications of the heterogeneous definitions used in trials on new oral anticoagulants","volume":"16","author":"Boriani","year":"2015","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"key20200713231539_b13-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/0092-8674(91)90244-S","article-title":"Scrambled exons","volume":"64","author":"Nigro","year":"1991","journal-title":"Cell"},{"key":"key20200713231539_b14-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"key20200713231539_b15-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"key":"key20200713231539_b16-mmr-19-01-0638","first-page":"527","article-title":"Emerging functions of circular RNAs","volume":"89","author":"Cort\u00e9s-L\u00f3pez","year":"2016","journal-title":"Yale J Biol Med"},{"issue":"pii","key":"key20200713231539_b17-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"E1977","DOI":"10.3390\/ijms18091977","article-title":"Deep circular RNA sequencing provides insights into the mechanism underlying grass carp reovirus infection","volume":"18","author":"He","year":"2017","journal-title":"Int J Mol Sci"},{"key":"key20200713231539_b18-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/j.ymthe.2017.06.009","article-title":"Characterization of circRNA-associated-ceRNA networks in a senescence-accelerated mouse prone 8 brain","volume":"25","author":"Zhang","year":"2017","journal-title":"Mol Ther"},{"key":"key20200713231539_b19-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1007\/s00204-016-1837-1","article-title":"A novel regulatory network among LncRpa, CircRar1, MiR-671 and apoptotic genes promotes lead-induced neuronal cell apoptosis","volume":"91","author":"Nan","year":"2017","journal-title":"Arch Toxicol"},{"key":"key20200713231539_b20-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"10026","DOI":"10.1073\/pnas.95.17.10026","article-title":"Self-identification of protein-coding regions in microbial genomes","volume":"95","author":"Audic","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713231539_b21-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713231539_b22-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s12967-016-0977-7","article-title":"Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells","volume":"14","author":"Su","year":"2016","journal-title":"J Transl Med"},{"key":"key20200713231539_b23-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.canlet.2015.06.003","article-title":"Circular RNA: A new star of noncoding RNAs","volume":"365","author":"Qu","year":"2015","journal-title":"Cancer Lett"},{"key":"key20200713231539_b24-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nbt.2890","article-title":"Detecting and characterizing circular RNAs","volume":"32","author":"Jeck","year":"2014","journal-title":"Nat Biotechnol"},{"key":"key20200713231539_b25-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/15476286.2015.1020271","article-title":"Regulation of circRNA biogenesis","volume":"12","author":"Chen","year":"2015","journal-title":"RNA Biol"},{"key":"key20200713231539_b26-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1261\/rna.035667.112","article-title":"Circular RNAs are abundant, conserved, and associated with ALU repeats","volume":"19","author":"Jeck","year":"2013","journal-title":"RNA"},{"key":"key20200713231539_b27-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.celrep.2014.12.002","article-title":"Exon circularization requires canonical splice signals","volume":"10","author":"Starke","year":"2015","journal-title":"Cell Rep"},{"key":"key20200713231539_b28-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"7451","DOI":"10.2147\/OTT.S123220","article-title":"Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer","volume":"9","author":"Guo","year":"2016","journal-title":"Onco Targets Ther"},{"key":"key20200713231539_b29-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"4503840","DOI":"10.1155\/2016\/4503840","article-title":"Profiling of the predicted circular RNAs in ductal in situ and invasive breast cancer: A pilot study","volume":"2016","author":"Galasso","year":"2016","journal-title":"Int J Genomics"},{"key":"key20200713231539_b30-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.canlet.2016.12.006","article-title":"Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer","volume":"388","author":"Chen","year":"2017","journal-title":"Cancer Lett"},{"key":"key20200713231539_b31-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"40342","DOI":"10.1038\/srep40342","article-title":"CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts","volume":"7","author":"Tang","year":"2017","journal-title":"Sci Rep"},{"key":"key20200713231539_b32-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1161\/CIRCRESAHA.114.302362","article-title":"Atrial fibrillation therapy now and in the