{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:24:52Z","timestamp":1790565892468,"version":"4.1.0"},"reference-count":45,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.9697","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T12:34:45Z","timestamp":1543235685000},"source":"Crossref","is-referenced-by-count":19,"title":["IL\u201118 promotes the secretion of matrix metalloproteinases in human periodontal ligament fibroblasts by activating NF\u2011\u03baB signaling"],"prefix":"10.3892","author":[{"given":"Fang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Stomatology, Tianjin Nankai Hospital, Tianjin 300010, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia 010017, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Changchun Stomatological Hospital, Changchun, Jilin 130022, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Tianjin Nankai Hospital, Tianjin 300010, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"key20200713231550_b1-mmr-19-01-0703","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1002\/j.0022-0337.2015.79.5suppl.tb05927.x","article-title":"Ethical considerations in community oral health","volume":"79","author":"Naidoo","year":"2015","journal-title":"J Dent Educ"},{"key":"key20200713231550_b2-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"e12338","DOI":"10.1111\/jicd.12338","article-title":"Systematic review and meta-analysis of double-blind, placebo-controlled, randomized clinical trials using probiotics in chronic periodontitis","volume":"9","author":"Ikram","year":"2018","journal-title":"J Investig Clin Dent"},{"key":"key20200713231550_b3-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"287","DOI":"10.5005\/jp-journals-10024-2254","article-title":"Assessment of lipid peroxidation levels and total antioxidant status in chronic and aggressive periodontitis patients: An in vivo study","volume":"19","author":"Tripathi","year":"2018","journal-title":"J Contemp Dent Pract"},{"key":"key20200713231550_b4-mmr-19-01-0703","first-page":"99","article-title":"Effect of inflammaging on periodontitis","volume":"36","author":"Qi","year":"2018","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"key":"key20200713231550_b5-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2147\/PPA.S152984","article-title":"Application of health quotient to enhance chronic periodontitis treatments","volume":"12","author":"Zhang","year":"2018","journal-title":"Patient Prefer Adherence"},{"key":"key20200713231550_b6-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2334\/josnusd.16-0669","article-title":"Aggressive periodontitis presents a higher degree of bilateral symmetry in comparison with chronic periodontitis","volume":"60","author":"Brito","year":"2018","journal-title":"J Oral Sci"},{"key":"key20200713231550_b7-mmr-19-01-0703","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4103\/jisp.jisp_205_17","article-title":"Detection of cytomegalovirus, epstein-barr virus, and torque teno virus in subgingival and atheromatous plaques of cardiac patients with chronic periodontitis","volume":"21","author":"Priyanka","year":"2017","journal-title":"J Indian Soc Periodontol"},{"key":"key20200713231550_b8-mmr-19-01-0703","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4103\/0972-124X.183098","article-title":"Estimation of interleukin-18 in the gingival crevicular fluid and serum of Bengali population with periodontal health and disease","volume":"20","author":"Nair","year":"2016","journal-title":"J Indian Soc Periodontol"},{"key":"key20200713231550_b9-mmr-19-01-0703","first-page":"383","article-title":"Effects of interleukin-18 and hypoxia-inducible factor-1\u03b1 in serum and gingival tissues of rat model with periodontitis exposed to chronic intermittent hypoxia","volume":"33","author":"Wang","year":"2015","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"key":"key20200713231550_b10-mmr-19-01-0703","first-page":"19","article-title":"Interleukin-1 family: From genes to human disease","volume":"143","author":"Laurincov\u00e1","year":"2000","journal-title":"Acta Univ Palacki Olomuc Fac Med"},{"key":"key20200713231550_b11-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"21091","DOI":"10.1074\/jbc.M500754200","article-title":"Coactivators and corepressors of NF- kappaB in ikappaB alpha gene promoter","volume":"280","author":"Gao","year":"2005","journal-title":"J Biol Chem"},{"key":"key20200713231550_b12-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1177\/154405910508401105","article-title":"NF-kappaB activation in human dental pulp stem cells by TNF and LPS","volume":"84","author":"Chang","year":"2005","journal-title":"J Dent Res"},{"key":"key20200713231550_b13-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.lfs.2017.11.024","article-title":"Matrine inhibiting pancreatic cells epithelial-mesenchymal transition and invasion through ROS\/NF-\u03baB\/MMPs pathway","volume":"192","author":"Huang","year":"2018","journal-title":"Life Sci"},{"key":"key20200713231550_b14-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/jre.12524","article-title":"The role of extracellular matrix metalloproteinase