{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:53:31Z","timestamp":1783133611733,"version":"3.54.6"},"reference-count":48,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2019.10525","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T07:15:46Z","timestamp":1564038946000},"source":"Crossref","is-referenced-by-count":2,"title":["Quantitative profiling of regional protein expression in rat retina after partial optic nerve transection using fluorescence difference two\u2011dimensional gel electrophoresis"],"prefix":"10.3892","author":[{"given":"Chuen","family":"Lam","sequence":"first","affiliation":[{"name":"School of Optometry, Hong Kong Polytechnic University, Hong Kong 999077, SAR, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King","family":"Li","sequence":"additional","affiliation":[{"name":"School of Optometry, Hong Kong Polytechnic University, Hong Kong 999077, SAR, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Do","sequence":"additional","affiliation":[{"name":"School of Optometry, Hong Kong Polytechnic University, Hong Kong 999077, SAR, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Chan","sequence":"additional","affiliation":[{"name":"School of Optometry, Hong Kong Polytechnic University, Hong Kong 999077, SAR, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"To","sequence":"additional","affiliation":[{"name":"School of Optometry, Hong Kong Polytechnic University, Hong Kong 999077, SAR, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky","family":"Kwong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"key20200713233606_b1-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1089\/neu.1995.12.791","article-title":"Mediators of injury in neurotrauma: Intracellular signal transduction and gene expression","volume":"12","author":"Bazan","year":"1995","journal-title":"J Neurotrauma"},{"key":"key20200713233606_b2-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/nm0197-73","article-title":"Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys","volume":"3","author":"Crowe","year":"1997","journal-title":"Nat Med"},{"key":"key20200713233606_b3-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1111\/j.1460-9568.1994.tb00983.x","article-title":"Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord","volume":"6","author":"Dusart","year":"1994","journal-title":"Eur J Neurosci"},{"key":"key20200713233606_b4-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1600-0773.1996.tb00173.x","article-title":"Pharmacological treatment of central nervous system trauma","volume":"78","author":"Faden","year":"1996","journal-title":"Pharmacol Toxicol"},{"key":"key20200713233606_b5-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1089\/neu.1993.10.349","article-title":"An experimental model combining microdialysis with electrophysiology, histology and neurochemistry for exploring mechanisms of secondary damage in spinal cord injury: Effect of potassium","volume":"10","author":"Liu","year":"1993","journal-title":"J Neurotrauma"},{"key":"key20200713233606_b6-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S1350-9462(98)00014-7","article-title":"Neuronal death in glaucoma","volume":"18","author":"Quigley","year":"1999","journal-title":"Prog Retin Eye Res"},{"key":"key20200713233606_b7-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1001\/archopht.1981.03930010635009","article-title":"Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage","volume":"99","author":"Quigley","year":"1981","journal-title":"Arch Ophthalmol"},{"key":"key20200713233606_b8-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/exnr.1998.6811","article-title":"Degeneration of spared axons following partial white matter lesion: Implications for optic nerve neuropathies","volume":"153","author":"Yoles","year":"1998","journal-title":"Exp Neurol"},{"key":"key20200713233606_b9-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S0039-6257(97)00123-9","article-title":"Potential neuroprotective therapy for glaucomatous optic neuropathy","volume":"42","author":"Yoles","year":"1998","journal-title":"Surv Ophthalmol"},{"key":"key20200713233606_b10-mmr-20-03-2734","first-page":"975","article-title":"Optic nerve transection in monkeys may result in secondary degeneration of retinal ganglion cells","volume":"42","author":"Levkovitch-Verbin","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233606_b11-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"3388","DOI":"10.1167\/iovs.02-0646","article-title":"A model to study differences between primary and secondary degeneration of retinal ganglion cells in rats by partial optic nerve transection","volume":"44","author":"Levkovitch-Verbin","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233606_b12-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"16031","DOI":"10.1038\/cddiscovery.2016.31","article-title":"Automatic quantitative analysis of experimental primary and secondary retinal neurodegeneration: Implications for optic neuropathies","volume":"2","author":"Davis","year":"2016","journal-title":"Cell Death Discov"},{"key":"key20200713233606_b13-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1089\/neu.2009.1112","article-title":"Early events of secondary degeneration after partial optic nerve transection: An immunohistochemical study","volume":"27","author":"Fitzgerald","year":"2010","journal-title":"J