{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:33:08Z","timestamp":1790317988267,"version":"4.1.0"},"reference-count":41,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2018.9777","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T12:38:49Z","timestamp":1545136729000},"source":"Crossref","is-referenced-by-count":23,"title":["Kaempferol inhibits multiple pathways involved in the secretion of inflammatory mediators from LPS\u2011induced rat intestinal microvascular endothelial cells"],"prefix":"10.3892","author":[{"given":"Yifei","family":"Bian","sequence":"first","affiliation":[{"name":"Division of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhong","sequence":"additional","affiliation":[{"name":"Division of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingsai","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Division of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjie","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"key20200713231923_b1-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3390\/nu8040211","article-title":"Flavonoids in inflammatory bowel disease: A review","volume":"8","author":"Vezza","year":"2016","journal-title":"Nutrients"},{"key":"key20200713231923_b2-mmr-19-03-1958","first-page":"118","article-title":"Cytokines in inflammatory bowel disease","volume":"53","author":"Moldoveanu","year":"2015","journal-title":"Rom J Intern Med"},{"key":"key20200713231923_b3-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"451","DOI":"10.2174\/156800911795538066","article-title":"Cytokines, inflammation and colon cancer","volume":"11","author":"Klampfer","year":"2011","journal-title":"Curr Cancer Drug Targets"},{"key":"key20200713231923_b4-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev-pathol-012615-044152","article-title":"Genetics and pathogenesis of inflammatory bowel disease","volume":"11","author":"Liu","year":"2016","journal-title":"Annu Rev Pathol"},{"key":"key20200713231923_b5-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/ncpgasthep1000","article-title":"Drug Insight: Pharmacology and toxicity of thiopurine therapy in patients with IBD","volume":"4","author":"de Boer","year":"2007","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"key20200713231923_b6-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.pharep.2013.08.013","article-title":"Protective effect of quercetin against acetic acid induced inflammatory bowel disease (IBD) like symptoms in rats: Possible morphological and biochemical alterations","volume":"66","author":"Dodda","year":"2014","journal-title":"Pharmacol Rep"},{"key":"key20200713231923_b7-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s10620-011-1883-8","article-title":"Dietary kaempferol suppresses inflammation of dextran sulfate sodium-induced colitis in mice","volume":"57","author":"Park","year":"2012","journal-title":"Dig Dis Sci"},{"key":"key20200713231923_b8-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/nu8030167","article-title":"Quercetin, Inflammation and Immunity","volume":"8","author":"Yao","year":"2016","journal-title":"Nutrients"},{"key":"key20200713231923_b9-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.cellimm.2016.08.011","article-title":"Quercetin attenuates atherosclerotic inflammation and adhesion molecule expression by modulating TLR-NF-\u03baB signaling pathway","volume":"310","author":"Bhaskar","year":"2016","journal-title":"Cell Immunol"},{"key":"key20200713231923_b10-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1023\/A:1021624520740","article-title":"Quercetin suppresses proinflammatory cytokines production through MAP kinases andNF-kappaB pathway in lipopolysaccharide-stimulated macrophage","volume":"243","author":"Cho","year":"2003","journal-title":"Mol Cell Biochem"},{"key":"key20200713231923_b11-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1271\/bbb.80714","article-title":"Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages","volume":"73","author":"Park","year":"2009","journal-title":"Biosci Biotechnol Biochem"},{"key":"key20200713231923_b12-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1053\/gast.1997.v112.pm9178682","article-title":"Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease","volume":"112","author":"Binion","year":"1997","journal-title":"Gastroenterology"},{"key":"key20200713231923_b13-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"111S","DOI":"10.1111\/1523-1747.ep12356595","article-title":"Role of microvascular endothelial cells in