{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T15:04:02Z","timestamp":1776524642457,"version":"3.51.2"},"reference-count":41,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2019.10586","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T05:31:36Z","timestamp":1565587896000},"source":"Crossref","is-referenced-by-count":39,"title":["Impaired intestinal barrier function in a mouse model of hyperuricemia"],"prefix":"10.3892","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2909-9887","authenticated-orcid":false,"given":"Yingjie","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Diseases, Qingdao University, Qingdao, Shandong 266000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Diseases, Qingdao University, Qingdao, Shandong 266000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changgui","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Diseases, Qingdao University, Qingdao, Shandong 266000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Diseases, Qingdao University, Qingdao, Shandong 266000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3211-2934","authenticated-orcid":false,"given":"Zibin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2019,8,12]]},"reference":[{"key":"key20200713233735_b1-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1146\/annurev-physiol-021113-170343","article-title":"The molecular physiology of uric acid homeostasis","volume":"77","author":"Mandal","year":"2015","journal-title":"Annu Rev Physiol"},{"key":"key20200713233735_b2-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1093\/rheumatology\/keq204","article-title":"Uric acid and evolution","volume":"49","author":"\u00c1lvarez-Lario","year":"2010","journal-title":"Rheumatology"},{"key":"key20200713233735_b3-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"762820","DOI":"10.1155\/2015\/762820","article-title":"Prevalence of hyperuricemia and gout in mainland China from 2000 to 2014: A systematic review and meta-analysis","volume":"2015","author":"Liu","year":"2015","journal-title":"Biomed Res Int"},{"key":"key20200713233735_b4-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1136\/annrheumdis-2011-201254","article-title":"Epidemiology of gout and hyperuricaemia in Italy during the years 2005\u20132009: A nationwide population-based study","volume":"72","author":"Trifiro","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"key20200713233735_b5-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.maturitas.2018.10.012","article-title":"Gout-an update of aetiology, genetics, co-morbidities and management","volume":"118","author":"Robinson","year":"2018","journal-title":"Maturitas"},{"key":"key20200713233735_b6-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1053\/j.ajkd.2017.12.009","article-title":"Hyperuricemia, acute and chronic kidney disease, hypertension, and cardiovascular disease: Report of a scientific workshop organized by the national kidney foundation","volume":"71","author":"Johnson","year":"2018","journal-title":"Am J Kidney Dis"},{"key":"key20200713233735_b7-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2174\/1573399810666140228160938","article-title":"Association of serum uric acid and metabolic syndrome in type 2 diabetes","volume":"10","author":"Bonakdaran","year":"2014","journal-title":"Cur Diabetes Rev"},{"key":"key20200713233735_b8-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"e0190194","DOI":"10.1371\/journal.pone.0190194","article-title":"Intestinal tract is an important organ for lowering serum uric acid in rats","volume":"12","author":"Yun","year":"2017","journal-title":"PLoS One"},{"key":"key20200713233735_b9-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1080\/13880209.2016.1195847","article-title":"Uric acid transporters hiding in the intestine","volume":"54","author":"Xu","year":"2016","journal-title":"Pharm Biol"},{"key":"key20200713233735_b10-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/2001-1326-1-16","article-title":"Contribution of uric acid to cancer risk, recurrence and mortality","volume":"1","author":"Fini","year":"2012","journal-title":"Clin Transl Med"},{"key":"key20200713233735_b11-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3109\/08820139.2013.864667","article-title":"Pro-inflammatory effects of uric acid in the gastrointestinal tract","volume":"43","author":"Crane","year":"2014","journal-title":"Immunol Invest"},{"key":"key20200713233735_b12-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.kint.2017.04.031","article-title":"Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders","volume":"93","author":"Lu","year":"2018","journal-title":"Kidney Int"},{"key":"key20200713233735_b13-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"e3952","DOI":"10.1371\/journal.pone.0003952","article-title":"Mucin dynamics in intestinal bacterial infection","volume":"3","author":"Lind\u00e9n","year":"2008","journal-title":"PLoS One"},{"key":"key20200713233735_b14-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: Minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin Chem"},{"key":"key20200713233735_b15-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20200713233735_b16-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s12253-017-0344-x","article-title":"Immunohistochemistry with Anti-BRAF V600E (VE1) mouse monoclonal antibody is a sensitive method for detection of the BRAF V600E mutation in colon cancer: Evaluation of 120 cases with and without KRAS mutation and literature review","volume":"25","author":"Dvorak","year":"2019","journal-title":"Pathol Oncol Res"},{"issue":"pii","key":"key20200713233735_b17-mmr-20-04-3292","first-page":"e01347","article-title":"Antischistosomiasis liver fibrosis effects of chlorogenic acid through IL-13\/miR-21\/Smad7 signaling interactions in vivo and in vitro","volume":"61","author":"Wang","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"key20200713233735_b18-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"8502","DOI":"10.3390\/ijms12128502","article-title":"Effects of soybean agglutinin on intestinal barrier permeability and tight junction protein expression in weaned piglets","volume":"12","author":"Zhao","year":"2011","journal-title":"Int J Mol Sci"},{"issue":"pii","key":"key20200713233735_b19-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"BSR20170939","DOI":"10.1042\/BSR20170939","article-title":"Uric acid promotes oxidative stress and enhances vascular endothelial cell apoptosis in rats with middle cerebral artery occlusion","volume":"38","author":"Song","year":"2018","journal-title":"Biosci Rep"},{"key":"key20200713233735_b20-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1749-6632.2012.06613.x","article-title":"Tight junctions on the move: Molecular mechanisms for epithelial barrier