Neurotrauma"},{"key":"key20200713233606_b14-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.exer.2009.11.014","article-title":"Mechanism of retinal ganglion cells death in secondary degeneration of the optic nerve","volume":"91","author":"Levkovitch-Verbin","year":"2010","journal-title":"Exp Eye Res"},{"key":"key20200713233606_b15-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"565","DOI":"10.4103\/1673-5374.130093","article-title":"Mechanisms of secondary degeneration after partial optic nerve transection","volume":"9","author":"Li","year":"2014","journal-title":"Neural Regen Res"},{"key":"key20200713233606_b16-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s00417-010-1608-2","article-title":"Similarities and differences between primary and secondary degeneration of the optic nerve and the effect of minocycline","volume":"249","author":"Levkovitch-Verbin","year":"2011","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"key20200713233606_b17-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1080\/01616412.2019.1609164","article-title":"Voluntary running delays primary degeneration in rat retinas after partial optic nerve transection","volume":"14","author":"Li","year":"2019","journal-title":"Neural Regen Res"},{"key":"key20200713233606_b18-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12868-017-0380-1","article-title":"Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma","volume":"18","author":"O'Hare Doig","year":"2017","journal-title":"BMC Neurosci"},{"key":"key20200713233606_b19-mmr-20-03-2734","first-page":"5571","article-title":"Early quantitative profiling of differential retinal protein expression in lens-induced myopia in guinea pig using fluorescence difference two-dimensional gel electrophoresis","volume":"17","author":"Wu","year":"2018","journal-title":"Mol Med Rep"},{"key":"key20200713233606_b20-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1167\/iovs.09-4098","article-title":"RNA binding protein with multiple splicing: A new marker for retinal ganglion cells","volume":"51","author":"Kwong","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233606_b21-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"9694","DOI":"10.1167\/iovs.11-7869","article-title":"Quantitative analysis of retinal ganglion cell survival with Rbpms immunolabeling in animal models of optic neuropathies","volume":"52","author":"Kwong","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233606_b22-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1167\/iovs.02-0912","article-title":"Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model","volume":"44","author":"Ishii","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233606_b23-mmr-20-03-2734","first-page":"1380","article-title":"Patterns of intraocular pressure elevation after aqueous humor outflow obstruction in rats","volume":"41","author":"Jia","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233606_b24-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.1021\/pr0701097","article-title":"Application of fluorescence difference gel electrophoresis technology in searching for protein biomarkers in chick myopia","volume":"6","author":"Lam","year":"2007","journal-title":"J Proteome Res"},{"key":"key20200713233606_b25-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1021\/pr050280n","article-title":"A chick retinal proteome database and differential retinal protein expressions during early ocular development","volume":"5","author":"Lam","year":"2006","journal-title":"J Proteome Res"},{"key":"key20200713233606_b26-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2006.11.095","article-title":"Modulation of alpha and beta crystallin expression in rat retinas with ocular hypertension-induced ganglion cell degeneration","volume":"1141","author":"Piri","year":"2007","journal-title":"Brain Res"},{"key":"key20200713233606_b27-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.1167\/iovs.08-3138","article-title":"The role of alphaA- and alphaB-crystallins in the survival of retinal ganglion cells after optic nerve axotomy","volume":"50","author":"Munemasa","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233606_b28-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s12035-013-8470-2","article-title":"Crystallins in retinal ganglion cell survival and regeneration","volume":"48","author":"Piri","year":"2013","journal-title":"Mol Neurobiol"},{"key":"key20200713233606_b29-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.preteyeres.2016.03.001","article-title":"Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival","volume":"52","author":"Piri","year":"2016","journal-title":"Prog Retin Eye Res"},{"key":"key20200713233606_b30-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"e1661","DOI":"10.1038\/cddis.2015.22","article-title":"Neuritin 1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush","volume":"6","author":"Sharma","year":"2015","journal-title":"Cell Death Dis"},{"key":"key20200713233606_b31-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/02713683.2015.1045083","article-title":"Programmed cell death-1 is expressed in large retinal ganglion cells and is upregulated after optic nerve crush","volume":"140","author":"Wang","year":"2015","journal-title":"Exp Eye Res"},{"key":"key20200713233606_b32-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"4661","DOI":"10.1167\/iovs.16-19997","article-title":"Loss of Melanopsin-expressing retinal