inducer glycosylation in regulating matrix metalloproteinases in periodontitis","volume":"53","author":"Zhang","year":"2018","journal-title":"J Periodontal Res"},{"key":"key20200713231550_b15-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"4023","DOI":"10.4049\/jimmunol.1700672","article-title":"Gingival tissue inflammation promotes increased matrix metalloproteinase-12 production by CD200R(low) monocyte-derived cells in periodontitis","volume":"15","author":"Bj\u00f6rnfot Holmstr\u00f6m","year":"2017","journal-title":"J Immunol"},{"key":"key20200713231550_b16-mmr-19-01-0703","first-page":"360","article-title":"Correlation of matrix metalloproteinase-9 polymorphisms with chronic periodontitis in Uygur adults","volume":"52","author":"Ma","year":"2017","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"key20200713231550_b17-mmr-19-01-0703","first-page":"37","article-title":"Analysis of salivary protease spectrum in chronic periodontitis","volume":"35","author":"Qian","year":"2017","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"issue":"pii","key":"key20200713231550_b18-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"E440","DOI":"10.3390\/ijms18020440","article-title":"Matrix metalloproteinases as regulators of periodontal inflammation","volume":"18","author":"Franco","year":"2017","journal-title":"Int J Mol Sci"},{"key":"key20200713231550_b19-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1111\/jre.12423","article-title":"Matrix metalloproteinase-8 activity in gingival crevicular fluid: Development of a novel assay","volume":"52","author":"Mc Crudden","year":"2017","journal-title":"J Periodontal Res"},{"key":"key20200713231550_b20-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.cyto.2016.07.013","article-title":"Porphyromonas gingivalis increases the invasiveness of oral cancer cells by upregulating IL-8 and MMPs","volume":"86","author":"Ha","year":"2016","journal-title":"Cytokine"},{"key":"key20200713231550_b21-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713231550_b22-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.intimp.2018.10.004","article-title":"Methylsulfonylmethane and mobilee prevent negative effect of IL-1\u03b2 in human chondrocyte cultures via NF-\u03baB signaling pathway","volume":"65","author":"Cheleschi","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"key20200713231550_b23-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"6393","DOI":"10.1002\/jcp.26521","article-title":"Biological effects of interleukin-6 on Gingival Fibroblasts: Cytokine regulation in periodontitis","volume":"233","author":"Naruishi","year":"2018","journal-title":"J Cell Physiol"},{"issue":"pii","key":"key20200713231550_b24-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"E944","DOI":"10.3390\/ijms19040944","article-title":"Mesenchymal stem cells of dental origin for inducing tissue regeneration in periodontitis: A mini-review","volume":"19","author":"Hern\u00e1ndez-Monjaraz","year":"2018","journal-title":"Int J Mol Sci"},{"key":"key20200713231550_b25-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1620\/tjem.243.159","article-title":"The IL18 promoter polymorphism, rs1946518, is associated with the risk of periodontitis in japanese women: The kyushu okinawa maternal and child health study","volume":"243","author":"Tanaka","year":"2017","journal-title":"Tohoku J Exp Med"},{"key":"key20200713231550_b26-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.5005\/jp-journals-10024-2180","article-title":"Effect of periodontal therapy on crevicular fluid interleukin-18 level in periodontal health and disease in central maharashtra (India) population","volume":"18","author":"Mahajani","year":"2017","journal-title":"J Contemp Dent Pract"},{"key":"key20200713231550_b27-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00011-013-0669-1","article-title":"Interleukin-18 promoter polymorphisms and plasma levels are associated with increased risk of periodontitis: A meta-analysis","volume":"63","author":"Li","year":"2014","journal-title":"Inflamm Res"},{"key":"key20200713231550_b28-mmr-19-01-0703","first-page":"153","article-title":"IL-18 gene promoter polymorphisms are only moderately associated with periodontal disease in Italian population","volume":"9","author":"Martelli","year":"2012","journal-title":"Clin Cases Miner Bone Metab"},{"key":"key20200713231550_b29-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1902\/jop.2010.100046","article-title":"Periodontal disease in association with systemic levels of interleukin-18 and CXC ligand 16 in patients undergoing cardiac catheterization","volume":"81","author":"Schallhorn","year":"2010","journal-title":"J Periodontol"},{"key":"key20200713231550_b30-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/jre.12545","article-title":"Nicotine inhibits osteogenic differentiation of human periodontal ligament cells under cyclic tensile stress through canonical Wnt pathway and \u03b17 nicotinic acetylcholine receptor","volume":"53","author":"Yu","year":"2018","journal-title":"J Periodontal Res"},{"key":"key20200713231550_b31-mmr-19-01-0703","first-page":"825","article-title":"Combining