future: Drugs, biologicals, and ablation","volume":"114","author":"Woods","year":"2014","journal-title":"Circ Res"},{"key":"key20200713231539_b33-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/S0735-1097(00)01195-5","article-title":"Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: Differential regulation of protein and mRNA levels for K+ channels","volume":"37","author":"Brundel","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"key20200713231539_b34-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"245.e17","DOI":"10.1016\/j.cjca.2011.11.001","article-title":"Development of atrial fibrillation in recipients of cardiac resynchronization therapy: The role of atrial reverse remodelling","volume":"28","author":"Santulli","year":"2012","journal-title":"Can J Cardiol"},{"key":"key20200713231539_b35-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.yjmcc.2013.09.003","article-title":"Imaging atrial arrhythmic intracellular calcium in intact heart","volume":"64","author":"Xie","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"key20200713231539_b36-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1161\/CIRCRESAHA.114.303211","article-title":"The clinical profile and pathophysiology of atrial fibrillation: Relationships among clinical features, epidemiology, and mechanisms","volume":"114","author":"Andrade","year":"2014","journal-title":"Circ Res"},{"key":"key20200713231539_b37-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/FJC.0b013e318171924d","article-title":"Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics","volume":"52","author":"Dobrev","year":"2008","journal-title":"J Cardiovasc Pharmacol"},{"key":"key20200713231539_b38-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1172\/JCI62185","article-title":"MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation","volume":"123","author":"Luo","year":"2013","journal-title":"J Clin Invest"},{"key":"key20200713231539_b39-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.yjmcc.2016.08.012","article-title":"miR-208b upregulation interferes with calcium handling in HL-1 atrial myocytes: Implications in human chronic atrial fibrillation","volume":"99","author":"Ca\u00f1\u00f3n","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"key20200713231539_b40-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0735-1097(99)00008-X","article-title":"Down-regulation of L-type calcium channel and sarcoplasmic reticular Ca(2+)-ATPase mRNA in human atrial fibrillation without significant change in the mRNA of ryanodine receptor, calsequestrin and phospholamban: An insight into the mechanism of atrial electrical remodeling","volume":"33","author":"Lai","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"key20200713231539_b41-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.hlc.2016.01.022","article-title":"MicroRNA-21 via dysregulation of WW domain-containing protein 1 regulate atrial fibrosis in atrial fibrillation","volume":"27","author":"Tao","year":"2018","journal-title":"Heart Lung Circ"},{"key":"key20200713231539_b42-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.yjmcc.2016.03.014","article-title":"miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2","volume":"94","author":"Wang","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"key20200713231539_b43-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1093\/cvr\/cvu254","article-title":"miR-21-3p regulates cardiac hypertrophic response by targeting histone deacetylase-8","volume":"105","author":"Yan","year":"2015","journal-title":"Cardiovasc Res"},{"key":"key20200713231539_b44-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/j.hrthm.2009.08.035","article-title":"Changes in microRNA-1 expression and I-K1 up-regulation in human atrial fibrillation","volume":"6","author":"Girmatsion","year":"2009","journal-title":"Heart Rhythm"},{"key":"key20200713231539_b45-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/FJC.0b013e31816c4325","article-title":"Inward rectifier potassium currents as a target for atrial fibrillation therapy","volume":"52","author":"Ehrlich","year":"2008","journal-title":"J Cardiovasc Pharmacol"},{"key":"key20200713231539_b46-mmr-19-01-0638","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1186\/s12864-015-2156-2","article-title":"A comprehensive joint analysis of the long and short RNA transcriptomes of human erythrocytes","volume":"16","author":"Doss","year":"2015","journal-title":"BMC Genomics"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T23:46:54Z","timestamp":1594684014000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.9695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,26]]},"references-count":46,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.9695","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,26]]}}}