inflammation","volume":"100","author":"Swerlick","year":"1993","journal-title":"J Invest Dermatol"},{"key":"key20200713231923_b14-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.jep.2005.09.034","article-title":"Effect of anemonin on NO, ET-1 and ICAM-1 production in rat intestinal microvascular endothelial cells","volume":"104","author":"Duan","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"key20200713231923_b15-mmr-19-03-1958","first-page":"214","article-title":"In vitro culture of rat intestinal mucous microvascular endothelial cells","volume":"36","author":"Suo","year":"2005","journal-title":"Acta Anatomica Sinica"},{"key":"key20200713231923_b16-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"6353","DOI":"10.2147\/IJN.S92608","article-title":"The role of the intestinal microvasculature in inflammatory bowel disease: Studies with a modified Caco-2 model including endothelial cells resembling the intestinal barrier in vitro","volume":"11","author":"Kasper","year":"2016","journal-title":"Int J Nanomedicine"},{"key":"key20200713231923_b17-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/MIB.0000000000000236","article-title":"Cytokines, IBD, and colitis-associated cancer","volume":"21","author":"Francescone","year":"2015","journal-title":"Inflam Bowel Dis"},{"key":"key20200713231923_b18-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1111\/jgh.13723","article-title":"Crosstalk between intestinal epithelial cell and adaptive immune cell in intestinal mucosal immunity","volume":"32","author":"Lu","year":"2017","journal-title":"J Gastroenterol Hepatol"},{"key":"key20200713231923_b19-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"473","DOI":"10.3923\/ijp.2017.473.480","article-title":"Protective effect of kushenlu on lipopolysaccharide-induced small intestinal inflammation in rats","volume":"13","author":"Hu","year":"2017","journal-title":"Int J Pharmacol"},{"key":"key20200713231923_b20-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/S1671-2927(11)60081-3","article-title":"Lactic acid inhibits NF-\u03baB activation by lipopolysaccharide in rat intestinal mucosa microvascular endothelial cells","volume":"10","author":"Liu","year":"2011","journal-title":"Agr Sci China"},{"key":"key20200713231923_b21-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nature06005","article-title":"Unravelling the pathogenesis of inflammatory bowel disease","volume":"448","author":"Xavier","year":"2007","journal-title":"Nature"},{"key":"key20200713231923_b22-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1084\/jem.20040435","article-title":"Tumor Necrosis Factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases","volume":"200","author":"Xanthoulea","year":"2004","journal-title":"J Exp Med"},{"key":"key20200713231923_b23-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1053\/j.gastro.2008.12.029","article-title":"Is inflammatory bowel disease a vascular disease? Targeting angiogenesis improves chronic inflammation in inflammatory bowel disease","volume":"136","author":"Binion","year":"2009","journal-title":"Gastroenterology"},{"key":"key20200713231923_b24-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.mvr.2014.10.008","article-title":"Anti inflammatory and anti angiogenic effect of black raspberry extract on human esophageal and intestinal microvascular endothelial cells","volume":"97","author":"Medda","year":"2015","journal-title":"Microvasc Res"},{"key":"key20200713231923_b25-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1093\/carcin\/bgw057","article-title":"Breast cancer cells compete with hematopoietic stem and progenitor cells for intercellular adhesion molecule 1-mediated binding to the bone marrow microenvironment","volume":"37","author":"Dhawan","year":"2016","journal-title":"Carcinogenesis"},{"key":"key20200713231923_b26-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.intimp.2012.07.007","article-title":"Kaempferol regulates MAPKs and NF-\u03baB signaling pathways to attenuate LPS-induced acute lung injury in mice","volume":"14","author":"Chen","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"key20200713231923_b27-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1002\/eji.200425778","article-title":"In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway","volume":"35","author":"Comalada","year":"2005","journal-title":"Eur J Immunol"},{"key":"key20200713231923_b28-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.intimp.2014.09.005","article-title":"The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4\/NF-\u03baB