enamel matrix proteins with mechanical stimuli potentiates human periodontal ligament fibroblasts proliferation and periodontium remodeling","volume":"33","author":"Zou","year":"2018","journal-title":"Histol Histopathol"},{"key":"key20200713231550_b32-mmr-19-01-0703","first-page":"102","article-title":"Vitamin D modulatory effect on cytokines expression by human gingival fibroblasts and periodontal ligament cells","volume":"67","author":"Nastri","year":"2018","journal-title":"Minerva Stomatol"},{"issue":"pii","key":"key20200713231550_b33-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"BSR20171420","DOI":"10.1042\/BSR20171420","article-title":"IL-12-mediated transcriptional regulation of matrix metalloproteinases","volume":"38","author":"Roupakia","year":"2018","journal-title":"Biosci Rep"},{"issue":"pii","key":"key20200713231550_b34-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"BSR20170973","DOI":"10.1042\/BSR20170973","article-title":"Interleukin-12-mediated expression of matrix metalloproteinases in human periodontal ligament fibroblasts involves in NF-\u03baB activation","volume":"37","author":"Miao","year":"2017","journal-title":"Biosci Rep"},{"key":"key20200713231550_b35-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"5193572","DOI":"10.1155\/2017\/5193572","article-title":"The role of proteinase-activated receptors 1 and 2 in the regulation of periodontal tissue metabolism and disease","volume":"2017","author":"Rovai","year":"2017","journal-title":"J Immunol Res"},{"key":"key20200713231550_b36-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1902\/jop.2015.150397","article-title":"Activation of receptor activator of nuclear factor-\u03baB ligand and matrix metalloproteinase production in periodontal fibroblasts by endothelin signaling","volume":"87","author":"Ruest","year":"2016","journal-title":"J Periodontol"},{"key":"key20200713231550_b37-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/jre.12267","article-title":"H2O2 activates matrix metalloproteinases through the nuclear factor kappa B pathway and Ca(2+) signals in human periodontal fibroblasts","volume":"50","author":"Osorio","year":"2015","journal-title":"J Periodontal Res"},{"key":"key20200713231550_b38-mmr-19-01-0703","first-page":"131","article-title":"Cytokine and metalloproteinases in gingival fluid from patients with chronic periodontitis","volume":"57","author":"Escalona","year":"2016","journal-title":"Invest Clin"},{"key":"key20200713231550_b39-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s10522-013-9449-0","article-title":"Senescent human periodontal ligament fibroblasts after replicative exhaustion or ionizing radiation have a decreased capacity towards osteoblastic differentiation","volume":"14","author":"Konstantonis","year":"2013","journal-title":"Biogerontology"},{"key":"key20200713231550_b40-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.archoralbio.2012.12.009","article-title":"Toll-like receptor activation and mechanical force stimulation promote the secretion of matrix metalloproteinases 1, 3 and 10 of human periodontal fibroblasts via p38, JNK and NF-\u03baB","volume":"58","author":"Lisboa","year":"2013","journal-title":"Arch Oral Biol"},{"key":"key20200713231550_b41-mmr-19-01-0703","first-page":"599","article-title":"Effect of hypoxia on the expression of matrix metalloproteinase and tissue inhibitors of matrix metalloproteinase mRNA in human periodontal ligament fibroblasts in vitro","volume":"47","author":"Song","year":"2012","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"key20200713231550_b42-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1007\/s10072-014-1981-4","article-title":"NF-\u03baB1 gene expression in Down syndrome patients","volume":"36","author":"Salemi","year":"2015","journal-title":"Neurol Sci"},{"key":"key20200713231550_b43-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"R139","DOI":"10.1186\/ar2564","article-title":"Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression","volume":"10","author":"Burrage","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"key20200713231550_b44-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"S75","DOI":"10.1097\/01.blo.0000093048.96273.aa","article-title":"NFkappaB: A pivotal transcription factor in prostate cancer metastasis to bone","author":"Andela","year":"2003","journal-title":"Clin Orthop Relat Res"},{"key":"key20200713231550_b45-mmr-19-01-0703","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s10719-006-7927-1","article-title":"Nuclear factor inducing kinase: A key regulator in osteopontin-induced MAPK\/IkappaB kinase dependent NF-kappaB-mediated promatrix metalloproteinase-9 activation","volume":"23","author":"Rangaswami","year":"2006","journal-title":"Glycoconj J"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T19:25:17Z","timestamp":1720812317000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.9697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,26]]},"references-count":45,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.9697","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,26]]}}}