{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:10:51Z","timestamp":1773277851612,"version":"3.50.1"},"reference-count":40,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2019.10506","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T11:04:03Z","timestamp":1563447843000},"source":"Crossref","is-referenced-by-count":5,"title":["MPZL1 is highly expressed in advanced gallbladder carcinoma and promotes the aggressive behavior of human gallbladder carcinoma GBC\u2011SD cells"],"prefix":"10.3892","author":[{"given":"Xiaolei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hepato\u2011Pancreato\u2011Biliary Surgical Oncology, Chinese PLA General Hospital, Beijing 100853, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, China\u2011Japan Friendship Hospital, Beijing 100029, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, China\u2011Japan Friendship Hospital, Beijing 100029, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2011Pancreato\u2011Biliary Surgical Oncology, Chinese PLA General Hospital, Beijing 100853, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"key20200713233605_b1-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.ctrv.2015.01.003","article-title":"Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy","volume":"41","author":"Bizama","year":"2015","journal-title":"Cancer Treat Rev"},{"key":"key20200713233605_b2-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/annonc\/mdn533","article-title":"Epidemiology of biliary tract cancers: An update","volume":"20","author":"Randi","year":"2009","journal-title":"Ann Oncol"},{"key":"key20200713233605_b3-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"12211","DOI":"10.3748\/wjg.v21.i43.12211","article-title":"Gallbladder carcinoma: Prognostic factors and therapeutic options","volume":"21","author":"Goetze","year":"2015","journal-title":"World J Gastroenterol"},{"key":"key20200713233605_b4-mmr-20-03-2725","first-page":"99","article-title":"Gallbladder cancer: Epidemiology and outcome","volume":"6","author":"Hundal","year":"2014","journal-title":"Clin Epidemiol"},{"key":"key20200713233605_b5-mmr-20-03-2725","first-page":"87","article-title":"Amplification of MPZL1\/PZR gene in hepatocellular carcinoma","volume":"3","author":"Yeh","year":"2014","journal-title":"Hepatobiliary Surg Nutr"},{"key":"key20200713233605_b6-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"29367","DOI":"10.1074\/jbc.273.45.29367","article-title":"Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2","volume":"273","author":"Zhao","year":"1998","journal-title":"J Biol Chem"},{"key":"key20200713233605_b7-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.smim.2014.01.001","article-title":"IL-6 and related cytokines as the critical lynchpins between inflammation and cancer","volume":"26","author":"Taniguchi","year":"2014","journal-title":"Semin Immunol"},{"key":"key20200713233605_b8-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1042\/bj20020935","article-title":"Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: Identification, molecular cloning and effects on cell migration","volume":"370","author":"Zannettino","year":"2003","journal-title":"Biochem J"},{"key":"key20200713233605_b9-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1111\/jcmm.12618","article-title":"Functions of Shp2 in cancer","volume":"19","author":"Zhang","year":"2015","journal-title":"J Cell Mol Med"},{"key":"key20200713233605_b10-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/B978-0-12-396456-4.00009-2","article-title":"Protein tyrosine phosphatases in cancer","volume":"106","author":"Labb\u00e9","year":"2012","journal-title":"Friends and foes! Prog Mol Biol Transl Sci"},{"key":"key20200713233605_b11-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"567","DOI":"10.2174\/1568009614666140717105001","article-title":"Structure, function, and pathogenesis of SHP2 in developmental disorders and tumorigenesis","volume":"14","author":"Huang","year":"2014","journal-title":"Curr Cancer Drug Targets"},{"key":"key20200713233605_b12-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s10555-008-9126-y","article-title":"The tyrosine phosphatase Shp2 (PTPN11) in cancer","volume":"27","author":"Chan","year":"2008","journal-title":"Cancer Metastasis Rev"},{"key":"key20200713233605_b13-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0065-230X(10)06002-1","article-title":"The tyrosine phosphatase Shp2 in development and cancer","volume":"106","author":"Grossmann","year":"2010","journal-title":"Adv Cancer Res"},{"key":"key20200713233605_b14-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1002\/jcb.21334","article-title":"The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation","volume":"102","author":"Roubelakis","year":"2007","journal-title":"J Cell Biochem"},{"key":"key20200713233605_b15-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"15328","DOI":"10.1074\/jbc.M801382200","article-title":"Bennett: Noonan syndrome-associated SHP-2\/Ptpn11 mutants enhance SIRP\u03b1 and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation","volume":"283","author":"Seda","year":"2008","journal-title":"J Biol Chem"},{"key":"key20200713233605_b16-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1080\/10623320802125250","article-title":"Phosphorylation and localization of protein-zero related (PZR) in cultured endothelial cells","volume":"15","author":"Kusano","year":"2008","journal-title":"Endothelium"},{"key":"key20200713233605_b17-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/cr.2013.158","article-title":"Amplification of MPZL1\/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma","volume":"24","author":"Jia","year":"2014","journal-title":"Cell Res"},{"key":"key20200713233605_b18-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.bbrc.2018.10.161","article-title":"Structural and biochemical studies of the extracellular domain of Myelin protein zero-like protein 1","volume":"506","author":"Yu","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"key20200713233605_b19-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713233605_b20-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1002\/mc.22215","article-title":"Long