{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:27:49Z","timestamp":1785796069930,"version":"3.56.0"},"reference-count":45,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2019.10287","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T09:15:01Z","timestamp":1558602901000},"source":"Crossref","is-referenced-by-count":6,"title":["Expression of transforming growth factor \u03b2 and matrix metalloproteinases in the aqueous humor of patients with congenital ectopia lentis"],"prefix":"10.3892","author":[{"given":"Qianzhong","family":"Cao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiang","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of California, San Francisco, CA 94115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxiong","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhe","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danying","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat\u2011Sen University, Guangzhou, Guangdong 510060, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"key20200713233019_b1-mmr-20-01-0559","first-page":"NBK1335","article-title":"Marfan syndrome. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K and Amemiya A (eds). GeneReviews","author":"Dietz","year":"2017","journal-title":"University of Washington, Seattle, Bookshelf ID"},{"key":"key20200713233019_b2-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"key20200713233019_b3-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"565","DOI":"10.2174\/156652410792231286","article-title":"Role of transforming growth factor Beta in corneal function, biology and pathology","volume":"10","author":"Tandon","year":"2010","journal-title":"Curr Mol Med"},{"key":"key20200713233019_b4-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.exer.2015.12.010","article-title":"Rho GTPase signaling promotes constitutive expression and release of TGF-\u03b22 by human trabecular meshwork cells","volume":"146","author":"Pervan","year":"2016","journal-title":"Exp Eye Res"},{"key":"key20200713233019_b5-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0021-5155(01)00523-8","article-title":"Higher concentration of transforming growth factor-beta in aqueous humor of glaucomatous eyes and diabetic eyes","volume":"46","author":"Ochiai","year":"2002","journal-title":"Jpn J Ophthalmol"},{"key":"key20200713233019_b6-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1126\/science.1124287","article-title":"Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome","volume":"312","author":"Habashi","year":"2006","journal-title":"Science"},{"key":"key20200713233019_b7-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/ng1116","article-title":"Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome","volume":"33","author":"Neptune","year":"2003","journal-title":"Nat Genet"},{"key":"key20200713233019_b8-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.1074\/jbc.M209256200","article-title":"Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein","volume":"278","author":"Isogai","year":"2003","journal-title":"J Biol Chem"},{"key":"key20200713233019_b9-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1126\/science.1176009","article-title":"The extracellular matrix: Not just pretty fibrils","volume":"326","author":"Hynes","year":"2009","journal-title":"Science"},{"key":"key20200713233019_b10-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1093\/cvr\/cvq291","article-title":"Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms","volume":"89","author":"Gomez","year":"2011","journal-title":"Cardiovasc Res"},{"key":"key20200713233019_b11-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00441-011-1201-y","article-title":"Non-Smad signaling pathways","volume":"347","author":"Mu","year":"2012","journal-title":"Cell Tissue Res"},{"key":"key20200713233019_b12-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.tcb.2009.05.008","article-title":"New regulatory mechanisms of TGF-beta receptor function","volume":"19","author":"Kang","year":"2009","journal-title":"Trends Cell Biol"},{"key":"key20200713233019_b13-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad- independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"key20200713233019_b14-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"3957","DOI":"10.1038\/sj.emboj.7601818","article-title":"TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA","volume":"26","author":"Lee","year":"2007","journal-title":"EMBO J"},{"key":"key20200713233019_b15-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.molcel.2008.09.002","article-title":"TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta","volume":"31","author":"Yamashita","year":"2008","journal-title":"Mol Cell"},{"key":"key20200713233019_b16-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1126\/science.1192149","article-title":"Noncanonical TGF\u03b2 signaling contributes to aortic aneurysm progression in Marfan syndrome mice","volume":"332","author":"Holm","year":"2011","journal-title":"Science"},{"key":"key20200713233019_b17-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1471-2407-12-26","article-title":"TGF-\u03b21 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1\/2 in highly invasive breast cancer cells","volume":"12","author":"Gomes","year":"2012","journal-title":"BMC cancer"},{"key":"key20200713233019_b18-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1161\/CIRCRESAHA.107.157776","article-title":"Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and \u22129 in the thoracic aortic aneurysm in Marfan syndrome","volume":"101","author":"Chung","year":"2007","journal-title":"Circ Res"},{"key":"key20200713233019_b19-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1172\/JCI38136","article-title":"TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice","volume":"120","author":"Wang","year":"2010","journal-title":"J Clin Invest"},{"key":"key20200713233019_b20-mmr-20-01-0559","first-page":"146","article-title":"A narrative review of pathophysiological mechanisms associated with cervical artery dissection","volume":"51","author":"Haneline","year":"2007","journal-title":"J Can Chiropr Assoc"},{"key":"key20200713233019_b21-mmr-20-01-0559","first-page":"I371","article-title":"Overexpression of transforming growth factor-beta is associated with increased hyaluronan content and impairment of repair in Marfan syndrome aortic aneurysm","author":"Nataatmadja","year":"2006","journal-title":"Circulation 114 (1 Suppl)"},{"key":"key20200713233019_b22-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1083\/jcb.200608167","article-title":"Fibrillin-1 regulates the bioavailability of TGFbeta1","volume":"176","author":"Chaudhry","year":"2007","journal-title":"J Cell Biol"},{"key":"key20200713233019_b23-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/nrm2262","article-title":"Extracellular control of TGFbeta signalling in vascular development and