regulation","volume":"1258","author":"Shen","year":"2012","journal-title":"Ann NY Acad Sci"},{"key":"key20200713233735_b21-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ijbiomac.2019.06.041","article-title":"Surface-layer protein from Lactobacillus acidophilus NCFM attenuates tumor necrosis factor-\u03b1-induced intestinal barrier dysfunction and inflammation","volume":"136","author":"Wang","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"key20200713233735_b22-mmr-20-04-3292","first-page":"S482","article-title":"Animal models for abnormal purine metabolism","volume":"61","author":"Morisaki","year":"2003","journal-title":"Nihon Rinsho"},{"key":"key20200713233735_b23-mmr-20-04-3292","first-page":"860","article-title":"An update on the animal models in hyperuricaemia research","volume":"35","author":"Zhu","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"key20200713233735_b24-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1002\/art.1780080429","article-title":"Role of the intestinal tract in the elimination of uric acid","volume":"8","author":"Sorensen","year":"1965","journal-title":"Arthritis Rheum"},{"key":"key20200713233735_b25-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"31003","DOI":"10.1038\/srep31003","article-title":"Hyperuricemia in acute gastroenteritis is caused by decreased urate excretion via ABCG2","volume":"6","author":"Matsuo","year":"2016","journal-title":"Sci Rep"},{"key":"key20200713233735_b26-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"e97815","DOI":"10.1371\/journal.pone.0097815","article-title":"Chlorogenic acid decreases intestinal permeability and increases expression of intestinal tight junction proteins in weaned rats challenged with LPS","volume":"9","author":"Ruan","year":"2014","journal-title":"PLoS One"},{"key":"key20200713233735_b27-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"943","DOI":"10.3892\/etm.2016.3015","article-title":"Effects of lactadherin on plasma D-lactic acid and small intestinal MUC2 and claudin-1 expression levels in rats with rotavirus-induced diarrhea","volume":"11","author":"Xu","year":"2016","journal-title":"Exp Ther Med"},{"key":"key20200713233735_b28-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1053\/j.gastro.2011.01.004","article-title":"The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding","volume":"140","author":"Marchiando","year":"2011","journal-title":"Gastroenterology"},{"key":"key20200713233735_b29-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1136\/gut.2006.098160","article-title":"Comparative study of the intestinal mucus barrier in normal and inflamed colon","volume":"56","author":"Swidsinski","year":"2007","journal-title":"Gut"},{"key":"key20200713233735_b30-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.3748\/wjg.v23.i12.2106","article-title":"Regulation of intestinal permeability: The role of proteases","volume":"23","author":"Van Spaendonk","year":"2017","journal-title":"World J Gastroenterol"},{"key":"key20200713233735_b31-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.cgh.2013.07.001","article-title":"Intestinal permeability defects: Is it time to treat?","volume":"11","author":"Odenwald","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key20200713233735_b32-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"387","DOI":"10.2174\/1871520615666150812125955","article-title":"Evaluating intestinal permeability by measuring plasma endotoxin and diamine oxidase in children with acute lymphoblastic leukemia treated with high-dose methotrexate","volume":"16","author":"Meng","year":"2016","journal-title":"Anticancer Agents Med Chem"},{"key":"key20200713233735_b33-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"E23","DOI":"10.1002\/ibd.21588","article-title":"Clinical significance of serum diamine oxidase activity in inflammatory bowel disease: Importance of evaluation of small intestinal permeability","volume":"17","author":"Honzawa","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"key20200713233735_b34-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1159\/000381990","article-title":"The Gut as a source of inflammation in chronic kidney disease","volume":"130","author":"Lau","year":"2015","journal-title":"Nephron"},{"key":"key20200713233735_b35-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1093\/ndt\/gfr624","article-title":"Disintegration of colonic epithelial tight junction in uremia: A likely cause of CKD-associated inflammation","volume":"27","author":"Vaziri","year":"2012","journal-title":"Nephrol Dial Transplant"},{"issue":"pii","key":"key20200713233735_b36-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"E2280","DOI":"10.3390\/ijms20092280","article-title":"Effect of indoxyl sulfate on the repair and intactness of intestinal epithelial cells: Role of reactive oxygen Species' release","volume":"20","author":"Adesso","year":"2019","journal-title":"Int J Mol Sci"},{"key":"key20200713233735_b37-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1093\/ndt\/gfv095","article-title":"Altered intestinal microbial flora and impaired epithelial barrier structure and function in CKD: The nature, mechanisms, consequences and potential treatment","volume":"31","author":"Vaziri","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"key20200713233735_b38-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1053\/j.gastro.2016.07.008","article-title":"Inflammation and the intestinal barrier: Leukocyte-epithelial cell interactions, cell junction remodeling, and mucosal repair","volume":"151","author":"Luissint","year":"2016","journal-title":"Gastroenterology"},{"key":"key20200713233735_b39-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.3892\/etm.2016.3493","article-title":"Mechanism of intestinal mucosal barrier dysfunction in a rat model of chronic obstructive pulmonary disease: An observational study","volume":"12","author":"Xin","year":"2016","journal-title":"Exp Ther Med"},{"key":"key20200713233735_b40-mmr-20-04-3292","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0002-9440(10)62264-X","article-title":"Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression","volume":"166","author":"Wang","year":"2005","journal-title":"Am J Pathol"},{"key":"key20200713233735_b41-mmr-20-04-3292","first-page":"e13108","article-title":"Relationship between oxidative stress and inflammatory response in young patients with primary hyperuricemia","volume":"97","author":"Zhou","year":"2017","journal-title":"China J Modern Med"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:35:07Z","timestamp":1594686907000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2019.10586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,12]]},"references-count":41,"URL":"https:\/\/doi.org\/10.3892\/mmr.2019.10586","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,12]]}}}