{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:25:01Z","timestamp":1791919501998,"version":"4.3.4"},"reference-count":37,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2019.10408","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T09:15:08Z","timestamp":1561022108000},"source":"Crossref","is-referenced-by-count":3,"title":["Overexpression of microRNA\u201121 inhibits the growth and metastasis of melanoma cells by targeting MKK3"],"prefix":"10.3892","author":[{"given":"Meng","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Dermatology, Qilu Hospital of Shandong University, Qingdao, Shandong 266000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Qingdao Hiser Medical Group, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong 266032, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhai","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Oncology, Qingdao Hiser Medical Group, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong 266032, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Qingdao Agricultural University, Qingdao, Shandong 266179, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Qilu Hospital of Shandong University, Qingdao, Shandong 266000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2019,6,20]]},"reference":[{"key":"key20200713233333_b1-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"S109","DOI":"10.1038\/515S109a","article-title":"Melanoma","volume":"515","author":"Owens","year":"2014","journal-title":"Nature"},{"key":"key20200713233333_b2-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1002\/jcp.27286","article-title":"Melanoma: Where we are and where we go","volume":"234","author":"Mohammadpour","year":"2019","journal-title":"J Cell Physiol"},{"key":"key20200713233333_b3-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.det.2012.04.001","article-title":"Update on the current state of melanoma incidence","volume":"30","author":"Little","year":"2012","journal-title":"Dermatol Clin"},{"key":"key20200713233333_b4-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.cll.2017.06.001","article-title":"The immunology of melanoma","volume":"37","author":"Ko","year":"2017","journal-title":"Clin Lab Med"},{"key":"key20200713233333_b5-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nature22071","article-title":"Whole-genome landscapes of major melanoma subtypes","volume":"545","author":"Hayward","year":"2017","journal-title":"Nature"},{"key":"key20200713233333_b6-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1136\/jcp.2004.022509","article-title":"BRAF and NRAS mutations are uncommon in melanomas arising in diverse internal organs","volume":"58","author":"Wong","year":"2005","journal-title":"J Clin Pathol"},{"key":"key20200713233333_b7-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1055\/s-0034-1397344","article-title":"Overview of microRNA biology","volume":"35","author":"Mohr","year":"2015","journal-title":"Semin Liver Dis"},{"key":"key20200713233333_b8-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20200713233333_b9-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3389\/fgene.2018.00435","article-title":"Target RNAs strike back on MicroRNAs","volume":"9","author":"Fuchs Wightman","year":"2018","journal-title":"Front Genet"},{"key":"key20200713233333_b10-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41580-018-0059-1","article-title":"Regulation of microRNA biogenesis and its crosstalk with other cellular pathways","volume":"20","author":"Treiber","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key20200713233333_b11-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"E21","DOI":"10.3390\/biom8020021","article-title":"Circulating MicroRNA biomarkers in melanoma: Tools and challenges in personalised medicine","volume":"8","author":"Mumford","year":"2018","journal-title":"Biomolecules"},{"key":"key20200713233333_b12-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ejca.2015.10.009","article-title":"MicroRNAs as potential diagnostic and prognostic biomarkers in melanoma","volume":"53","author":"Mirzaei","year":"2016","journal-title":"Eur J Cancer"},{"key":"key20200713233333_b13-mmr-20-02-1797","first-page":"119","article-title":"Overexpression of microRNA-612 restrains the growth, invasion, and tumorigenesis of melanoma cells by targeting espin","volume":"41","author":"Zhu","year":"2018","journal-title":"Mol Cells"},{"key":"key20200713233333_b14-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"50","DOI":"10.14715\/cmb\/2018.64.11.10","article-title":"MiR-637 suppresses melanoma progression through directly targeting P-REX2a and inhibiting PTEN\/AKT signaling pathway","volume":"64","author":"Zhang","year":"2018","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"key20200713233333_b15-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.bcp.2018.08.008","article-title":"MicroRNA-143-3p inhibits growth and invasiveness of melanoma cells by targeting cyclooxygenase-2 and inversely correlates with malignant melanoma progression","volume":"156","author":"Panza","year":"2018","journal-title":"Biochem Pharmacol"},{"key":"key20200713233333_b16-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/ddr.21257","article-title":"The role of miR-21 in cancer","volume":"76","author":"Pfeffer","year":"2015","journal-title":"Drug Dev Res"},{"key":"key20200713233333_b17-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"5363","DOI":"10.3892\/mmr.2016.5894","article-title":"Effects of celastrol on enhancing apoptosis of ovarian cancer cells via the downregulation of microRNA21 and the suppression of the PI3K\/Akt-NF-\u03baB signaling pathway in an in vitro model of ovarian carcinoma","volume":"14","author":"Zhang","year":"2016","journal-title":"Mol Med Rep"},{"key":"key20200713233333_b18-mmr-20-02-1797","first-page":"4603","article-title":"Cantharidin