non-coding RNA-LET is a positive prognostic factor and exhibits tumor-suppressive activity in gallbladder cancer","volume":"54","author":"Ma","year":"2015","journal-title":"Mol Carcinog"},{"key":"key20200713233605_b21-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"9742","DOI":"10.1073\/pnas.171251798","article-title":"Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems","volume":"98","author":"Caplen","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713233605_b22-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"4023","DOI":"10.3748\/wjg.v17.i35.4023","article-title":"Clinicopathological significance of altered Notch signaling in extrahepatic cholangiocarcinoma and gallbladder carcinoma","volume":"17","author":"Yoon","year":"2011","journal-title":"World J Gastroenterol"},{"key":"key20200713233605_b23-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"22339","DOI":"10.18632\/oncotarget.7970","article-title":"miR-101 targeting ZFX suppresses tumor proliferation and metastasis by regulating the MAPK\/Erk and Smad pathways in gallbladder carcinoma","volume":"7","author":"Bao","year":"2016","journal-title":"Oncotarget"},{"key":"key20200713233605_b24-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"e0136193","DOI":"10.1371\/journal.pone.0136193","article-title":"Histone deacetylase inhibitors inhibit the proliferation of gallbladder carcinoma cells by suppressing AKT\/mTOR signaling","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"key":"key20200713233605_b25-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.humpath.2013.10.017","article-title":"Aberrant activation of Sonic hedgehog signaling in chronic cholecystitis and gallbladder carcinoma","volume":"45","author":"Xie","year":"2014","journal-title":"Hum Pathol"},{"key":"key20200713233605_b26-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ceb.2009.01.028","article-title":"Tyrosine phosphorylation: Thirty years and counting","volume":"21","author":"Hunter","year":"2009","journal-title":"Curr Opin Cell Biol"},{"key":"key20200713233605_b27-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/0092-8674(95)90405-0","article-title":"Protein kinases and phosphatases: The yin and yang of protein phosphorylation and signaling","volume":"80","author":"Hunter","year":"1995","journal-title":"Cell"},{"key":"key20200713233605_b28-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1056\/NEJMra044389","article-title":"Tyrosine kinases as targets for cancer therapy","volume":"353","author":"Krause","year":"2005","journal-title":"N Engl J Med"},{"key":"key20200713233605_b29-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"3885","DOI":"10.1038\/onc.2014.326","article-title":"Genetic alterations of protein tyrosine phosphatases in human cancers","volume":"34","author":"Zhao","year":"2015","journal-title":"Oncogene"},{"key":"key20200713233605_b30-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/ijc.29499","article-title":"Receptor tyrosine kinase inhibitors: Are they Real Tumor Killers?","volume":"138","author":"Gaumann","year":"2016","journal-title":"Int J Cancer"},{"key":"key20200713233605_b31-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/febs.12077","article-title":"Protein tyrosine phosphatases-from housekeeping enzymes to master regulators of signal transduction","volume":"280","author":"Tonks","year":"2013","journal-title":"FEBS J"},{"key":"key20200713233605_b32-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/nrc2980","article-title":"Inside the human cancer tyrosine phosphatome","volume":"11","author":"Julien","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"key20200713233605_b33-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1038\/aps.2014.80","article-title":"Protein tyrosine phosphatases as potential therapeutic targets","volume":"35","author":"He","year":"2014","journal-title":"Acta Pharmacol Sin"},{"key":"key20200713233605_b34-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/ng.3030","article-title":"Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway","volume":"46","author":"Li","year":"2014","journal-title":"Nat Genet"},{"key":"key20200713233605_b35-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"42893","DOI":"10.1074\/jbc.M306136200","article-title":"Blocking the function of tyrosine phosphatase SHP-2 by targeting its Src homology 2 domains","volume":"278","author":"Zhao","year":"2003","journal-title":"J Biol Chem"},{"key":"key20200713233605_b36-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"15328","DOI":"10.1074\/jbc.M801382200","article-title":"Noonan syndrome-associated SHP-2\/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation","volume":"283","author":"Eminaga","year":"2008","journal-title":"J Biol Chem"},{"key":"key20200713233605_b37-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1745-7270.2006.00141.x","article-title":"Roles of cortactin, an actin polymerization mediator, in cell endocytosis","volume":"38","author":"Chen","year":"2006","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"key20200713233605_b38-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1016\/j.cub.2011.06.065","article-title":"Cortactin controls cell motility and lamellipodial dynamics by regulating ECM secretion","volume":"21","author":"Sung","year":"2011","journal-title":"Curr Biol"},{"key":"key20200713233605_b39-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.ccr.2011.01.036","article-title":"Twist1-induced invadopodia formation promotes tumor metastasis","volume":"19","author":"Eckert","year":"2011","journal-title":"Cancer Cell"},{"key":"key20200713233605_b40-mmr-20-03-2725","doi-asserted-by":"publisher","first-page":"7882","DOI":"10.1074\/jbc.M111914200","article-title":"Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling","volume":"277","author":"Zhao","year":"2002","journal-title":"J Biol Chem"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:34:19Z","timestamp":1594686859000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2019.10506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,18]]},"references-count":40,"URL":"https:\/\/doi.org\/10.3892\/mmr.2019.10506","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,18]]}}}