{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:34:35Z","timestamp":1790710475833,"version":"4.1.0"},"reference-count":39,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2019.10017","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T13:08:26Z","timestamp":1552396106000},"source":"Crossref","is-referenced-by-count":7,"title":["c\u2011Jun\/Ap\u20111 is upregulated in an Ang II\u2011induced abdominal aortic aneurysm formation model and mediates Chop expression in mouse aortic smooth muscle cells"],"prefix":"10.3892","author":[{"given":"Dating","family":"Sun","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430030, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Mei","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Qin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangtao","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"key20200713232329_b1-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jvs.2006.09.004","article-title":"Challenges and opportunities in abdominal aortic aneurysm research","volume":"45","author":"Wassef","year":"2007","journal-title":"J Vasc Surg"},{"key":"key20200713232329_b2-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1007\/s11883-012-0271-y","article-title":"Novel mechanisms of abdominal aortic aneurysms","volume":"14","author":"Lu","year":"2012","journal-title":"Curr Atheroscler Rep"},{"key":"key20200713232329_b3-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ejvs.2013.10.007","article-title":"Editor's choice: Five-year outcomes in men screened for abdominal aortic aneurysm at 65 years of age: A population-based cohort study","volume":"47","author":"Svensj\u00f6","year":"2014","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"key20200713232329_b4-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"e0174821","DOI":"10.1371\/journal.pone.0174821","article-title":"Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One"},{"key":"key20200713232329_b5-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1038\/nm1335","article-title":"Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase","volume":"11","author":"Yoshimura","year":"2005","journal-title":"Nat Med"},{"key":"key20200713232329_b6-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1161\/ATVBAHA.114.304428","article-title":"Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in patients with abdominal aortic aneurysms: Nation-wide cohort study","volume":"35","author":"Kristensen","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key20200713232329_b7-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1056\/NEJMcp1401430","article-title":"Clinical practice. Abdominal aortic aneurysms","volume":"371","author":"Kent","year":"2014","journal-title":"N Engl J Med"},{"key":"key20200713232329_b8-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"E131","DOI":"10.1038\/ncb0502-e131","article-title":"AP-1 as a regulator of cell life and death","volume":"4","author":"Shaulian","year":"2002","journal-title":"Nat Cell Biol"},{"key":"key20200713232329_b9-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1093\/emboj\/18.1.188","article-title":"c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms","volume":"18","author":"Wisdom","year":"1999","journal-title":"EMBO J"},{"key":"key20200713232329_b10-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.cellsig.2009.12.008","article-title":"AP-1-The Jun proteins: Oncogenes or tumor suppressors in disguise?","volume":"22","author":"Shaulian","year":"2010","journal-title":"Cell Signal"},{"key":"key20200713232329_b11-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"5965","DOI":"10.1242\/jcs.01589","article-title":"AP-1 subunits: Quarrel and harmony among siblings","volume":"117","author":"Hess","year":"2004","journal-title":"J Cell Sci"},{"key":"key20200713232329_b12-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1038\/sj.onc.1204385","article-title":"Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity","volume":"20","author":"Chinenov","year":"2001","journal-title":"Oncogene"},{"key":"key20200713232329_b13-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1016\/j.bbamcr.2010.12.012","article-title":"The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation","volume":"1813","author":"Plotnikov","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"key20200713232329_b14-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/j.freeradbiomed.2005.08.006","article-title":"Activation of AP-1 through reactive oxygen species by angiotensin II in rat cardiomyocytes","volume":"39","author":"Wu","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"key20200713232329_b15-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"3120","DOI":"10.1210\/endo.141.9.7630","article-title":"Involvement of reactive oxygen species in the activation of tyrosine kinase and extracellular signal-regulated kinase by angiotensin II","volume":"141","author":"Frank","year":"2000","journal-title":"Endocrinology"},{"key":"key20200713232329_b16-mmr-19-05-3459","first-page":"3250","article-title":"GADD153\/CHOP, a DNA damage-inducible protein, reduced CAAT\/enhancer binding protein activities and increased apoptosis in 32D c13 myeloid cells","volume":"56","author":"Friedman","year":"1996","journal-title":"Cancer Res"},{"key":"key20200713232329_b17-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nm0410-396","article-title":"Endoplasmic reticulum stress and atherosclerosis","volume":"16","author":"Hotamisligil","year":"2010","journal-title":"Nat Med"},{"key":"key20200713232329_b18-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/nrd2755","article-title":"Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities","volume":"7","author":"Kim","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"key20200713232329_b19-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","article-title":"Roles of CHOP\/GADD153 in endoplasmic reticulum stress","volume":"11","author":"Oyadomari","year":"2004","journal-title":"Cell Death