{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:42:48Z","timestamp":1790476968408,"version":"4.1.0"},"reference-count":27,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2019.10227","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T12:13:20Z","timestamp":1557404000000},"source":"Crossref","is-referenced-by-count":5,"title":["Formaldehyde induces the apoptosis of BMCs of BALB\/c mice via the PTEN\/PI3K\/Akt signal transduction pathway"],"prefix":"10.3892","author":[{"given":"Guangyan","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangfu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lida","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, School of Public Health, Jilin University, Changchun, Jilin 130021, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"key20200713232947_b1-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s00204-016-1760-5","article-title":"Formaldehyde induces toxicity in mouse bone marrow and hematopoietic stem\/progenitor cells and enhances benzene-induced adverse effects","volume":"91","author":"Wei","year":"2017","journal-title":"Arch Toxicol"},{"key":"key20200713232947_b2-mmr-20-01-0341","first-page":"401","article-title":"A review of human carcinogens: Chemical agents and related occupations: Formaldehyde","author":"IARC (International agency for Research on Cancer)","year":"2012","journal-title":"Monographs on the Evaluation of Carcinogenic Risks to Humans 100F"},{"key":"key20200713232947_b3-mmr-20-01-0341","first-page":"195","article-title":"Report on carcinogens, 12th edition","author":"NTP (National Toxicology Program)","year":"2011","journal-title":"National Toxicology Program"},{"key":"key20200713232947_b4-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.cbi.2009.11.012","article-title":"How the niche regulates hematopoietic stem cells","volume":"184","author":"Renstr\u00f6m","year":"2010","journal-title":"Chem Biol Interact"},{"key":"key20200713232947_b5-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/onc.2014.4","article-title":"SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model","volume":"34","author":"Kim","year":"2015","journal-title":"Oncogene"},{"key":"key20200713232947_b6-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1101\/gad.274134.115","article-title":"Atg7 cooperates with Pten loss to drive prostate cancer tumor growth","volume":"30","author":"Santanam","year":"2016","journal-title":"Genes Dev"},{"key":"key20200713232947_b7-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.3324\/haematol.2016.146381","article-title":"The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia","volume":"101","author":"Mendes","year":"2016","journal-title":"Haematologica"},{"key":"key20200713232947_b8-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1084\/jem.20122768","article-title":"Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization","volume":"210","author":"Tesio","year":"2013","journal-title":"J Exp Med"},{"key":"key20200713232947_b9-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1182\/blood-2013-05-501544","article-title":"Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish","volume":"123","author":"Choorapoikayil","year":"2014","journal-title":"Blood"},{"key":"key20200713232947_b10-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40591-015-0040-8","article-title":"Outlook on PI3K\/AKT\/mTOR inhibition in acute leukemia","volume":"3","author":"Fransecky","year":"2015","journal-title":"Mol Cell Ther"},{"key":"key20200713232947_b11-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"21138","DOI":"10.3390\/ijms160921138","article-title":"PI3K and AKT: Unfaithful partners in cancer","volume":"16","author":"Faes","year":"2015","journal-title":"Int J Mol Sci"},{"key":"key20200713232947_b12-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jbior.2014.10.004","article-title":"PLC and PI3K\/Akt\/mTOR signalling in disease and cancer","volume":"57","author":"Follo","year":"2015","journal-title":"Adv Bio Regul"},{"key":"key20200713232947_b13-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jphotobiol.2009.10.004","article-title":"Down-regulation of Bcl-2 and Akt induced by combination of photoactivated hypericin and genistein in human breast cancer cells","volume":"98","author":"Ferenc","year":"2010","journal-title":"J Photochem Photobiol B"},{"key":"key20200713232947_b14-mmr-20-01-0341","article-title":"Guide for the care and use of laboratory animals (8th edition)","author":"NIH (National Institutes of Health USA)","year":"2011"},{"key":"key20200713232947_b15-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713232947_b16-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1002\/ptr.5167","article-title":"Curcumin modulates miR-19\/PTEN\/AKT\/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation","volume":"28","author":"Li","year":"2014","journal-title":"Phytother Res"},{"key":"key20200713232947_b17-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1093\/annonc\/mdv175","article-title":"Benefit to neoadjuvant anti-human epidermal growth factor receptor 2 (HER2)-targeted therapies in HER2-positive primary breast cancer is independent of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) status","volume":"26","author":"Nuciforo","year":"2015","journal-title":"Ann Oncol"},{"key":"key20200713232947_b18-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1038\/modpathol.2014.70","article-title":"Heterogeneity and chronology of PTEN deletion and ERG fusion in prostate cancer","volume":"27","author":"Krohn","year":"2014","journal-title":"Mod Pathol"},{"key":"key20200713232947_b19-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.bbrc.2013.03.018","article-title":"Downregulated microRNA-32 expression induced by high glucose inhibits cell cycle progression via PTEN upregulation and Akt inactivation in bone marrow-derived mesenchymal stem cells","volume":"433","author":"Zhu","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713232947_b20-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1002\/em.21821","article-title":"Inhaled formaldehyde induces DNA-protein crosslinks and oxidative stress in bone marrow and other distant organs of exposed mice","volume":"54","author":"Ye","year":"2013","journal-title":"Environ Mol Mutagen"},{"key":"key20200713232947_b21-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/sj.leu.2402824","article-title":"Involvement of PI3K\/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy","volume":"17","author":"Chang","year":"2003","journal-title":"Leukemia"},{"key":"key20200713232947_b22-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1091\/mbc.02-02-0030.","article-title":"Identification of genes periodically expressed in the human cell cycle and their expression in tumors","volume":"13","author":"Whitfield","year":"2002","journal-title":"Mol Biol Cell"},{"key":"key20200713232947_b23-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1002\/path.3022","article-title":"The cell cycle and cancer","volume":"226","author":"Williams","year":"2012","journal-title":"J Pathol"},{"key":"key20200713232947_b24-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3892\/or.2015.4384","article-title":"Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN-regulated PI3K\/Akt signaling pathway","volume":"35","author":"Jing","year":"2016","journal-title":"Oncol Rep"},{"key":"key20200713232947_b25-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/hmg\/10.3.237","article-title":"PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase\/Akt-dependent and -independent pathways","volume":"10","author":"Weng","year":"2001","journal-title":"Hum Mol Genet"},{"key":"key20200713232947_b26-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1158\/0008-5472.CAN-12-1365","article-title":"Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism","volume":"73","author":"Rahmani","year":"2013","journal-title":"Cancer Res"},{"key":"key20200713232947_b27-mmr-20-01-0341","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1152\/physiolgenomics.00173.2013","article-title":"Rational combination of dual PI3K\/mTOR blockade and Bcl-2\/-xL inhibition in AML","volume":"46","author":"Vachhani","year":"2014","journal-title":"Physiol Genomics"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:23:13Z","timestamp":1594686193000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2019.10227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,9]]},"references-count":27,"URL":"https:\/\/doi.org\/10.3892\/mmr.2019.10227","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,9]]}}}