inhibits melanoma cell proliferation via the miR21mediated PTEN pathway","volume":"18","author":"Mu","year":"2018","journal-title":"Mol Med Rep"},{"key":"key20200713233333_b19-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1097\/CMR.0000000000000374","article-title":"Quantification of microRNA-21 and microRNA-125b in melanoma tissue","volume":"27","author":"Wandler","year":"2017","journal-title":"Melanoma Res"},{"key":"key20200713233333_b20-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1002\/mc.22542","article-title":"MicroRNA-21 regulates the ERK\/NF-\u03baB signaling pathway to affect the proliferation, migration, and apoptosis of human melanoma A375 cells by targeting SPRY1, PDCD4, and PTEN","volume":"56","author":"Mao","year":"2017","journal-title":"Mol Carcinog"},{"key":"key20200713233333_b21-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1002\/jcb.26455","article-title":"MicroRNA-21 antisense oligonucleotide improves the sensitivity of human melanoma cells to cisplatin: An in vitro study","volume":"119","author":"Zhang","year":"2018","journal-title":"J Cell Biochem"},{"key":"key20200713233333_b22-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18632\/aging.100878","article-title":"MKK3 as oncotarget","volume":"8","author":"Bossi","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"key20200713233333_b23-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/j.cellsig.2016.05.009","article-title":"MEK2 controls the activation of MKK3\/MKK6-p38 axis involved in the MDA-MB-231 breast cancer cell survival: Correlation with cyclin D1 expression","volume":"28","author":"Huth","year":"2016","journal-title":"Cell Signal"},{"key":"key20200713233333_b24-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713233333_b25-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.molcel.2007.06.017","article-title":"MicroRNA targeting specificity in mammals: Determinants beyond seed pairing","volume":"27","author":"Grimson","year":"2007","journal-title":"Mol Cell"},{"key":"key20200713233333_b26-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1111\/tri.13011","article-title":"Increasing incidence of melanoma after solid organ transplantation: A retrospective epidemiological study","volume":"30","author":"Fattouh","year":"2017","journal-title":"Transpl Int"},{"key":"key20200713233333_b27-mmr-20-02-1797","first-page":"151","article-title":"Current evidence about the causes of malignant melanoma","volume":"6","author":"Lee","year":"1975","journal-title":"Prog Clin Cancer"},{"key":"key20200713233333_b28-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"e0205517","DOI":"10.1371\/journal.pone.0205517","article-title":"Differences in cutaneous melanoma treatment and patient satisfaction","volume":"13","author":"Wikstrom","year":"2018","journal-title":"PLoS One"},{"key":"key20200713233333_b29-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10565-018-9446-9","article-title":"Challenging the heterogeneity of disease presentation in malignant melanoma-impact on patient treatment","volume":"39","author":"Marcell Szasz","year":"2019","journal-title":"Cell Biol Toxicol"},{"key":"key20200713233333_b30-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1002\/ijc.30407","article-title":"Epidemiology of cutaneous melanoma in Sweden-Stage-specific survival and rate of recurrence","volume":"139","author":"Rockberg","year":"2016","journal-title":"Int J Cancer"},{"key":"key20200713233333_b31-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"e1621","DOI":"10.1038\/cddis.2014.591","article-title":"Targeting MKK3 as a novel anticancer strategy: Molecular mechanisms and therapeutical implications","volume":"6","author":"Baldari","year":"2015","journal-title":"Cell Death Dis"},{"key":"key20200713233333_b32-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1159\/000481648","article-title":"MicroRNA-21 (Mir-21) promotes cell growth and invasion by repressing tumor suppressor PTEN in colorectal cancer","volume":"43","author":"Wu","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"key20200713233333_b33-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"4784","DOI":"10.1073\/pnas.83.13.4784","article-title":"Evidence for soluble factors regulating cell death and cell proliferation in primary cultures of rabbit endometrial cells grown on collagen","volume":"83","author":"Lynch","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713233333_b34-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4068\/cmj.2018.54.3.135","article-title":"Melanoma cell death mechanisms","volume":"54","author":"Broussard","year":"2018","journal-title":"Chonnam Med J"},{"key":"key20200713233333_b35-mmr-20-02-1797","first-page":"293","article-title":"Immune mechanisms in the sequential steps of metastasis","volume":"4","author":"Miller","year":"1993","journal-title":"Crit Rev Oncog"},{"key":"key20200713233333_b36-mmr-20-02-1797","first-page":"311","article-title":"Breast cancer metastasis","volume":"9","author":"Scully","year":"2012","journal-title":"Cancer Genomics Proteomics"},{"key":"key20200713233333_b37-mmr-20-02-1797","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1111\/his.13778","article-title":"Expression of epithelial-mesenchymal transition regulatorsTWIST, SLUG and SNAIL in follicular thyroid tumours may relate to widely invasive, poorly differentiated and distant metastasis","volume":"74","author":"Wu","year":"2019","journal-title":"Histopathology"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:29:37Z","timestamp":1594686577000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2019.10408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,20]]},"references-count":37,"URL":"https:\/\/doi.org\/10.3892\/mmr.2019.10408","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,20]]}}}