{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:04:27Z","timestamp":1787882667046,"version":"build-2784847793"},"reference-count":26,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2019.10672","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T10:52:58Z","timestamp":1568199178000},"source":"Crossref","is-referenced-by-count":5,"title":["Dihydroartemisinin inhibits multiplication of Brucella suis vaccine strain 2 in murine microglia BV2 cells via stimulation of caspase\u2011dependent apoptosis"],"prefix":"10.3892","author":[{"given":"Juan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haining","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2019,9,11]]},"reference":[{"key":"key20200713233938_b1-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1186\/1471-2334-13-547","article-title":"Epidemiological features and risk factors associated with the spatial and temporal distribution of human brucellosis in China","volume":"13","author":"Li","year":"2013","journal-title":"BMC Infect Dis"},{"key":"key20200713233938_b2-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1186\/s12889-015-1761-y","article-title":"Expansion of brucellosis detection in the country of Georgia by screening household members of cases and neighboring community members","volume":"15","author":"Sanodze","year":"2015","journal-title":"BMC Public Health"},{"key":"key20200713233938_b3-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/tmi.12856","article-title":"Human-to-human transmission of Brucella-a systematic review","volume":"22","author":"Tuon","year":"2017","journal-title":"Trop Med Int Health"},{"key":"key20200713233938_b4-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"5712920","DOI":"10.1155\/2018\/5712920","article-title":"A systematic review and meta-analysis of epidemiology and clinical manifestations of human brucellosis in China","volume":"2018","author":"Zheng","year":"2018","journal-title":"Biomed Res Int"},{"key":"key20200713233938_b5-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3855\/jidc.6625","article-title":"Host response to Brucella infection: Review and future perspective","volume":"9","author":"Elfaki","year":"2015","journal-title":"J Infect Dev Ctries"},{"key":"key20200713233938_b6-mmr-20-05-4067","first-page":"17530","article-title":"Brucella outer membrane protein Omp25 induces microglial cells in vitro to secrete inflammatory cytokines and inhibit apoptosis","volume":"8","author":"Ma","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"key20200713233938_b7-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1007\/s00436-014-3822-z","article-title":"A review of dihydroartemisinin as another gift from traditional Chinese medicine not only for malaria control but also for schistosomiasis control","volume":"113","author":"Zhang","year":"2014","journal-title":"Parasitol Res"},{"key":"key20200713233938_b8-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.4161\/15384047.2014.955728","article-title":"Dihydroartemisinin targets VEGFR2 via the NF-\u03baB pathway in endothelial cells to inhibit angiogenesis","volume":"15","author":"Dong","year":"2014","journal-title":"Cancer Biol Ther"},{"key":"key20200713233938_b9-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.3892\/ol.2016.4870","article-title":"Dihydroartemisinin induces endothelial cell anoikis through the activation of the JNK signaling pathway","volume":"12","author":"Zhang","year":"2016","journal-title":"Oncol Lett"},{"key":"key20200713233938_b10-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.lfs.2017.11.008","article-title":"Dihydroartemisinin induced caspase-dependent apoptosis through inhibiting the specificity protein 1 pathway in hepatocellular carcinoma SK-Hep-1 cells","volume":"192","author":"Im","year":"2018","journal-title":"Life Sci"},{"key":"key20200713233938_b11-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fcimb.2016.00019","article-title":"Brucella suis vaccine strain 2 induces endoplasmic reticulum stress that affects intracellular replication in goat trophoblast cells in vitro","volume":"6","author":"Wang","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"key20200713233938_b12-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1007\/s13277-013-1326-6","article-title":"Bufalin exerts antitumor effects by inducing cell cycle arrest and triggering apoptosis in pancreatic cancer cells","volume":"35","author":"Li","year":"2014","journal-title":"Tumour Biol"},{"key":"key20200713233938_b13-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1002\/jbm.a.33295","article-title":"Biological response of endothelial cells to diamond-like carbon-coated NiTi alloy","volume":"100","author":"Hang","year":"2012","journal-title":"J Biomed Mater Res A"},{"key":"key20200713233938_b14-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"11544","DOI":"10.1038\/srep11544","article-title":"Synthesis, characterization and apoptotic activity of quinazolinone Schiff base derivatives toward MCF-7 cells via intrinsic and extrinsic apoptosis pathways","volume":"5","author":"Zahedifard","year":"2015","journal-title":"Sci Rep"},{"key":"key20200713233938_b15-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"3445","DOI":"10.1038\/s41467-018-05821-1","article-title":"Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens","volume":"9","author":"Lin","year":"2018","journal-title":"Nat Commun"},{"key":"key20200713233938_b16-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13567-017-0476-8","article-title":"Variability in the response of canine and human dendritic cells stimulated with Brucella canis","volume":"48","author":"Pujol","year":"2017","journal-title":"Vet Res"},{"key":"key20200713233938_b17-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"317.e7","DOI":"10.1016\/j.chom.2017.07.017","article-title":"A brucella type IV effector targets the COG tethering complex to remodel host secretory traffic and promote intracellular replication","volume":"22","author":"Miller","year":"2017","journal-title":"Cell Host Microbe"},{"key":"key20200713233938_b18-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3389\/fcimb.2018.00171","article-title":"MptpB promotes mycobacteria survival by inhibiting the expression of inflammatory mediators and cell apoptosis in macrophages","volume":"8","author":"Fan","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"key20200713233938_b19-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"e12467","DOI":"10.1111\/cpr.12467","article-title":"Alterations in the nucleocytoplasmic transport in apoptosis: Caspases lead the way","volume":"51","author":"Kopeina","year":"2018","journal-title":"Cell Prolif"},{"key":"key20200713233938_b20-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"E2001","DOI":"10.1073\/pnas.1524900113","article-title":"Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles","volume":"113","author":"Julien","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20200713233938_b21-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.vetmic.2014.08.033","article-title":"Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2","volume":"174","author":"Cui","year":"2014","journal-title":"Vet Microbiol"},{"key":"key20200713233938_b22-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/j.ajpath.2015.03.003","article-title":"Pathogenesis and immunobiology of brucellosis: Review of Brucella-host interactions","volume":"185","author":"de Figueiredo","year":"2015","journal-title":"Am J Pathol"},{"key":"key20200713233938_b23-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1086\/591195","article-title":"The antiviral activities of artemisinin and artesunate","volume":"47","author":"Efferth","year":"2008","journal-title":"Clin Infect Dis"},{"key":"key20200713233938_b24-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.phrs.2018.04.025","article-title":"Artemisinin and its derivatives in treating helminthic infections beyond schistosomiasis","volume":"133","author":"Lam","year":"2018","journal-title":"Pharmacol Res"},{"key":"key20200713233938_b25-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1128\/AAC.01066-05","article-title":"The antimalarial artemisinin synergizes with antibiotics to protect against lethal live Escherichia coli challenge by decreasing proinflammatory cytokine release","volume":"50","author":"Wang","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"key20200713233938_b26-mmr-20-05-4067","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.intimp.2011.02.028","article-title":"Artesunate in combination with oxacillin protect sepsis model mice challenged with lethal live methicillin-resistant Staphylococcus aureus (MRSA) via its inhibition on proinflammatory cytokines release and enhancement on antibacterial activity of oxacillin","volume":"11","author":"Jiang","year":"2011","journal-title":"Int Immunopharmacol"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:36:26Z","timestamp":1594686986000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2019.10672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,11]]},"references-count":26,"URL":"https:\/\/doi.org\/10.3892\/mmr.2019.10672","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,11]]}}}