ganglion cells in severely staged glaucoma patients","volume":"57","author":"Obara","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233606_b33-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"e0182407","DOI":"10.1371\/journal.pone.0182407","article-title":"Protective effects on the retina after ranibizumab treatment in an ischemia model","volume":"12","author":"Joachim","year":"2017","journal-title":"PLoS One"},{"key":"key20200713233606_b34-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1016\/S0042-6989(97)00341-6","article-title":"Prolonged administration of NT-4\/5 fails to rescue most axotomized retinal ganglion cells in adult rats","volume":"38","author":"Clarke","year":"1998","journal-title":"Vision Res"},{"key":"key20200713233606_b35-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"5456","DOI":"10.1167\/iovs.09-3717","article-title":"Secondary retinal ganglion cell death and the neuroprotective effects of the calcium channel blocker lomerizine","volume":"50","author":"Fitzgerald","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233606_b36-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"e81339","DOI":"10.1371\/journal.pone.0081339","article-title":"Effect of lycium barbarum (wolfberry) polysaccharides on preserving retinal function after partial optic nerve transection","volume":"8","author":"Chu","year":"2013","journal-title":"PLoS One"},{"key":"key20200713233606_b37-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3727\/096368915X686896","article-title":"Effect of Lycium barbarum (Wolfberry) on alleviating axonal degeneration after partial optic nerve transection","volume":"24","author":"Li","year":"2015","journal-title":"Cell Transplant"},{"key":"key20200713233606_b38-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"e68881","DOI":"10.1371\/journal.pone.0068881","article-title":"Lycium barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"key20200713233606_b39-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"6093","DOI":"10.1167\/iovs.12-10080","article-title":"Myelin sheath decompaction, axon swelling, and functional loss during chronic secondary degeneration in rat optic nerve","volume":"53","author":"Payne","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233606_b40-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"e65710","DOI":"10.1371\/journal.pone.0065710","article-title":"Early proliferation does not prevent the loss of oligodendrocyte progenitor cells during the chronic phase of secondary degeneration in a CNS white matter tract","volume":"8","author":"Payne","year":"2013","journal-title":"PLoS One"},{"key":"key20200713233606_b41-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"e0192348","DOI":"10.1371\/journal.pone.0192348","article-title":"Retinal genes are differentially expressed in areas of primary versus secondary degeneration following partial optic nerve injury","volume":"13","author":"Chiha","year":"2018","journal-title":"PLoS One"},{"key":"key20200713233606_b42-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1167\/iovs.09-4331","article-title":"Elevated albumin in retinas of monkeys with experimental glaucoma","volume":"51","author":"Carter-Dawson","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"key20200713233606_b43-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s12031-007-9010-1","article-title":"Alpha-crystallin protected axons from optic nerve degeneration after crushing in rats","volume":"35","author":"Ying","year":"2008","journal-title":"J Mol Neurosci"},{"key":"key20200713233606_b44-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.lfs.2013.10.034","article-title":"\u03b1-Crystallin protects RGC survival and inhibits microglial activation after optic nerve crush","volume":"94","author":"Wu","year":"2014","journal-title":"Life Sci"},{"key":"key20200713233606_b45-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.3727\/096368914X684583","article-title":"\u03b2B2-crystallin promotes axonal regeneration in the injured optic nerve in adult rats","volume":"24","author":"B\u00f6hm","year":"2015","journal-title":"Cell Transplant"},{"key":"key20200713233606_b46-mmr-20-03-2734","first-page":"955","article-title":"Promotion of axon regeneration and inhibition of astrocyte activation by alpha A-crystallin on crushed optic nerve","volume":"9","author":"Shao","year":"2016","journal-title":"Int J Ophthalmol"},{"key":"key20200713233606_b47-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"e0175451","DOI":"10.1371\/journal.pone.0175451","article-title":"Intravitreal injection of \u03b2-crystallin B2 improves retinal ganglion cell survival in an experimental animal model of glaucoma","volume":"12","author":"Anders","year":"2017","journal-title":"PLoS One"},{"key":"key20200713233606_b48-mmr-20-03-2734","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.neulet.2016.12.042","article-title":"Synergistic effect of olfactory ensheathing cells and alpha-crystallin on restoration of adult rat optic nerve injury","volume":"638","author":"Wang","year":"2017","journal-title":"Neurosci Lett"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:34:21Z","timestamp":1594686861000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2019.10525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,25]]},"references-count":48,"URL":"https:\/\/doi.org\/10.3892\/mmr.2019.10525","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,25]]}}}