pathway activation","volume":"23","author":"Cui","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"key20200713231923_b29-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.arcmed.2008.08.001","article-title":"NF-kappaB p65 antisense oligonucleotides may serve as a novel molecular approach for the treatment of patients with ulcerative colitis","volume":"39","author":"Li","year":"2008","journal-title":"Arch Med Res"},{"key":"key20200713231923_b30-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s12035-013-8425-7","article-title":"Role of the toll like receptor (TLR) radical cycle in chronic inflammation: Possible treatments targeting the TLR4 pathway","volume":"48","author":"Lucas","year":"2013","journal-title":"Mol Neurobiol"},{"key":"key20200713231923_b31-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1177\/09680519000060050901","article-title":"The role of Toll-like receptors and MyD88 in innate immune responses","volume":"6","author":"Akira","year":"2000","journal-title":"J Endotoxin Res"},{"key":"key20200713231923_b32-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1046\/j.1365-2567.1999.00747.x","article-title":"Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages","volume":"97","author":"Chen","year":"1999","journal-title":"Immunology"},{"key":"key20200713231923_b33-mmr-19-03-1958","first-page":"598","article-title":"Suppression of MAPK and NF-\u03baB pathways by schisandrin B contributes to attenuation of DSS-induced mice model of inflammatory bowel disease","volume":"70","author":"Liu","year":"2015","journal-title":"Pharmazie"},{"key":"key20200713231923_b34-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1177\/1756283X14558193","article-title":"Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases","volume":"8","author":"Amiot","year":"2015","journal-title":"Ther Adv Gastroenter"},{"key":"key20200713231923_b35-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"H254","DOI":"10.1111\/j.1750-3841.2010.01812.x","article-title":"Natural flavone kaempferol suppresses chemokines expression in human monocyte THP-1 cells through MAPK pathways","volume":"75","author":"Huang","year":"2010","journal-title":"J Food Sci"},{"key":"key20200713231923_b36-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"971","DOI":"10.3892\/ijmm.2013.1468","article-title":"Kaempferol inhibits IL-1\u03b2-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs","volume":"32","author":"Yoon","year":"2013","journal-title":"Int J Mol Med"},{"key":"key20200713231923_b37-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jff.2016.09.003","article-title":"Protective effect of kaempferol, a flavonoid widely present in varieties of edible plants, on IL-1\u03b2-induced inflammatory response via inhibiting MAPK, Akt, and NF-\u03baB signalling in SW982 cells","volume":"27","author":"Lian","year":"2016","journal-title":"J Funct Foods"},{"key":"key20200713231923_b38-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/mc.21841","article-title":"JAK\/STAT\/SOCS-signaling pathway and colon and rectal cancer","volume":"52","author":"Slattery","year":"2013","journal-title":"Mol Carcinog"},{"key":"key20200713231923_b39-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1039\/C6FO01529H","article-title":"Luteolin suppresses the JAK\/STAT pathway in a cellular model of intestinal inflammation","volume":"8","author":"Nunes","year":"2017","journal-title":"Food Funct"},{"key":"key20200713231923_b40-mmr-19-03-1958","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3389\/fphar.2016.00455","article-title":"Curcumin suppressed activation of dendritic cells via JAK\/STAT\/SOCS signal in mice with experimental colitis","volume":"7","author":"Zhao","year":"2016","journal-title":"Front Pharmacol"},{"key":"key20200713231923_b41-mmr-19-03-1958","doi-asserted-by":"crossref","first-page":"lb1","DOI":"10.1096\/fasebj.25.1_supplement.995.10","article-title":"Kaempferol inhibits chemokine expression and attenuates airway inflammation by suppressing STAT\/JAK and NF-kB activity in human airway epithelial cells","volume":"25","author":"Gong","year":"2011","journal-title":"FASEB J"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T18:11:17Z","timestamp":1662660677000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2018.9777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,18]]},"references-count":41,"URL":"https:\/\/doi.org\/10.3892\/mmr.2018.9777","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,18]]}}}