{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:23:30Z","timestamp":1787505810517,"version":"build-2736575974"},"reference-count":33,"publisher":"Spandidos Publications","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Med Report"],"DOI":"10.3892\/mmr.2019.10686","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T03:25:40Z","timestamp":1568604340000},"source":"Crossref","is-referenced-by-count":9,"title":["Spinosin and 6'''\u2011Feruloylspinosin protect the heart against acute myocardial ischemia and reperfusion in rats"],"prefix":"10.3892","author":[{"given":"Minhua","family":"Gu","sequence":"first","affiliation":[{"name":"School of Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peikun","family":"He","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfei","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saibo","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"key20200713234008_b1-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1177\/1089253211436350","article-title":"Myocardial ischemia reperfusion injury: From basic science to clinical bedside","volume":"16","author":"Frank","year":"2012","journal-title":"Semin Cardiothorac Vasc Anesth"},{"key":"key20200713234008_b2-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1586\/14779072.2015.1070669","article-title":"Myocardial protection from ischemia-reperfusion injury post coronary revascularization","volume":"13","author":"Binder","year":"2015","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"key20200713234008_b3-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jep.2010.03.023","article-title":"Hypnotic effect of jujubosides from Semen Ziziphi Spinosae","volume":"130","author":"Cao","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"key20200713234008_b4-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s11655-012-0998-x","article-title":"Dingxin recipe prevents ischemia\/reperfusion-induced arrhythmias via up-regulating prohibitin and suppressing inflammatory responses","volume":"18","author":"Jia","year":"2012","journal-title":"Chin J Integr Med"},{"key":"key20200713234008_b5-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.pbb.2014.11.003","article-title":"GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice","volume":"128","author":"Liu","year":"2015","journal-title":"Pharmacol Biochem Behav"},{"key":"key20200713234008_b6-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.pbb.2016.03.007","article-title":"Spinosin, a C-glycoside flavonoid, enhances cognitive performance and adult hippocampal neurogenesis in mice","volume":"145","author":"Lee","year":"2016","journal-title":"Pharmacol Biochem Behav"},{"key":"key20200713234008_b7-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"156","DOI":"10.4062\/biomolther.2014.110","article-title":"Spinosin, a C-Glucosylflavone, from Zizyphus jujuba var. Spinosa ameliorates abeta1-42 oligomer-induced memory impairment in Mice","volume":"23","author":"Ko","year":"2015","journal-title":"Biomol Ther (Seoul)"},{"key":"key20200713234008_b8-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"71","DOI":"10.4062\/biomolther.2018.051","article-title":"Neuroprotective effects of spinosin on recovery of learning and memory in a mouse model of Alzheimer's disease","volume":"27","author":"Xu","year":"2019","journal-title":"Biomol Ther (Seoul)"},{"key":"key20200713234008_b9-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.jss.2013.02.051","article-title":"Dobutamine-mediated heme oxygenase-1 induction via PI3K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia\/reperfusion injury in vivo","volume":"183","author":"Wang","year":"2013","journal-title":"J Surg Res"},{"key":"key20200713234008_b10-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.3892\/mmr.2014.2954","article-title":"Cardioprotective effects of tilianin in rat myocardial ischemia-reperfusion injury","volume":"11","author":"Guo","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20200713234008_b11-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1111\/jphp.12945","article-title":"Low-flow ischaemia and reperfusion in rat hearts: Energetic of stunning and cardioprotection of genistein","volume":"70","author":"Colareda","year":"2018","journal-title":"J Pharm Pharmacol"},{"key":"key20200713234008_b12-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"4407","DOI":"10.3892\/mmr.2016.5789","article-title":"Cardioprotective potential of Dendrobium officinale Kimura et Migo against myocardial ischemia in mice","volume":"14","author":"Dou","year":"2016","journal-title":"Mol Med Rep"},{"key":"key20200713234008_b13-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"30373","DOI":"10.1074\/jbc.M602097200","article-title":"NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy","volume":"281","author":"Djavaheri-Mergny","year":"2006","journal-title":"J Biol Chem"},{"key":"key20200713234008_b14-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1161\/CIRCRESAHA.117.311082","article-title":"Autophagy and mitophagy in cardiovascular disease","volume":"120","author":"Bravo-San Pedro","year":"2017","journal-title":"Circ Res"},{"issue":"pii","key":"key20200713234008_b15-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"e00382","DOI":"10.1042\/BSR20160174","article-title":"Knockdown of GSK3\u03b2 increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells","volume":"36","author":"Weikel","year":"2016","journal-title":"Biosci Rep"},{"key":"key20200713234008_b16-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1161\/CIRCRESAHA.109.197996","article-title":"Role of glycogen synthase kinase-3beta in cardioprotection","volume":"104","author":"Juhaszova","year":"2009","journal-title":"Circ Res"},{"key":"key20200713234008_b17-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1002\/ptr.5023","article-title":"Novel insights into the pharmacology of flavonoids","volume":"27","author":"Romano","year":"2013","journal-title":"Phytother Res"},{"key":"key20200713234008_b18-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"11031","DOI":"10.2217\/bmm-2017-0110","article-title":"Oxidative stress in ischemia and reperfusion: Current concepts, novel ideas and future perspectives","volume":"11","author":"Sinning","year":"2017","journal-title":"Biomark Med"},{"key":"key20200713234008_b19-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.bbabio.2006.04.029","article-title":"Mitochondrial ROS-induced ROS release: An update and review","volume":"1757","author":"Zorov","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"key20200713234008_b20-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s10495-017-1376-0","article-title":"Role of glycogen synthase kinase following myocardial infarction and ischemia-reperfusion","volume":"22","author":"Ghaderi","year":"2017","journal-title":"Apoptosis"},{"key":"key20200713234008_b21-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"5592","DOI":"10.1074\/jbc.M114.616714","article-title":"Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells","volume":"290","author":"Marchand","year":"2015","journal-title":"J Biol Chem"},{"key":"key20200713234008_b22-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"4319","DOI":"10.1038\/s41598-017-04593-w","article-title":"PGC-1\u03b1 attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3\u03b2 inactivation mediated by activated p38 in HK-2 Cells","volume":"7","author":"Choi","year":"2017","journal-title":"Sci Rep"},{"key":"key20200713234008_b23-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/ncb2815","article-title":"Emerging regulation and functions of autophagy","volume":"15","author":"Boya","year":"2013","journal-title":"Nat Cell Biol"},{"key":"key20200713234008_b24-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1126\/science.1193497","article-title":"Autophagy and metabolism","volume":"330","author":"Rabinowitz","year":"2010","journal-title":"Science"},{"key":"key20200713234008_b25-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1111\/1440-1681.12309","article-title":"Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: Role of autophagy","volume":"41","author":"Zhang","year":"2014","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"key20200713234008_b26-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1111\/jphp.12567","article-title":"Cardioprotective effect of Salvianolic acid B on acute myocardial infarction by promoting autophagy and neovascularization and inhibiting apoptosis","volume":"68","author":"Lin","year":"2016","journal-title":"J Pharm Pharmacol"},{"key":"key20200713234008_b27-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.molcel.2013.12.014","article-title":"Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy","volume":"53","author":"Rogov","year":"2014","journal-title":"Mol Cell"},{"key":"key20200713234008_b28-mmr-20-05-4253","author":"Gottlieb","year":"2013"},{"key":"key20200713234008_b29-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1172\/JCI10268","article-title":"Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis","volume":"106","author":"Lehman","year":"2000","journal-title":"J Clin Invest"},{"key":"key20200713234008_b30-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1101\/gad.1624208","article-title":"SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis","volume":"22","author":"Olson","year":"2008","journal-title":"Genes Dev"},{"key":"key20200713234008_b31-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"e1373","DOI":"10.1038\/cddis.2014.328","article-title":"The protease Omi regulates mitochondrial biogenesis through the GSK3\u03b2\/PGC-1\u03b1 pathway","volume":"5","author":"Xu","year":"2014","journal-title":"Cell Death Dis"},{"key":"key20200713234008_b32-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: An evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"key20200713234008_b33-mmr-20-05-4253","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jpba.2016.01.005","article-title":"A HPLC-MS\/MS method for determination of 6\u2034-feruloylspinosin in rat plasma and tissues: Pharmacokinetics and tissue distribution study","volume":"121","author":"Qiao","year":"2016","journal-title":"J Pharm Biomed Anal"}],"container-title":["Molecular Medicine Reports"],"original-title":[],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T20:36:39Z","timestamp":1594672599000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/mmr.2019.10686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,16]]},"references-count":33,"URL":"https:\/\/doi.org\/10.3892\/mmr.2019.10686","relation":{},"ISSN":["1791-2997","1791-3004"],"issn-type":[{"value":"1791-2997","type":"print"},{"value":"1791-3004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,16]]}}}