disease","volume":"8","author":"ten-Dijke","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20200713233019_b24-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"II329","DOI":"10.1161\/01.cir.0000087660.82721.15","article-title":"Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm","volume":"108","author":"Nataatmadja","year":"2003","journal-title":"Circulation"},{"key":"key20200713233019_b25-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.3109\/02713689609017656","article-title":"Increased matrix metalloproteinases in the aqueous humor of patients and experimental animals with uveitis","volume":"15","author":"Di-Girolamo","year":"1996","journal-title":"Curr Eye Res"},{"key":"key20200713233019_b26-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"4075","DOI":"10.1167\/iovs.03-1336","article-title":"Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in the human lens: Implications for cortical cataract formation","volume":"45","author":"Sachdev","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233019_b27-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1006\/exer.2000.0916","article-title":"Induction of matrix metalloproteinases 2 and 9 following stress to the lens","volume":"71","author":"Tamiya","year":"2000","journal-title":"Exp Eye Res"},{"key":"key20200713233019_b28-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1042\/0264-6021:3580041","article-title":"Overexpression of matrix metalloproteinase-2 mediates phenotypic transformation of lens epithelial cells","volume":"358","author":"Seomun","year":"2001","journal-title":"Biochem J"},{"key":"key20200713233019_b29-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"69","DOI":"10.2353\/ajpath.2006.041089","article-title":"Matrix metalloproteinase inhibitors suppress transforming growth factor-beta-induced subcapsular cataract formation","volume":"168","author":"Dwivedi","year":"2006","journal-title":"Am J Pathol"},{"key":"key20200713233019_b30-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1159\/000084508","article-title":"Transforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: A model for cataract formation","volume":"179","author":"de-Iongh","year":"2005","journal-title":"Cells Tissues Organs"},{"key":"key20200713233019_b31-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.exer.2011.01.009","article-title":"Comparative effects of TGF-\u03b22\/Smad2 and TGF-\u03b22\/Smad3 signaling pathways on proliferation, migration, and extracellular matrix production in a human lens cell line","volume":"92","author":"Li","year":"2011","journal-title":"Exp Eye Res"},{"key":"key20200713233019_b32-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.bbrc.2008.04.128","article-title":"TGF-beta1 induced MMP-9 expression in HNSCC cell lines via Smad\/MLCK pathway","volume":"371","author":"Sinpitaksakul","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713233019_b33-mmr-20-01-0559","first-page":"1509","article-title":"Dexamethasone inhibits TGF-\u03b22-induced migration of human lens epithelial cells: implications for posterior capsule opacification prevention","volume":"5","author":"Yao","year":"2012","journal-title":"Mol Med Rep"},{"key":"key20200713233019_b34-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1016\/j.jcrs.2008.08.016","article-title":"Matrix metalloproteinase-9 activity in human lens epithelial cells of cortical, posterior subcapsular, and nuclear cataracts","volume":"34","author":"Alapure","year":"2008","journal-title":"J Cataract Refract Surg"},{"key":"key20200713233019_b35-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1124\/jpet.105.092858","article-title":"R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells","volume":"316","author":"R\u00f6sch","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"key20200713233019_b36-mmr-20-01-0559","first-page":"3713","article-title":"Scleral remodeling during the development of and recovery from axial myopia in the tree shrew","volume":"41","author":"McBrien","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233019_b37-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1111\/j.1600-0749.2004.00181.x","article-title":"Uveal melanocytes produce matrix metalloproteinases-2 and \u22129 in vitro","volume":"17","author":"Chu","year":"2004","journal-title":"Pigment Cell Res"},{"key":"key20200713233019_b38-mmr-20-01-0559","first-page":"716","article-title":"Metalloproteinase gene transcription in human ciliary muscle cells with latanoprost","volume":"43","author":"Weinreb","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233019_b39-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1167\/iovs.05-0516","article-title":"Analysis of expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human ciliary body after latanoprost","volume":"47","author":"Oh","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233019_b40-mmr-20-01-0559","first-page":"1977","article-title":"Suppression of IkappaBalpha increases the expression of matrix metalloproteinase-2 in human ciliary muscle cells","volume":"15","author":"Lan","year":"2009","journal-title":"Mol Vis"},{"key":"key20200713233019_b41-mmr-20-01-0559","first-page":"172","article-title":"Expression of matrix metalloproteinases and inhibitor by human trabecular meshwork","volume":"32","author":"Alexander","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233019_b42-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"3485","DOI":"10.1167\/iovs.02-0756","article-title":"Expression of matrix metalloproteinases and their inhibitors in human trabecular meshwork cells","volume":"44","author":"Pang","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233019_b43-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1167\/iovs.11-8638","article-title":"Matrix metalloproteinase activity creates pro-angiogenic environment in primary human retinal pigment epithelial cells exposed to complement","volume":"53","author":"Bandyopadhyay","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233019_b44-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/BF02829577","article-title":"Modulation of matrix metalloproteinase and TIMP-1 expression by TGF-beta1 in cultured human RPE cells","volume":"26","author":"Zeng","year":"2006","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"key20200713233019_b45-mmr-20-01-0559","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.exer.2012.11.005","article-title":"Comparative effects of posterior eye cup tissues from myopic and hyperopic chick eyes on cultured scleral fibroblasts","volume":"107","author":"Christian","year":"2013","journal-title":"Exp Eye Res"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:23:30Z","timestamp":1594686210000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2019.10287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,23]]},"references-count":45,"URL":"https:\/\/doi.org\/10.3892\/mmr.2019.10287","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,23]]}}}