Differ"},{"key":"key20200713232329_b20-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"7589","DOI":"10.1128\/MCB.19.11.7589","article-title":"CHOP enhancement of gene transcription by interactions with Jun\/Fos AP-1 complex proteins","volume":"19","author":"Ubeda","year":"1999","journal-title":"Mol Cell Biol"},{"key":"key20200713232329_b21-mmr-19-05-3459","first-page":"85","volume-title":"NIH Publication No","author":"Guide for the Care and Use of Laboratory Animals","year":"1996"},{"key":"key20200713232329_b22-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1172\/JCI7818","article-title":"Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice","volume":"105","author":"Daugherty","year":"2000","journal-title":"J Clin Invest"},{"key":"key20200713232329_b23-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713232329_b24-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1161\/01.HYP.37.2.308","article-title":"Signaling events mediating the additive effects of oleic acid and angiotensin II on vascular smooth muscle cell migration","volume":"37","author":"Greene","year":"2001","journal-title":"Hypertension"},{"key":"key20200713232329_b25-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.2174\/0929867322666150311150829","article-title":"The atherosclerotic plaque vulnerability: Focus on the oxidative and endoplasmic reticulum stress in orchestrating the macrophage apoptosis in the formation of the necrotic core","volume":"22","author":"Cominacini","year":"2015","journal-title":"Curr Med Chem"},{"key":"key20200713232329_b26-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1159\/000368481","article-title":"Induction of apoptosis by hypertension via endoplasmic reticulum stress","volume":"40","author":"Sun","year":"2015","journal-title":"Kidney Blood Press Res"},{"key":"key20200713232329_b27-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ejvs.2016.10.026","article-title":"Tauroursodeoxycholic acid attenuates angiotensin ii induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice by inhibiting endoplasmic reticulum stress","volume":"53","author":"Qin","year":"2017","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"key20200713232329_b28-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1101\/gad.12.7.982","article-title":"CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum","volume":"12","author":"Zinszner","year":"1998","journal-title":"Genes Dev"},{"key":"key20200713232329_b29-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"Harding","year":"2000","journal-title":"Mol Cell"},{"key":"key20200713232329_b30-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"11269","DOI":"10.1073\/pnas.0400541101","article-title":"Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells","volume":"101","author":"Vattem","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713232329_b31-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1161\/CIRCRESAHA.110.232306","article-title":"Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure","volume":"108","author":"Dai","year":"2011","journal-title":"Circ Res"},{"key":"key20200713232329_b32-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1530\/JOE-13-0261","article-title":"Angiotensin II and the JNK pathway mediate urotensin II expression in response to hypoxia in rat cardiomyocytes","volume":"220","author":"Chiu","year":"2014","journal-title":"J Endocrinol"},{"key":"key20200713232329_b33-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1172\/JCI8931","article-title":"Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms","volume":"105","author":"Pyo","year":"2000","journal-title":"J Clin Invest"},{"key":"key20200713232329_b34-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"e68476","DOI":"10.1371\/journal.pone.0068476","article-title":"Development of a novel rabbit model of abdominal aortic aneurysm via a combination of periaortic calcium chloride and elastase incubation","volume":"8","author":"Bi","year":"2013","journal-title":"PLoS One"},{"key":"key20200713232329_b35-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"e44369","DOI":"10.1371\/journal.pone.0044369","article-title":"Cyclooxygenase-2 inhibition attenuates abdominal aortic aneurysm progression in hyperlipidemic mice","volume":"7","author":"Ghoshal","year":"2012","journal-title":"PLoS One"},{"key":"key20200713232329_b36-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1093\/cvr\/cvu257","article-title":"Dissecting abdominal aortic aneurysm in Ang II-infused mice: Suprarenal branch ruptures and apparent luminal dilatation","volume":"105","author":"Trachet","year":"2015","journal-title":"Cardiovasc Res"},{"key":"key20200713232329_b37-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1159\/000087451","article-title":"Angiotensin II stimulates matrix metalloproteinase secretion in human vascular smooth muscle cells via nuclear factor-kappaB and activator protein 1 in a redox-sensitive manner","volume":"42","author":"Browatzki","year":"2005","journal-title":"J Vasc Res"},{"key":"key20200713232329_b38-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jss.2008.04.032","article-title":"Upregulation of protein kinase cdelta in vascular smooth muscle cells promotes inflammation in abdominal aortic aneurysm","volume":"153","author":"Schubl","year":"2009","journal-title":"J Surg Res"},{"key":"key20200713232329_b39-mmr-19-05-3459","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1194\/jlr.M036533","article-title":"CYP2J2 overexpression increases EETs and protects against angiotensin II-induced abdominal aortic aneurysm in mice","volume":"54","author":"Cai","year":"2013","journal-title":"J Lipid Res"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:16:50Z","timestamp":1594685810000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2019.10017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,12]]},"references-count":39,"URL":"https:\/\/doi.org\/10.3892\/mmr.2019.10017","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,12]]}}}